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Items: 1 to 50 of 141

1.

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis.

Elgendy M, Cirò M, Hosseini A, Weiszmann J, Mazzarella L, Ferrari E, Cazzoli R, Curigliano G, DeCensi A, Bonanni B, Budillon A, Pelicci PG, Janssens V, Ogris M, Baccarini M, Lanfrancone L, Weckwerth W, Foiani M, Minucci S.

Cancer Cell. 2019 May 13;35(5):798-815.e5. doi: 10.1016/j.ccell.2019.03.007. Epub 2019 Apr 25.

PMID:
31031016
2.

RAF dimers control vascular permeability and cytoskeletal rearrangements at endothelial cell-cell junctions.

Dorard C, Cseh B, Ehrenreiter K, Wimmer R, Varga A, Hirschmugl T, Maier B, Kramer K, Fürlinger S, Doma E, Baccarini M.

FEBS J. 2019 Jun;286(12):2277-2294. doi: 10.1111/febs.14802. Epub 2019 Mar 18.

3.

Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis.

Yuan J, Ng WH, Tian Z, Yap J, Baccarini M, Chen Z, Hu J.

Sci Signal. 2018 Oct 30;11(554). pii: eaar6795. doi: 10.1126/scisignal.aar6795.

PMID:
30377225
4.

The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants.

Yuan J, Ng WH, Lam PYP, Wang Y, Xia H, Yap J, Guan SP, Lee ASG, Wang M, Baccarini M, Hu J.

Oncogene. 2018 Oct;37(43):5719-5734. doi: 10.1038/s41388-018-0365-2. Epub 2018 Jun 21.

5.

An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion.

Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, Sexl V, Bock C, Baccarini M.

Cell Stem Cell. 2018 Jun 1;22(6):879-892.e6. doi: 10.1016/j.stem.2018.05.003. Epub 2018 May 24.

6.

RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma.

Dorard C, Estrada C, Barbotin C, Larcher M, Garancher A, Leloup J, Beermann F, Baccarini M, Pouponnot C, Larue L, Eychène A, Druillennec S.

Nat Commun. 2017 May 12;8:15262. doi: 10.1038/ncomms15262.

7.

RAF1/BRAF dimerization integrates the signal from RAS to ERK and ROKα.

Varga A, Ehrenreiter K, Aschenbrenner B, Kocieniewski P, Kochanczyk M, Lipniacki T, Baccarini M.

Sci Signal. 2017 Mar 7;10(469). pii: eaai8482. doi: 10.1126/scisignal.aai8482.

PMID:
28270557
8.

Deciphering the RAS/ERK pathway in vivo.

Dorard C, Vucak G, Baccarini M.

Biochem Soc Trans. 2017 Feb 8;45(1):27-36. doi: 10.1042/BST20160135. Review.

PMID:
28202657
9.

Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development.

Papaioannou G, Petit ET, Liu ES, Baccarini M, Pritchard C, Demay MB.

J Biol Chem. 2017 Feb 24;292(8):3164-3171. doi: 10.1074/jbc.M116.763342. Epub 2017 Jan 10.

10.

A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.

Jeric I, Maurer G, Cavallo AL, Raguz J, Desideri E, Tarkowski B, Parrini M, Fischer I, Zatloukal K, Baccarini M.

Nat Commun. 2016 Dec 21;7:13781. doi: 10.1038/ncomms13781.

11.

MEK1 is required for the development of NRAS-driven leukemia.

Nowacka JD, Baumgartner C, Pelorosso C, Roth M, Zuber J, Baccarini M.

Oncotarget. 2016 Dec 6;7(49):80113-80130. doi: 10.18632/oncotarget.12555.

12.

Epidermal RAF prevents allergic skin disease.

Raguz J, Jeric I, Niault T, Nowacka JD, Kuzet SE, Rupp C, Fischer I, Biggi S, Borsello T, Baccarini M.

Elife. 2016 Jul 19;5. pii: e14012. doi: 10.7554/eLife.14012.

13.

Editorial overview: Cell regulation.

Baccarini M, Dikic I.

Curr Opin Cell Biol. 2016 Apr;39:iv-vi. doi: 10.1016/j.ceb.2016.03.010. Epub 2016 Mar 24. No abstract available.

