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Items: 1 to 50 of 157


New hypothesis for the etiology of SPAST-based hereditary spastic paraplegia.

Qiang L, Piermarini E, Baas PW.

Cytoskeleton (Hoboken). 2019 Apr;76(4):289-297. doi: 10.1002/cm.21528. Epub 2019 Jul 3.


Tau: It's Not What You Think.

Baas PW, Qiang L.

Trends Cell Biol. 2019 Jun;29(6):452-461. doi: 10.1016/j.tcb.2019.02.007. Epub 2019 Mar 28. Review.


Mitotic Motor KIFC1 Is an Organizer of Microtubules in the Axon.

Muralidharan H, Baas PW.

J Neurosci. 2019 May 15;39(20):3792-3811. doi: 10.1523/JNEUROSCI.3099-18.2019. Epub 2019 Feb 25.


Knockdown of Fidgetin Improves Regeneration of Injured Axons by a Microtubule-Based Mechanism.

Matamoros AJ, Tom VJ, Wu D, Rao Y, Sharp DJ, Baas PW.

J Neurosci. 2019 Mar 13;39(11):2011-2024. doi: 10.1523/JNEUROSCI.1888-18.2018. Epub 2019 Jan 15.


Hereditary spastic paraplegia: gain-of-function mechanisms revealed by new transgenic mouse.

Qiang L, Piermarini E, Muralidharan H, Yu W, Leo L, Hennessy LE, Fernandes S, Connors T, Yates PL, Swift M, Zholudeva LV, Lane MA, Morfini G, Alexander GM, Heiman-Patterson TD, Baas PW.

Hum Mol Genet. 2019 Apr 1;28(7):1136-1152. doi: 10.1093/hmg/ddy419.


Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-mediated kif15 mutations accelerate axonal outgrowth during neuronal development and regeneration in zebrafish.

Dong Z, Wu S, Zhu C, Wang X, Li Y, Chen X, Liu D, Qiang L, Baas PW, Liu M.

Traffic. 2019 Jan;20(1):71-81. doi: 10.1111/tra.12621. Epub 2018 Nov 29.


Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains.

Qiang L, Sun X, Austin TO, Muralidharan H, Jean DC, Liu M, Yu W, Baas PW.

Curr Biol. 2018 Jul 9;28(13):2181-2189.e4. doi: 10.1016/j.cub.2018.05.045. Epub 2018 Jun 28.


Polarity Sorting of Microtubules in the Axon.

Rao AN, Baas PW.

Trends Neurosci. 2018 Feb;41(2):77-88. doi: 10.1016/j.tins.2017.11.002. Epub 2017 Nov 30. Review.


Polarity sorting of axonal microtubules: a computational study.

Craig EM, Yeung HT, Rao AN, Baas PW.

Mol Biol Cell. 2017 Nov 7;28(23):3271-3285. doi: 10.1091/mbc.E17-06-0380. Epub 2017 Oct 4.


Nanoparticle Delivery of Fidgetin siRNA as a Microtubule-based Therapy to Augment Nerve Regeneration.

Austin TO, Matamoros AJ, Friedman JM, Friedman AJ, Nacharaju P, Yu W, Sharp DJ, Baas PW.

Sci Rep. 2017 Aug 29;7(1):9675. doi: 10.1038/s41598-017-10250-z.


Cytoplasmic Dynein Transports Axonal Microtubules in a Polarity-Sorting Manner.

Rao AN, Patil A, Black MM, Craig EM, Myers KA, Yeung HT, Baas PW.

Cell Rep. 2017 Jun 13;19(11):2210-2219. doi: 10.1016/j.celrep.2017.05.064.


Reprogramming cells from Gulf War veterans into neurons to study Gulf War illness.

Qiang L, Rao AN, Mostoslavsky G, James MF, Comfort N, Sullivan K, Baas PW.

Neurology. 2017 May 16;88(20):1968-1975. doi: 10.1212/WNL.0000000000003938.


Truncating mutations of SPAST associated with hereditary spastic paraplegia indicate greater accumulation and toxicity of the M1 isoform of spastin.

Solowska JM, Rao AN, Baas PW.

Mol Biol Cell. 2017 Jul 1;28(13):1728-1737. doi: 10.1091/mbc.E17-01-0047. Epub 2017 May 11.


Pharmacologically increasing microtubule acetylation corrects stress-exacerbated effects of organophosphates on neurons.

Rao AN, Patil A, Brodnik ZD, Qiang L, España RA, Sullivan KA, Black MM, Baas PW.

Traffic. 2017 Jul;18(7):433-441. doi: 10.1111/tra.12489. Epub 2017 May 25.


Mutant spastin proteins promote deficits in axonal transport through an isoform-specific mechanism involving casein kinase 2 activation.

Leo L, Weissmann C, Burns M, Kang M, Song Y, Qiang L, Brady ST, Baas PW, Morfini G.

Hum Mol Genet. 2017 Jun 15;26(12):2321-2334. doi: 10.1093/hmg/ddx125.


Microtubules in health and degenerative disease of the nervous system.

