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Items: 1 to 50 of 54

1.

Iron, Hepcidin, and Death in Human AKI.

Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Boerger EAS, Mc Causland FR, Eisenga MF, Singh K, Babitt JL, Kellum JA, Palevsky PM, Christov M, Waikar SS.

J Am Soc Nephrol. 2019 Feb 8. pii: ASN.2018100979. doi: 10.1681/ASN.2018100979. [Epub ahead of print]

PMID:
30737269
2.

Antiviral activity of bone morphogenetic proteins and activins.

Eddowes LA, Al-Hourani K, Ramamurthy N, Frankish J, Baddock HT, Sandor C, Ryan JD, Fusco DN, Arezes J, Giannoulatou E, Boninsegna S, Chevaliez S, Owens BMJ, Sun CC, Fabris P, Giordani MT, Martines D, Vukicevic S, Crowe J, Lin HY, Rehwinkel J, McHugh PJ, Binder M, Babitt JL, Chung RT, Lawless MW, Armitage AE, Webber C, Klenerman P, Drakesmith H.

Nat Microbiol. 2019 Feb;4(2):339-351. doi: 10.1038/s41564-018-0301-9. Epub 2018 Dec 3.

PMID:
30510168
3.

Iron, erythropoietin, and inflammation regulate hepcidin in Bmp2-deficient mice, but serum iron fails to induce hepcidin in Bmp6-deficient mice.

Wang CY, Canali S, Bayer A, Dev S, Agarwal A, Babitt JL.

Am J Hematol. 2019 Feb;94(2):240-248. doi: 10.1002/ajh.25366. Epub 2018 Dec 10.

PMID:
30478858
4.

Liver iron sensing and body iron homeostasis.

Wang CY, Babitt JL.

Blood. 2019 Jan 3;133(1):18-29. doi: 10.1182/blood-2018-06-815894. Epub 2018 Nov 6. Review.

PMID:
30401708
5.

Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo.

He Q, Bouley R, Liu Z, Wein MN, Zhu Y, Spatz JM, Wang CY, Divieti Pajevic P, Plagge A, Babitt JL, Bastepe M.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9559-E9568. doi: 10.1073/pnas.1712670114. Epub 2017 Oct 23.

6.

Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6.

Canali S, Wang CY, Zumbrennen-Bullough KB, Bayer A, Babitt JL.

Am J Hematol. 2017 Nov;92(11):1204-1213. doi: 10.1002/ajh.24888. Epub 2017 Sep 25.

7.

Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice.

Wang CY, Core AB, Canali S, Zumbrennen-Bullough KB, Ozer S, Umans L, Zwijsen A, Babitt JL.

Blood. 2017 Jul 6;130(1):73-83. doi: 10.1182/blood-2016-12-759423. Epub 2017 Apr 24.

8.

Overview of iron metabolism in health and disease.

Dev S, Babitt JL.

Hemodial Int. 2017 Jun;21 Suppl 1:S6-S20. doi: 10.1111/hdi.12542. Epub 2017 Mar 15. Review.

9.

Lupus-like Immune Complex-mediated Glomerulonephritis in Patients with Hepatitis C Virus Infection Treated with Oral, Interferon-free, Direct-acting Antiviral Therapy.

Sise ME, Wisocky J, Rosales IA, Chute D, Holmes JA, Corapi KM, Babitt JL, Tangren JS, Hashemi N, Lundquist AL, Williams WW, Mount DB, Andersson KL, Rennke HG, Smith RN, Colvin R, Thadhani RI, Chung RT.

Kidney Int Rep. 2016 Sep;1(3):135-143.

10.

Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice.

Canali S, Zumbrennen-Bullough KB, Core AB, Wang CY, Nairz M, Bouley R, Swirski FK, Babitt JL.

Blood. 2017 Jan 26;129(4):405-414. doi: 10.1182/blood-2016-06-721571. Epub 2016 Nov 18.

11.

Ironing out the cross talk between FGF23 and inflammation.

