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Items: 1 to 50 of 586

1.

Extended sequencing of vaccine and wild-type capripoxvirus isolates provides insights into genes modulating virulence and host range.

Biswas S, Noyce RS, Babiuk LA, Lung O, Bulach DM, Bowden TR, Boyle DB, Babiuk S, Evans DH.

Transbound Emerg Dis. 2019 Aug 4. doi: 10.1111/tbed.13322. [Epub ahead of print]

PMID:
31379093
2.

Natural and inducible regulatory B cells are widely distributed in ovine lymphoid tissues.

Jimbo S, Griebel PJ, Lai K, Babiuk LA, Mutwiri G.

Vet Immunol Immunopathol. 2019 May;211:44-48. doi: 10.1016/j.vetimm.2019.04.005. Epub 2019 Apr 19.

PMID:
31084893
3.

HDAC6 Restricts Influenza A Virus by Deacetylation of the RNA Polymerase PA Subunit.

Chen H, Qian Y, Chen X, Ruan Z, Ye Y, Chen H, Babiuk LA, Jung YS, Dai J.

J Virol. 2019 Feb 5;93(4). pii: e01896-18. doi: 10.1128/JVI.01896-18. Print 2019 Feb 15.

4.

Defining a standard and weighted mathematical index for maturation of dendritic cells.

Landi A, Aligodarzi MT, Khodadadi A, Babiuk LA, van Drunen Littel-van den Hurk S.

Immunology. 2018 Apr;153(4):532-544. doi: 10.1111/imm.12856. Epub 2017 Nov 24.

5.

Intranasal vaccination with an adjuvanted polyphosphazenes nanoparticle-based vaccine formulation stimulates protective immune responses in mice.

Schulze K, Ebensen T, Babiuk LA, Gerdts V, Guzman CA.

Nanomedicine. 2017 Oct;13(7):2169-2178. doi: 10.1016/j.nano.2017.05.012. Epub 2017 Jun 1.

PMID:
28579436
6.

Protective Role of Passively Transferred Maternal Cytokines against Bordetella pertussis Infection in Newborn Piglets.

Elahi S, Thompson DR, Van Kessel J, Babiuk LA, Gerdts V.

Infect Immun. 2017 Mar 23;85(4). pii: e01063-16. doi: 10.1128/IAI.01063-16. Print 2017 Apr.

7.

Restrictions on the Importation of Zebrafish into Canada Associated with Spring Viremia of Carp Virus.

Hanwell D, Hutchinson SA, Collymore C, Bruce AE, Louis R, Ghalami A, Allison WT, Ekker M, Eames BF, Childs S, Kurrasch DM, Gerlai R, Thiele T, Scott I, Ciruna B, Dowling JJ, McFarlane S, Huang P, Wen XY, Akimenko MA, Waskiewicz AJ, Drapeau P, Babiuk LA, Dragon D, Smida A, Buret AG, O'Grady E, Wilson J, Sowden-Plunkett L, Robertson JV, Tropepe V.

Zebrafish. 2016 Jul;13 Suppl 1:S153-63. doi: 10.1089/zeb.2016.1286. Epub 2016 Jun 1. Erratum in: Zebrafish. 2016 Dec;13(6):596.

PMID:
27248438
8.

Evidence for the existence of regulatory and effector B cell populations in Peyer's patches of sheep.

Jimbo S, Griebel PJ, Townsend H, Babiuk LA, Mutwiri G.

Vet Immunol Immunopathol. 2016 Jun;174:26-34. doi: 10.1016/j.vetimm.2016.04.006. Epub 2016 Apr 8.

PMID:
27185260
9.

Protein-prime/modified vaccinia virus Ankara vector-boost vaccination overcomes tolerance in high-antigenemic HBV-transgenic mice.

Backes S, Jäger C, Dembek CJ, Kosinska AD, Bauer T, Stephan AS, Dišlers A, Mutwiri G, Busch DH, Babiuk LA, Gasteiger G, Protzer U.

Vaccine. 2016 Feb 10;34(7):923-32. doi: 10.1016/j.vaccine.2015.12.060. Epub 2016 Jan 15.

PMID:
26776470
10.

Review: Capripoxvirus Diseases: Current Status and Opportunities for Control.

