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Items: 1 to 50 of 128

1.

Human Diseases from Gain-of-Function Mutations in Disordered Protein Regions.

Li XH, Babu MM.

Cell. 2018 Sep 20;175(1):40-42. doi: 10.1016/j.cell.2018.08.059.

PMID:
30241614
2.

Mechanisms of signalling and biased agonism in G protein-coupled receptors.

Wootten D, Christopoulos A, Marti-Solano M, Babu MM, Sexton PM.

Nat Rev Mol Cell Biol. 2018 Oct;19(10):638-653. doi: 10.1038/s41580-018-0049-3. Review.

PMID:
30104700
3.

Molecular Deconvolution Platform to Establish Disease Mechanisms by Surveying GPCR Signaling.

Masuho I, Chavali S, Muntean BS, Skamangas NK, Simonyan K, Patil DN, Kramer GM, Ozelius L, Babu MM, Martemyanov KA.

Cell Rep. 2018 Jul 17;24(3):557-568.e5. doi: 10.1016/j.celrep.2018.06.080.

4.

Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation.

Sente A, Peer R, Srivastava A, Baidya M, Lesk AM, Balaji S, Shukla AK, Babu MM, Flock T.

Nat Struct Mol Biol. 2018 Jun;25(6):538-545. doi: 10.1038/s41594-018-0071-3. Epub 2018 Jun 5.

PMID:
29872229
5.

High-throughput discovery of functional disordered regions: investigation of transactivation domains.

Ravarani CN, Erkina TY, De Baets G, Dudman DC, Erkine AM, Babu MM.

Mol Syst Biol. 2018 May 14;14(5):e8190. doi: 10.15252/msb.20188190.

6.

Pathway perturbations in signaling networks: Linking genotype to phenotype.

Li Y, McGrail DJ, Latysheva N, Yi S, Babu MM, Sahni N.

Semin Cell Dev Biol. 2018 May 10. pii: S1084-9521(17)30528-1. doi: 10.1016/j.semcdb.2018.05.001. [Epub ahead of print] Review.

PMID:
29738884
7.

Capturing dynamic protein interactions.

Li XH, Chavali PL, Babu MM.

Science. 2018 Mar 9;359(6380):1105-1106. doi: 10.1126/science.aat0576. No abstract available.

PMID:
29590031
8.

Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins.

Natan E, Endoh T, Haim-Vilmovsky L, Flock T, Chalancon G, Hopper JTS, Kintses B, Horvath P, Daruka L, Fekete G, Pál C, Papp B, Oszi E, Magyar Z, Marsh JA, Elcock AH, Babu MM, Robinson CV, Sugimoto N, Teichmann SA.

Nat Struct Mol Biol. 2018 Mar;25(3):279-288. doi: 10.1038/s41594-018-0029-5. Epub 2018 Feb 12.

9.

Function and Regulation of Phase-Separated Biological Condensates.

Li XH, Chavali PL, Pancsa R, Chavali S, Babu MM.

Biochemistry. 2018 May 1;57(17):2452-2461. doi: 10.1021/acs.biochem.7b01228. Epub 2018 Feb 12.

PMID:
29392932
10.

Contrasting Function of Structured N-Terminal and Unstructured C-Terminal Segments of Mycobacterium tuberculosis PPE37 Protein.

Ahmad J, Farhana A, Pancsa R, Arora SK, Srinivasan A, Tyagi AK, Babu MM, Ehtesham NZ, Hasnain SE.

MBio. 2018 Jan 23;9(1). pii: e01712-17. doi: 10.1128/mBio.01712-17.

11.

Visualization and analysis of non-covalent contacts using the Protein Contacts Atlas.

Kayikci M, Venkatakrishnan AJ, Scott-Brown J, Ravarani CNJ, Flock T, Babu MM.

Nat Struct Mol Biol. 2018 Feb;25(2):185-194. doi: 10.1038/s41594-017-0019-z. Epub 2018 Jan 15.

12.

Pharmacogenomics of GPCR Drug Targets.

Hauser AS, Chavali S, Masuho I, Jahn LJ, Martemyanov KA, Gloriam DE, Babu MM.

