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(p)ppGpp and the Stringent Response: An Emerging Threat to Antibiotic Therapy.

Hobbs JK, Boraston AB.

ACS Infect Dis. 2019 Sep 13;5(9):1505-1517. doi: 10.1021/acsinfecdis.9b00204. Epub 2019 Jul 22.


Two complementary α-fucosidases from Streptococcus pneumoniae promote complete degradation of host-derived carbohydrate antigens.

Hobbs JK, Pluvinage B, Robb M, Smith SP, Boraston AB.

J Biol Chem. 2019 Aug 23;294(34):12670-12682. doi: 10.1074/jbc.RA119.009368. Epub 2019 Jul 2.


Structural analysis of broiler chicken small intestinal mucin O-glycan modification by Clostridium perfringens.

MacMillan JL, Vicaretti SD, Noyovitz B, Xing X, Low KE, Inglis GD, Zaytsoff SJM, Boraston AB, Smith SP, Uwiera RRE, Selinger LB, Zandberg WF, Abbott DW.

Poult Sci. 2019 Jun 10. pii: pez297. doi: 10.3382/ps/pez297. [Epub ahead of print]


Biochemical Reconstruction of a Metabolic Pathway from a Marine Bacterium Reveals Its Mechanism of Pectin Depolymerization.

Hobbs JK, Hettle AG, Vickers C, Boraston AB.

Appl Environ Microbiol. 2018 Dec 13;85(1). pii: e02114-18. doi: 10.1128/AEM.02114-18. Print 2019 Jan 1.


Endo-fucoidan hydrolases from glycoside hydrolase family 107 (GH107) display structural and mechanistic similarities to α-l-fucosidases from GH29.

Vickers C, Liu F, Abe K, Salama-Alber O, Jenkins M, Springate CMK, Burke JE, Withers SG, Boraston AB.

J Biol Chem. 2018 Nov 23;293(47):18296-18308. doi: 10.1074/jbc.RA118.005134. Epub 2018 Oct 3.


The Molecular Basis of Polysaccharide Sulfatase Activity and a Nomenclature for Catalytic Subsites in this Class of Enzyme.

Hettle AG, Vickers C, Robb CS, Liu F, Withers SG, Hehemann JH, Boraston AB.

Structure. 2018 May 1;26(5):747-758.e4. doi: 10.1016/j.str.2018.03.012. Epub 2018 Apr 19.


Glycan-metabolizing enzymes in microbe-host interactions: the Streptococcus pneumoniae paradigm.

Hobbs JK, Pluvinage B, Boraston AB.

FEBS Lett. 2018 Dec;592(23):3865-3897. doi: 10.1002/1873-3468.13045. Epub 2018 Apr 19. Review.


Molecular basis of an agarose metabolic pathway acquired by a human intestinal symbiont.

Pluvinage B, Grondin JM, Amundsen C, Klassen L, Moote PE, Xiao Y, Thomas D, Pudlo NA, Anele A, Martens EC, Inglis GD, Uwiera RER, Boraston AB, Abbott DW.

Nat Commun. 2018 Mar 13;9(1):1043. doi: 10.1038/s41467-018-03366-x.


Properties of a family 56 carbohydrate-binding module and its role in the recognition and hydrolysis of β-1,3-glucan.

Hettle A, Fillo A, Abe K, Massel P, Pluvinage B, Langelaan DN, Smith SP, Boraston AB.

J Biol Chem. 2017 Oct 13;292(41):16955-16968. doi: 10.1074/jbc.M117.806711. Epub 2017 Aug 21.


Structural Analysis of a Family 81 Glycoside Hydrolase Implicates Its Recognition of β-1,3-Glucan Quaternary Structure.

Pluvinage B, Fillo A, Massel P, Boraston AB.

Structure. 2017 Sep 5;25(9):1348-1359.e3. doi: 10.1016/j.str.2017.06.019. Epub 2017 Aug 3.


Discovery and characterization of family 39 glycoside hydrolases from rumen anaerobic fungi with polyspecific activity on rare arabinosyl substrates.

Jones DR, Uddin MS, Gruninger RJ, Pham TTM, Thomas D, Boraston AB, Briggs J, Pluvinage B, McAllister TA, Forster RJ, Tsang A, Selinger LB, Abbott DW.

J Biol Chem. 2017 Jul 28;292(30):12606-12620. doi: 10.1074/jbc.M117.789008. Epub 2017 Jun 6.


Separation and Visualization of Glycans by Fluorophore-Assisted Carbohydrate Electrophoresis.

Robb M, Hobbs JK, Boraston AB.

Methods Mol Biol. 2017;1588:215-221. doi: 10.1007/978-1-4939-6899-2_17.


