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Association of caspase 8 polymorphisms -652 6N InsDel and Asp302His with progression-free survival and tumor infiltrating lymphocytes in early breast cancer.

Kuhlmann JD, Bachmann HS, Link T, Wimberger P, Kröber E, Thomssen C, Mallé B, Bethmann D, Vetter M, Kantelhardt EJ.

Sci Rep. 2019 Aug 29;9(1):12594. doi: 10.1038/s41598-019-47601-x.


SNPs Within the MTOR Gene Are Associated With an Increased Risk of Developing De Novo Diabetes Mellitus Following the Administration of Everolimus in Liver Transplant Recipients.

Husen P, Straub K, Willuweit K, Hagemann A, Wedemeyer H, Bachmann HS, Herzer K.

Transplant Proc. 2019 Jul - Aug;51(6):1962-1971. doi: 10.1016/j.transproceed.2019.03.027. Epub 2019 Jul 11.


Genetic contribution to PONV risk.

Klenke S, de Vries GJ, Schiefer L, Seyffert N, Bachmann HS, Peters J, Frey UH.

Anaesth Crit Care Pain Med. 2019 May 8. pii: S2352-5568(18)30570-8. doi: 10.1016/j.accpm.2019.04.012. [Epub ahead of print]


Side Effects of Frequently Used Antihypertensive Drugs on Wound Healing in vitro.

Stuermer EK, Besser M, Terberger N, Bachmann HS, Severing AL.

Skin Pharmacol Physiol. 2019;32(3):162-172. doi: 10.1159/000499433. Epub 2019 Apr 24.


The small molecule Bcl-2/Mcl-1 inhibitor TW-37 shows single-agent cytotoxicity in neuroblastoma cell lines.

Klenke S, Akdeli N, Stelmach P, Heukamp L, Schulte JH, Bachmann HS.

BMC Cancer. 2019 Mar 18;19(1):243. doi: 10.1186/s12885-019-5439-1.


Side effects of frequently used oral antidiabetics on wound healing in vitro.

Stuermer EK, Besser M, Terberger N, Koester V, Bachmann HS, Severing AL.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Mar;392(3):371-380. doi: 10.1007/s00210-018-01597-9. Epub 2018 Dec 7.


No Association of CALCA Polymorphisms and Aseptic Loosening after Primary Total Hip Arthroplasty.

Aydin-Yüce T, Kurscheid G, Bachmann HS, Gehrke T, Dudda M, Jäger M, Wedemeyer C, Kauther MD.

Biomed Res Int. 2018 Jun 5;2018:3687415. doi: 10.1155/2018/3687415. eCollection 2018.


CHRM3 rs2165870 polymorphism is independently associated with postoperative nausea and vomiting, but combined prophylaxis is effective.

Klenke S, de Vries GJ, Schiefer L, Seyffert N, Bachmann HS, Peters J, Frey UH.

Br J Anaesth. 2018 Jul;121(1):58-65. doi: 10.1016/j.bja.2018.02.025. Epub 2018 Apr 4.


Allosteric Activation of GDP-Bound Ras Isoforms by Bisphenol Derivative Plasticisers.

Schöpel M, Shkura O, Seidel J, Kock K, Zhong X, Löffek S, Helfrich I, Bachmann HS, Scherkenbeck J, Herrmann C, Stoll R.

Int J Mol Sci. 2018 Apr 10;19(4). pii: E1133. doi: 10.3390/ijms19041133.


Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit.

Hagemann A, Müller G, Manthey I, Bachmann HS.

FEBS Lett. 2017 Nov;591(21):3637-3648. doi: 10.1002/1873-3468.12862. Epub 2017 Oct 11.


A single intraperitoneal injection of bovine fetuin-A attenuates bone resorption in a murine calvarial model of particle-induced osteolysis.

Jablonski H, Polan C, Wedemeyer C, Hilken G, Schlepper R, Bachmann HS, Grabellus F, Dudda M, Jäger M, Kauther MD.

