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Items: 38

1.

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo.

Courtney KD, Bezwada D, Mashimo T, Pichumani K, Vemireddy V, Funk AM, Wimberly J, McNeil SS, Kapur P, Lotan Y, Margulis V, Cadeddu JA, Pedrosa I, DeBerardinis RJ, Malloy CR, Bachoo RM, Maher EA.

Cell Metab. 2018 Aug 21. pii: S1550-4131(18)30463-7. doi: 10.1016/j.cmet.2018.07.020. [Epub ahead of print]

PMID:
30146487
2.

Targeting orthotopic gliomas with renal-clearable luminescent gold nanoparticles.

Peng C, Gao X, Xu J, Du B, Ning X, Tang S, Bachoo RM, Yu M, Ge WP, Zheng J.

Nano Res. 2017 Apr;10(4):1366-1376. doi: 10.1007/s12274-017-1472-z. Epub 2017 Feb 21.

3.

Measurement of 13 C turnover into glutamate and glutamine pools in brain tumor patients.

Pichumani K, Mashimo T, Vemireddy V, Ijare OB, Mickey BE, Malloy CR, Marin-Valencia I, Baskin DS, Bachoo RM, Maher EA.

FEBS Lett. 2017 Nov;591(21):3548-3554. doi: 10.1002/1873-3468.12867. Epub 2017 Oct 27.

PMID:
28963851
4.

Rapid progression to glioblastoma in a subset of IDH-mutated astrocytomas: a genome-wide analysis.

Richardson TE, Snuderl M, Serrano J, Karajannis MA, Heguy A, Oliver D, Raisanen JM, Maher EA, Pan E, Barnett S, Cai C, Habib AA, Bachoo RM, Hatanpaa KJ.

J Neurooncol. 2017 May;133(1):183-192. doi: 10.1007/s11060-017-2431-y. Epub 2017 Apr 18.

PMID:
28421459
5.

Prospective Longitudinal Analysis of 2-Hydroxyglutarate Magnetic Resonance Spectroscopy Identifies Broad Clinical Utility for the Management of Patients With IDH-Mutant Glioma.

Choi C, Raisanen JM, Ganji SK, Zhang S, McNeil SS, An Z, Madan A, Hatanpaa KJ, Vemireddy V, Sheppard CA, Oliver D, Hulsey KM, Tiwari V, Mashimo T, Battiste J, Barnett S, Madden CJ, Patel TR, Pan E, Malloy CR, Mickey BE, Bachoo RM, Maher EA.

J Clin Oncol. 2016 Nov 20;34(33):4030-4039. doi: 10.1200/JCO.2016.67.1222. Epub 2016 Oct 31.

6.

Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma.

Singh DK, Kollipara RK, Vemireddy V, Yang XL, Sun Y, Regmi N, Klingler S, Hatanpaa KJ, Raisanen J, Cho SK, Sirasanagandla S, Nannepaga S, Piccirillo S, Mashimo T, Wang S, Humphries CG, Mickey B, Maher EA, Zheng H, Kim RS, Kittler R, Bachoo RM.

Cell Rep. 2017 Jan 24;18(4):961-976. doi: 10.1016/j.celrep.2016.12.064.

7.

Hepatic gluconeogenesis influences (13)C enrichment in lactate in human brain tumors during metabolism of [1,2-(13)C]acetate.

Pichumani K, Mashimo T, Vemireddy V, Kovacs Z, Ratnakar J, Mickey B, Malloy CR, DeBerardinis RJ, Bachoo RM, Maher EA.

Neurochem Int. 2016 Jul;97:133-6. doi: 10.1016/j.neuint.2016.03.015. Epub 2016 Mar 26.

8.

Conditions for (13)C NMR detection of 2-hydroxyglutarate in tissue extracts from isocitrate dehydrogenase-mutated gliomas.

Pichumani K, Mashimo T, Baek HM, Ratnakar J, Mickey B, DeBerardinis RJ, Maher EA, Bachoo RM, Malloy CR, Kovacs Z.

Anal Biochem. 2015 Jul 15;481:4-6. doi: 10.1016/j.ab.2015.04.017. Epub 2015 Apr 20.

9.

Acetate is a bioenergetic substrate for human glioblastoma and brain metastases.

Mashimo T, Pichumani K, Vemireddy V, Hatanpaa KJ, Singh DK, Sirasanagandla S, Nannepaga S, Piccirillo SG, Kovacs Z, Foong C, Huang Z, Barnett S, Mickey BE, DeBerardinis RJ, Tu BP, Maher EA, Bachoo RM.

Cell. 2014 Dec 18;159(7):1603-14. doi: 10.1016/j.cell.2014.11.025.

10.

¹H MRS characterization of neurochemical profiles in orthotopic mouse models of human brain tumors.

