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Items: 1 to 50 of 129

1.

Direct Binding of the Flexible C-Terminal Segment of Periaxin to β4 Integrin Suggests a Molecular Basis for CMT4F.

Raasakka A, Linxweiler H, Brophy PJ, Sherman DL, Kursula P.

Front Mol Neurosci. 2019 Apr 9;12:84. doi: 10.3389/fnmol.2019.00084. eCollection 2019.

2.

Homozygous mutation in the Neurofascin gene affecting the glial isoform of Neurofascin causes severe neurodevelopment disorder with hypotonia, amimia and areflexia.

Smigiel R, Sherman DL, Rydzanicz M, Walczak A, Mikolajkow D, Krolak-Olejnik B, Kosinska J, Gasperowicz P, Biernacka A, Stawinski P, Marciniak M, Andrzejewski W, Boczar M, Krajewski P, Sasiadek MM, Brophy PJ, Ploski R.

Hum Mol Genet. 2018 Nov 1;27(21):3669-3674. doi: 10.1093/hmg/ddy277.

3.

A murine model of Charcot-Marie-Tooth disease 4F reveals a role for the C-terminus of periaxin in the formation and stabilization of Cajal bands.

Sherman DL, Brophy PJ.

Wellcome Open Res. 2018 Mar 1;3:20. doi: 10.12688/wellcomeopenres.13673.1. eCollection 2018.

4.

The Axonal Cytoskeleton and the Assembly of Nodes of Ranvier.

Ghosh A, Sherman DL, Brophy PJ.

Neuroscientist. 2018 Apr;24(2):104-110. doi: 10.1177/1073858417710897. Epub 2017 May 23. Review.

5.

Assembly of CNS Nodes of Ranvier in Myelinated Nerves Is Promoted by the Axon Cytoskeleton.

Brivio V, Faivre-Sarrailh C, Peles E, Sherman DL, Brophy PJ.

Curr Biol. 2017 Apr 3;27(7):1068-1073. doi: 10.1016/j.cub.2017.01.025. Epub 2017 Mar 16.

6.

The paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier.

Amor V, Zhang C, Vainshtein A, Zhang A, Zollinger DR, Eshed-Eisenbach Y, Brophy PJ, Rasband MN, Peles E.

Elife. 2017 Jan 30;6. pii: e21392. doi: 10.7554/eLife.21392.

7.

Loss of protohaem IX farnesyltransferase in mature dentate granule cells impairs short-term facilitation at mossy fibre to CA3 pyramidal cell synapses.

Booker SA, Campbell GR, Mysiak KS, Brophy PJ, Kind PC, Mahad DJ, Wyllie DJ.

J Physiol. 2017 Mar 15;595(6):2147-2160. doi: 10.1113/JP273581.

8.

Paranodal lesions in chronic inflammatory demyelinating polyneuropathy associated with anti-Neurofascin 155 antibodies.

Vallat JM, Yuki N, Sekiguchi K, Kokubun N, Oka N, Mathis S, Magy L, Sherman DL, Brophy PJ, Devaux JJ.

Neuromuscul Disord. 2017 Mar;27(3):290-293. doi: 10.1016/j.nmd.2016.10.008. Epub 2016 Oct 24.

9.

Schwann Cell O-GlcNAc Glycosylation Is Required for Myelin Maintenance and Axon Integrity.

Kim S, Maynard JC, Sasaki Y, Strickland A, Sherman DL, Brophy PJ, Burlingame AL, Milbrandt J.

J Neurosci. 2016 Sep 14;36(37):9633-46. doi: 10.1523/JNEUROSCI.1235-16.2016.

10.

Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy.

Hunter G, Powis RA, Jones RA, Groen EJ, Shorrock HK, Lane FM, Zheng Y, Sherman DL, Brophy PJ, Gillingwater TH.

Hum Mol Genet. 2016 Jul 1;25(13):2853-2861. Epub 2016 May 11.

11.

Kif13b Regulates PNS and CNS Myelination through the Dlg1 Scaffold.

Noseda R, Guerrero-Valero M, Alberizzi V, Previtali SC, Sherman DL, Palmisano M, Huganir RL, Nave KA, Cuenda A, Feltri ML, Brophy PJ, Bolino A.

PLoS Biol. 2016 Apr 12;14(4):e1002440. doi: 10.1371/journal.pbio.1002440. eCollection 2016 Apr.