Cell. 2018 Jan 11;172(1-2):41-54.e19. doi: 10.1016/j.cell.2017.11.033. Epub 2017 Dec 14.

13.

Revealing the Determinants of Widespread Alternative Splicing Perturbation in Cancer.

Li Y, Sahni N, Pancsa R, McGrail DJ, Xu J, Hua X, Coulombe-Huntington J, Ryan M, Tychhon B, Sudhakar D, Hu L, Tyers M, Jiang X, Lin SY, Babu MM, Yi S.

Cell Rep. 2017 Oct 17;21(3):798-812. doi: 10.1016/j.celrep.2017.09.071.

14.

Constraints and consequences of the emergence of amino acid repeats in eukaryotic proteins.

Chavali S, Chavali PL, Chalancon G, de Groot NS, Gemayel R, Latysheva NS, Ing-Simmons E, Verstrepen KJ, Balaji S, Babu MM.

Nat Struct Mol Biol. 2017 Sep;24(9):765-777. doi: 10.1038/nsmb.3441. Epub 2017 Aug 14.

15.

Selectivity determinants of GPCR-G-protein binding.

Flock T, Hauser AS, Lund N, Gloriam DE, Balaji S, Babu MM.

Nature. 2017 May 18;545(7654):317-322. doi: 10.1038/nature22070. Epub 2017 May 10.

16.

Intrinsically Disordered Proteins Adaptively Reorganize Cellular Matter During Stress.

Chavali S, Gunnarsson A, Babu MM.

Trends Biochem Sci. 2017 Jun;42(6):410-412. doi: 10.1016/j.tibs.2017.04.007. Epub 2017 May 6.

PMID:
28487210
17.

Simultaneous quantification of protein order and disorder.

Sormanni P, Piovesan D, Heller GT, Bonomi M, Kukic P, Camilloni C, Fuxreiter M, Dosztanyi Z, Pappu RV, Babu MM, Longhi S, Tompa P, Dunker AK, Uversky VN, Tosatto SC, Vendruscolo M.

Nat Chem Biol. 2017 Mar 22;13(4):339-342. doi: 10.1038/nchembio.2331. No abstract available.

PMID:
28328918
18.

Patients' Awareness toward Implant-supported Prosthesis: An Observational Study.

Raju CM, Gunupati S, Babu MM, Reddy CS, Biradavolu S, Saravanan M.

J Contemp Dent Pract. 2017 Jan 1;18(1):49-51.

PMID:
28050985
19.
20.

Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer.

Latysheva NS, Oates ME, Maddox L, Flock T, Gough J, Buljan M, Weatheritt RJ, Babu MM.

Mol Cell. 2016 Aug 18;63(4):579-592. doi: 10.1016/j.molcel.2016.07.008.

21.

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region.

Venkatakrishnan AJ, Deupi X, Lebon G, Heydenreich FM, Flock T, Miljus T, Balaji S, Bouvier M, Veprintsev DB, Tate CG, Schertler GF, Babu MM.

Nature. 2016 Aug 25;536(7617):484-7. Epub 2016 Aug 15.

22.

Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.

Yu H, Singh Gautam AK, Wilmington SR, Wylie D, Martinez-Fonts K, Kago G, Warburton M, Chavali S, Inobe T, Finkelstein IJ, Babu MM, Matouschek A.

J Biol Chem. 2016 Jul 8;291(28):14526-39. doi: 10.1074/jbc.M116.727578. Epub 2016 May 17.

23.

Discovering and understanding oncogenic gene fusions through data intensive computational approaches.

Latysheva NS, Babu MM.

Nucleic Acids Res. 2016 Jun 2;44(10):4487-503. doi: 10.1093/nar/gkw282. Epub 2016 Apr 21. Review.

24.

Affinity and competition for TBP are molecular determinants of gene expression noise.

Ravarani CN, Chalancon G, Breker M, de Groot NS, Babu MM.

Nat Commun. 2016 Feb 2;7:10417. doi: 10.1038/ncomms10417.

25.

Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity.

Gemayel R, Chavali S, Pougach K, Legendre M, Zhu B, Boeynaems S, van der Zande E, Gevaert K, Rousseau F, Schymkowitz J, Babu MM, Verstrepen KJ.