Bone. 2017 Dec;105:262-268. doi: 10.1016/j.bone.2017.09.006. Epub 2017 Sep 21.


Relationship between GNAS1 T393C polymorphism and aseptic loosening after total hip arthroplasty.

Stelmach P, Kauther MD, Fuest L, Kurscheid G, Gehrke T, Klenke S, Jäger M, Wedemeyer C, Bachmann HS.

Eur J Med Res. 2017 Aug 23;22(1):29. doi: 10.1186/s40001-017-0271-z.


Hypoxia Inducible Factor-2 Alpha and Prolinhydroxylase 2 Polymorphisms in Patients with Acute Respiratory Distress Syndrome (ARDS).

Dötsch A, Eisele L, Rabeling M, Rump K, Walstein K, Bick A, Cox L, Engler A, Bachmann HS, Jöckel KH, Adamzik M, Peters J, Schäfer ST.

Int J Mol Sci. 2017 Jun 14;18(6). pii: E1266. doi: 10.3390/ijms18061266.


Impact of BCL2 polymorphisms on survival in transitional cell carcinoma of the bladder.

Hess J, Stelmach P, Eisenhardt A, Rübben H, Reis H, Schmid KW, Bachmann HS.

J Cancer Res Clin Oncol. 2017 Sep;143(9):1659-1670. doi: 10.1007/s00432-017-2404-8. Epub 2017 Apr 17.


Hypoxia inducible factor-1 alpha and prolinhydroxlase 2 polymorphisms in patients with severe sepsis: a prospective observational trial.

Höcker A, Rabeling M, Bick A, Cox L, Kreuzer M, Engler A, Walstein K, Bachmann HS, Jöckel KH, Eisele L, Adamzik M, Peters J, Schäfer ST.

BMC Anesthesiol. 2016 Aug 11;16(1):61. doi: 10.1186/s12871-016-0225-y.


Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer.

Kuhlmann JD, Bankfalvi A, Schmid KW, Callies R, Kimmig R, Wimberger P, Siffert W, Bachmann HS.

BMC Cancer. 2016 Aug 9;16:618. doi: 10.1186/s12885-016-2662-x.


Association of a Common Oxytocin Receptor Gene Polymorphism with Self-Reported 'Empathic Concern' in a Large Population of Healthy Volunteers.

Huetter FK, Bachmann HS, Reinders A, Siffert D, Stelmach P, Knop D, Horn PA, Siffert W.

PLoS One. 2016 Jul 28;11(7):e0160059. doi: 10.1371/journal.pone.0160059. eCollection 2016.


A Single Dose of the Anti-Resorptive Peptide Human Calcitonin Paradoxically Augments Particle- and Endotoxin-Mediated Pro-Inflammatory Cytokine Production In Vitro.

Jablonski H, Wedemeyer C, Bachmann HS, Schlagkamp M, Bernstein A, Jäger M, Kauther MD.

Horm Metab Res. 2016 Sep;48(9):607-12. doi: 10.1055/s-0042-108338. Epub 2016 Jun 3.


The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty.

Stelmach P, Wedemeyer C, Fuest L, Kurscheid G, Gehrke T, Klenke S, Jäger M, Kauther MD, Bachmann HS.

PLoS One. 2016 Feb 16;11(2):e0149528. doi: 10.1371/journal.pone.0149528. eCollection 2016.


Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging.

Stoffels I, Morscher S, Helfrich I, Hillen U, Leyh J, Burton NC, Sardella TC, Claussen J, Poeppel TD, Bachmann HS, Roesch A, Griewank K, Schadendorf D, Gunzer M, Klode J.

Sci Transl Med. 2015 Dec 9;7(317):317ra199. doi: 10.1126/scitranslmed.aad1278. Erratum in: Sci Transl Med. 2015 Dec 23;7(319):319er8. Lehy, Julia [corrected to Leyh, Julia].


