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Items: 1 to 50 of 141

1.

HU-671, a Novel Oleoyl Serine Derivative, Exhibits Enhanced Efficacy in Reversing Ovariectomy-Induced Osteoporosis and Bone Marrow Adiposity.

Baraghithy S, Smoum R, Attar-Namdar M, Mechoulam R, Bab I, Tam J.

Molecules. 2019 Oct 16;24(20). pii: E3719. doi: 10.3390/molecules24203719.

2.

Magel2 Modulates Bone Remodeling and Mass in Prader-Willi Syndrome by Affecting Oleoyl Serine Levels and Activity.

Baraghithy S, Smoum R, Drori A, Hadar R, Gammal A, Hirsch S, Attar-Namdar M, Nemirovski A, Gabet Y, Langer Y, Pollak Y, Schaaf CP, Rech ME, Gross-Tsur V, Bab I, Mechoulam R, Tam J.

J Bone Miner Res. 2019 Jan;34(1):93-105. doi: 10.1002/jbmr.3591. Epub 2018 Oct 22.

PMID:
30347474
3.

Age-related regulation of bone formation by the sympathetic cannabinoid CB1 receptor.

Deis S, Srivastava RK, Ruiz de Azua I, Bindila L, Baraghithy S, Lutz B, Bab I, Tam J.

Bone. 2018 Mar;108:34-42. doi: 10.1016/j.bone.2017.12.018. Epub 2017 Dec 20.

PMID:
29274505
4.

A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice.

Bilkei-Gorzo A, Albayram O, Draffehn A, Michel K, Piyanova A, Oppenheimer H, Dvir-Ginzberg M, Rácz I, Ulas T, Imbeault S, Bab I, Schultze JL, Zimmer A.

Nat Med. 2017 Jun;23(6):782-787. doi: 10.1038/nm.4311. Epub 2017 May 8.

PMID:
28481360
5.

Bone loss in C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 genes.

Liron T, Raphael B, Hiram-Bab S, Bab IA, Gabet Y.

J Cell Physiol. 2018 Jan;233(1):371-377. doi: 10.1002/jcp.25895. Epub 2017 Jun 5.

PMID:
28266709
6.

Behavioural changes induced by a conditional disruption of bone formation.

Zimmer A, Otte DM, Bilkei-Gorzo A, Armin SM, Bab I.

J Basic Clin Physiol Pharmacol. 2016 May 1;27(3):203-7. doi: 10.1515/jbcpp-2015-0155.

7.

CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency.

Smoum R, Baraghithy S, Chourasia M, Breuer A, Mussai N, Attar-Namdar M, Kogan NM, Raphael B, Bolognini D, Cascio MG, Marini P, Pertwee RG, Shurki A, Mechoulam R, Bab I.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8774-9. doi: 10.1073/pnas.1503395112. Epub 2015 Jun 29.

8.

The mammalian lectin galectin-8 induces RANKL expression, osteoclastogenesis, and bone mass reduction in mice.

Vinik Y, Shatz-Azoulay H, Vivanti A, Hever N, Levy Y, Karmona R, Brumfeld V, Baraghithy S, Attar-Lamdar M, Boura-Halfon S, Bab I, Zick Y.

Elife. 2015 May 8;4:e05914. doi: 10.7554/eLife.05914.

9.

Cannabidiol, a Major Non-Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts.

Kogan NM, Melamed E, Wasserman E, Raphael B, Breuer A, Stok KS, Sondergaard R, Escudero AV, Baraghithy S, Attar-Namdar M, Friedlander-Barenboim S, Mathavan N, Isaksson H, Mechoulam R, Müller R, Bajayo A, Gabet Y, Bab I.

J Bone Miner Res. 2015 Oct;30(10):1905-13. doi: 10.1002/jbmr.2513. Epub 2015 May 10.

10.

Endocannabinoid signaling at the periphery: 50 years after THC.

Maccarrone M, Bab I, Bíró T, Cabral GA, Dey SK, Di Marzo V, Konje JC, Kunos G, Mechoulam R, Pacher P, Sharkey KA, Zimmer A.

Trends Pharmacol Sci. 2015 May;36(5):277-96. doi: 10.1016/j.tips.2015.02.008. Epub 2015 Mar 18. Review.

11.

CB1 cannabinoid receptors mediate endochondral skeletal growth attenuation by Δ9-tetrahydrocannabinol.

