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Loss-of-Function Mutations in the CFH Gene Affecting Alternatively Encoded Factor H-like 1 Protein Cause Dominant Early-Onset Macular Drusen.

Taylor RL, Poulter JA, Downes SM, McKibbin M, Khan KN, Inglehearn CF, Webster AR, Hardcastle AJ, Michaelides M, Bishop PN, Clark SJ, Black GC; United Kingdom Inherited Retinal Dystrophy Consortium.

Ophthalmology. 2019 Mar 21. pii: S0161-6420(18)33171-3. doi: 10.1016/j.ophtha.2019.03.013. [Epub ahead of print]


Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes.

Porter LF, Saptarshi N, Fang Y, Rathi S, den Hollander AI, de Jong EK, Clark SJ, Bishop PN, Olsen TW, Liloglou T, Chavali VRM, Paraoan L.

Clin Epigenetics. 2019 Jan 14;11(1):6. doi: 10.1186/s13148-019-0608-2.


The Royal College of Ophthalmologists recommendations on screening for hydroxychloroquine and chloroquine users in the United Kingdom: executive summary.

Yusuf IH, Foot B, Galloway J, Ardern-Jones MR, Watson SL, Yelf C, Burdon MA, Bishop PN, Lotery AJ.

Eye (Lond). 2018 Jul;32(7):1168-1173. doi: 10.1038/s41433-018-0136-x. Epub 2018 Jun 11. Review. No abstract available.


Efficacy and Safety of Glycosidic Enzymes for Improved Gene Delivery to the Retina following Intravitreal Injection in Mice.

Cehajic-Kapetanovic J, Milosavljevic N, Bedford RA, Lucas RJ, Bishop PN.

Mol Ther Methods Clin Dev. 2017 Dec 22;9:192-202. doi: 10.1016/j.omtm.2017.12.002. eCollection 2018 Jun 15.


In vivo effect of opticin deficiency in cartilage in a surgically induced mouse model of osteoarthritis.

Farrán A, Valverde-Franco G, Tío L, Lussier B, Fahmi H, Pelletier JP, Bishop PN, Monfort J, Martel-Pelletier J.

Sci Rep. 2018 Jan 11;8(1):457. doi: 10.1038/s41598-017-18047-w.


Bruch's Membrane Compartmentalizes Complement Regulation in the Eye with Implications for Therapeutic Design in Age-Related Macular Degeneration.

Clark SJ, McHarg S, Tilakaratna V, Brace N, Bishop PN.

Front Immunol. 2017 Dec 19;8:1778. doi: 10.3389/fimmu.2017.01778. eCollection 2017.


The eye as a complement dysregulation hotspot.

Clark SJ, Bishop PN.

Semin Immunopathol. 2018 Jan;40(1):65-74. doi: 10.1007/s00281-017-0649-6. Epub 2017 Sep 25. Review.


Characterisation of the metabolome of ocular tissues and post-mortem changes in the rat retina.

Tan SZ, Mullard G, Hollywood KA, Dunn WB, Bishop PN.

Exp Eye Res. 2016 Aug;149:8-15. doi: 10.1016/j.exer.2016.05.019. Epub 2016 May 24.


Molecular findings from 537 individuals with inherited retinal disease.

Ellingford JM, Barton S, Bhaskar S, O'Sullivan J, Williams SG, Lamb JA, Panda B, Sergouniotis PI, Gillespie RL, Daiger SP, Hall G, Gale T, Lloyd IC, Bishop PN, Ramsden SC, Black GCM.

J Med Genet. 2016 Nov;53(11):761-767. doi: 10.1136/jmedgenet-2016-103837. Epub 2016 May 11.


Introduction to metabolomics and its applications in ophthalmology.

Tan SZ, Begley P, Mullard G, Hollywood KA, Bishop PN.

Eye (Lond). 2016 Jun;30(6):773-83. doi: 10.1038/eye.2016.37. Epub 2016 Mar 18. Review.


Vitrectomy for primary symptomatic vitreous opacities: an evidence-based review.

Ivanova T, Jalil A, Antoniou Y, Bishop PN, Vallejo-Garcia JL, Patton N.