David V, Francis C, Babitt JL.

Am J Physiol Renal Physiol. 2017 Jan 1;312(1):F1-F8. doi: 10.1152/ajprenal.00359.2016. Epub 2016 Aug 31. Review.

12.

The SMAD Pathway Is Required for Hepcidin Response During Endoplasmic Reticulum Stress.

Canali S, Vecchi C, Garuti C, Montosi G, Babitt JL, Pietrangelo A.

Endocrinology. 2016 Oct;157(10):3935-3945. Epub 2016 Aug 2.

13.

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver.

Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK.

Nat Med. 2016 Aug;22(8):945-51. doi: 10.1038/nm.4146. Epub 2016 Jul 18.

14.

Hepcidin regulation in the anemia of inflammation.

Wang CY, Babitt JL.

Curr Opin Hematol. 2016 May;23(3):189-97. doi: 10.1097/MOH.0000000000000236. Review.

15.

Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.

Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL.

Endocrinology. 2016 Mar;157(3):1146-62. doi: 10.1210/en.2015-1747. Epub 2016 Jan 6.

16.

Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production.

David V, Martin A, Isakova T, Spaulding C, Qi L, Ramirez V, Zumbrennen-Bullough KB, Sun CC, Lin HY, Babitt JL, Wolf M.

Kidney Int. 2016 Jan;89(1):135-46. doi: 10.1038/ki.2015.290. Epub 2016 Jan 4.

17.

Shear wave elastography in chronic kidney disease: a pilot experience in native kidneys.

Samir AE, Allegretti AS, Zhu Q, Dhyani M, Anvari A, Sullivan DA, Trottier CA, Dougherty S, Williams WW, Babitt JL, Wenger J, Thadhani RI, Lin HY.

BMC Nephrol. 2015 Jul 31;16:119. doi: 10.1186/s12882-015-0120-7.

18.

Hepcidin regulation in prostate and its disruption in prostate cancer.

Tesfay L, Clausen KA, Kim JW, Hegde P, Wang X, Miller LD, Deng Z, Blanchette N, Arvedson T, Miranti CK, Babitt JL, Lin HY, Peehl DM, Torti FM, Torti SV.

Cancer Res. 2015 Jun 1;75(11):2254-63. doi: 10.1158/0008-5472.CAN-14-2465. Epub 2015 Apr 9.

19.

Exogenous BMP7 corrects plasma iron overload and bone loss in Bmp6-/- mice.

Pauk M, Grgurevic L, Brkljacic J, Kufner V, Bordukalo-Niksic T, Grabusic K, Razdorov G, Rogic D, Zuvic M, Oppermann H, Babitt JL, Lin HY, Volarevic S, Vukicevic S.

Int Orthop. 2015 Jan;39(1):161-72. doi: 10.1007/s00264-014-2550-4. Epub 2014 Oct 11.

PMID:
25300398
20.

MicroRNA-130a is up-regulated in mouse liver by iron deficiency and targets the bone morphogenetic protein (BMP) receptor ALK2 to attenuate BMP signaling and hepcidin transcription.

Zumbrennen-Bullough KB, Wu Q, Core AB, Canali S, Chen W, Theurl I, Meynard D, Babitt JL.

J Biol Chem. 2014 Aug 22;289(34):23796-808. doi: 10.1074/jbc.M114.577387. Epub 2014 Jul 7.

21.

Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis.

Core AB, Canali S, Babitt JL.

Front Pharmacol. 2014 May 13;5:104. doi: 10.3389/fphar.2014.00104. eCollection 2014. Review.

22.

BuMPing iron with modified heparins.

Babitt JL, Lin HY.

Blood. 2014 Mar 6;123(10):1440-1. doi: 10.1182/blood-2014-01-549519.

23.

Inflammation regulates TMPRSS6 expression via STAT5.

Meynard D, Sun CC, Wu Q, Chen W, Chen S, Nelson CN, Waters MJ, Babitt JL, Lin HY.

