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The pre-synaptic fusion machinery.

Brunger AT, Choi UB, Lai Y, Leitz J, White KI, Zhou Q.

Curr Opin Struct Biol. 2019 Feb;54:179-188. doi: 10.1016/ Epub 2019 Apr 12. Review.


Resolving indexing ambiguities in X-ray free-electron laser diffraction patterns.

Uervirojnangkoorn M, Lyubimov AY, Zhou Q, Weis WI, Brunger AT.

Acta Crystallogr D Struct Biol. 2019 Feb 1;75(Pt 2):234-241. doi: 10.1107/S2059798318013177. Epub 2019 Feb 6.


Structural principles of SNARE complex recognition by the AAA+ protein NSF.

White KI, Zhao M, Choi UB, Pfuetzner RA, Brunger AT.

Elife. 2018 Sep 10;7. pii: e38888. doi: 10.7554/eLife.38888.


NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin.

Choi UB, Zhao M, White KI, Pfuetzner RA, Esquivies L, Zhou Q, Brunger AT.

Elife. 2018 Jul 9;7. pii: e36497. doi: 10.7554/eLife.36497.


Molecular Mechanisms of Fast Neurotransmitter Release.

Brunger AT, Choi UB, Lai Y, Leitz J, Zhou Q.

Annu Rev Biophys. 2018 May 20;47:469-497. doi: 10.1146/annurev-biophys-070816-034117. Review.


Ca2+-Triggered Synaptic Vesicle Fusion Initiated by Release of Inhibition.

Brunger AT, Leitz J, Zhou Q, Choi UB, Lai Y.

Trends Cell Biol. 2018 Aug;28(8):631-645. doi: 10.1016/j.tcb.2018.03.004. Epub 2018 Apr 26. Review.


The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography.

Mathews II, Allison K, Robbins T, Lyubimov AY, Uervirojnangkoorn M, Brunger AT, Khosla C, DeMirci H, McPhillips SE, Hollenbeck M, Soltis M, Cohen AE.

Biochemistry. 2017 Sep 12;56(36):4751-4756. doi: 10.1021/acs.biochem.7b00711. Epub 2017 Aug 31.


The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis.

Zhou Q, Zhou P, Wang AL, Wu D, Zhao M, Südhof TC, Brunger AT.

Nature. 2017 Aug 24;548(7668):420-425. doi: 10.1038/nature23484. Epub 2017 Aug 16.


Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.

Lai Y, Choi UB, Leitz J, Rhee HJ, Lee C, Altas B, Zhao M, Pfuetzner RA, Wang AL, Brose N, Rhee J, Brunger AT.

Neuron. 2017 Aug 2;95(3):591-607.e10. doi: 10.1016/j.neuron.2017.07.004.


Morphologies of synaptic protein membrane fusion interfaces.

Gipson P, Fukuda Y, Danev R, Lai Y, Chen DH, Baumeister W, Brunger AT.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9110-9115. doi: 10.1073/pnas.1708492114. Epub 2017 Jul 24.


Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis.

Wang S, Choi UB, Gong J, Yang X, Li Y, Wang AL, Yang X, Brunger AT, Ma C.

EMBO J. 2017 Mar 15;36(6):816-829. doi: 10.15252/embj.201695775. Epub 2017 Jan 30.


Structure of photosystem II and substrate binding at room temperature.

Young ID, Ibrahim M, Chatterjee R, Gul S, Fuller F, Koroidov S, Brewster AS, Tran R, Alonso-Mori R, Kroll T, Michels-Clark T, Laksmono H, Sierra RG, Stan CA, Hussein R, Zhang M, Douthit L, Kubin M, de Lichtenberg C, Long Vo P, Nilsson H, Cheah MH, Shevela D, Saracini C, Bean MA, Seuffert I, Sokaras D, Weng TC, Pastor E, Weninger C, Fransson T, Lassalle L, Bräuer P, Aller P, Docker PT, Andi B, Orville AM, Glownia JM, Nelson S, Sikorski M, Zhu D, Hunter MS, Lane TJ, Aquila A, Koglin JE, Robinson J, Liang M, Boutet S, Lyubimov AY, Uervirojnangkoorn M, Moriarty NW, Liebschner D, Afonine PV, Waterman DG, Evans G, Wernet P, Dobbek H, Weis WI, Brunger AT, Zwart PH, Adams PD, Zouni A, Messinger J, Bergmann U, Sauter NK, Kern J, Yachandra VK, Yano J.

Nature. 2016 Dec 15;540(7633):453-457. doi: 10.1038/nature20161. Epub 2016 Nov 21.