Eye (Lond). 2016 May;30(5):645-55. doi: 10.1038/eye.2016.30. Epub 2016 Mar 4. Review.


Whole Genome Sequencing Increases Molecular Diagnostic Yield Compared with Current Diagnostic Testing for Inherited Retinal Disease.

Ellingford JM, Barton S, Bhaskar S, Williams SG, Sergouniotis PI, O'Sullivan J, Lamb JA, Perveen R, Hall G, Newman WG, Bishop PN, Roberts SA, Leach R, Tearle R, Bayliss S, Ramsden SC, Nemeth AH, Black GC.

Ophthalmology. 2016 May;123(5):1143-50. doi: 10.1016/j.ophtha.2016.01.009. Epub 2016 Feb 9.


Age and Smoking Related Changes in Metal Ion Levels in Human Lens: Implications for Cataract Formation.

Langford-Smith A, Tilakaratna V, Lythgoe PR, Clark SJ, Bishop PN, Day AJ.

PLoS One. 2016 Jan 21;11(1):e0147576. doi: 10.1371/journal.pone.0147576. eCollection 2016.


Enrichment of Bruch's Membrane from Human Donor Eyes.

McHarg S, Brace N, Bishop PN, Clark SJ.

J Vis Exp. 2015 Nov 15;(105). doi: 10.3791/53382.


Restoration of Vision with Ectopic Expression of Human Rod Opsin.

Cehajic-Kapetanovic J, Eleftheriou C, Allen AE, Milosavljevic N, Pienaar A, Bedford R, Davis KE, Bishop PN, Lucas RJ.

Curr Biol. 2015 Aug 17;25(16):2111-22. doi: 10.1016/j.cub.2015.07.029. Epub 2015 Jul 30.


Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH-to-F13B.

Keenan TD, Toso M, Pappas C, Nichols L, Bishop PN, Hageman GS.

Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4870-9. doi: 10.1167/iovs.15-17009.


WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.

Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, Shokat KM, Medina I.

Sci Signal. 2015 Jun 30;8(383):ra65. doi: 10.1126/scisignal.aaa0354.


Routine versus As-Needed Bevacizumab with 12-Weekly Assessment Intervals for Neovascular Age-Related Macular Degeneration: 92-Week Results of the GMAN Trial.

Mahmood S, Roberts SA, Aslam TM, Parkes J, Barugh K, Bishop PN; GMAN Study Group.

Ophthalmology. 2015 Jul;122(7):1348-55. doi: 10.1016/j.ophtha.2015.03.017. Epub 2015 Apr 17.


The role of extracellular matrix in retinal vascular development and preretinal neovascularization.

Bishop PN.

Exp Eye Res. 2015 Apr;133:30-6. doi: 10.1016/j.exer.2014.10.021. Review.


Age-related macular degeneration and the role of the complement system.

McHarg S, Clark SJ, Day AJ, Bishop PN.

Mol Immunol. 2015 Sep;67(1):43-50. doi: 10.1016/j.molimm.2015.02.032. Epub 2015 Mar 21. Review.


Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease.

Church SJ, Begley P, Kureishy N, McHarg S, Bishop PN, Bechtold DA, Unwin RD, Cooper GJ.

Biochem Biophys Res Commun. 2015 May 8;460(3):549-54. doi: 10.1016/j.bbrc.2015.03.067. Epub 2015 Mar 20.


Complementing the Sugar Code: Role of GAGs and Sialic Acid in Complement Regulation.

Langford-Smith A, Day AJ, Bishop PN, Clark SJ.

Front Immunol. 2015 Feb 2;6:25. doi: 10.3389/fimmu.2015.00025. eCollection 2015. Review.


Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration.

Clark SJ, Schmidt CQ, White AM, Hakobyan S, Morgan BP, Bishop PN.

J Immunol. 2014 Nov 15;193(10):4962-70. doi: 10.4049/jimmunol.1401613. Epub 2014 Oct 10.


Age-dependent changes in heparan sulfate in human Bruch's membrane: implications for age-related macular degeneration.