Matamoros AJ, Baas PW.

Brain Res Bull. 2016 Sep;126(Pt 3):217-225. doi: 10.1016/j.brainresbull.2016.06.016. Epub 2016 Jun 27. Review.


Microtubules and Growth Cones: Motors Drive the Turn.

Kahn OI, Baas PW.

Trends Neurosci. 2016 Jul;39(7):433-440. doi: 10.1016/j.tins.2016.04.009. Epub 2016 May 24. Review.


Depletion of kinesin-12, a myosin-IIB-interacting protein, promotes migration of cortical astrocytes.

Feng J, Hu Z, Chen H, Hua J, Wu R, Dong Z, Qiang L, Liu Y, Baas PW, Liu M.

J Cell Sci. 2016 Jun 15;129(12):2438-47. doi: 10.1242/jcs.181867. Epub 2016 May 11.


Sliding of centrosome-unattached microtubules defines key features of neuronal phenotype.

Rao AN, Falnikar A, O'Toole ET, Morphew MK, Hoenger A, Davidson MW, Yuan X, Baas PW.

J Cell Biol. 2016 May 9;213(3):329-41. doi: 10.1083/jcb.201506140. Epub 2016 May 2.


Stability properties of neuronal microtubules.

Baas PW, Rao AN, Matamoros AJ, Leo L.

Cytoskeleton (Hoboken). 2016 Sep;73(9):442-60. doi: 10.1002/cm.21286. Review.


Using siRNA to study microtubule-related proteins in cultured neurons.

Leo L, Yu W, Baas PW.

Methods Cell Biol. 2016;131:163-76. doi: 10.1016/bs.mcb.2015.06.005. Epub 2015 Sep 3.


Vertebrate Fidgetin Restrains Axonal Growth by Severing Labile Domains of Microtubules.

Leo L, Yu W, D'Rozario M, Waddell EA, Marenda DR, Baird MA, Davidson MW, Zhou B, Wu B, Baker L, Sharp DJ, Baas PW.

Cell Rep. 2015 Sep 22;12(11):1723-30. doi: 10.1016/j.celrep.2015.08.017. Epub 2015 Sep 3.


International Meeting Molecular Neurodegeneration: News and Views in Molecular Neuroscience in Health and Disease. Delmenhorst, Germany, July 20-22, 2015.

Gozes I, Baas PW, Richter-Landsberg C.

J Mol Neurosci. 2015 Oct;57(2):153-9. doi: 10.1007/s12031-015-0637-z. No abstract available.


Ablation of the 14-3-3gamma Protein Results in Neuronal Migration Delay and Morphological Defects in the Developing Cerebral Cortex.

Wachi T, Cornell B, Marshall C, Zhukarev V, Baas PW, Toyo-oka K.

Dev Neurobiol. 2016 Jun;76(6):600-14. doi: 10.1002/dneu.22335. Epub 2015 Aug 28.


TPX2 regulates neuronal morphology through kinesin-5 interaction.

Kahn OI, Ha N, Baird MA, Davidson MW, Baas PW.

Cytoskeleton (Hoboken). 2015 Jul;72(7):340-8. doi: 10.1002/cm.21234. Epub 2015 Aug 22.


Inhibition of kinesin-5 improves regeneration of injured axons by a novel microtubule-based mechanism.

Baas PW, Matamoros AJ.

Neural Regen Res. 2015 Jun;10(6):845-9. doi: 10.4103/1673-5374.158351. Review.


Hereditary spastic paraplegia SPG4: what is known and not known about the disease.

Solowska JM, Baas PW.

Brain. 2015 Sep;138(Pt 9):2471-84. doi: 10.1093/brain/awv178. Epub 2015 Jun 20. Review.


Emerging microtubule targets in glioma therapy.

Katsetos CD, Reginato MJ, Baas PW, D'Agostino L, Legido A, Tuszyn Ski JA, Dráberová E, Dráber P.

Semin Pediatr Neurol. 2015 Mar;22(1):49-72. doi: 10.1016/j.spen.2015.03.009. Epub 2015 Apr 4. Review.


Histone acetylation inhibitors promote axon growth in adult dorsal root ganglia neurons.

Lin S, Nazif K, Smith A, Baas PW, Smith GM.

J Neurosci Res. 2015 Aug;93(8):1215-28. doi: 10.1002/jnr.23573. Epub 2015 Feb 20.


Pharmacologically inhibiting kinesin-5 activity with monastrol promotes axonal regeneration following spinal cord injury.

Xu C, Klaw MC, Lemay MA, Baas PW, Tom VJ.

Exp Neurol. 2015 Jan;263:172-6. doi: 10.1016/j.expneurol.2014.10.013. Epub 2014 Oct 24.


Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization.

Kahn OI, Sharma V, González-Billault C, Baas PW.

Mol Biol Cell. 2015 Jan 1;26(1):66-77. doi: 10.1091/mbc.E14-08-1313. Epub 2014 Oct 29.


Kinesin-12 influences axonal growth during zebrafish neural development.

Xu M, Liu D, Dong Z, Wang X, Wang X, Liu Y, Baas PW, Liu M.