12.

Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics.

Maddala R, Walters M, Brophy PJ, Bennett V, Rao PV.

Am J Physiol Cell Physiol. 2016 Jan 15;310(2):C115-26. doi: 10.1152/ajpcell.00111.2015. Epub 2015 Nov 4.

13.

Absence of Dystrophin Related Protein-2 disrupts Cajal bands in a patient with Charcot-Marie-Tooth disease.

Brennan KM, Bai Y, Pisciotta C, Wang S, Feely SM, Hoegger M, Gutmann L, Moore SA, Gonzalez M, Sherman DL, Brophy PJ, Züchner S, Shy ME.

Neuromuscul Disord. 2015 Oct;25(10):786-93. doi: 10.1016/j.nmd.2015.07.001. Epub 2015 Jul 7.

14.

Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier.

Zhang A, Desmazieres A, Zonta B, Melrose S, Campbell G, Mahad D, Li Q, Sherman DL, Reynolds R, Brophy PJ.

J Neurosci. 2015 Feb 4;35(5):2246-54. doi: 10.1523/JNEUROSCI.3552-14.2015.

15.

Acceleration of conduction velocity linked to clustering of nodal components precedes myelination.

Freeman SA, Desmazières A, Simonnet J, Gatta M, Pfeiffer F, Aigrot MS, Rappeneau Q, Guerreiro S, Michel PP, Yanagawa Y, Barbin G, Brophy PJ, Fricker D, Lubetzki C, Sol-Foulon N.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):E321-8. doi: 10.1073/pnas.1419099112. Epub 2015 Jan 5.

16.

Glial ankyrins facilitate paranodal axoglial junction assembly.

Chang KJ, Zollinger DR, Susuki K, Sherman DL, Makara MA, Brophy PJ, Cooper EC, Bennett V, Mohler PJ, Rasband MN.

Nat Neurosci. 2014 Dec;17(12):1673-81. doi: 10.1038/nn.3858. Epub 2014 Nov 2.

17.
18.

Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction.

Roche SL, Sherman DL, Dissanayake K, Soucy G, Desmazieres A, Lamont DJ, Peles E, Julien JP, Wishart TM, Ribchester RR, Brophy PJ, Gillingwater TH.

J Neurosci. 2014 Sep 17;34(38):12904-18. doi: 10.1523/JNEUROSCI.1725-14.2014.

19.

Differential stability of PNS and CNS nodal complexes when neuronal neurofascin is lost.

Desmazieres A, Zonta B, Zhang A, Wu LM, Sherman DL, Brophy PJ.

J Neurosci. 2014 Apr 9;34(15):5083-8. doi: 10.1523/JNEUROSCI.4662-13.2014.

20.

Neuronal expression of GalNAc transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice.

Yao D, McGonigal R, Barrie JA, Cappell J, Cunningham ME, Meehan GR, Fewou SN, Edgar JM, Rowan E, Ohmi Y, Furukawa K, Furukawa K, Brophy PJ, Willison HJ.

J Neurosci. 2014 Jan 15;34(3):880-91. doi: 10.1523/JNEUROSCI.3996-13.2014.

21.

Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2.

de Monasterio-Schrader P, Patzig J, Möbius W, Barrette B, Wagner TL, Kusch K, Edgar JM, Brophy PJ, Werner HB.

Glia. 2013 Nov;61(11):1832-47. doi: 10.1002/glia.22561. Epub 2013 Aug 30.

PMID:
24038504
22.

In vivo assembly of the axon initial segment in motor neurons.

Le Bras B, Fréal A, Czarnecki A, Legendre P, Bullier E, Komada M, Brophy PJ, Davenne M, Couraud F.

Brain Struct Funct. 2014 Jul;219(4):1433-50. doi: 10.1007/s00429-013-0578-7. Epub 2013 Jun 2.

23.

Effect of limb lengthening on internodal length and conduction velocity of peripheral nerve.

Simpson AH, Gillingwater TH, Anderson H, Cottrell D, Sherman DL, Ribchester RR, Brophy PJ.

J Neurosci. 2013 Mar 6;33(10):4536-9. doi: 10.1523/JNEUROSCI.4176-12.2013.

24.

Increasing internodal distance in myelinated nerves accelerates nerve conduction to a flat maximum.

Wu LM, Williams A, Delaney A, Sherman DL, Brophy PJ.