PMID:
27017261
14.

Knock-in(g) RAF for a loop.

Varga A, Baccarini M.

EMBO J. 2016 Jan 18;35(2):118-20. doi: 10.15252/embj.201593566. Epub 2015 Dec 15. No abstract available.

15.

c-Raf promotes angiogenesis during normal growth plate maturation.

Liu ES, Raimann A, Chae BT, Martins JS, Baccarini M, Demay MB.

Development. 2016 Jan 15;143(2):348-55. doi: 10.1242/dev.127142. Epub 2015 Dec 10.

16.

Alike but Different: RAF Paralogs and Their Signaling Outputs.

Desideri E, Cavallo AL, Baccarini M.

Cell. 2015 May 21;161(5):967-970. doi: 10.1016/j.cell.2015.04.045. Review.

17.

p38 links RAS to GATA2.

Baumgartner C, Baccarini M.

EMBO Rep. 2014 Sep;15(9):912-3. doi: 10.15252/embr.201439309. Epub 2014 Aug 3. No abstract available.

18.

"RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway.

Cseh B, Doma E, Baccarini M.

FEBS Lett. 2014 Aug 1;588(15):2398-406. doi: 10.1016/j.febslet.2014.06.025. Epub 2014 Jun 14.

19.

Tool use imagery triggers tool incorporation in the body schema.

Baccarini M, Martel M, Cardinali L, Sillan O, Farnè A, Roy AC.

Front Psychol. 2014 May 30;5:492. doi: 10.3389/fpsyg.2014.00492. eCollection 2014.

20.

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.

Vin H, Ojeda SS, Ching G, Leung ML, Chitsazzadeh V, Dwyer DW, Adelmann CH, Restrepo M, Richards KN, Stewart LR, Du L, Ferguson SB, Chakravarti D, Ehrenreiter K, Baccarini M, Ruggieri R, Curry JL, Kim KB, Ciurea AM, Duvic M, Prieto VG, Ullrich SE, Dalby KN, Flores ER, Tsai KY.

Elife. 2013 Nov 5;2:e00969. doi: 10.7554/eLife.00969.

21.

Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK.

Vin H, Ching G, Ojeda SS, Adelmann CH, Chitsazzadeh V, Dwyer DW, Ma H, Ehrenreiter K, Baccarini M, Ruggieri R, Curry JL, Ciurea AM, Duvic M, Busaidy NL, Tannir NM, Tsai KY.

Mol Cancer Ther. 2014 Jan;13(1):221-9. doi: 10.1158/1535-7163.MCT-13-0561. Epub 2013 Oct 29.

22.

Skin tumorigenesis stimulated by Raf inhibitors relies upon Raf functions that are dependent and independent of ERK.

Doma E, Rupp C, Varga A, Kern F, Riegler B, Baccarini M.

Cancer Res. 2013 Dec 1;73(23):6926-37. doi: 10.1158/0008-5472.CAN-13-0748. Epub 2013 Oct 15.

23.

Sigmoid volvulus: is it a possible complication after stapled transanal rectal resection (STARR)?

Resta G, Scagliarini L, Bandi M, Vedana L, Marzetti A, Ferrocci G, Santini M, Anania G, Cavallesco G, Baccarini M.

G Chir. 2013 Jul-Aug;34(7-8):224-6. doi: 10.11138/gchir/2013.34.7.224.

24.

EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers.

Doma E, Rupp C, Baccarini M.

Int J Mol Sci. 2013 Sep 25;14(10):19361-84. doi: 10.3390/ijms141019361. Review.

25.

Amygdalar connections of the macaque areas 45A and 45B.

Gerbella M, Baccarini M, Borra E, Rozzi S, Luppino G.

Brain Struct Funct. 2014 May;219(3):831-42. doi: 10.1007/s00429-013-0538-2. Epub 2013 Mar 26.

PMID:
23529193
26.

MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance.

Zmajkovicova K, Jesenberger V, Catalanotti F, Baumgartner C, Reyes G, Baccarini M.

Mol Cell. 2013 Apr 11;50(1):43-55. doi: 10.1016/j.molcel.2013.01.037. Epub 2013 Feb 28.

27.

Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer.

Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M, Hieber M, Arbeiter A, Klein S, Kong B, Michalski CW, Schlitter AM, Esposito I, Kind AJ, Rad L, Schnieke AE, Baccarini M, Alessi DR, Rad R, Schmid RM, Schneider G, Saur D.

Cancer Cell. 2013 Mar 18;23(3):406-20. doi: 10.1016/j.ccr.2013.01.023. Epub 2013 Feb 28.

28.

RKIP regulates MAP kinase signaling in cells with defective B-Raf activity.

Zeng L, Ehrenreiter K, Menon J, Menard R, Kern F, Nakazawa Y, Bevilacqua E, Imamoto A, Baccarini M, Rosner MR.

Cell Signal. 2013 May;25(5):1156-65. doi: 10.1016/j.cellsig.2013.02.005. Epub 2013 Feb 14.

29.

Metabolic response to pegylated arginine deiminase in mesothelioma with promoter methylation of argininosuccinate synthetase.

Szlosarek PW, Luong P, Phillips MM, Baccarini M, Stephen E, Szyszko T, Sheaff MT, Avril N.

J Clin Oncol. 2013 Mar 1;31(7):e111-3. doi: 10.1200/JCO.2012.42.1784. Epub 2013 Jan 14. No abstract available.

PMID:
23319692
30.

B-Raf and C-Raf are required for melanocyte stem cell self-maintenance.

Valluet A, Druillennec S, Barbotin C, Dorard C, Monsoro-Burq AH, Larcher M, Pouponnot C, Baccarini M, Larue L, Eychène A.

Cell Rep. 2012 Oct 25;2(4):774-80. doi: 10.1016/j.celrep.2012.08.020. Epub 2012 Sep 27.

31.

Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis.

Kern F, Doma E, Rupp C, Niault T, Baccarini M.

Oncogene. 2013 May 9;32(19):2483-92. doi: 10.1038/onc.2012.254. Epub 2012 Jun 25.

PMID:
22733131
32.

Angiogenic sprouting requires the fine tuning of endothelial cell cohesion by the Raf-1/Rok-α complex.

Wimmer R, Cseh B, Maier B, Scherrer K, Baccarini M.

Dev Cell. 2012 Jan 17;22(1):158-71. doi: 10.1016/j.devcel.2011.11.012. Epub 2011 Dec 29.

33.

ERK signaling, but not c-Raf, is required for gonadotropin-releasing hormone (GnRH)-induced regulation of Nur77 in pituitary gonadotropes.

Bliss SP, Navratil AM, Xie J, Miller A, Baccarini M, Roberson MS.

Endocrinology. 2012 Feb;153(2):700-11. doi: 10.1210/en.2011-0247. Epub 2011 Dec 20.

34.

C-Raf is required for the initiation of lung cancer by K-Ras(G12D).

Karreth FA, Frese KK, DeNicola GM, Baccarini M, Tuveson DA.

Cancer Discov. 2011 Jul;1(2):128-36. doi: 10.1158/2159-8290.CD-10-0044. Epub 2011 May 11.

35.

Conservation of Salmonella infection mechanisms in plants and animals.

Schikora A, Virlogeux-Payant I, Bueso E, Garcia AV, Nilau T, Charrier A, Pelletier S, Menanteau P, Baccarini M, Velge P, Hirt H.

PLoS One. 2011;6(9):e24112. doi: 10.1371/journal.pone.0024112. Epub 2011 Sep 6.

36.

Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription.

Alejandro EU, Lim GE, Mehran AE, Hu X, Taghizadeh F, Pelipeychenko D, Baccarini M, Johnson JD.

FASEB J. 2011 Nov;25(11):3884-95. doi: 10.1096/fj.10-180349. Epub 2011 Aug 4.

37.

Raf kinases in cancer-roles and therapeutic opportunities.

Maurer G, Tarkowski B, Baccarini M.

Oncogene. 2011 Aug 11;30(32):3477-88. doi: 10.1038/onc.2011.160. Epub 2011 May 16. Review.

PMID:
21577205
38.

c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma.

Blasco RB, Francoz S, Santamaría D, Cañamero M, Dubus P, Charron J, Baccarini M, Barbacid M.