Hulsey KM, Mashimo T, Banerjee A, Soesbe TC, Spence JS, Vemireddy V, Maher EA, Bachoo RM, Choi C.

NMR Biomed. 2015 Jan;28(1):108-15. doi: 10.1002/nbm.3231. Epub 2014 Nov 13.

PMID:
25394324
11.

Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo.

Madan A, Ganji SK, An Z, Choe KS, Pinho MC, Bachoo RM, Maher EM, Choi C.

Magn Reson Med. 2015 Jun;73(6):2094-9. doi: 10.1002/mrm.25352. Epub 2014 Jul 7.

12.

In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma.

Sagiyama K, Mashimo T, Togao O, Vemireddy V, Hatanpaa KJ, Maher EA, Mickey BE, Pan E, Sherry AD, Bachoo RM, Takahashi M.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4542-7. doi: 10.1073/pnas.1323855111. Epub 2014 Mar 10.

13.

High expression of the stem cell marker nestin is an adverse prognostic factor in WHO grade II-III astrocytomas and oligoastrocytomas.

Hatanpaa KJ, Hu T, Vemireddy V, Foong C, Raisanen JM, Oliver D, Hiemenz MC, Burns DK, White CL 3rd, Whitworth LA, Mickey B, Stegner M, Habib AA, Fink K, Maher EA, Bachoo RM.

J Neurooncol. 2014 Mar;117(1):183-189. doi: 10.1007/s11060-014-1376-7. Epub 2014 Feb 12.

14.

In vivo detection of citrate in brain tumors by 1H magnetic resonance spectroscopy at 3T.

Choi C, Ganji SK, Madan A, Hulsey KM, An Z, Zhang S, Pinho MC, DeBerardinis RJ, Bachoo RM, Maher EA.

Magn Reson Med. 2014 Aug;72(2):316-23. doi: 10.1002/mrm.24946. Epub 2013 Oct 1.

15.

Progenitor cell line (hPheo1) derived from a human pheochromocytoma tumor.

Ghayee HK, Bhagwandin VJ, Stastny V, Click A, Ding LH, Mizrachi D, Zou YS, Chari R, Lam WL, Bachoo RM, Smith AL, Story MD, Sidhu S, Robinson BG, Nwariaku FE, Gazdar AF, Auchus RJ, Shay JW.

PLoS One. 2013 Jun 13;8(6):e65624. doi: 10.1371/journal.pone.0065624. Print 2013.

16.

Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.

Fenton TR, Nathanson D, Ponte de Albuquerque C, Kuga D, Iwanami A, Dang J, Yang H, Tanaka K, Oba-Shinjo SM, Uno M, Inda MM, Wykosky J, Bachoo RM, James CD, DePinho RA, Vandenberg SR, Zhou H, Marie SK, Mischel PS, Cavenee WK, Furnari FB.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14164-9. doi: 10.1073/pnas.1211962109. Epub 2012 Aug 13.

17.

Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo.

Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, Cai L, Good L, Tu BP, Hatanpaa KJ, Mickey BE, Matés JM, Pascual JM, Maher EA, Malloy CR, Deberardinis RJ, Bachoo RM.

Cell Metab. 2012 Jun 6;15(6):827-37. doi: 10.1016/j.cmet.2012.05.001. Erratum in: Cell Metab. 2012 Nov 7;16(5):686.

18.

Metabolism of [U-13 C]glucose in human brain tumors in vivo.

Maher EA, Marin-Valencia I, Bachoo RM, Mashimo T, Raisanen J, Hatanpaa KJ, Jindal A, Jeffrey FM, Choi C, Madden C, Mathews D, Pascual JM, Mickey BE, Malloy CR, DeBerardinis RJ.

NMR Biomed. 2012 Nov;25(11):1234-44. doi: 10.1002/nbm.2794. Epub 2012 Mar 15.

19.

Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.

Marin-Valencia I, Cho SK, Rakheja D, Hatanpaa KJ, Kapur P, Mashimo T, Jindal A, Vemireddy V, Good LB, Raisanen J, Sun X, Mickey B, Choi C, Takahashi M, Togao O, Pascual JM, Deberardinis RJ, Maher EA, Malloy CR, Bachoo RM.

NMR Biomed. 2012 Oct;25(10):1177-86. doi: 10.1002/nbm.2787. Epub 2012 Mar 1.

20.

2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.

Choi C, Ganji SK, DeBerardinis RJ, Hatanpaa KJ, Rakheja D, Kovacs Z, Yang XL, Mashimo T, Raisanen JM, Marin-Valencia I, Pascual JM, Madden CJ, Mickey BE, Malloy CR, Bachoo RM, Maher EA.

Nat Med. 2012 Jan 26;18(4):624-9. doi: 10.1038/nm.2682.

21.

Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression.

Zhang L, Li P, Hsu T, Aguilar HR, Frantz DE, Schneider JW, Bachoo RM, Hsieh J.