Absence of telomerase reverse transcriptase promoter mutations in neuroblastoma.

Lindner S, Bachmann HS, Odersky A, Schaefers S, Klein-Hitpass L, Hero B, Fischer M, Eggert A, Schramm A, Schulte JH.

Biomed Rep. 2015 Jul;3(4):443-446. Epub 2015 May 13.


AQP1, AQP5, Bcl-2 and p16 in pharyngeal squamous cell carcinoma.

Lehnerdt GF, Bachmann HS, Adamzik M, Panic A, Köksal E, Weller P, Lang S, Schmid KW, Siffert W, Bankfalvi A.

J Laryngol Otol. 2015 Jun;129(6):580-6. doi: 10.1017/S002221511500119X.


The FNTB promoter polymorphism rs11623866 as a potential predictive biomarker for lonafarnib treatment of ovarian cancer patients.

Bachmann HS, Meier W, du Bois A, Kimmig R, Kuhlmann JD, Siffert W, Sehouli J, Wollschlaeger K, Huober J, Hillemanns P, Burges A, Schmalfeldt B, Aminossadati B, Wimberger P.

Br J Clin Pharmacol. 2015 Nov;80(5):1139-48. doi: 10.1111/bcp.12688. Epub 2015 Jul 22.


Calcitonin gene-related peptide modulates the production of pro-inflammatory cytokines associated with periprosthetic osteolysis by THP-1 macrophage-like cells.

Jablonski H, Kauther MD, Bachmann HS, Jäger M, Wedemeyer C.

Neuroimmunomodulation. 2015;22(3):152-65. doi: 10.1159/000360988. Epub 2014 May 14.


A 3'UTR polymorphism modulates mRNA stability of the oncogene and drug target Polo-like Kinase 1.

Akdeli N, Riemann K, Westphal J, Hess J, Siffert W, Bachmann HS.

Mol Cancer. 2014 Apr 26;13:87. doi: 10.1186/1476-4598-13-87.


The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia.

Künkele A, Grosse-Lordemann A, Schramm A, Eggert A, Schulte JH, Bachmann HS.

BMC Cancer. 2013 Oct 2;13:452. doi: 10.1186/1471-2407-13-452.


Risk factors for thrombus formation on the Amplatzer Cardiac Plug after left atrial appendage occlusion.

Plicht B, Konorza TF, Kahlert P, Al-Rashid F, Kaelsch H, Jánosi RA, Buck T, Bachmann HS, Siffert W, Heusch G, Erbel R.

JACC Cardiovasc Interv. 2013 Jun;6(6):606-13. doi: 10.1016/j.jcin.2013.02.014.


Expression of aquaporin 5 and the AQP5 polymorphism A(-1364)C in association with peritumoral brain edema in meningioma patients.

Lambertz N, Hindy NE, Adler C, Rump K, Adamzik M, Keyvani K, Bankfalvi A, Siffert W, Erol Sandalcioglu I, Bachmann HS.

J Neurooncol. 2013 Apr;112(2):297-305. doi: 10.1007/s11060-013-1064-z. Epub 2013 Feb 8.


RANKL-associated suppression of particle-induced osteolysis in an aged model of Calcitonin and α-CGRP deficiency.

Kauther MD, Neuerburg C, Wefelnberg F, Bachmann HS, Schlepper R, Hilken G, Broecker-Preuss M, Grabellus F, Schilling AF, Jäger M, Wedemeyer C.

Biomaterials. 2013 Apr;34(12):2911-9. doi: 10.1016/j.biomaterials.2013.01.034. Epub 2013 Jan 26.


Role of the GNAS1 T393C polymorphism in patients with glioblastoma multiforme.

El Hindy N, Lambertz N, Bachmann HS, Frey UH, Adamzik M, Zhu Y, Sure U, Siffert W, Sandalcioglu IE.

J Clin Neurosci. 2011 Nov;18(11):1495-9. doi: 10.1016/j.jocn.2011.02.044. Epub 2011 Sep 15.


Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas.

Bergmann C, Bachmann HS, Bankfalvi A, Lotfi R, Pütter C, Wild CA, Schuler PJ, Greve J, Hoffmann TK, Lang S, Scherag A, Lehnerdt GF.

J Transl Med. 2011 Aug 21;9:139. doi: 10.1186/1479-5876-9-139.


Calcitonin substitution in calcitonin deficiency reduces particle-induced osteolysis.

Kauther MD, Bachmann HS, Neuerburg L, Broecker-Preuss M, Hilken G, Grabellus F, Koehler G, von Knoch M, Wedemeyer C.

BMC Musculoskelet Disord. 2011 Aug 15;12:186. doi: 10.1186/1471-2474-12-186.


The prevalence of the c-kit exon 10 variant, M541L, in aggressive fibromatosis does not differ from the general population.

Grabellus F, Worm K, Sheu SY, Siffert W, Schmid KW, Bachmann HS.

J Clin Pathol. 2011 Nov;64(11):1021-4. doi: 10.1136/jcp.2011.090498. Epub 2011 Jul 13.


Influence of the 393T>C polymorphism of the GNAS1 gene on the intensity of opiate withdrawal.

Bachmann HS, Lieb B, Bonnet U, Specka M, Augener S, Siffert W, Scherbaum N.

Pharmacopsychiatry. 2011 Jun;44(4):159-60. doi: 10.1055/s-0031-1279727. Epub 2011 Jun 27.


High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma.

Schulte JH, Bachmann HS, Brockmeyer B, Depreter K, Oberthür A, Ackermann S, Kahlert Y, Pajtler K, Theissen J, Westermann F, Vandesompele J, Speleman F, Berthold F, Eggert A, Brors B, Hero B, Schramm A, Fischer M.

Clin Cancer Res. 2011 Aug 1;17(15):5082-92. doi: 10.1158/1078-0432.CCR-10-2809. Epub 2011 Jun 1.


Association of the CC genotype of the regulatory BCL2 promoter polymorphism (-938C>A) with better 2-year survival in patients with glioblastoma multiforme.

El Hindy N, Bachmann HS, Lambertz N, Adamzik M, Nückel H, Worm K, Zhu Y, Sure U, Siffert W, Sandalcioglu IE.

J Neurosurg. 2011 Jun;114(6):1631-9. doi: 10.3171/2010.12.JNS10478. Epub 2011 Jan 21.


Regulatory BCL2 promoter polymorphism (-938C>A) is associated with adverse outcome in patients with prostate carcinoma.

Bachmann HS, Heukamp LC, Schmitz KJ, Hilburn CF, Kahl P, Buettner R, Nückel H, Eisenhardt A, Rübben H, Schmid KW, Siffert W, Eggert A, Schramm A, Schulte JH.

Int J Cancer. 2011 Nov 15;129(10):2390-9. doi: 10.1002/ijc.25904. Epub 2011 Mar 25.


A Rare Case of Propofol-Induced Acute Liver Failure and Literature Review.

Kneiseler G, Bachmann HS, Bechmann LP, Dechene A, Heyer T, Baba H, Saner F, Jochum C, Gerken G, Canbay A.

Case Rep Gastroenterol. 2010 Feb 6;4(1):57-65.


The XbaI G>T polymorphism of the glucose transporter 1 gene modulates 18F-FDG uptake and tumor aggressiveness in breast cancer.

Grabellus F, Sheu SY, Bachmann HS, Lehmann N, Otterbach F, Heusner TA, Antoch G, Bockisch A, Kimmig R, Schmid KW, Stahl AR.

J Nucl Med. 2010 Aug;51(8):1191-7. doi: 10.2967/jnumed.110.075721.


The G-Allele of the PSMA6-8C>G polymorphism is associated with poor outcome in multiple myeloma independently of circulating proteasome serum levels.