PLoS One. 2013 Dec 23;8(12):e82127. doi: 10.1371/journal.pone.0082127. eCollection 2013.

24.

The iron cycle in chronic kidney disease (CKD): from genetics and experimental models to CKD patients.

Zumbrennen-Bullough K, Babitt JL.

Nephrol Dial Transplant. 2014 Feb;29(2):263-73. doi: 10.1093/ndt/gft443. Epub 2013 Nov 13. Review.

25.

The liver: conductor of systemic iron balance.

Meynard D, Babitt JL, Lin HY.

Blood. 2014 Jan 9;123(2):168-76. doi: 10.1182/blood-2013-06-427757. Epub 2013 Nov 7. Review.

26.

A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats.

Sun CC, Vaja V, Chen S, Theurl I, Stepanek A, Brown DE, Cappellini MD, Weiss G, Hong CC, Lin HY, Babitt JL.

Nephrol Dial Transplant. 2013 Jul;28(7):1733-43. doi: 10.1093/ndt/gfs584. Epub 2013 Jan 22.

27.

Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin.

Bouley R, Nunes P, Andriopoulos B Jr, McLaughlin M, Webber MJ, Lin HY, Babitt JL, Gardella TJ, Ausiello DA, Brown D.

Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F553-64. doi: 10.1152/ajprenal.00438.2011. Epub 2012 Dec 12.

28.

Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs).

Wu Q, Sun CC, Lin HY, Babitt JL.

PLoS One. 2012;7(9):e46307. doi: 10.1371/journal.pone.0046307. Epub 2012 Sep 27.

29.

Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent.

Wu X, Yung LM, Cheng WH, Yu PB, Babitt JL, Lin HY, Xia Y.

PLoS One. 2012;7(9):e44622. doi: 10.1371/journal.pone.0044622. Epub 2012 Sep 13.

30.

Statement of concern about a commercial assay used to measure soluble hemojuvelin in humans.

Gutiérrez OM, Sun CC, Chen W, Babitt JL, Lin HY.

Am J Nephrol. 2012;36(4):332-3; author reply 333. doi: 10.1159/000342519. Epub 2012 Sep 22. No abstract available.

31.

Mechanisms of anemia in CKD.

Babitt JL, Lin HY.

J Am Soc Nephrol. 2012 Oct;23(10):1631-4. Epub 2012 Aug 30. Review.

32.

A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum.

Chen W, Sun CC, Chen S, Meynard D, Babitt JL, Lin HY.

Haematologica. 2013 Feb;98(2):296-304. doi: 10.3324/haematol.2012.070136. Epub 2012 Aug 8.

33.

Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation.

Sun CC, Vaja V, Babitt JL, Lin HY.

Am J Hematol. 2012 Apr;87(4):392-400. doi: 10.1002/ajh.23110. Epub 2012 Jan 31. Review.

34.

The molecular pathogenesis of hereditary hemochromatosis.

Babitt JL, Lin HY.

Semin Liver Dis. 2011 Aug;31(3):280-92. doi: 10.1055/s-0031-1286059. Epub 2011 Sep 7. Review.

PMID:
21901658
35.

Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe.

Corradini E, Rozier M, Meynard D, Odhiambo A, Lin HY, Feng Q, Migas MC, Britton RS, Babitt JL, Fleming RE.

Gastroenterology. 2011 Nov;141(5):1907-14. doi: 10.1053/j.gastro.2011.06.077. Epub 2011 Jul 13.

36.

Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats.

Theurl I, Schroll A, Sonnweber T, Nairz M, Theurl M, Willenbacher W, Eller K, Wolf D, Seifert M, Sun CC, Babitt JL, Hong CC, Menhall T, Gearing P, Lin HY, Weiss G.

Blood. 2011 Nov 3;118(18):4977-84. doi: 10.1182/blood-2011-03-345066. Epub 2011 Jul 5.

37.

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.

Meynard D, Vaja V, Sun CC, Corradini E, Chen S, López-Otín C, Grgurevic L, Hong CC, Stirnberg M, Gütschow M, Vukicevic S, Babitt JL, Lin HY.