Tuppurainen ESM, Venter EH, Shisler JL, Gari G, Mekonnen GA, Juleff N, Lyons NA, De Clercq K, Upton C, Bowden TR, Babiuk S, Babiuk LA.

Transbound Emerg Dis. 2017 Jun;64(3):729-745. doi: 10.1111/tbed.12444. Epub 2015 Nov 13. Review.

11.

A lumpy skin disease virus deficient of an IL-10 gene homologue provides protective immunity against virulent capripoxvirus challenge in sheep and goats.

Boshra H, Truong T, Nfon C, Bowden TR, Gerdts V, Tikoo S, Babiuk LA, Kara P, Mather A, Wallace DB, Babiuk S.

Antiviral Res. 2015 Nov;123:39-49. doi: 10.1016/j.antiviral.2015.08.016. Epub 2015 Sep 1.

PMID:
26341190
12.

CSCI/RCPSC Henry Friesen lecture: controlling infectious diseases through vaccination.

Babiuk LA.

Clin Invest Med. 2014 Dec 1;37(6):E409-13.

PMID:
25618274
13.

Interaction of VP8 with mRNAs of bovine herpesvirus-1.

Islam A, Schulz S, Afroz S, Babiuk LA, van Drunen Littel-van den Hurk S.

Virus Res. 2015 Feb 2;197:116-26. doi: 10.1016/j.virusres.2014.12.017. Epub 2014 Dec 18. Erratum in: Virus Res. 2015 Dec 2;210():356.

PMID:
25529439
14.

Immunogenicity of a bovine herpesvirus 1 glycoprotein D DNA vaccine complexed with bovine neutrophil beta-defensin 3.

Mackenzie-Dyck S, Latimer L, Atanley E, Kovacs-Nolan J, Attah-Poku S, Babiuk LA, van Drunen Littel-van den Hurk S.

Clin Vaccine Immunol. 2015 Jan;22(1):79-90. doi: 10.1128/CVI.00476-14. Epub 2014 Nov 5.

15.

c-di-GMP enhances protective innate immunity in a murine model of pertussis.

Elahi S, Van Kessel J, Kiros TG, Strom S, Hayakawa Y, Hyodo M, Babiuk LA, Gerdts V.

PLoS One. 2014 Oct 15;9(10):e109778. doi: 10.1371/journal.pone.0109778. eCollection 2014.

16.
17.

CpG-ODNs induced changes in cytokine/chemokines genes expression associated with suppression of infectious bronchitis virus replication in chicken lungs.

Dar A, Tikoo S, Potter A, Babiuk LA, Townsend H, Gerdts V, Mutwiri G.

Vet Immunol Immunopathol. 2014 Aug 15;160(3-4):209-17. doi: 10.1016/j.vetimm.2014.05.004. Epub 2014 May 21.

PMID:
25012000
18.

Mucosal immunization of calves with recombinant bovine adenovirus-3 coexpressing truncated form of bovine herpesvirus-1 gD and bovine IL-6.

Kumar P, Ayalew LE, Godson DL, Gaba A, Babiuk LA, Tikoo SK.

Vaccine. 2014 May 30;32(26):3300-6. doi: 10.1016/j.vaccine.2014.03.073. Epub 2014 Apr 13.

PMID:
24731813
19.

The adjuvant PCEP induces recruitment of myeloid and lymphoid cells at the injection site and draining lymph node.

Awate S, Wilson HL, Singh B, Babiuk LA, Mutwiri G.

Vaccine. 2014 May 1;32(21):2420-7. doi: 10.1016/j.vaccine.2014.03.014. Epub 2014 Mar 21.

PMID:
24662707
20.

Peste des petits ruminants virus tissue tropism and pathogenesis in sheep and goats following experimental infection.

Truong T, Boshra H, Embury-Hyatt C, Nfon C, Gerdts V, Tikoo S, Babiuk LA, Kara P, Chetty T, Mather A, Wallace DB, Babiuk S.

PLoS One. 2014 Jan 30;9(1):e87145. doi: 10.1371/journal.pone.0087145. eCollection 2014.

21.

Inclusion of the bovine neutrophil beta-defensin 3 with glycoprotein D of bovine herpesvirus 1 in a DNA vaccine modulates immune responses of mice and cattle.