C-terminal domain of mammalian complexin-1 localizes to highly curved membranes.

Gong J, Lai Y, Li X, Wang M, Leitz J, Hu Y, Zhang Y, Choi UB, Cipriano D, Pfuetzner RA, Südhof TC, Yang X, Brunger AT, Diao J.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7590-E7599. Epub 2016 Nov 7.


Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex.

Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Zhou Q, Zhao M, Brewster AS, Michels-Clark T, Holton JM, Sauter NK, Weis WI, Brunger AT.

Elife. 2016 Oct 12;5. pii: e18740. doi: 10.7554/eLife.18740.


De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure.

Colletier JP, Sawaya MR, Gingery M, Rodriguez JA, Cascio D, Brewster AS, Michels-Clark T, Hice RH, Coquelle N, Boutet S, Williams GJ, Messerschmidt M, DePonte DP, Sierra RG, Laksmono H, Koglin JE, Hunter MS, Park HW, Uervirojnangkoorn M, Bideshi DK, Brunger AT, Federici BA, Sauter NK, Eisenberg DS.

Nature. 2016 Nov 3;539(7627):43-47. doi: 10.1038/nature19825. Epub 2016 Sep 28.


Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors.

Martinelli DC, Chew KS, Rohlmann A, Lum MY, Ressl S, Hattar S, Brunger AT, Missler M, Südhof TC.

Neuron. 2016 Sep 7;91(5):1034-1051. doi: 10.1016/j.neuron.2016.07.002. Epub 2016 Jul 28.


N-terminal domain of complexin independently activates calcium-triggered fusion.

Lai Y, Choi UB, Zhang Y, Zhao M, Pfuetzner RA, Wang AL, Diao J, Brunger AT.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4698-707. doi: 10.1073/pnas.1604348113. Epub 2016 Jul 21.


Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion.

Malmersjö S, Di Palma S, Diao J, Lai Y, Pfuetzner RA, Wang AL, McMahon MA, Hayer A, Porteus M, Bodenmiller B, Brunger AT, Meyer T.

EMBO J. 2016 Aug 15;35(16):1810-21. doi: 10.15252/embj.201694071. Epub 2016 Jul 11.


IOTA: integration optimization, triage and analysis tool for the processing of XFEL diffraction images.

Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Brewster AS, Murray TD, Sauter NK, Berger JM, Weis WI, Brunger AT.

J Appl Crystallogr. 2016 May 11;49(Pt 3):1057-1064. eCollection 2016 Jun 1.


Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex.

Choi UB, Zhao M, Zhang Y, Lai Y, Brunger AT.

Elife. 2016 Jun 2;5. pii: e16886. doi: 10.7554/eLife.16886.


Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation.

Song CX, Diao J, Brunger AT, Quake SR.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4338-43. doi: 10.1073/pnas.1600223113. Epub 2016 Mar 28.


Atomic resolution experimental phase information reveals extensive disorder and bound 2-methyl-2,4-pentanediol in Ca(2+)-calmodulin.

Lin J, van den Bedem H, Brunger AT, Wilson MA.

Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):83-92. doi: 10.1107/S2059798315021609. Epub 2016 Jan 1.


High-density grids for efficient data collection from multiple crystals.

Baxter EL, Aguila L, Alonso-Mori R, Barnes CO, Bonagura CA, Brehmer W, Brunger AT, Calero G, Caradoc-Davies TT, Chatterjee R, Degrado WF, Fraser JS, Ibrahim M, Kern J, Kobilka BK, Kruse AC, Larsson KM, Lemke HT, Lyubimov AY, Manglik A, McPhillips SE, Norgren E, Pang SS, Soltis SM, Song J, Thomaston J, Tsai Y, Weis WI, Woldeyes RA, Yachandra V, Yano J, Zouni A, Cohen AE.

Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):2-11. doi: 10.1107/S2059798315020847. Epub 2016 Jan 1.


Recent Advances in Deciphering the Structure and Molecular Mechanism of the AAA+ ATPase N-Ethylmaleimide-Sensitive Factor (NSF).

Zhao M, Brunger AT.

J Mol Biol. 2016 May 8;428(9 Pt B):1912-26. doi: 10.1016/j.jmb.2015.10.026. Epub 2015 Nov 3. Review.


Correction: Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion.

Diao J, Grob P, Cipriano DJ, Kyoung M, Zhang Y, Shah S, Nguyen A, Padolina M, Srivastava A, Vrljic M, Shah A, Nogales E, Chu S, Brunger AT.