Cancer Cell. 2011 May 17;19(5):652-63. doi: 10.1016/j.ccr.2011.04.002. Epub 2011 Apr 21.

39.

Ras and Raf pathways in epidermis development and carcinogenesis.

Kern F, Niault T, Baccarini M.

Br J Cancer. 2011 Jan 18;104(2):229-34. doi: 10.1038/sj.bjc.6606009. Epub 2010 Nov 16. Review. Erratum in: Br J Cancer. 2011 Mar 29;104(7):1240.

40.

Keratinocyte-specific stat3 heterozygosity impairs development of skin tumors in human papillomavirus 8 transgenic mice.

De Andrea M, Rittà M, Landini MM, Borgogna C, Mondini M, Kern F, Ehrenreiter K, Baccarini M, Marcuzzi GP, Smola S, Pfister H, Landolfo S, Gariglio M.

Cancer Res. 2010 Oct 15;70(20):7938-48. doi: 10.1158/0008-5472.CAN-10-1128. Epub 2010 Sep 28.

41.

Thalamic projections to the macaque caudal ventrolateral prefrontal areas 45A and 45B.

Contini M, Baccarini M, Borra E, Gerbella M, Rozzi S, Luppino G.

Eur J Neurosci. 2010 Oct;32(8):1337-53. doi: 10.1111/j.1460-9568.2010.07390.x. Epub 2010 Sep 16.

PMID:
20846328
42.

Deciphering signaling pathways in vivo: the Ras/Raf/MEK/ERK cascade.

Galabova-Kovacs G, Baccarini M.

Methods Mol Biol. 2010;661:421-31. doi: 10.1007/978-1-60761-795-2_26.

PMID:
20811999
43.

Partner exchange: protein-protein interactions in the Raf pathway.

Wimmer R, Baccarini M.

Trends Biochem Sci. 2010 Dec;35(12):660-8. doi: 10.1016/j.tibs.2010.06.001. Review.

PMID:
20621483
44.

Targets of Raf in tumorigenesis.

Niault TS, Baccarini M.

Carcinogenesis. 2010 Jul;31(7):1165-74. doi: 10.1093/carcin/bgp337. Epub 2010 Jan 4. Review.

PMID:
20047953
45.

From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity.

Niault T, Sobczak I, Meissl K, Weitsman G, Piazzolla D, Maurer G, Kern F, Ehrenreiter K, Hamerl M, Moarefi I, Leung T, Carugo O, Ng T, Baccarini M.

J Cell Biol. 2009 Nov 2;187(3):335-42. doi: 10.1083/jcb.200906178.

46.

Raf-1 addiction in Ras-induced skin carcinogenesis.

Ehrenreiter K, Kern F, Velamoor V, Meissl K, Galabova-Kovacs G, Sibilia M, Baccarini M.

Cancer Cell. 2009 Aug 4;16(2):149-60. doi: 10.1016/j.ccr.2009.06.008.

47.

A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.

Catalanotti F, Reyes G, Jesenberger V, Galabova-Kovacs G, de Matos Simoes R, Carugo O, Baccarini M.

Nat Struct Mol Biol. 2009 Mar;16(3):294-303. doi: 10.1038/nsmb.1564. Epub 2009 Feb 15.

PMID:
19219045
48.

Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB.

Edelblum KL, Washington MK, Koyama T, Robine S, Baccarini M, Polk DB.

Gastroenterology. 2008 Aug;135(2):539-51. doi: 10.1053/j.gastro.2008.04.025. Epub 2008 Apr 30.

49.

Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling.

Telci D, Wang Z, Li X, Verderio EA, Humphries MJ, Baccarini M, Basaga H, Griffin M.

J Biol Chem. 2008 Jul 25;283(30):20937-47. doi: 10.1074/jbc.M801763200. Epub 2008 May 22.

50.

B-Raf is required for ERK activation and tumor progression in a mouse model of pancreatic beta-cell carcinogenesis.

Sobczak I, Galabova-Kovacs G, Sadzak I, Kren A, Christofori G, Baccarini M.

Oncogene. 2008 Aug 14;27(35):4779-87. doi: 10.1038/onc.2008.128. Epub 2008 May 19.

PMID:
18490924

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