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Items: 43


Next-Generation Sequencing Reveals Increased Anti-oxidant Response and Ecdysone Signaling in STAT Supercompetitors in Drosophila.

Sitaram P, Lu S, Harsh S, Herrera SC, Bach EA.

G3 (Bethesda). 2019 Aug 8;9(8):2609-2622. doi: 10.1534/g3.119.400345.


Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity.

Bailetti AA, Negrón-Piñeiro LJ, Dhruva V, Harsh S, Lu S, Bosula A, Bach EA.

Dis Model Mech. 2019 May 30;12(5). pii: dmm038679. doi: 10.1242/dmm.038679.


JAK/STAT signaling in stem cells and regeneration: from Drosophila to vertebrates.

Herrera SC, Bach EA.

Development. 2019 Jan 29;146(2). pii: dev167643. doi: 10.1242/dev.167643. Review.


Super-Competitors Game the Fitness Sensing System.

Herrera SC, Bach EA.

Dev Cell. 2018 Sep 24;46(6):672-674. doi: 10.1016/j.devcel.2018.09.006.


Chinmo prevents transformer alternative splicing to maintain male sex identity.

Grmai L, Hudry B, Miguel-Aliaga I, Bach EA.

PLoS Genet. 2018 Feb 1;14(2):e1007203. doi: 10.1371/journal.pgen.1007203. eCollection 2018 Feb.


Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT.

Court H, Ahearn IM, Amoyel M, Bach EA, Philips MR.

J Cell Biol. 2017 Dec 4;216(12):4165-4182. doi: 10.1083/jcb.201701053. Epub 2017 Oct 19.


A Genetic Screen Reveals an Unexpected Role for Yorkie Signaling in JAK/STAT-Dependent Hematopoietic Malignancies in Drosophila melanogaster.

Anderson AM, Bailetti AA, Rodkin E, De A, Bach EA.

G3 (Bethesda). 2017 Aug 7;7(8):2427-2438. doi: 10.1534/g3.117.044172.


Somatic stem cell differentiation is regulated by PI3K/Tor signaling in response to local cues.

Amoyel M, Hillion KH, Margolis SR, Bach EA.

Development. 2016 Nov 1;143(21):3914-3925. Epub 2016 Sep 15.


Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila Testis.

Amoyel M, Anderson J, Suisse A, Glasner J, Bach EA.

PLoS Genet. 2016 Jan 25;12(1):e1005815. doi: 10.1371/journal.pgen.1005815. eCollection 2016 Jan.


MT-Nanotubes: Lifelines for Stem Cells.

Amoyel M, Bach EA.

Cell Stem Cell. 2015 Aug 6;17(2):133-4. doi: 10.1016/j.stem.2015.07.004.


Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo.

Amoyel M, Simons BD, Bach EA.

EMBO J. 2014 Oct 16;33(20):2295-313. doi: 10.15252/embj.201387500. Epub 2014 Aug 4.


JAK/STAT pathway dysregulation in tumors: a Drosophila perspective.

Amoyel M, Anderson AM, Bach EA.

Semin Cell Dev Biol. 2014 Apr;28:96-103. doi: 10.1016/j.semcdb.2014.03.023. Epub 2014 Mar 28. Review.


Cell competition: how to eliminate your neighbours.

Amoyel M, Bach EA.

Development. 2014 Mar;141(5):988-1000. doi: 10.1242/dev.079129. Review.


Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.

Court H, Amoyel M, Hackman M, Lee KE, Xu R, Miller G, Bar-Sagi D, Bach EA, Bergö MO, Philips MR.

J Clin Invest. 2013 Nov;123(11):4681-94.


Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.

Zoranovic T, Grmai L, Bach EA.

JAKSTAT. 2013 Jul 1;2(3):e25408. doi: 10.4161/jkst.25408. Epub 2013 Jun 17. Review.


JAK/STAT signaling is required for hinge growth and patterning in the Drosophila wing disc.

Ayala-Camargo A, Anderson AM, Amoyel M, Rodrigues AB, Flaherty MS, Bach EA.

Dev Biol. 2013 Oct 15;382(2):413-26. doi: 10.1016/j.ydbio.2013.08.016. Epub 2013 Aug 23.


Hedgehog is required for CySC self-renewal but does not contribute to the GSC niche in the Drosophila testis.

Amoyel M, Sanny J, Burel M, Bach EA.

Development. 2013 Jan 1;140(1):56-65. doi: 10.1242/dev.086413. Epub 2012 Nov 22.


Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis.

Rodrigues AB, Zoranovic T, Ayala-Camargo A, Grewal S, Reyes-Robles T, Krasny M, Wu DC, Johnston LA, Bach EA.

Development. 2012 Nov;139(21):4051-61. doi: 10.1242/dev.076760. Epub 2012 Sep 19.


Functions of the Drosophila JAK-STAT pathway: Lessons from stem cells.

Amoyel M, Bach EA.

JAKSTAT. 2012 Jul 1;1(3):176-83. doi: 10.4161/jkst.21621. Review.