Curr Biol. 2012 Oct 23;22(20):1957-61. doi: 10.1016/j.cub.2012.08.025. Epub 2012 Sep 27.

25.

Live imaging of targeted cell ablation in Xenopus: a new model to study demyelination and repair.

Kaya F, Mannioui A, Chesneau A, Sekizar S, Maillard E, Ballagny C, Houel-Renault L, Dupasquier D, Bronchain O, Holtzmann I, Desmazieres A, Thomas JL, Demeneix BA, Brophy PJ, Zalc B, Mazabraud A.

J Neurosci. 2012 Sep 12;32(37):12885-95.

26.

Drp2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth.

Sherman DL, Wu LM, Grove M, Gillespie CS, Brophy PJ.

J Neurosci. 2012 Jul 4;32(27):9419-28. doi: 10.1523/JNEUROSCI.1220-12.2012.

27.

Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.

Sherman DL, Krols M, Wu LM, Grove M, Nave KA, Gangloff YG, Brophy PJ.

J Neurosci. 2012 Feb 1;32(5):1817-25. doi: 10.1523/JNEUROSCI.4814-11.2012.

28.

Rapid disruption of axon-glial integrity in response to mild cerebral hypoperfusion.

Reimer MM, McQueen J, Searcy L, Scullion G, Zonta B, Desmazieres A, Holland PR, Smith J, Gliddon C, Wood ER, Herzyk P, Brophy PJ, McCulloch J, Horsburgh K.

J Neurosci. 2011 Dec 7;31(49):18185-94. doi: 10.1523/JNEUROSCI.4936-11.2011.

29.

Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers.

Maddala R, Skiba NP, Lalane R 3rd, Sherman DL, Brophy PJ, Rao PV.

Dev Biol. 2011 Sep 1;357(1):179-90. doi: 10.1016/j.ydbio.2011.06.036. Epub 2011 Jul 2.

30.

A critical role for Neurofascin in regulating action potential initiation through maintenance of the axon initial segment.

Zonta B, Desmazieres A, Rinaldi A, Tait S, Sherman DL, Nolan MF, Brophy PJ.

Neuron. 2011 Mar 10;69(5):945-56. doi: 10.1016/j.neuron.2011.02.021.

31.

Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis.

Howell OW, Rundle JL, Garg A, Komada M, Brophy PJ, Reynolds R.

J Neuropathol Exp Neurol. 2010 Oct;69(10):1017-1033. doi: 10.1097/NEN.0b013e3181f3a5b1.

32.

A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier.

Feinberg K, Eshed-Eisenbach Y, Frechter S, Amor V, Salomon D, Sabanay H, Dupree JL, Grumet M, Brophy PJ, Shrager P, Peles E.

Neuron. 2010 Feb 25;65(4):490-502. doi: 10.1016/j.neuron.2010.02.004.

33.

Novel forms of neurofascin 155 in the central nervous system: alterations in paranodal disruption models and multiple sclerosis.

Pomicter AD, Shroff SM, Fuss B, Sato-Bigbee C, Brophy PJ, Rasband MN, Bhat MA, Dupree JL.

Brain. 2010 Feb;133(Pt 2):389-405. doi: 10.1093/brain/awp341. Epub 2010 Feb 3. Erratum in: Brain. 2011 Apr;134(Pt 4):1250.

34.

Integrin-mediated axoglial interactions initiate myelination in the central nervous system.

Câmara J, Wang Z, Nunes-Fonseca C, Friedman HC, Grove M, Sherman DL, Komiyama NH, Grant SG, Brophy PJ, Peterson A, ffrench-Constant C.

J Cell Biol. 2009 May 18;185(4):699-712. doi: 10.1083/jcb.200807010.

35.

Molecular domains of myelinated axons in the peripheral nervous system.

Salzer JL, Brophy PJ, Peles E.

Glia. 2008 Nov 1;56(14):1532-40. doi: 10.1002/glia.20750. Review.

PMID:
18803321
36.

Glial and neuronal isoforms of Neurofascin have distinct roles in the assembly of nodes of Ranvier in the central nervous system.

Zonta B, Tait S, Melrose S, Anderson H, Harroch S, Higginson J, Sherman DL, Brophy PJ.

J Cell Biol. 2008 Jun 30;181(7):1169-77. doi: 10.1083/jcb.200712154. Epub 2008 Jun 23.