Structural characterization of the PTS IIA and IIB proteins associated with pneumococcal fucose utilization.

Higgins MA, Hamilton AM, Boraston AB.

Proteins. 2017 May;85(5):963-968. doi: 10.1002/prot.25264. Epub 2017 Mar 24.


Diverse modes of galacto-specific carbohydrate recognition by a family 31 glycoside hydrolase from Clostridium perfringens.

Grondin JM, Duan D, Kirlin AC, Abe KT, Chitayat S, Spencer HL, Spencer C, Campigotto A, Houliston S, Arrowsmith CH, Allingham JS, Boraston AB, Smith SP.

PLoS One. 2017 Feb 3;12(2):e0171606. doi: 10.1371/journal.pone.0171606. eCollection 2017.


Recognition of protein-linked glycans as a determinant of peptidase activity.

Noach I, Ficko-Blean E, Pluvinage B, Stuart C, Jenkins ML, Brochu D, Buenbrazo N, Wakarchuk W, Burke JE, Gilbert M, Boraston AB.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E679-E688. doi: 10.1073/pnas.1615141114. Epub 2017 Jan 17.


Molecular Characterization of N-glycan Degradation and Transport in Streptococcus pneumoniae and Its Contribution to Virulence.

Robb M, Hobbs JK, Woodiga SA, Shapiro-Ward S, Suits MD, McGregor N, Brumer H, Yesilkaya H, King SJ, Boraston AB.

PLoS Pathog. 2017 Jan 5;13(1):e1006090. doi: 10.1371/journal.ppat.1006090. eCollection 2017 Jan.


Structure of a glycoside hydrolase family 50 enzyme from a subfamily that is enriched in human gut microbiome bacteroidetes.

Giles K, Pluvinage B, Boraston AB.

Proteins. 2017 Jan;85(1):182-187. doi: 10.1002/prot.25189. Epub 2016 Nov 4.


KdgF, the missing link in the microbial metabolism of uronate sugars from pectin and alginate.

Hobbs JK, Lee SM, Robb M, Hof F, Barr C, Abe KT, Hehemann JH, McLean R, Abbott DW, Boraston AB.

Proc Natl Acad Sci U S A. 2016 May 31;113(22):6188-93. doi: 10.1073/pnas.1524214113. Epub 2016 May 16.


The Details of Glycolipid Glycan Hydrolysis by the Structural Analysis of a Family 123 Glycoside Hydrolase from Clostridium perfringens.

Noach I, Pluvinage B, Laurie C, Abe KT, Alteen MG, Vocadlo DJ, Boraston AB.

J Mol Biol. 2016 Aug 14;428(16):3253-3265. doi: 10.1016/j.jmb.2016.03.020. Epub 2016 Mar 30.


The Structure of the Toxin and Type Six Secretion System Substrate Tse2 in Complex with Its Immunity Protein.

Robb CS, Robb M, Nano FE, Boraston AB.

Structure. 2016 Feb 2;24(2):277-84. doi: 10.1016/j.str.2015.11.012. Epub 2015 Dec 31.


A Second β-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans.

Robb M, Robb CS, Higgins MA, Hobbs JK, Paton JC, Boraston AB.

J Biol Chem. 2015 Dec 25;290(52):30888-900. doi: 10.1074/jbc.M115.688630. Epub 2015 Oct 21.


Structural Analysis of a Family 101 Glycoside Hydrolase in Complex with Carbohydrates Reveals Insights into Its Mechanism.

Gregg KJ, Suits MD, Deng L, Vocadlo DJ, Boraston AB.

J Biol Chem. 2015 Oct 16;290(42):25657-69. doi: 10.1074/jbc.M115.680470. Epub 2015 Aug 24.


Functional Analyses of Resurrected and Contemporary Enzymes Illuminate an Evolutionary Path for the Emergence of Exolysis in Polysaccharide Lyase Family 2.

McLean R, Hobbs JK, Suits MD, Tuomivaara ST, Jones DR, Boraston AB, Abbott DW.

J Biol Chem. 2015 Aug 28;290(35):21231-43. doi: 10.1074/jbc.M115.664847. Epub 2015 Jul 9.


Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution.

Kwan DH, Constantinescu I, Chapanian R, Higgins MA, Kötzler MP, Samain E, Boraston AB, Kizhakkedathu JN, Withers SG.

J Am Chem Soc. 2015 May 6;137(17):5695-705. doi: 10.1021/ja5116088. Epub 2015 Apr 24.


Protein-glycolipid interactions studied in vitro using ESI-MS and nanodiscs: insights into the mechanisms and energetics of binding.

