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Mast cells signal their importance in health and disease.

Olivera A, Beaven MA, Metcalfe DD.

J Allergy Clin Immunol. 2018 Aug;142(2):381-393. doi: 10.1016/j.jaci.2018.01.034. Epub 2018 Feb 15. Review.


DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation.

Kim HS, Nam ST, Mun SH, Lee SK, Kim HW, Park YH, Kim B, Won KJ, Kim HR, Park YM, Kim HS, Beaven MA, Kim YM, Choi WS.

Nat Commun. 2017 Nov 15;8(1):1519. doi: 10.1038/s41467-017-01527-y.


Interaction of DJ-1 with Lyn is essential for IgE-mediated stimulation of human mast cells.

Kim DK, Beaven MA, Metcalfe DD, Olivera A.

J Allergy Clin Immunol. 2018 Jul;142(1):195-206.e8. doi: 10.1016/j.jaci.2017.08.030. Epub 2017 Oct 13.


Exon skipping of FcεRIβ eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy.

Cruse G, Yin Y, Fukuyama T, Desai A, Arthur GK, Bäumer W, Beaven MA, Metcalfe DD.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14115-14120. Epub 2016 Nov 21.


Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis.

Kim DK, Beaven MA, Kulinski JM, Desai A, Bandara G, Bai Y, Prussin C, Schwartz LB, Komarow H, Metcalfe DD, Olivera A.

PLoS One. 2016 Sep 9;11(9):e0162831. doi: 10.1371/journal.pone.0162831. eCollection 2016.


Mesenteric IL-10-producing CD5+ regulatory B cells suppress cow's milk casein-induced allergic responses in mice.

Kim AR, Kim HS, Kim DK, Nam ST, Kim HW, Park YH, Lee D, Lee MB, Lee JH, Kim B, Beaven MA, Kim HS, Kim YM, Choi WS.

Sci Rep. 2016 Jan 20;6:19685. doi: 10.1038/srep19685.


IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3.

Desai A, Jung MY, Olivera A, Gilfillan AM, Prussin C, Kirshenbaum AS, Beaven MA, Metcalfe DD.

J Allergy Clin Immunol. 2016 Jun;137(6):1863-1871.e6. doi: 10.1016/j.jaci.2015.09.059. Epub 2016 Jan 7.


Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33.

Bandara G, Beaven MA, Olivera A, Gilfillan AM, Metcalfe DD.

Eur J Immunol. 2015 Nov;45(11):3034-44. doi: 10.1002/eji.201545501. Epub 2015 Sep 9.


Interleukin-10-producing CD5+ B cells inhibit mast cells during immunoglobulin E-mediated allergic responses.

Kim HS, Kim AR, Kim DK, Kim HW, Park YH, Jang GH, Kim B, Park YM, You JS, Kim HS, Beaven MA, Kim YM, Choi WS.

Sci Signal. 2015 Mar 17;8(368):ra28. doi: 10.1126/scisignal.2005861.


The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling.

Cruse G, Beaven MA, Music SC, Bradding P, Gilfillan AM, Metcalfe DD.

Mol Biol Cell. 2015 May 1;26(9):1711-27. doi: 10.1091/mbc.E14-07-1221. Epub 2015 Feb 25.


Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation.

Smrz D, Cruse G, Beaven MA, Kirshenbaum A, Metcalfe DD, Gilfillan AM.

J Immunol. 2014 Dec 15;193(12):5924-32. doi: 10.4049/jimmunol.1303495. Epub 2014 Nov 5.


The scaffold protein prohibitin is required for antigen-stimulated signaling in mast cells.

Kim DK, Kim HS, Kim AR, Jang GH, Kim HW, Park YH, Kim B, Park YM, Beaven MA, Kim YM, Choi WS.

Sci Signal. 2013 Sep 10;6(292):ra80. doi: 10.1126/scisignal.2004098.


A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells.

Cruse G, Beaven MA, Ashmole I, Bradding P, Gilfillan AM, Metcalfe DD.