Blood. 2011 Jul 21;118(3):747-56. doi: 10.1182/blood-2011-04-348698. Epub 2011 May 26.

38.

Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice.

Corradini E, Meynard D, Wu Q, Chen S, Ventura P, Pietrangelo A, Babitt JL.

Hepatology. 2011 Jul;54(1):273-84. doi: 10.1002/hep.24359.

39.

The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease.

Wang L, Trebicka E, Fu Y, Ellenbogen S, Hong CC, Babitt JL, Lin HY, Cherayil BJ.

Inflamm Bowel Dis. 2012 Jan;18(1):112-9. doi: 10.1002/ibd.21675. Epub 2011 Feb 23.

40.

BMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelin.

Gibert Y, Lattanzi VJ, Zhen AW, Vedder L, Brunet F, Faasse SA, Babitt JL, Lin HY, Hammerschmidt M, Fraenkel PG.

PLoS One. 2011 Jan 21;6(1):e14553. doi: 10.1371/journal.pone.0014553.

41.

Altered hepatic BMP signaling pathway in human HFE hemochromatosis.

Bolondi G, Garuti C, Corradini E, Zoller H, Vogel W, Finkenstedt A, Babitt JL, Lin HY, Pietrangelo A.

Blood Cells Mol Dis. 2010 Dec 15;45(4):308-12. doi: 10.1016/j.bcmd.2010.08.010. Epub 2010 Sep 21.

42.

BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice.

Corradini E, Schmidt PJ, Meynard D, Garuti C, Montosi G, Chen S, Vukicevic S, Pietrangelo A, Lin HY, Babitt JL.

Gastroenterology. 2010 Nov;139(5):1721-9. doi: 10.1053/j.gastro.2010.07.044. Epub 2010 Aug 1.

43.

Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD.

Babitt JL, Lin HY.

Am J Kidney Dis. 2010 Apr;55(4):726-41. doi: 10.1053/j.ajkd.2009.12.030. Epub 2010 Feb 26. Review.

44.

Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells.

Xia Y, Babitt JL, Bouley R, Zhang Y, Da Silva N, Chen S, Zhuang Z, Samad TA, Brenner GJ, Anderson JL, Hong CC, Schneyer AL, Brown D, Lin HY.

J Am Soc Nephrol. 2010 Apr;21(4):666-77. doi: 10.1681/ASN.2009050511. Epub 2010 Feb 18.

45.

The RGM/DRAGON family of BMP co-receptors.

Corradini E, Babitt JL, Lin HY.

Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):389-98. doi: 10.1016/j.cytogfr.2009.10.008. Epub 2009 Nov 7. Review.

46.

Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice.

Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ.

J Clin Invest. 2009 Nov;119(11):3322-8. doi: 10.1172/JCI39939. Epub 2009 Oct 5.

47.

Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis.

Corradini E, Garuti C, Montosi G, Ventura P, Andriopoulos B Jr, Lin HY, Pietrangelo A, Babitt JL.

Gastroenterology. 2009 Oct;137(4):1489-97. doi: 10.1053/j.gastro.2009.06.057. Epub 2009 Jul 7.

48.

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism.

Andriopoulos B Jr, Corradini E, Xia Y, Faasse SA, Chen S, Grgurevic L, Knutson MD, Pietrangelo A, Vukicevic S, Lin HY, Babitt JL.

Nat Genet. 2009 Apr;41(4):482-7. doi: 10.1038/ng.335. Epub 2009 Mar 1.

49.

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.

Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY.

Blood. 2008 May 15;111(10):5195-204. doi: 10.1182/blood-2007-09-111567. Epub 2008 Mar 7.

50.

Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.

Yu PB, Hong CC, Sachidanandan C, Babitt JL, Deng DY, Hoyng SA, Lin HY, Bloch KD, Peterson RT.

Nat Chem Biol. 2008 Jan;4(1):33-41. Epub 2007 Nov 18.

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