Han L, Kitova EN, Li J, Nikjah S, Lin H, Pluvinage B, Boraston AB, Klassen JS.

Anal Chem. 2015;87(9):4888-96. doi: 10.1021/acs.analchem.5b00678. Epub 2015 Apr 23.


Corrigendum: Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism.

Cuskin F, Lowe EC, Temple MJ, Zhu Y, Cameron EA, Pudlo NA, Porter NT, Urs K, Thompson AJ, Cartmell A, Rogowski A, Hamilton BS, Chen R, Tolbert TJ, Piens K, Bracke D, Vervecken W, Hakki Z, Speciale G, Munōz-Munōz JL, Day A, Peña MJ, McLean R, Suits MD, Boraston AB, Atherly T, Ziemer CJ, Williams SJ, Davies GJ, Abbott DW, Martens EC, Gilbert HJ.

Nature. 2015 Apr 16;520(7547):388. doi: 10.1038/nature14334. Epub 2015 Mar 4. No abstract available.


Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism.

Cuskin F, Lowe EC, Temple MJ, Zhu Y, Cameron E, Pudlo NA, Porter NT, Urs K, Thompson AJ, Cartmell A, Rogowski A, Hamilton BS, Chen R, Tolbert TJ, Piens K, Bracke D, Vervecken W, Hakki Z, Speciale G, Munōz-Munōz JL, Day A, Peña MJ, McLean R, Suits MD, Boraston AB, Atherly T, Ziemer CJ, Williams SJ, Davies GJ, Abbott DW, Martens EC, Gilbert HJ.

Nature. 2015 Jan 8;517(7533):165-169. doi: 10.1038/nature13995. Erratum in: Nature. 2015 Apr 16;520(7547):388.


Affinities of human histo-blood group antigens for norovirus capsid protein complexes.

Han L, Kitova EN, Tan M, Jiang X, Pluvinage B, Boraston AB, Klassen JS.

Glycobiology. 2015 Feb;25(2):170-80. doi: 10.1093/glycob/cwu100. Epub 2014 Oct 1.


Unravelling the multiple functions of the architecturally intricate Streptococcus pneumoniae β-galactosidase, BgaA.

Singh AK, Pluvinage B, Higgins MA, Dalia AB, Woodiga SA, Flynn M, Lloyd AR, Weiser JN, Stubbs KA, Boraston AB, King SJ.

PLoS Pathog. 2014 Sep 11;10(9):e1004364. doi: 10.1371/journal.ppat.1004364. eCollection 2014 Sep.


A sweet new wave: structures and mechanisms of enzymes that digest polysaccharides from marine algae.

Hehemann JH, Boraston AB, Czjzek M.

Curr Opin Struct Biol. 2014 Oct;28:77-86. doi: 10.1016/ Epub 2014 Aug 17. Review.


Conformational analysis of the Streptococcus pneumoniae hyaluronate lyase and characterization of its hyaluronan-specific carbohydrate-binding module.

Suits MD, Pluvinage B, Law A, Liu Y, Palma AS, Chai W, Feizi T, Boraston AB.

J Biol Chem. 2014 Sep 26;289(39):27264-77. doi: 10.1074/jbc.M114.578435. Epub 2014 Aug 6.


The structure of RdDddP from Roseobacter denitrificans reveals that DMSP lyases in the DddP-family are metalloenzymes.

Hehemann JH, Law A, Redecke L, Boraston AB.

PLoS One. 2014 Jul 23;9(7):e103128. doi: 10.1371/journal.pone.0103128. eCollection 2014.


Structural and functional analysis of fucose-processing enzymes from Streptococcus pneumoniae.

Higgins MA, Suits MD, Marsters C, Boraston AB.

J Mol Biol. 2014 Apr 3;426(7):1469-82. doi: 10.1016/j.jmb.2013.12.006. Epub 2013 Dec 12.


An unusual mode of galactose recognition by a family 32 carbohydrate-binding module.

Grondin JM, Chitayat S, Ficko-Blean E, Houliston S, Arrowsmith CH, Boraston AB, Smith SP.

J Mol Biol. 2014 Feb 20;426(4):869-80. doi: 10.1016/j.jmb.2013.11.029. Epub 2013 Dec 8.


Inhibition of the family 20 glycoside hydrolase catalytic modules in the Streptococcus pneumoniae exo-β-D-N-acetylglucosaminidase, StrH.

Pluvinage B, Stubbs KA, Hattie M, Vocadlo DJ, Boraston AB.

Org Biomol Chem. 2013 Dec 7;11(45):7907-15. doi: 10.1039/c3ob41579a. Epub 2013 Oct 16.