Wasserman E, Tam J, Mechoulam R, Zimmer A, Maor G, Bab I.

Ann N Y Acad Sci. 2015 Jan;1335:110-9. doi: 10.1111/nyas.12642.

PMID:
25573322
12.

N-Acyl amino acids and their impact on biological processes.

Hanuš L, Shohami E, Bab I, Mechoulam R.

Biofactors. 2014 Jul-Aug;40(4):381-8. doi: 10.1002/biof.1166. Epub 2014 Apr 21.

PMID:
24753374
13.

Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes.

Iqbal J, Sun L, Cao J, Yuen T, Lu P, Bab I, Leu NA, Srinivasan S, Wagage S, Hunter CA, Nebert DW, Zaidi M, Avadhani NG.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11115-20. doi: 10.1073/pnas.1220919110. Epub 2013 Jun 17.

14.

Differential load-regulated global gene expression in mouse trabecular osteocytes.

Wasserman E, Webster D, Kuhn G, Attar-Namdar M, Müller R, Bab I.

Bone. 2013 Mar;53(1):14-23. doi: 10.1016/j.bone.2012.11.017. Epub 2012 Nov 28.

PMID:
23201221
15.

Skeletal parasympathetic innervation communicates central IL-1 signals regulating bone mass accrual.

Bajayo A, Bar A, Denes A, Bachar M, Kram V, Attar-Namdar M, Zallone A, Kovács KJ, Yirmiya R, Bab I.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15455-60. Epub 2012 Sep 4.

16.

Bone marrow oxytocin mediates the anabolic action of estrogen on the skeleton.

Colaianni G, Sun L, Di Benedetto A, Tamma R, Zhu LL, Cao J, Grano M, Yuen T, Colucci S, Cuscito C, Mancini L, Li J, Nishimori K, Bab I, Lee HJ, Iqbal J, Young WS 3rd, Rosen C, Zallone A, Zaidi M.

J Biol Chem. 2012 Aug 17;287(34):29159-67. doi: 10.1074/jbc.M112.365049. Epub 2012 Jul 2.

17.

Microarchitectural changes in the aging skeleton.

Gabet Y, Bab I.

Curr Osteoporos Rep. 2011 Dec;9(4):177-83. doi: 10.1007/s11914-011-0072-1. Review.

PMID:
21901426
18.

Themed issue on cannabinoids in biology and medicine.

Bab I.

Br J Pharmacol. 2011 Aug;163(7):1327-8. doi: 10.1111/j.1476-5381.2011.01536.x. No abstract available.

19.

Skeletal lipidomics: regulation of bone metabolism by fatty acid amide family.

Bab I, Smoum R, Bradshaw H, Mechoulam R.

Br J Pharmacol. 2011 Aug;163(7):1441-6. doi: 10.1111/j.1476-5381.2011.01474.x. Review.

20.

Osteocalcin-insulin relationship in obese children: a role for the skeleton in energy metabolism.

Rochefort GY, Rocher E, Aveline PC, Garnero P, Bab I, Chappard C, Jaffré C, Benhamou CL.

Clin Endocrinol (Oxf). 2011 Aug;75(2):265-70. doi: 10.1111/j.1365-2265.2011.04031.x.

PMID:
21521300
21.

Oleoyl serine, an endogenous N-acyl amide, modulates bone remodeling and mass.

Smoum R, Bar A, Tan B, Milman G, Attar-Namdar M, Ofek O, Stuart JM, Bajayo A, Tam J, Kram V, O'Dell D, Walker MJ, Bradshaw HB, Bab I, Mechoulam R.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17710-5. doi: 10.1073/pnas.0912479107. Epub 2010 Sep 27.

22.

Depression, selective serotonin reuptake inhibitors, and osteoporosis.

Bab I, Yirmiya R.

Curr Osteoporos Rep. 2010 Dec;8(4):185-91. doi: 10.1007/s11914-010-0026-z. Review.

PMID:
20809204
23.

CB2 cannabinoid receptor targets mitogenic Gi protein-cyclin D1 axis in osteoblasts.

Ofek O, Attar-Namdar M, Kram V, Dvir-Ginzberg M, Mechoulam R, Zimmer A, Frenkel B, Shohami E, Bab I.

J Bone Miner Res. 2011 Feb;26(2):308-16. doi: 10.1002/jbmr.228.

24.

Depression and bone mass.

Bab IA, Yirmiya R.