Mol Cell. 2015 Aug 20;59(4):615-27. doi: 10.1016/j.molcel.2015.07.003. Epub 2015 Aug 6.

26.

Editorial overview: Linking protein sequence and structural changes to function in the era of next-generation sequencing.

Panchenko AR, Babu MM.

Curr Opin Struct Biol. 2015 Jun;32:viii-x. doi: 10.1016/j.sbi.2015.06.005. No abstract available.

PMID:
26199202
27.

Universal allosteric mechanism for Gα activation by GPCRs.

Flock T, Ravarani CNJ, Sun D, Venkatakrishnan AJ, Kayikci M, Tate CG, Veprintsev DB, Babu MM.

Nature. 2015 Aug 13;524(7564):173-179. doi: 10.1038/nature14663. Epub 2015 Jul 6.

28.

Classifying pairs with trees for supervised biological network inference.

Schrynemackers M, Wehenkel L, Babu MM, Geurts P.

Mol Biosyst. 2015 Aug;11(8):2116-25. doi: 10.1039/c5mb00174a.

29.

How do disordered regions achieve comparable functions to structured domains?

Latysheva NS, Flock T, Weatheritt RJ, Chavali S, Babu MM.

Protein Sci. 2015 Jun;24(6):909-22. doi: 10.1002/pro.2674. Epub 2015 May 15. Review.

30.

Proteome response at the edge of protein aggregation.

Sanchez de Groot N, Gomes RA, Villar-Pique A, Babu MM, Coelho AV, Ventura S.

Open Biol. 2015 Feb;5(2):140221. doi: 10.1098/rsob.140221.

31.

Sequence composition of disordered regions fine-tunes protein half-life.

Fishbain S, Inobe T, Israeli E, Chavali S, Yu H, Kago G, Babu MM, Matouschek A.

Nat Struct Mol Biol. 2015 Mar;22(3):214-21. doi: 10.1038/nsmb.2958. Epub 2015 Feb 2.

32.

Optimizing membrane-protein biogenesis through nonoptimal-codon usage.

Morgunov AS, Babu MM.

Nat Struct Mol Biol. 2014 Dec;21(12):1023-5. doi: 10.1038/nsmb.2926. No abstract available.

PMID:
25469841
33.

Intrinsically disordered segments affect protein half-life in the cell and during evolution.

van der Lee R, Lang B, Kruse K, Gsponer J, Sánchez de Groot N, Huynen MA, Matouschek A, Fuxreiter M, Babu MM.

Cell Rep. 2014 Sep 25;8(6):1832-1844. doi: 10.1016/j.celrep.2014.07.055. Epub 2014 Sep 15.

34.

Asymmetric mRNA localization contributes to fidelity and sensitivity of spatially localized systems.

Weatheritt RJ, Gibson TJ, Babu MM.

Nat Struct Mol Biol. 2014 Sep;21(9):833-9. doi: 10.1038/nsmb.2876. Epub 2014 Aug 24.

35.

A million peptide motifs for the molecular biologist.

Tompa P, Davey NE, Gibson TJ, Babu MM.

Mol Cell. 2014 Jul 17;55(2):161-9. doi: 10.1016/j.molcel.2014.05.032. Review.

36.

Controlling entropy to tune the functions of intrinsically disordered regions.

Flock T, Weatheritt RJ, Latysheva NS, Babu MM.

Curr Opin Struct Biol. 2014 Jun;26:62-72. doi: 10.1016/j.sbi.2014.05.007. Epub 2014 Jun 12. Review.

PMID:
24930020
37.

Use of host-like peptide motifs in viral proteins is a prevalent strategy in host-virus interactions.

Hagai T, Azia A, Babu MM, Andino R.

Cell Rep. 2014 Jun 12;7(5):1729-1739. doi: 10.1016/j.celrep.2014.04.052. Epub 2014 May 29.

38.

Classification of intrinsically disordered regions and proteins.

van der Lee R, Buljan M, Lang B, Weatheritt RJ, Daughdrill GW, Dunker AK, Fuxreiter M, Gough J, Gsponer J, Jones DT, Kim PM, Kriwacki RW, Oldfield CJ, Pappu RV, Tompa P, Uversky VN, Wright PE, Babu MM.