Mackenzie-Dyck S, Kovacs-Nolan J, Snider M, Babiuk LA, van Drunen Littel-van den Hurk S.

Clin Vaccine Immunol. 2014 Apr;21(4):463-77. doi: 10.1128/CVI.00696-13. Epub 2014 Jan 22.

22.

Caspase-1 Dependent IL-1β Secretion and Antigen-Specific T-Cell Activation by the Novel Adjuvant, PCEP.

Awate S, Eng NF, Gerdts V, Babiuk LA, Mutwiri G.

Vaccines (Basel). 2014 Jun 26;2(3):500-14. doi: 10.3390/vaccines2030500.

23.

Mechanisms of action of adjuvants.

Awate S, Babiuk LA, Mutwiri G.

Front Immunol. 2013 May 16;4:114. doi: 10.3389/fimmu.2013.00114. eCollection 2013.

24.

Novel vaccine formulations against pertussis offer earlier onset of immunity and provide protection in the presence of maternal antibodies.

Polewicz M, Gracia A, Garlapati S, van Kessel J, Strom S, Halperin SA, Hancock RE, Potter AA, Babiuk LA, Gerdts V.

Vaccine. 2013 Jun 28;31(31):3148-55. doi: 10.1016/j.vaccine.2013.05.008. Epub 2013 May 15.

PMID:
23684829
25.

Porcine neonatal blood dendritic cells, but not monocytes, are more responsive to TLRs stimulation than their adult counterparts.

Auray G, Facci MR, van Kessel J, Buchanan R, Babiuk LA, Gerdts V.

PLoS One. 2013 May 8;8(5):e59629. doi: 10.1371/journal.pone.0059629. Print 2013.

26.

Capripoxvirus-vectored vaccines against livestock diseases in Africa.

Boshra H, Truong T, Nfon C, Gerdts V, Tikoo S, Babiuk LA, Kara P, Mather A, Wallace D, Babiuk S.

Antiviral Res. 2013 May;98(2):217-27. doi: 10.1016/j.antiviral.2013.02.016. Epub 2013 Mar 7. Review.

PMID:
23499648
27.

Future vaccines for a globalized world.

Babiuk LA, Gerdts V.

Emerg Microbes Infect. 2012 Jul;1(7):e4. doi: 10.1038/emi.2012.17. No abstract available.

28.

Enhanced immune responses and protection by vaccination with respiratory syncytial virus fusion protein formulated with CpG oligodeoxynucleotide and innate defense regulator peptide in polyphosphazene microparticles.

Garlapati S, Garg R, Brownlie R, Latimer L, Simko E, Hancock RE, Babiuk LA, Gerdts V, Potter A, van Drunen Littel-van den Hurk S.

Vaccine. 2012 Jul 27;30(35):5206-14. doi: 10.1016/j.vaccine.2012.06.011. Epub 2012 Jun 17.

PMID:
22713718
29.

Bovine herpesvirus-1 VP8 interacts with DNA damage binding protein-1 (DDB1) and is monoubiquitinated during infection.

Vasilenko NL, Snider M, Labiuk SL, Lobanov VA, Babiuk LA, van Drunen Littel-van den Hurk S.

Virus Res. 2012 Jul;167(1):56-66. doi: 10.1016/j.virusres.2012.04.005. Epub 2012 Apr 19.

PMID:
22542975
30.

Activation of adjuvant core response genes by the novel adjuvant PCEP.

Awate S, Wilson HL, Lai K, Babiuk LA, Mutwiri G.

Mol Immunol. 2012 Jul;51(3-4):292-303. doi: 10.1016/j.molimm.2012.03.026. Epub 2012 Apr 21.

PMID:
22521769
31.

Administration of poly[di(sodium carboxylatoethylphenoxy)]phosphazene (PCEP) as adjuvant activated mixed Th1/Th2 immune responses in pigs.

Dar A, Lai K, Dent D, Potter A, Gerdts V, Babiuk LA, Mutwiri GK.

Vet Immunol Immunopathol. 2012 May 15;146(3-4):289-95. doi: 10.1016/j.vetimm.2012.01.021. Epub 2012 Feb 6.

PMID:
22377627
32.