Immunity. 2013 May 23;38(5):906-17. doi: 10.1016/j.immuni.2013.04.007. Epub 2013 May 2.


Prevention of F-actin assembly switches the response to SCF from chemotaxis to degranulation in human mast cells.

Smrž D, Bandara G, Beaven MA, Metcalfe DD, Gilfillan AM.

Eur J Immunol. 2013 Jul;43(7):1873-82. doi: 10.1002/eji.201243214. Epub 2013 Jun 4.


Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-α production.

Medic N, Desai A, Olivera A, Abramowitz J, Birnbaumer L, Beaven MA, Gilfillan AM, Metcalfe DD.

Cell Calcium. 2013 May-Jun;53(5-6):315-26. doi: 10.1016/j.ceca.2013.02.001. Epub 2013 Mar 13.


A novel KIT-deficient mouse mast cell model for the examination of human KIT-mediated activation responses.

Smrž D, Bandara G, Zhang S, Mock BA, Beaven MA, Metcalfe DD, Gilfillan AM.

J Immunol Methods. 2013 Apr 30;390(1-2):52-62. doi: 10.1016/j.jim.2013.01.008. Epub 2013 Jan 25.


IL-33 induces a hyporesponsive phenotype in human and mouse mast cells.

Jung MY, Smrž D, Desai A, Bandara G, Ito T, Iwaki S, Kang JH, Andrade MV, Hilderbrand SC, Brown JM, Beaven MA, Metcalfe DD, Gilfillan AM.

J Immunol. 2013 Jan 15;190(2):531-8. doi: 10.4049/jimmunol.1201576. Epub 2012 Dec 17.


DJ-1 regulates mast cell activation and IgE-mediated allergic responses.

Kim DK, Kim HS, Kim AR, Kim JH, Kim B, Noh G, Kim HS, Beaven MA, Kim YM, Choi WS.

J Allergy Clin Immunol. 2013 Jun;131(6):1653-62. doi: 10.1016/j.jaci.2012.10.012. Epub 2012 Nov 22.


Stem cell factor programs the mast cell activation phenotype.

Ito T, Smrž D, Jung MY, Bandara G, Desai A, Smržová Š, Kuehn HS, Beaven MA, Metcalfe DD, Gilfillan AM.

J Immunol. 2012 Jun 1;188(11):5428-37. doi: 10.4049/jimmunol.1103366. Epub 2012 Apr 23.


Regulation of mast cell responses in health and disease.

Gilfillan AM, Beaven MA.

Crit Rev Immunol. 2011;31(6):475-529. Review.


Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.

Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, Kim MK, Beaven MA, Burgin AB, Manganiello V, Chung JH.

Cell. 2012 Feb 3;148(3):421-33. doi: 10.1016/j.cell.2012.01.017.


Examination of the role of TRPM8 in human mast cell activation and its relevance to the etiology of cold-induced urticaria.

Medic N, Desai A, Komarow H, Burch LH, Bandara G, Beaven MA, Metcalfe DD, Gilfillan AM.

Cell Calcium. 2011 Nov;50(5):473-80. doi: 10.1016/j.ceca.2011.08.003. Epub 2011 Sep 8.


Distinct PGE2-responder and non-responder phenotypes in human mast cell populations: "all or nothing" enhancement of antigen-dependent mediator release.

Kuehn HS, Jung MY, Beaven MA, Metcalfe DD, Gilfillan AM.

Immunol Lett. 2011 Dec 30;141(1):45-54. doi: 10.1016/j.imlet.2011.07.002. Epub 2011 Jul 20.


The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice.

Lee JH, Kim JW, Kim DK, Kim HS, Park HJ, Park DK, Kim AR, Kim B, Beaven MA, Park KL, Kim YM, Choi WS.

J Immunol. 2011 Aug 15;187(4):1807-15. doi: 10.4049/jimmunol.1100296. Epub 2011 Jul 11.


Regulators of Ca(2+) signaling in mast cells: potential targets for treatment of mast cell-related diseases?