Elife. 2015 Oct 21;4:e12289. doi: 10.7554/eLife.12289. No abstract available.


A high-transparency, micro-patternable chip for X-ray diffraction analysis of microcrystals under native growth conditions.

Murray TD, Lyubimov AY, Ogata CM, Vo H, Uervirojnangkoorn M, Brunger AT, Berger JM.

Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):1987-97. doi: 10.1107/S1399004715015011. Epub 2015 Sep 26.


Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography.

Keedy DA, Kenner LR, Warkentin M, Woldeyes RA, Hopkins JB, Thompson MC, Brewster AS, Van Benschoten AH, Baxter EL, Uervirojnangkoorn M, McPhillips SE, Song J, Alonso-Mori R, Holton JM, Weis WI, Brunger AT, Soltis SM, Lemke H, Gonzalez A, Sauter NK, Cohen AE, van den Bedem H, Thorne RE, Fraser JS.

Elife. 2015 Sep 30;4. pii: e07574. doi: 10.7554/eLife.07574.


Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.

Zhou Q, Lai Y, Bacaj T, Zhao M, Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Brewster AS, Sauter NK, Cohen AE, Soltis SM, Alonso-Mori R, Chollet M, Lemke HT, Pfuetzner RA, Choi UB, Weis WI, Diao J, Südhof TC, Brunger AT.

Nature. 2015 Sep 3;525(7567):62-7. doi: 10.1038/nature14975. Epub 2015 Aug 17.


Capture and X-ray diffraction studies of protein microcrystals in a microfluidic trap array.

Lyubimov AY, Murray TD, Koehl A, Araci IE, Uervirojnangkoorn M, Zeldin OB, Cohen AE, Soltis SM, Baxter EL, Brewster AS, Sauter NK, Brunger AT, Berger JM.

Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):928-40. doi: 10.1107/S1399004715002308. Epub 2015 Mar 27.


Towards reconstitution of membrane fusion mediated by SNAREs and other synaptic proteins.

Brunger AT, Cipriano DJ, Diao J.

Crit Rev Biochem Mol Biol. 2015;50(3):231-41. doi: 10.3109/10409238.2015.1023252. Epub 2015 Mar 19. Review.


Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals.

Uervirojnangkoorn M, Zeldin OB, Lyubimov AY, Hattne J, Brewster AS, Sauter NK, Brunger AT, Weis WI.

Elife. 2015 Mar 17;4. doi: 10.7554/eLife.05421.


Tools to assist determination and validation of carbohydrate 3D structure data.

Emsley P, Brunger AT, Lütteke T.

Methods Mol Biol. 2015;1273:229-40. doi: 10.1007/978-1-4939-2343-4_17.


Structures of C1q-like proteins reveal unique features among the C1q/TNF superfamily.

Ressl S, Vu BK, Vivona S, Martinelli DC, Südhof TC, Brunger AT.

Structure. 2015 Apr 7;23(4):688-99. doi: 10.1016/j.str.2015.01.019. Epub 2015 Mar 5.


Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexin.

Zhang Y, Diao J, Colbert KN, Lai Y, Pfuetzner RA, Padolina MS, Vivona S, Ressl S, Cipriano DJ, Choi UB, Shah N, Weis WI, Brunger AT.

J Biol Chem. 2015 Apr 17;290(16):10518-34. doi: 10.1074/jbc.M114.630772. Epub 2015 Feb 25.


ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.

Diao J, Liu R, Rong Y, Zhao M, Zhang J, Lai Y, Zhou Q, Wilz LM, Li J, Vivona S, Pfuetzner RA, Brunger AT, Zhong Q.

Nature. 2015 Apr 23;520(7548):563-6. doi: 10.1038/nature14147. Epub 2015 Feb 9.


Data Exploration Toolkit for serial diffraction experiments.

Zeldin OB, Brewster AS, Hattne J, Uervirojnangkoorn M, Lyubimov AY, Zhou Q, Zhao M, Weis WI, Sauter NK, Brunger AT.

Acta Crystallogr D Biol Crystallogr. 2015 Feb;71(Pt 2):352-6. doi: 10.1107/S1399004714025875. Epub 2015 Jan 23.


Mechanistic insights into the recycling machine of the SNARE complex.

Zhao M, Wu S, Zhou Q, Vivona S, Cipriano DJ, Cheng Y, Brunger AT.

Nature. 2015 Feb 5;518(7537):61-7. doi: 10.1038/nature14148. Epub 2015 Jan 12.


Direct visualization of trans-synaptic neurexin-neuroligin interactions during synapse formation.