Interferon-gamma and B-cell Activating Factor (BAFF) promote bovine B cell activation independent of TLR9 and T-cell signaling.

Buchanan R, Popowych Y, Dagenais C, Arsic N, Mutwiri GK, Potter AA, Babiuk LA, Griebel PJ, Wilson HL.

Vet Immunol Immunopathol. 2012 Jan 15;145(1-2):453-63. doi: 10.1016/j.vetimm.2012.01.001. Epub 2012 Jan 10.

PMID:
22264737
33.

Induction, regulation and physiological role of IL-17 secreting helper T-cells isolated from PBMC, thymus, and lung lymphocytes of young pigs.

Kiros TG, van Kessel J, Babiuk LA, Gerdts V.

Vet Immunol Immunopathol. 2011 Dec 15;144(3-4):448-54. doi: 10.1016/j.vetimm.2011.08.021. Epub 2011 Sep 10.

PMID:
21955445
34.

Influence of maternal antibodies on active pertussis toxoid immunization of neonatal mice and piglets.

Polewicz M, Gracia A, Buchanan R, Strom S, Halperin SA, Potter AA, Babiuk LA, Gerdts V.

Vaccine. 2011 Oct 13;29(44):7718-26. doi: 10.1016/j.vaccine.2011.07.135. Epub 2011 Aug 19.

PMID:
21856353
35.

Immunization with PCEP microparticles containing pertussis toxoid, CpG ODN and a synthetic innate defense regulator peptide induces protective immunity against pertussis.

Garlapati S, Eng NF, Kiros TG, Kindrachuk J, Mutwiri GK, Hancock RE, Halperin SA, Potter AA, Babiuk LA, Gerdts V.

Vaccine. 2011 Sep 2;29(38):6540-8. doi: 10.1016/j.vaccine.2011.07.009. Epub 2011 Jul 21.

36.

The synthetic peptides bovine enteric β-defensin (EBD), bovine neutrophil β-defensin (BNBD) 9 and BNBD 3 are chemotactic for immature bovine dendritic cells.

Mackenzie-Dyck S, Attah-Poku S, Juillard V, Babiuk LA, van Drunen Littel-van den Hurk S.

Vet Immunol Immunopathol. 2011 Sep 15;143(1-2):87-107. doi: 10.1016/j.vetimm.2011.06.028. Epub 2011 Jun 24.

PMID:
21764462
37.

B-cell activating factor (BAFF) promotes CpG ODN-induced B cell activation and proliferation.

Buchanan RM, Popowych Y, Arsic N, Townsend HG, Mutwiri GK, Potter AA, Babiuk LA, Griebel PJ, Wilson HL.

Cell Immunol. 2011;271(1):16-28. doi: 10.1016/j.cellimm.2011.05.016. Epub 2011 Jun 14.

PMID:
21724179
38.

An elastase-dependent attenuated heterologous swine influenza virus protects against pandemic H1N1 2009 influenza challenge in swine.

Babiuk S, Masic A, Graham J, Neufeld J, van der Loop M, Copps J, Berhane Y, Pasick J, Potter A, Babiuk LA, Weingartl H, Zhou Y.

Vaccine. 2011 Apr 12;29(17):3118-23. doi: 10.1016/j.vaccine.2011.02.069. Epub 2011 Mar 5.

PMID:
21382482
39.

Antibody responses in adult and neonatal BALB/c mice to immunization with novel Bordetella pertussis vaccine formulations.

Gracia A, Polewicz M, Halperin SA, Hancock RE, Potter AA, Babiuk LA, Gerdts V.

Vaccine. 2011 Feb 11;29(8):1595-604. doi: 10.1016/j.vaccine.2010.12.083. Epub 2011 Jan 5.

PMID:
21215343
40.

Dendritic cells matured by a prostaglandin E2-containing cocktail can produce high levels of IL-12p70 and are more mature and Th1-biased than dendritic cells treated with TNF-α or LPS.

Landi A, Babiuk LA, van Drunen Littel-van den Hurk S.

Immunobiology. 2011 Jun;216(6):649-62. doi: 10.1016/j.imbio.2010.11.004. Epub 2010 Nov 25.

PMID:
21183242
41.