37.

The ABCA1 cholesterol transporter associates with one of two distinct dystrophin-based scaffolds in Schwann cells.

Albrecht DE, Sherman DL, Brophy PJ, Froehner SC.

Glia. 2008 Apr 15;56(6):611-8. doi: 10.1002/glia.20636.

38.

Remodeling of motor nerve terminals in demyelinating axons of periaxin-null mice.

Court FA, Brophy PJ, Ribchester RR.

Glia. 2008 Mar;56(4):471-9. doi: 10.1002/glia.20620.

39.

Functional, histopathologic and natural history study of neuropathy associated with EGR2 mutations.

Szigeti K, Wiszniewski W, Saifi GM, Sherman DL, Sule N, Adesina AM, Mancias P, Papasozomenos SCh, Miller G, Keppen L, Daentl D, Brophy PJ, Lupski JR.

Neurogenetics. 2007 Nov;8(4):257-62. Epub 2007 Aug 24.

PMID:
17717711
40.

FAK is required for axonal sorting by Schwann cells.

Grove M, Komiyama NH, Nave KA, Grant SG, Sherman DL, Brophy PJ.

J Cell Biol. 2007 Jan 29;176(3):277-82. Epub 2007 Jan 22.

41.

A functional FERM domain binding motif in neurofascin.

Gunn-Moore FJ, Hill M, Davey F, Herron LR, Tait S, Sherman D, Brophy PJ.

Mol Cell Neurosci. 2006 Dec;33(4):441-6. Epub 2006 Oct 12.

PMID:
17045809
42.

Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis.

Howell OW, Palser A, Polito A, Melrose S, Zonta B, Scheiermann C, Vora AJ, Brophy PJ, Reynolds R.

Brain. 2006 Dec;129(Pt 12):3173-85. Epub 2006 Oct 14.

PMID:
17041241
43.

Charcot-Marie-Tooth type 4F disease caused by S399fsx410 mutation in the PRX gene.

Kabzinska D, Drac H, Sherman DL, Kostera-Pruszczyk A, Brophy PJ, Kochanski A, Hausmanowa-Petrusewicz I.

Neurology. 2006 Mar 14;66(5):745-7.

PMID:
16534116
44.

Neurofascins are required to establish axonal domains for saltatory conduction.

Sherman DL, Tait S, Melrose S, Johnson R, Zonta B, Court FA, Macklin WB, Meek S, Smith AJ, Cottrell DF, Brophy PJ.

Neuron. 2005 Dec 8;48(5):737-42.

45.

A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'.

Gunn-Moore FJ, Welsh GI, Herron LR, Brannigan F, Venkateswarlu K, Gillespie S, Brandwein-Gensler M, Madan R, Tavaré JM, Brophy PJ, Prystowsky MB, Guild S.

FEBS Lett. 2005 Sep 12;579(22):5089-94.

46.

Mechanisms of axon ensheathment and myelin growth.

Sherman DL, Brophy PJ.

Nat Rev Neurosci. 2005 Sep;6(9):683-90. Review.

PMID:
16136172
47.

Clinicopathological and genetic study of early-onset demyelinating neuropathy.

Parman Y, Battaloglu E, Baris I, Bilir B, Poyraz M, Bissar-Tadmouri N, Williams A, Ammar N, Nelis E, Timmerman V, De Jonghe P, Najafov A, Deymeer F, Serdaroglu P, Brophy PJ, Said G.

Brain. 2004 Nov;127(Pt 11):2540-50. Epub 2004 Oct 6. Erratum in: Brain. 2007 Jul;130(7):1972. Necefov, Ayaz [corrected to Najafov, Ayaz].

PMID:
15469949
48.

Restricted growth of Schwann cells lacking Cajal bands slows conduction in myelinated nerves.

Court FA, Sherman DL, Pratt T, Garry EM, Ribchester RR, Cottrell DF, Fleetwood-Walker SM, Brophy PJ.

Nature. 2004 Sep 9;431(7005):191-5.

PMID:
15356632
49.

New roles for an old molecule in axon-glial interaction.

Brophy PJ.

Neuron. 2004 Jul 22;43(2):154-5.

50.

Myelinated nerves: filling in the juxtaparanodal gap.

Brophy PJ.

Curr Biol. 2003 Dec 16;13(24):R956-7. Review. No abstract available.

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