Keenan TD, Pickford CE, Holley RJ, Clark SJ, Lin W, Dowsey AW, Merry CL, Day AJ, Bishop PN.

Invest Ophthalmol Vis Sci. 2014 Jul 29;55(8):5370-9. doi: 10.1167/iovs.14-14126.


Vision impairment and dual sensory problems in middle age.

Dawes P, Dickinson C, Emsley R, Bishop PN, Cruickshanks KJ, Edmondson-Jones M, McCormack A, Fortnum H, Moore DR, Norman P, Munro K.

Ophthalmic Physiol Opt. 2014 Jul;34(4):479-88. doi: 10.1111/opo.12138. Epub 2014 May 29.


Opticin, a small leucine-rich proteoglycan, is uniquely expressed and translocated to the nucleus of chronic lymphocytic leukemia cells.

Mikaelsson E, Osterborg A, Tahmasebi Fard Z, Mahmoudi A, Mahmoudian J, Jeddi-Tehrani M, Akhondi M, Shokri F, Bishop PN, Rabbani H, Mellstedt H.

Exp Hematol Oncol. 2013 Aug 28;2(1):23. doi: 10.1186/2162-3619-2-23.


The role of complement in age-related macular degeneration: heparan sulphate, a ZIP code for complement factor H?

Langford-Smith A, Keenan TD, Clark SJ, Bishop PN, Day AJ.

J Innate Immun. 2014;6(4):407-16. doi: 10.1159/000356513. Epub 2013 Dec 7. Review.


The proteoglycan glycomatrix: a sugar microenvironment essential for complement regulation.

Clark SJ, Bishop PN, Day AJ.

Front Immunol. 2013 Nov 26;4:412. doi: 10.3389/fimmu.2013.00412. Review. No abstract available.


Iron, zinc, and copper in retinal physiology and disease.

Ugarte M, Osborne NN, Brown LA, Bishop PN.

Surv Ophthalmol. 2013 Nov-Dec;58(6):585-609. doi: 10.1016/j.survophthal.2012.12.002. Review.


Repeatability of visual function measures in age-related macular degeneration.

Aslam T, Mahmood S, Balaskas K, Patton N, Tanawade RG, Tan SZ, Roberts SA, Parkes J, Bishop PN.

Graefes Arch Clin Exp Ophthalmol. 2014 Feb;252(2):201-6. doi: 10.1007/s00417-013-2421-5. Epub 2013 Jul 25.


Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration.

Ansari M, McKeigue PM, Skerka C, Hayward C, Rudan I, Vitart V, Polasek O, Armbrecht AM, Yates JR, Vatavuk Z, Bencic G, Kolcic I, Oostra BA, Van Duijn CM, Campbell S, Stanton CM, Huffman J, Shu X, Khan JC, Shahid H, Harding SP, Bishop PN, Deary IJ, Moore AT, Dhillon B, Rudan P, Zipfel PF, Sim RB, Hastie ND, Campbell H, Wright AF.

Hum Mol Genet. 2013 Dec 1;22(23):4857-69. doi: 10.1093/hmg/ddt336. Epub 2013 Jul 19.


Characterization of opticin digestion by proteases involved in osteoarthritis development.

Tío L, Martel-Pelletier J, Pelletier JP, Bishop PN, Roughley P, Farran A, Benito P, Monfort J.

Joint Bone Spine. 2014 Mar;81(2):137-41. doi: 10.1016/j.jbspin.2013.05.007. Epub 2013 Jul 8.


Seven new loci associated with age-related macular degeneration.