Combination adjuvants: the next generation of adjuvants?

Mutwiri G, Gerdts V, van Drunen Littel-van den Hurk S, Auray G, Eng N, Garlapati S, Babiuk LA, Potter A.

Expert Rev Vaccines. 2011 Jan;10(1):95-107. doi: 10.1586/erv.10.154. Review.

PMID:
21162624
42.

Swine outbreak of pandemic influenza A virus on a Canadian research farm supports human-to-swine transmission.

Forgie SE, Keenliside J, Wilkinson C, Webby R, Lu P, Sorensen O, Fonseca K, Barman S, Rubrum A, Stigger E, Marrie TJ, Marshall F, Spady DW, Hu J, Loeb M, Russell ML, Babiuk LA.

Clin Infect Dis. 2011 Jan 1;52(1):10-8. doi: 10.1093/cid/ciq030.

43.

PCPP (poly[di(carboxylatophenoxy)-phosphazene]) microparticles co-encapsulating ovalbumin and CpG oligo-deoxynucleotides are potent enhancers of antigen specific Th1 immune responses in mice.

Garlapati S, Eng NF, Wilson HL, Buchanan R, Mutwiri GK, Babiuk LA, Gerdts V.

Vaccine. 2010 Dec 6;28(52):8306-14. doi: 10.1016/j.vaccine.2010.09.080. Epub 2010 Oct 29.

PMID:
21036133
44.

Hepatitis C virus nonstructural protein-5A activates sterol regulatory element-binding protein-1c through transcription factor Sp1.

Xiang Z, Qiao L, Zhou Y, Babiuk LA, Liu Q.

Biochem Biophys Res Commun. 2010 Nov 19;402(3):549-53. doi: 10.1016/j.bbrc.2010.10.081. Epub 2010 Oct 29.

PMID:
20971080
45.

PCEP enhances IgA mucosal immune responses in mice following different immunization routes with influenza virus antigens.

Eng NF, Garlapati S, Gerdts V, Babiuk LA, Mutwiri GK.

J Immune Based Ther Vaccines. 2010 Aug 24;8:4. doi: 10.1186/1476-8518-8-4.

46.

Immunogenicity and protective efficacy of an elastase-dependent live attenuated swine influenza virus vaccine administered intranasally in pigs.

Masic A, Lu X, Li J, Mutwiri GK, Babiuk LA, Brown EG, Zhou Y.

Vaccine. 2010 Oct 8;28(43):7098-108. doi: 10.1016/j.vaccine.2010.08.003. Epub 2010 Aug 12.

PMID:
20708697
47.

Human dendritic cells expressing hepatitis C virus core protein display transcriptional and functional changes consistent with maturation.

Landi A, Yu H, Babiuk LA, van Drunen Littel-van den Hurk S.

J Viral Hepat. 2011 Oct;18(10):700-13. doi: 10.1111/j.1365-2893.2010.01357.x. Epub 2010 Aug 4.

PMID:
20701679
48.

Subcutaneous, but not intratracheal administration of the TLR9 agonist, CpG DNA transiently reduces parainfluenza-3 virus shedding in newborn lambs.

Nichani AK, Dar MA, Mirakhur KK, Krieg AM, Booth JS, Townsend HG, Potter AA, Babiuk LA, Mutwiri GK.

Comp Immunol Microbiol Infect Dis. 2010 Dec;33(6):e111-7. doi: 10.1016/j.cimid.2010.06.003. Epub 2010 Jul 8.

PMID:
20619456
49.

TLR9 signaling failure renders Peyer's patch regulatory B cells unresponsive to stimulation with CpG oligodeoxynucleotides.

Booth JS, Arsenault R, Napper S, Griebel PJ, Potter AA, Babiuk LA, Mutwiri GK.

J Innate Immun. 2010;2(5):483-94. doi: 10.1159/000316574. Epub 2010 Jun 11.

50.

Differential activation and maturation of two porcine DC populations following TLR ligand stimulation.

Auray G, Facci MR, van Kessel J, Buchanan R, Babiuk LA, Gerdts V.

Mol Immunol. 2010 Jul;47(11-12):2103-11. doi: 10.1016/j.molimm.2010.03.016. Epub 2010 May 11.

PMID:
20462636

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