Bachmann HS, Novotny J, Sixt S, Liebisch P, Frey UH, Dührsen U, Siffert W, Nückel H.

Eur J Haematol. 2010 Aug;85(2):108-13. doi: 10.1111/j.1600-0609.2010.01455.x. Epub 2010 Apr 8.


Association of the GNB3 825T-allele with better survival in patients with glioblastoma multiforme.

El Hindy N, Adamzik M, Lambertz N, Bachmann HS, Worm K, Egensperger R, Frey UH, Asgari S, Sure U, Siffert W, Sandalcioglu IE.

J Cancer Res Clin Oncol. 2010 Sep;136(9):1423-9. doi: 10.1007/s00432-010-0797-8. Epub 2010 Feb 10.


DNA repair gene XRCC1 polymorphisms and outcome of renal cell carcinoma in Caucasian patients.

Bachmann HS, Rübben H, Schmid KW, Siffert W, Riemann K.

Anticancer Res. 2009 Dec;29(12):5131-5.


BCL2-938C>A and CALCA-1786T>C polymorphisms in aseptic loosened total hip arthroplasty.

Wedemeyer C, Kauther MD, Hanenkamp S, Nückel H, Bau M, Siffert W, Bachmann HS.

Eur J Med Res. 2009 Jun 18;14(6):250-5.


Intensity of opiate withdrawal in relation to the 825C>T polymorphism of the G-protein beta 3 subunit gene.

Lieb B, Bonnet U, Specka M, Augener S, Bachmann HS, Siffert W, Scherbaum N.

Prog Neuropsychopharmacol Biol Psychiatry. 2009 Jun 15;33(4):663-7. doi: 10.1016/j.pnpbp.2009.03.008. Epub 2009 Mar 19.


The regulatory BCL2 promoter polymorphism (-938C>A) is associated with relapse and survival of patients with oropharyngeal squamous cell carcinoma.

Lehnerdt GF, Franz P, Bankfalvi A, Grehl S, Kelava A, Nückel H, Lang S, Schmid KW, Siffert W, Bachmann HS.

Ann Oncol. 2009 Jun;20(6):1094-9. doi: 10.1093/annonc/mdn763. Epub 2009 Feb 5.


PCR-amplification of GC-rich regions: 'slowdown PCR'.

Frey UH, Bachmann HS, Peters J, Siffert W.

Nat Protoc. 2008;3(8):1312-7. doi: 10.1038/nprot.2008.112.


Gender-dependent association of the GNAS1 T393C polymorphism with early aseptic loosening after total hip arthroplasty.

Bachmann HS, Hanenkamp S, Kornacki B, Frey UH, Bau M, Siffert W, Wedemeyer C.

J Orthop Res. 2008 Dec;26(12):1562-8. doi: 10.1002/jor.20699.


Methods to evaluate the pharmacology of oral antiplatelet drugs.

Weber AA, Adamzik M, Bachmann HS, Görlinger K, Grandoch M, Leineweber K, Müller-Beissenhirtz H, Wenzel F, Naber C; Interdisciplinary Study Group - Clinical Pharmacology of Haemostasis.

Herz. 2008 Jun;33(4):287-96. doi: 10.1007/s00059-008-3132-2. Review.


[Methods to evaluate aspirin and clopidogrel resistance].

Weber AA, Adamzik M, Bachmann HS, Görlinger K, Grandoch M, Leineweber K, Müller-Beissenhirtz H, Wenzel F, Naber C; für die interdisziplinäre Studiengruppe Clinical Pharmacology of Haemostasis.

Hamostaseologie. 2008 Feb;28(1-2):66-71. Review. German.


The AA genotype of the regulatory BCL2 promoter polymorphism ( 938C>A) is associated with a favorable outcome in lymph node negative invasive breast cancer patients.

Bachmann HS, Otterbach F, Callies R, Nückel H, Bau M, Schmid KW, Siffert W, Kimmig R.

Clin Cancer Res. 2007 Oct 1;13(19):5790-7.

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