An ancestral member of the polysaccharide lyase family 2 displays endolytic activity and magnesium dependence.

Abbott DW, Thomas D, Pluvinage B, Boraston AB.

Appl Biochem Biotechnol. 2013 Dec;171(7):1911-23. doi: 10.1007/s12010-013-0483-9. Epub 2013 Sep 7.


Substrate recognition and hydrolysis by a family 50 exo-β-agarase, Aga50D, from the marine bacterium Saccharophagus degradans.

Pluvinage B, Hehemann JH, Boraston AB.

J Biol Chem. 2013 Sep 27;288(39):28078-88. doi: 10.1074/jbc.M113.491068. Epub 2013 Aug 6.


Structure of the Streptococcus pneumoniae surface protein and adhesin PfbA.

Suits MD, Boraston AB.

PLoS One. 2013 Jul 22;8(7):e67190. doi: 10.1371/journal.pone.0067190. Print 2013.


Synthesis of 4-methylumbelliferyl α-d-mannopyranosyl-(1→6)-β-d-mannopyranoside and development of a coupled fluorescent assay for GH125 exo-α-1,6-mannosidases.

Deng L, Tsybina P, Gregg KJ, Mosi R, Zandberg WF, Boraston AB, Vocadlo DJ.

Bioorg Med Chem. 2013 Aug 15;21(16):4839-45. doi: 10.1016/j.bmc.2013.05.062. Epub 2013 Jun 11.


Advances in understanding the molecular basis of plant cell wall polysaccharide recognition by carbohydrate-binding modules.

Gilbert HJ, Knox JP, Boraston AB.

Curr Opin Struct Biol. 2013 Oct;23(5):669-77. doi: 10.1016/ Epub 2013 Jun 13. Review.


Structure of the T6SS lipoprotein TssJ1 from Pseudomonas aeruginosa.

Robb CS, Assmus M, Nano FE, Boraston AB.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):607-10. doi: 10.1107/S1744309113012220. Epub 2013 May 23.


Conformational analysis of StrH, the surface-attached exo-β-D-N-acetylglucosaminidase from Streptococcus pneumoniae.

Pluvinage B, Chitayat S, Ficko-Blean E, Abbott DW, Kunjachen JM, Grondin J, Spencer HL, Smith SP, Boraston AB.

J Mol Biol. 2013 Jan 23;425(2):334-49. doi: 10.1016/j.jmb.2012.11.005. Epub 2012 Nov 12.


Bacteria of the human gut microbiome catabolize red seaweed glycans with carbohydrate-active enzyme updates from extrinsic microbes.

Hehemann JH, Kelly AG, Pudlo NA, Martens EC, Boraston AB.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19786-91. doi: 10.1073/pnas.1211002109. Epub 2012 Nov 12.


Glycans: pervasive regulators of protein and cellular function.

Fernig D, Boraston AB.

Curr Opin Struct Biol. 2012 Oct;22(5):537-9. doi: 10.1016/ No abstract available.


Insights into the recognition of the human glycome by microbial carbohydrate-binding modules.

Ficko-Blean E, Boraston AB.

Curr Opin Struct Biol. 2012 Oct;22(5):570-7. doi: 10.1016/ Epub 2012 Aug 1. Review.


Quantitative approaches to the analysis of carbohydrate-binding module function.

Abbott DW, Boraston AB.

Methods Enzymol. 2012;510:211-31. doi: 10.1016/B978-0-12-415931-0.00011-2.


The structure of the conserved type six secretion protein TssL (DotU) from Francisella novicida.

Robb CS, Nano FE, Boraston AB.

J Mol Biol. 2012 Jun 22;419(5):277-83. doi: 10.1016/j.jmb.2012.04.003. Epub 2012 Apr 11.


Carbohydrate recognition by an architecturally complex α-N-acetylglucosaminidase from Clostridium perfringens.

Ficko-Blean E, Stuart CP, Suits MD, Cid M, Tessier M, Woods RJ, Boraston AB.

PLoS One. 2012;7(3):e33524. doi: 10.1371/journal.pone.0033524. Epub 2012 Mar 27.


Analysis of keystone enzyme in Agar hydrolysis provides insight into the degradation (of a polysaccharide from) red seaweeds.

Hehemann JH, Smyth L, Yadav A, Vocadlo DJ, Boraston AB.

J Biol Chem. 2012 Apr 20;287(17):13985-95. doi: 10.1074/jbc.M112.345645. Epub 2012 Mar 5.


Structure of a pectin methylesterase from Yersinia enterocolitica.

Boraston AB, Abbott DW.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Feb 1;68(Pt 2):129-33. doi: 10.1107/S1744309111055400. Epub 2012 Jan 21.

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