Ann N Y Acad Sci. 2010 Mar;1192:170-5. doi: 10.1111/j.1749-6632.2009.05218.x. Review.

PMID:
20392233
25.

Mechanical loading of mouse caudal vertebrae increases trabecular and cortical bone mass-dependence on dose and genotype.

Webster D, Wasserman E, Ehrbar M, Weber F, Bab I, Müller R.

Biomech Model Mechanobiol. 2010 Dec;9(6):737-47. doi: 10.1007/s10237-010-0210-1. Epub 2010 Mar 30.

26.

Transplanted blood-derived endothelial progenitor cells (EPC) enhance bridging of sheep tibia critical size defects.

Rozen N, Bick T, Bajayo A, Shamian B, Schrift-Tzadok M, Gabet Y, Yayon A, Bab I, Soudry M, Lewinson D.

Bone. 2009 Nov;45(5):918-24. doi: 10.1016/j.bone.2009.07.085. Epub 2009 Aug 6.

PMID:
19665064
27.

Endosseous implant anchorage is critically dependent on mechanostructural determinants of peri-implant bone trabeculae.

Gabet Y, Kohavi D, Voide R, Mueller TL, Müller R, Bab I.

J Bone Miner Res. 2010 Mar;25(3):575-83. doi: 10.1359/jbmr.090808.

28.

Cannabinoids and the skeleton: from marijuana to reversal of bone loss.

Bab I, Zimmer A, Melamed E.

Ann Med. 2009;41(8):560-7. doi: 10.1080/07853890903121025. Review.

PMID:
19634029
29.

Restrain of bone growth by estrogen-mimetic peptide-1 (EMP-1): a micro-computed tomographic study.

Kasher R, Bajayo A, Gabet Y, Nevo N, Fridkin M, Katchalski-Katzir E, Kohen F, Bab I.

Peptides. 2009 Jun;30(6):1181-6. doi: 10.1016/j.peptides.2009.02.019. Epub 2009 Mar 14.

PMID:
19463753
30.

Major depression is a risk factor for low bone mineral density: a meta-analysis.

Yirmiya R, Bab I.

Biol Psychiatry. 2009 Sep 1;66(5):423-32. doi: 10.1016/j.biopsych.2009.03.016. Epub 2009 May 15.

PMID:
19446797
31.

Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner.

Noh T, Gabet Y, Cogan J, Shi Y, Tank A, Sasaki T, Criswell B, Dixon A, Lee C, Tam J, Kohler T, Segev E, Kockeritz L, Woodgett J, Müller R, Chai Y, Smith E, Bab I, Frenkel B.

PLoS One. 2009;4(5):e5438. doi: 10.1371/journal.pone.0005438. Epub 2009 May 4.

32.

Oxytocin is an anabolic bone hormone.

Tamma R, Colaianni G, Zhu LL, DiBenedetto A, Greco G, Montemurro G, Patano N, Strippoli M, Vergari R, Mancini L, Colucci S, Grano M, Faccio R, Liu X, Li J, Usmani S, Bachar M, Bab I, Nishimori K, Young LJ, Buettner C, Iqbal J, Sun L, Zaidi M, Zallone A.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7149-54. doi: 10.1073/pnas.0901890106. Epub 2009 Apr 15.

33.

Dextran sodium sulfate-induced colitis causes rapid bone loss in mice.

Hamdani G, Gabet Y, Rachmilewitz D, Karmeli F, Bab I, Dresner-Pollak R.

Bone. 2008 Nov;43(5):945-50. doi: 10.1016/j.bone.2008.06.018. Epub 2008 Jul 14.

PMID:
18675386
34.

Endocannabinoids and the regulation of bone metabolism.

Bab I, Ofek O, Tam J, Rehnelt J, Zimmer A.

J Neuroendocrinol. 2008 May;20 Suppl 1:69-74. doi: 10.1111/j.1365-2826.2008.01675.x. Review.

PMID:
18426503
35.

Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss.

Sun L, Vukicevic S, Baliram R, Yang G, Sendak R, McPherson J, Zhu LL, Iqbal J, Latif R, Natrajan A, Arabi A, Yamoah K, Moonga BS, Gabet Y, Davies TF, Bab I, Abe E, Sampath K, Zaidi M.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4289-94. doi: 10.1073/pnas.0712395105. Epub 2008 Mar 10.

36.

Cannabinoid receptors and the regulation of bone mass.

Bab I, Zimmer A.