Fritsche LG, Chen W, Schu M, Yaspan BL, Yu Y, Thorleifsson G, Zack DJ, Arakawa S, Cipriani V, Ripke S, Igo RP Jr, Buitendijk GH, Sim X, Weeks DE, Guymer RH, Merriam JE, Francis PJ, Hannum G, Agarwal A, Armbrecht AM, Audo I, Aung T, Barile GR, Benchaboune M, Bird AC, Bishop PN, Branham KE, Brooks M, Brucker AJ, Cade WH, Cain MS, Campochiaro PA, Chan CC, Cheng CY, Chew EY, Chin KA, Chowers I, Clayton DG, Cojocaru R, Conley YP, Cornes BK, Daly MJ, Dhillon B, Edwards AO, Evangelou E, Fagerness J, Ferreyra HA, Friedman JS, Geirsdottir A, George RJ, Gieger C, Gupta N, Hagstrom SA, Harding SP, Haritoglou C, Heckenlively JR, Holz FG, Hughes G, Ioannidis JP, Ishibashi T, Joseph P, Jun G, Kamatani Y, Katsanis N, N Keilhauer C, Khan JC, Kim IK, Kiyohara Y, Klein BE, Klein R, Kovach JL, Kozak I, Lee CJ, Lee KE, Lichtner P, Lotery AJ, Meitinger T, Mitchell P, Mohand-Saïd S, Moore AT, Morgan DJ, Morrison MA, Myers CE, Naj AC, Nakamura Y, Okada Y, Orlin A, Ortube MC, Othman MI, Pappas C, Park KH, Pauer GJ, Peachey NS, Poch O, Priya RR, Reynolds R, Richardson AJ, Ripp R, Rudolph G, Ryu E, Sahel JA, Schaumberg DA, Scholl HP, Schwartz SG, Scott WK, Shahid H, Sigurdsson H, Silvestri G, Sivakumaran TA, Smith RT, Sobrin L, Souied EH, Stambolian DE, Stefansson H, Sturgill-Short GM, Takahashi A, Tosakulwong N, Truitt BJ, Tsironi EE, Uitterlinden AG, van Duijn CM, Vijaya L, Vingerling JR, Vithana EN, Webster AR, Wichmann HE, Winkler TW, Wong TY, Wright AF, Zelenika D, Zhang M, Zhao L, Zhang K, Klein ML, Hageman GS, Lathrop GM, Stefansson K, Allikmets R, Baird PN, Gorin MB, Wang JJ, Klaver CC, Seddon JM, Pericak-Vance MA, Iyengar SK, Yates JR, Swaroop A, Weber BH, Kubo M, Deangelis MM, Léveillard T, Thorsteinsdottir U, Haines JL, Farrer LA, Heid IM, Abecasis GR; AMD Gene Consortium.

Nat Genet. 2013 Apr;45(4):433-9, 439e1-2. doi: 10.1038/ng.2578. Epub 2013 Mar 3.


Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.

Clark SJ, Ridge LA, Herbert AP, Hakobyan S, Mulloy B, Lennon R, Würzner R, Morgan BP, Uhrín D, Bishop PN, Day AJ.

J Immunol. 2013 Mar 1;190(5):2049-57. doi: 10.4049/jimmunol.1201751. Epub 2013 Jan 30.


Concentration of various trace elements in the rat retina and their distribution in different structures.

Ugarte M, Grime GW, Lord G, Geraki K, Collingwood JF, Finnegan ME, Farnfield H, Merchant M, Bailey MJ, Ward NI, Foster PJ, Bishop PN, Osborne NN.

Metallomics. 2012 Dec;4(12):1245-54. doi: 10.1039/c2mt20157g.


Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera.

Keenan TD, Clark SJ, Unwin RD, Ridge LA, Day AJ, Bishop PN.

Invest Ophthalmol Vis Sci. 2012 Nov 7;53(12):7528-38. doi: 10.1167/iovs.12-10797.


Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.

Cipriani V, Leung HT, Plagnol V, Bunce C, Khan JC, Shahid H, Moore AT, Harding SP, Bishop PN, Hayward C, Campbell S, Armbrecht AM, Dhillon B, Deary IJ, Campbell H, Dunlop M, Dominiczak AF, Mann SS, Jenkins SA, Webster AR, Bird AC, Lathrop M, Zelenika D, Souied EH, Sahel JA, Léveillard T; French AMD Investigators, Cree AJ, Gibson J, Ennis S, Lotery AJ, Wright AF, Clayton DG, Yates JR.

Hum Mol Genet. 2012 Sep 15;21(18):4138-50. doi: 10.1093/hmg/dds225. Epub 2012 Jun 13.


Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness.

Le Goff MM, Sutton MJ, Slevin M, Latif A, Humphries MJ, Bishop PN.

J Biol Chem. 2012 Aug 10;287(33):28027-36. doi: 10.1074/jbc.M111.331157. Epub 2012 Jun 5.


Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA).

Ugarte M, Brown M, Hollywood KA, Cooper GJ, Bishop PN, Dunn WB.

Genome Med. 2012 Apr 30;4(4):35.


The vitreous glycoprotein opticin inhibits preretinal neovascularization.

Le Goff MM, Lu H, Ugarte M, Henry S, Takanosu M, Mayne R, Bishop PN.

Invest Ophthalmol Vis Sci. 2012 Jan 25;53(1):228-34. doi: 10.1167/iovs.11-8514.


No evidence of association between complement factor I genetic variant rs10033900 and age-related macular degeneration.

Cipriani V, Matharu BK, Khan JC, Shahid H, Hayward C, Wright AF, Armbrecht AM, Dhillon B, Harding SP, Bishop PN, Bunce C, Clayton DG, Moore AT, Yates JR.

Eur J Hum Genet. 2012 Jan;20(1):1-2; author reply 3. doi: 10.1038/ejhg.2011.118. Epub 2011 Oct 12. No abstract available.


Glycosidic enzymes enhance retinal transduction following intravitreal delivery of AAV2.

Cehajic-Kapetanovic J, Le Goff MM, Allen A, Lucas RJ, Bishop PN.

Mol Vis. 2011;17:1771-83. Epub 2011 Jun 30.


Mapping the differential distribution of glycosaminoglycans in the adult human retina, choroid, and sclera.

Clark SJ, Keenan TD, Fielder HL, Collinson LJ, Holley RJ, Merry CL, van Kuppevelt TH, Day AJ, Bishop PN.

Invest Ophthalmol Vis Sci. 2011 Aug 17;52(9):6511-21. doi: 10.1167/iovs.11-7909.


Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology.

Clark SJ, Bishop PN, Day AJ.

Biochem Soc Trans. 2010 Oct;38(5):1342-8. doi: 10.1042/BST0381342. Review.


Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.

Clark SJ, Perveen R, Hakobyan S, Morgan BP, Sim RB, Bishop PN, Day AJ.

J Biol Chem. 2010 Sep 24;285(39):30192-202. doi: 10.1074/jbc.M110.103986. Epub 2010 Jul 26.


Discovery and functional analysis of a retinitis pigmentosa gene, C2ORF71.

Nishimura DY, Baye LM, Perveen R, Searby CC, Avila-Fernandez A, Pereiro I, Ayuso C, Valverde D, Bishop PN, Manson FD, Urquhart J, Stone EM, Slusarski DC, Black GC, Sheffield VC.

Am J Hum Genet. 2010 May 14;86(5):686-95. doi: 10.1016/j.ajhg.2010.03.005. Epub 2010 Apr 15.


Localisation of opticin in human proliferative retinal disease.

Pattwell DM, Sheridan CM, Le Goff M, Bishop PN, Hiscott P.

Exp Eye Res. 2010 Mar;90(3):461-4. doi: 10.1016/j.exer.2009.12.007. Epub 2009 Dec 27.


Structural effects of fibulin 5 missense mutations associated with age-related macular degeneration and cutis laxa.

Jones RP, Ridley C, Jowitt TA, Wang MC, Howard M, Bobola N, Wang T, Bishop PN, Kielty CM, Baldock C, Lotery AJ, Trump D.

Invest Ophthalmol Vis Sci. 2010 May;51(5):2356-62. doi: 10.1167/iovs.09-4620. Epub 2009 Dec 10.


A novel Ocular Anaesthetic Scoring System, OASS, tool to measure both motor and sensory function following local anaesthesia.

Cehajic-Kapetanovic J, Bishop PN, Liyanage S, King T, Muldoon M, Wearne IM.

Br J Ophthalmol. 2010 Jan;94(1):28-32. doi: 10.1136/bjo.2008.155572. Epub 2009 Sep 1.


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