Tsetsenis T, Boucard AA, Araç D, Brunger AT, Südhof TC.

J Neurosci. 2014 Nov 5;34(45):15083-96. doi: 10.1523/JNEUROSCI.0348-14.2014.


Goniometer-based femtosecond crystallography with X-ray free electron lasers.

Cohen AE, Soltis SM, González A, Aguila L, Alonso-Mori R, Barnes CO, Baxter EL, Brehmer W, Brewster AS, Brunger AT, Calero G, Chang JF, Chollet M, Ehrensberger P, Eriksson TL, Feng Y, Hattne J, Hedman B, Hollenbeck M, Holton JM, Keable S, Kobilka BK, Kovaleva EG, Kruse AC, Lemke HT, Lin G, Lyubimov AY, Manglik A, Mathews II, McPhillips SE, Nelson S, Peters JW, Sauter NK, Smith CA, Song J, Stevenson HP, Tsai Y, Uervirojnangkoorn M, Vinetsky V, Wakatsuki S, Weis WI, Zadvornyy OA, Zeldin OB, Zhu D, Hodgson KO.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17122-7. doi: 10.1073/pnas.1418733111. Epub 2014 Oct 31.


Deformable elastic network refinement for low-resolution macromolecular crystallography.

Schröder GF, Levitt M, Brunger AT.

Acta Crystallogr D Biol Crystallogr. 2014 Sep;70(Pt 9):2241-55. doi: 10.1107/S1399004714016496. Epub 2014 Aug 29.


Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms.

Lai Y, Diao J, Cipriano DJ, Zhang Y, Pfuetzner RA, Padolina MS, Brunger AT.

Elife. 2014 Aug 13;3:e03756. doi: 10.7554/eLife.03756.


Gently does it for submicron crystals.

Zeldin OB, Brunger AT.

Elife. 2013 Nov 19;2:e01662. doi: 10.7554/eLife.01662. Erratum in: Elife. 2013;2:e01979.


Model morphing and sequence assignment after molecular replacement.

Terwilliger TC, Read RJ, Adams PD, Brunger AT, Afonine PV, Hung LW.

Acta Crystallogr D Biol Crystallogr. 2013 Nov;69(Pt 11):2244-50. doi: 10.1107/S0907444913017770. Epub 2013 Oct 18.


Complexin-1 enhances the on-rate of vesicle docking via simultaneous SNARE and membrane interactions.

Diao J, Cipriano DJ, Zhao M, Zhang Y, Shah S, Padolina MS, Pfuetzner RA, Brunger AT.

J Am Chem Soc. 2013 Oct 16;135(41):15274-7. doi: 10.1021/ja407392n. Epub 2013 Oct 4.


Disassembly of all SNARE complexes by N-ethylmaleimide-sensitive factor (NSF) is initiated by a conserved 1:1 interaction between α-soluble NSF attachment protein (SNAP) and SNARE complex.

Vivona S, Cipriano DJ, O'Leary S, Li YH, Fenn TD, Brunger AT.

J Biol Chem. 2013 Aug 23;288(34):24984-91. doi: 10.1074/jbc.M113.489807. Epub 2013 Jul 8.


Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ.

Pertsinidis A, Mukherjee K, Sharma M, Pang ZP, Park SR, Zhang Y, Brunger AT, Südhof TC, Chu S.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2812-20. doi: 10.1073/pnas.1310654110. Epub 2013 Jul 2.


Processive ATP-driven substrate disassembly by the N-ethylmaleimide-sensitive factor (NSF) molecular machine.

Cipriano DJ, Jung J, Vivona S, Fenn TD, Brunger AT, Bryant Z.

J Biol Chem. 2013 Aug 9;288(32):23436-45. doi: 10.1074/jbc.M113.476705. Epub 2013 Jun 17.


Properties of native brain α-synuclein.

Burré J, Vivona S, Diao J, Sharma M, Brunger AT, Südhof TC.

Nature. 2013 Jun 13;498(7453):E4-6; discussion E6-7. doi: 10.1038/nature12125. No abstract available.


Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2.

Diao J, Burré J, Vivona S, Cipriano DJ, Sharma M, Kyoung M, Südhof TC, Brunger AT.

Elife. 2013 Apr 30;2:e00592. doi: 10.7554/eLife.00592.


Studying protein-reconstituted proteoliposome fusion with content indicators in vitro.

Diao J, Zhao M, Zhang Y, Kyoung M, Brunger AT.

Bioessays. 2013 Jul;35(7):658-65. doi: 10.1002/bies.201300010. Epub 2013 Apr 29.

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