Differentiation. 2011 Apr;81(4):233-42. doi: 10.1016/j.diff.2011.02.005. Epub 2011 Mar 17.

22.

Loss of p15/Ink4b accompanies tumorigenesis triggered by complex DNA double-strand breaks.

Camacho CV, Mukherjee B, McEllin B, Ding LH, Hu B, Habib AA, Xie XJ, Nirodi CS, Saha D, Story MD, Balajee AS, Bachoo RM, Boothman DA, Burma S.

Carcinogenesis. 2010 Oct;31(10):1889-96. doi: 10.1093/carcin/bgq153. Epub 2010 Jul 26.

23.

PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.

McEllin B, Camacho CV, Mukherjee B, Hahm B, Tomimatsu N, Bachoo RM, Burma S.

Cancer Res. 2010 Jul 1;70(13):5457-64. doi: 10.1158/0008-5472.CAN-09-4295. Epub 2010 Jun 8.

24.

The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth.

Marian CO, Cho SK, McEllin BM, Maher EA, Hatanpaa KJ, Madden CJ, Mickey BE, Wright WE, Shay JW, Bachoo RM.

Clin Cancer Res. 2010 Jan 1;16(1):154-63. doi: 10.1158/1078-0432.CCR-09-2850.

25.

Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.

Yang C, Sudderth J, Dang T, Bachoo RM, McDonald JG, DeBerardinis RJ.

Cancer Res. 2009 Oct 15;69(20):7986-93. doi: 10.1158/0008-5472.CAN-09-2266. Epub 2009 Oct 13. Erratum in: Cancer Res. 2010 Feb 1;70(3):1275. Bachoo, Robert G [corrected to Bachoo, Robert M].

26.

EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma.

Mukherjee B, McEllin B, Camacho CV, Tomimatsu N, Sirasanagandala S, Nannepaga S, Hatanpaa KJ, Mickey B, Madden C, Maher E, Boothman DA, Furnari F, Cavenee WK, Bachoo RM, Burma S.

Cancer Res. 2009 May 15;69(10):4252-9. doi: 10.1158/0008-5472.CAN-08-4853. Epub 2009 May 12.

27.

The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma.

Park S, Hatanpaa KJ, Xie Y, Mickey BE, Madden CJ, Raisanen JM, Ramnarain DB, Xiao G, Saha D, Boothman DA, Zhao D, Bachoo RM, Pieper RO, Habib AA.

Cancer Res. 2009 Apr 1;69(7):2809-16. doi: 10.1158/0008-5472.CAN-08-4079.

28.

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway.

de la Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, Depinho RA, Bonni A.

Genes Dev. 2008 Feb 15;22(4):449-62. doi: 10.1101/gad.1606508. Epub 2008 Feb 7.

29.

Functional skeletal muscle regeneration from differentiating embryonic stem cells.

Darabi R, Gehlbach K, Bachoo RM, Kamath S, Osawa M, Kamm KE, Kyba M, Perlingeiro RC.

Nat Med. 2008 Feb;14(2):134-43. doi: 10.1038/nm1705. Epub 2008 Jan 20.

PMID:
18204461
30.

Malignant astrocytic glioma: genetics, biology, and paths to treatment.

Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK.

Genes Dev. 2007 Nov 1;21(21):2683-710. Review.

31.

Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.

Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD, Rowitch DH.

Neuron. 2007 Feb 15;53(4):503-17.

32.

Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma.

Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L.

Genes Dev. 2007 Jan 1;21(1):98-111. Erratum in: Genes Dev. 2007 Feb 15;21(4):481.

33.

PCAF modulates PTEN activity.

Okumura K, Mendoza M, Bachoo RM, DePinho RA, Cavenee WK, Furnari FB.

J Biol Chem. 2006 Sep 8;281(36):26562-8. Epub 2006 Jul 7.

34.

Three-dimensional visualization of microvessel architecture of whole-mount tissue by confocal microscopy.

Dickie R, Bachoo RM, Rupnick MA, Dallabrida SM, Deloid GM, Lai J, Depinho RA, Rogers RA.

Microvasc Res. 2006 Jul-Sep;72(1-2):20-6. Epub 2006 Jun 23.

PMID:
16806289
35.

Molecular diversity of astrocytes with implications for neurological disorders.

Bachoo RM, Kim RS, Ligon KL, Maher EA, Brennan C, Billings N, Chan S, Li C, Rowitch DH, Wong WH, DePinho RA.

Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8384-9. Epub 2004 May 21.

36.

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.

Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA.

Nature. 2003 Feb 6;421(6923):643-8. Epub 2003 Jan 22.

PMID:
12540856
37.

Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.

Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA.

Cancer Cell. 2002 Apr;1(3):269-77.

38.

Malignant glioma: genetics and biology of a grave matter.

Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA.

Genes Dev. 2001 Jun 1;15(11):1311-33. Review. No abstract available.

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