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Items: 11

1.

Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2.

Incio J, Ligibel JA, McManus DT, Suboj P, Jung K, Kawaguchi K, Pinter M, Babykutty S, Chin SM, Vardam TD, Huang Y, Rahbari NN, Roberge S, Wang D, Gomes-Santos IL, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Tolaney SM, Krop IE, Duda DG, Boucher Y, Fukumura D, Jain RK.

Sci Transl Med. 2018 Mar 14;10(432). pii: eaag0945. doi: 10.1126/scitranslmed.aag0945.

2.

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy.

Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, Chauhan VP, Martin JD, Kahn J, Huang P, Desphande V, Michaelson J, Michelakos TP, Ferrone CR, Soares R, Boucher Y, Fukumura D, Jain RK.

Cancer Discov. 2016 Aug;6(8):852-69. doi: 10.1158/2159-8290.CD-15-1177. Epub 2016 May 31.

3.

Arginine dependence of tumor cells: targeting a chink in cancer's armor.

Patil MD, Bhaumik J, Babykutty S, Banerjee UC, Fukumura D.

Oncogene. 2016 Sep 22;35(38):4957-72. doi: 10.1038/onc.2016.37. Epub 2016 Apr 25. Review.

4.

PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity.

Incio J, Tam J, Rahbari NN, Suboj P, McManus DT, Chin SM, Vardam TD, Batista A, Babykutty S, Jung K, Khachatryan A, Hato T, Ligibel JA, Krop IE, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Shibuya M, Carmeliet P, Soares R, Duda DG, Jain RK, Fukumura D.

Clin Cancer Res. 2016 Jun 15;22(12):2993-3004. doi: 10.1158/1078-0432.CCR-15-1839. Epub 2016 Feb 9.

5.

Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages.

Incio J, Suboj P, Chin SM, Vardam-Kaur T, Liu H, Hato T, Babykutty S, Chen I, Deshpande V, Jain RK, Fukumura D.

PLoS One. 2015 Dec 7;10(12):e0141392. doi: 10.1371/journal.pone.0141392. eCollection 2015.

6.

Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways.

Babykutty S, Suboj P, Srinivas P, Nair AS, Chandramohan K, Gopala S.

Clin Exp Metastasis. 2012 Jun;29(5):471-92. doi: 10.1007/s10585-012-9464-6. Epub 2012 Mar 15.

PMID:
22419013
7.

Aloe emodin induces G2/M cell cycle arrest and apoptosis via activation of caspase-6 in human colon cancer cells.

Suboj P, Babykutty S, Srinivas P, Gopala S.

Pharmacology. 2012;89(1-2):91-8. doi: 10.1159/000335659. Epub 2012 Feb 14.

PMID:
22343391
8.

Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB.

Suboj P, Babykutty S, Valiyaparambil Gopi DR, Nair RS, Srinivas P, Gopala S.

Eur J Pharm Sci. 2012 Apr 11;45(5):581-91. doi: 10.1016/j.ejps.2011.12.012. Epub 2011 Dec 30.

PMID:
22227305
9.

Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-κB in colon cancer cells.

Babykutty S, S PP, J NR, Kumar MA, Nair MS, Srinivas P, Gopala S.

Mol Carcinog. 2012 Jun;51(6):475-90. doi: 10.1002/mc.20812. Epub 2011 Jun 15.

PMID:
21678498
10.

Apoptosis induction of Centella asiatica on human breast cancer cells.

Babykutty S, Padikkala J, Sathiadevan PP, Vijayakurup V, Azis TK, Srinivas P, Gopala S.

Afr J Tradit Complement Altern Med. 2008 Oct 25;6(1):9-16.

11.

Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent.

Srinivas G, Babykutty S, Sathiadevan PP, Srinivas P.

Med Res Rev. 2007 Sep;27(5):591-608. Review.

PMID:
17019678

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