Chem Rev. 2014 Jul 9;114(13):6589-631. doi: 10.1021/cr400525m. Epub 2014 Apr 29. Review. No abstract available.

39.

Evolution. The hidden codes that shape protein evolution.

Weatheritt RJ, Babu MM.

Science. 2013 Dec 13;342(6164):1325-6. doi: 10.1126/science.1248425. No abstract available.

40.

Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity.

Wickramasinghe VO, Savill JM, Chavali S, Jonsdottir AB, Rajendra E, Grüner T, Laskey RA, Babu MM, Venkitaraman AR.

Mol Cell. 2013 Sep 26;51(6):737-50. doi: 10.1016/j.molcel.2013.08.031.

41.

Promiscuity as a functional trait: intrinsically disordered regions as central players of interactomes.

Cumberworth A, Lamour G, Babu MM, Gsponer J.

Biochem J. 2013 Sep 15;454(3):361-9. doi: 10.1042/BJ20130545. Review.

PMID:
23988124
42.

Network Biology editorial 2013.

Marcotte E, Boone C, Babu MM, Gavin AC.

Mol Biosyst. 2013 Jul;9(7):1557-8. doi: 10.1039/c3mb90018e. Epub 2013 May 28. No abstract available.

PMID:
23712464
43.

Alternative splicing of intrinsically disordered regions and rewiring of protein interactions.

Buljan M, Chalancon G, Dunker AK, Bateman A, Balaji S, Fuxreiter M, Babu MM.

Curr Opin Struct Biol. 2013 Jun;23(3):443-50. doi: 10.1016/j.sbi.2013.03.006. Epub 2013 May 22. Review.

PMID:
23706950
44.

Vaccination strategies to protect goldfish Carassius auratus against Aeromonas hydrophila infection.

Thanga Viji V, Deepa K, Velmurugan S, Donio MB, Adlin Jenifer J, Babu MM, Citarasu T.

Dis Aquat Organ. 2013 Apr 29;104(1):45-57. doi: 10.3354/dao02581.

PMID:
23670079
45.

A methodology to infer gene networks from spatial patterns of expression--an application to fluorescence in situ hybridization images.

Campiteli MG, Comin CH, Costa Lda F, Babu MM, Cesar RM.

Mol Biosyst. 2013 Jul;9(7):1926-30. doi: 10.1039/c3mb25475e. Epub 2013 Apr 17.

46.

What's in a name? Why these proteins are intrinsically disordered: Why these proteins are intrinsically disordered.

Dunker AK, Babu MM, Barbar E, Blackledge M, Bondos SE, Dosztányi Z, Dyson HJ, Forman-Kay J, Fuxreiter M, Gsponer J, Han KH, Jones DT, Longhi S, Metallo SJ, Nishikawa K, Nussinov R, Obradovic Z, Pappu RV, Rost B, Selenko P, Subramaniam V, Sussman JL, Tompa P, Uversky VN.

Intrinsically Disord Proteins. 2013 Apr 1;1(1):e24157. doi: 10.4161/idp.24157. eCollection 2013 Jan-Dec. Review.

47.

Molecular signatures of G-protein-coupled receptors.

Venkatakrishnan AJ, Deupi X, Lebon G, Tate CG, Schertler GF, Babu MM.

Nature. 2013 Feb 14;494(7436):185-94. doi: 10.1038/nature11896. Review.

PMID:
23407534
48.

A complex network framework for unbiased statistical analyses of DNA-DNA contact maps.

Kruse K, Sewitz S, Babu MM.

Nucleic Acids Res. 2013 Jan;41(2):701-10. doi: 10.1093/nar/gks1096. Epub 2012 Nov 21.

49.

Cellular strategies for regulating functional and nonfunctional protein aggregation.

Gsponer J, Babu MM.

Cell Rep. 2012 Nov 29;2(5):1425-37. doi: 10.1016/j.celrep.2012.09.036. Epub 2012 Nov 15.

50.

Structural biology. Versatility from protein disorder.

Babu MM, Kriwacki RW, Pappu RV.

Science. 2012 Sep 21;337(6101):1460-1. No abstract available.

PMID:
22997313

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