Br J Pharmacol. 2008 Jan;153(2):182-8. Epub 2007 Dec 10. Review.

37.

Human parathyroid hormone 1-34 prevents bone loss in experimental biliary cirrhosis in rats.

Dresner-Pollak R, Gabet Y, Steimatzky A, Hamdani G, Bab I, Ackerman Z, Weinreb M.

Gastroenterology. 2008 Jan;134(1):259-67. Epub 2007 Oct 18.

PMID:
18061175
38.
39.

The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling.

Tam J, Trembovler V, Di Marzo V, Petrosino S, Leo G, Alexandrovich A, Regev E, Casap N, Shteyer A, Ledent C, Karsak M, Zimmer A, Mechoulam R, Yirmiya R, Shohami E, Bab I.

FASEB J. 2008 Jan;22(1):285-94. Epub 2007 Aug 17.

PMID:
17704191
40.

Regulation of skeletal remodeling by the endocannabinoid system.

Bab IA.

Ann N Y Acad Sci. 2007 Nov;1116:414-22. Epub 2007 Jul 23. Review.

PMID:
17646266
41.

Depression induces bone loss through stimulation of the sympathetic nervous system.

Yirmiya R, Goshen I, Bajayo A, Kreisel T, Feldman S, Tam J, Trembovler V, Csernus V, Shohami E, Bab I.

Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16876-81. Epub 2006 Oct 30.

42.

Involvement of neuronal cannabinoid receptor CB1 in regulation of bone mass and bone remodeling.

Tam J, Ofek O, Fride E, Ledent C, Gabet Y, Müller R, Zimmer A, Mackie K, Mechoulam R, Shohami E, Bab I.

Mol Pharmacol. 2006 Sep;70(3):786-92. Epub 2006 Jun 13.

PMID:
16772520
43.

Parathyroid hormone 1-34 enhances titanium implant anchorage in low-density trabecular bone: a correlative micro-computed tomographic and biomechanical analysis.

Gabet Y, Müller R, Levy J, Dimarchi R, Chorev M, Bab I, Kohavi D.

Bone. 2006 Aug;39(2):276-82. Epub 2006 Apr 17.

PMID:
16617039
44.

Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass.

Kram V, Zcharia E, Yacoby-Zeevi O, Metzger S, Chajek-Shaul T, Gabet Y, Müller R, Vlodavsky I, Bab I.

J Cell Physiol. 2006 Jun;207(3):784-92.

PMID:
16514606
45.

Peripheral cannabinoid receptor, CB2, regulates bone mass.

Ofek O, Karsak M, Leclerc N, Fogel M, Frenkel B, Wright K, Tam J, Attar-Namdar M, Kram V, Shohami E, Mechoulam R, Zimmer A, Bab I.

Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):696-701. Epub 2006 Jan 9.

46.

Cannabinoid receptor type 2 gene is associated with human osteoporosis.

Karsak M, Cohen-Solal M, Freudenberg J, Ostertag A, Morieux C, Kornak U, Essig J, Erxlebe E, Bab I, Kubisch C, de Vernejoul MC, Zimmer A.

Hum Mol Genet. 2005 Nov 15;14(22):3389-96. Epub 2005 Oct 4.

PMID:
16204352
47.

ERK1/2-activated de novo Mapkapk2 synthesis is essential for osteogenic growth peptide mitogenic signaling in osteoblastic cells.

Miguel SM, Namdar-Attar M, Noh T, Frenkel B, Bab I.

J Biol Chem. 2005 Nov 11;280(45):37495-502. Epub 2005 Sep 2.

48.

Central IL-1 receptor signaling regulates bone growth and mass.

Bajayo A, Goshen I, Feldman S, Csernus V, Iverfeldt K, Shohami E, Yirmiya R, Bab I.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12956-61. Epub 2005 Aug 26.

49.

Intermittently administered parathyroid hormone 1-34 reverses bone loss and structural impairment in orchiectomized adult rats.

Gabet Y, Kohavi D, Müller R, Chorev M, Bab I.

Osteoporos Int. 2005 Nov;16(11):1436-43. Epub 2005 Apr 6.

PMID:
15812598
50.

Prediction of fracture callus mechanical properties using micro-CT images and voxel-based finite element analysis.

Shefelbine SJ, Simon U, Claes L, Gold A, Gabet Y, Bab I, Müller R, Augat P.

Bone. 2005 Mar;36(3):480-8.

PMID:
15777656

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