Cytoskeleton (Hoboken). 2014 Oct;71(10):555-63. doi: 10.1002/cm.21193. Epub 2014 Oct 30.


Beyond taxol: microtubule-based strategies for promoting nerve regeneration after injury.

Baas PW.

Neural Regen Res. 2014 Jul 1;9(13):1265-6. doi: 10.4103/1673-5374.137572. No abstract available.


Pathogenic mutation of spastin has gain-of-function effects on microtubule dynamics.

Solowska JM, D'Rozario M, Jean DC, Davidson MW, Marenda DR, Baas PW.

J Neurosci. 2014 Jan 29;34(5):1856-67. doi: 10.1523/JNEUROSCI.3309-13.2014.


The crystal structure and biochemical characterization of Kif15: a bifunctional molecular motor involved in bipolar spindle formation and neuronal development.

Klejnot M, Falnikar A, Ulaganathan V, Cross RA, Baas PW, Kozielski F.

Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):123-33. doi: 10.1107/S1399004713028721. Epub 2013 Dec 24.


Microtubules in neurons as information carriers.

Dent EW, Baas PW.

J Neurochem. 2014 Apr;129(2):235-9. doi: 10.1111/jnc.12621. Epub 2013 Dec 11. Review.


Neuronal migration re-purposes mechanisms of cytokinesis.

Falnikar A, Baas PW.

Cell Cycle. 2013 Dec 1;12(23):3577-8. doi: 10.4161/cc.26821. Epub 2013 Oct 21. No abstract available.


It cuts two ways: microtubule loss during Alzheimer disease.

Jean DC, Baas PW.

EMBO J. 2013 Nov 13;32(22):2900-2. doi: 10.1038/emboj.2013.219. Epub 2013 Sep 27. No abstract available.


USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth.

Yang SW, Oh KH, Park E, Chang HM, Park JM, Seong MW, Ka SH, Song WK, Park DE, Baas PW, Jeon YJ, Chung CH.

J Neurosci. 2013 Jul 31;33(31):12728-38. doi: 10.1523/JNEUROSCI.0698-13.2013.


Beyond taxol: microtubule-based treatment of disease and injury of the nervous system.

Baas PW, Ahmad FJ.

Brain. 2013 Oct;136(Pt 10):2937-51. doi: 10.1093/brain/awt153. Epub 2013 Jun 27. Review.


Polarity in migrating neurons is related to a mechanism analogous to cytokinesis.

Falnikar A, Tole S, Liu M, Liu JS, Baas PW.

Curr Biol. 2013 Jul 8;23(13):1215-20. doi: 10.1016/j.cub.2013.05.027. Epub 2013 Jun 20.


Microtubule stability in the axon: new answers to an old mystery.

Baas PW.

Neuron. 2013 Apr 10;78(1):3-5. doi: 10.1016/j.neuron.2013.03.012.


Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of α-tubulin.

Yang W, Guo X, Thein S, Xu F, Sugii S, Baas PW, Radda GK, Han W.

Biochem J. 2013 Feb 1;449(3):605-12. doi: 10.1042/BJ20121121.


Mitotic motors coregulate microtubule patterns in axons and dendrites.

Lin S, Liu M, Mozgova OI, Yu W, Baas PW.

J Neurosci. 2012 Oct 3;32(40):14033-49. doi: 10.1523/JNEUROSCI.3070-12.2012.


A novel role for doublecortin and doublecortin-like kinase in regulating growth cone microtubules.

Jean DC, Baas PW, Black MM.

Hum Mol Genet. 2012 Dec 15;21(26):5511-27. doi: 10.1093/hmg/dds395. Epub 2012 Sep 21.


A gathering of neuronal cytoskeletal scientists in South America.

Baas PW, Gonzalez-Billault C.

Cytoskeleton (Hoboken). 2012 Jul;69(7):407-15. doi: 10.1002/cm.21038. Epub 2012 Jun 21.


Creative destruction of the microtubule array.

Baas PW, Yu W.

Cell Cycle. 2012 Jul 1;11(13):2420-1. doi: 10.4161/cc.21070. Epub 2012 Jul 1. No abstract available.


Septin-driven coordination of actin and microtubule remodeling regulates the collateral branching of axons.

Hu J, Bai X, Bowen JR, Dolat L, Korobova F, Yu W, Baas PW, Svitkina T, Gallo G, Spiliotis ET.

Curr Biol. 2012 Jun 19;22(12):1109-15. doi: 10.1016/j.cub.2012.04.019. Epub 2012 May 17.


Microtubule redistribution in growth cones elicited by focal inactivation of kinesin-5.

Nadar VC, Lin S, Baas PW.

J Neurosci. 2012 Apr 25;32(17):5783-94. doi: 10.1523/JNEUROSCI.0144-12.2012.


A novel role for retrograde transport of microtubules in the axon.

Baas PW, Mozgova OI.

Cytoskeleton (Hoboken). 2012 Jul;69(7):416-25. doi: 10.1002/cm.21013. Epub 2012 Feb 14. Review.


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