Inhibition of the signalling kinase JAK3 alleviates inflammation in monoarthritic rats.

Kim BH, Kim M, Yin CH, Jee JG, Sandoval C, Lee H, Bach EA, Hahm DH, Baeg GH.

Br J Pharmacol. 2011 Sep;164(1):106-18. doi: 10.1111/j.1476-5381.2011.01353.x.


Development of a high-throughput cell-based reporter assay for screening of JAK3 inhibitors.

Yin CH, Bach EA, Baeg GH.

J Biomol Screen. 2011 Apr;16(4):443-9. doi: 10.1177/1087057111400190. Epub 2011 Mar 10.


Cytosolic Ras supports eye development in Drosophila.

Sung PJ, Rodrigues AB, Kleinberger A, Quatela S, Bach EA, Philips MR.

Mol Cell Biol. 2010 Dec;30(24):5649-57. doi: 10.1128/MCB.00635-10. Epub 2010 Oct 11.


Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila.

Ekas LA, Cardozo TJ, Flaherty MS, McMillan EA, Gonsalves FC, Bach EA.

Dev Biol. 2010 Aug 15;344(2):621-36. doi: 10.1016/j.ydbio.2010.05.497. Epub 2010 May 23.


chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila.

Flaherty MS, Salis P, Evans CJ, Ekas LA, Marouf A, Zavadil J, Banerjee U, Bach EA.

Dev Cell. 2010 Apr 20;18(4):556-68. doi: 10.1016/j.devcel.2010.02.006.


NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3.

Kim BH, Jee JG, Yin CH, Sandoval C, Jayabose S, Kitamura D, Bach EA, Baeg GH.

Mol Cancer. 2010 Feb 11;9:36. doi: 10.1186/1476-4598-9-36.


MS-1020 is a novel small molecule that selectively inhibits JAK3 activity.

Kim BH, Oh SR, Yin CH, Lee S, Kim EA, Kim MS, Sandoval C, Jayabose S, Bach EA, Lee HK, Baeg GH.

Br J Haematol. 2010 Jan;148(1):132-43. doi: 10.1111/j.1365-2141.2009.07925.x. Epub 2009 Sep 29.


Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway.

Flaherty MS, Zavadil J, Ekas LA, Bach EA.

Dev Dyn. 2009 Sep;238(9):2235-53. doi: 10.1002/dvdy.21989.


A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells.

Kim BH, Yin CH, Guo Q, Bach EA, Lee H, Sandoval C, Jayabose S, Ulaczyk-Lesanko A, Hall DG, Baeg GH.

Mol Cancer Ther. 2008 Sep;7(9):2672-80. doi: 10.1158/1535-7163.MCT-08-0309.


The JAK/STAT pathway regulates proximo-distal patterning in Drosophila.

Ayala-Camargo A, Ekas LA, Flaherty MS, Baeg GH, Bach EA.

Dev Dyn. 2007 Oct;236(10):2721-30.


JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila.

Ekas LA, Baeg GH, Flaherty MS, Ayala-Camargo A, Bach EA.

Development. 2006 Dec;133(23):4721-9. Epub 2006 Nov 1.


GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo.

Bach EA, Ekas LA, Ayala-Camargo A, Flaherty MS, Lee H, Perrimon N, Baeg GH.

Gene Expr Patterns. 2007 Jan;7(3):323-31. Epub 2006 Aug 22.


Ken & barbie selectively regulates the expression of a subset of Jak/STAT pathway target genes.

Arbouzova NI, Bach EA, Zeidler MP.

Curr Biol. 2006 Jan 10;16(1):80-8.


Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis.

Ghiglione C, Bach EA, Paraiso Y, Carraway KL 3rd, Noselli S, Perrimon N.

Development. 2002 Jan;129(1):175-86.


The roles of the Drosophila JAK/STAT pathway.

Zeidler MP, Bach EA, Perrimon N.

Oncogene. 2000 May 15;19(21):2598-606. Review.


The IFN gamma receptor: a paradigm for cytokine receptor signaling.

Bach EA, Aguet M, Schreiber RD.

Annu Rev Immunol. 1997;15:563-91. Review.


Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells.

Verbsky JW, Bach EA, Fang YF, Yang L, Randolph DA, Fields LE.

J Biol Chem. 1996 Jun 14;271(24):13976-80.


Ligand-induced assembly and activation of the gamma interferon receptor in intact cells.

Bach EA, Tanner JW, Marsters S, Ashkenazi A, Aguet M, Shaw AS, Schreiber RD.

Mol Cell Biol. 1996 Jun;16(6):3214-21.


Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway.

Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, Carver-Moore K, DuBois RN, Clark R, Aguet M, Schreiber RD.

Cell. 1996 Feb 9;84(3):431-42.


Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets.

Bach EA, Szabo SJ, Dighe AS, Ashkenazi A, Aguet M, Murphy KM, Schreiber RD.

Science. 1995 Nov 17;270(5239):1215-8.


Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes.

Veis DJ, Sentman CL, Bach EA, Korsmeyer SJ.

J Immunol. 1993 Sep 1;151(5):2546-54.


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