Ma HT, Beaven MA.

Adv Exp Med Biol. 2011;716:62-90. doi: 10.1007/978-1-4419-9533-9_5. Review.


Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.

Andrade MV, Iwaki S, Ropert C, Gazzinelli RT, Cunha-Melo JR, Beaven MA.

Eur J Immunol. 2011 Mar;41(3):760-72. doi: 10.1002/eji.201040718. Epub 2011 Feb 10.


Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release.

Kuehn HS, Jung MY, Beaven MA, Metcalfe DD, Gilfillan AM.

J Biol Chem. 2011 Jan 7;286(1):391-402. doi: 10.1074/jbc.M110.164772. Epub 2010 Oct 27.


Btk-dependent Rac activation and actin rearrangement following FcepsilonRI aggregation promotes enhanced chemotactic responses of mast cells.

Kuehn HS, Rådinger M, Brown JM, Ali K, Vanhaesebroeck B, Beaven MA, Metcalfe DD, Gilfillan AM.

J Cell Sci. 2010 Aug 1;123(Pt 15):2576-85. doi: 10.1242/jcs.071043. Epub 2010 Jun 29.


Interleukin-33 stimulates formation of functional osteoclasts from human CD14(+) monocytes.

Mun SH, Ko NY, Kim HS, Kim JW, Kim DK, Kim AR, Lee SH, Kim YG, Lee CK, Lee SH, Kim BK, Beaven MA, Kim YM, Choi WS.

Cell Mol Life Sci. 2010 Nov;67(22):3883-92. doi: 10.1007/s00018-010-0410-y. Epub 2010 Jun 8.


Phospholipase d promotes lipid microdomain-associated signaling events in mast cells.

Lisboa FA, Peng Z, Combs CA, Beaven MA.

J Immunol. 2009 Oct 15;183(8):5104-12. doi: 10.4049/jimmunol.0802728. Epub 2009 Sep 30.


Regulation of Ca2+ signaling with particular focus on mast cells.

Ma HT, Beaven MA.

Crit Rev Immunol. 2009;29(2):155-86. Review.


Src-like adaptor protein (SLAP) is upregulated in antigen-stimulated mast cells and acts as a negative regulator.

Park SK, Qiao H, Beaven MA.

Mol Immunol. 2009 Jun;46(10):2133-9. doi: 10.1016/j.molimm.2009.03.013. Epub 2009 Apr 15.


Our perception of the mast cell from Paul Ehrlich to now.

Beaven MA.

Eur J Immunol. 2009 Jan;39(1):11-25. doi: 10.1002/eji.200838899.


Mechanism of upregulation of the inhibitory regulator, src-like adaptor protein (SLAP), by glucocorticoids in mast cells.

Park SK, Beaven MA.

Mol Immunol. 2009 Jan;46(3):492-7. doi: 10.1016/j.molimm.2008.10.011. Epub 2008 Nov 25.


Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk.

Lee JH, Kim JW, Ko NY, Mun SH, Her E, Kim BK, Han JW, Lee HY, Beaven MA, Kim YM, Choi WS.

J Allergy Clin Immunol. 2008 May;121(5):1225-31. doi: 10.1016/j.jaci.2007.12.1160. Epub 2008 Apr 18.


Synergistic activation of phospholipases Cgamma and Cbeta: a novel mechanism for PI3K-independent enhancement of FcepsilonRI-induced mast cell mediator release.

Kuehn HS, Beaven MA, Ma HT, Kim MS, Metcalfe DD, Gilfillan AM.

Cell Signal. 2008 Apr;20(4):625-36. doi: 10.1016/j.cellsig.2007.11.016. Epub 2008 Jan 22.


Concurrent inhibition of kit- and FcepsilonRI-mediated signaling: coordinated suppression of mast cell activation.

Jensen BM, Beaven MA, Iwaki S, Metcalfe DD, Gilfillan AM.

J Pharmacol Exp Ther. 2008 Jan;324(1):128-38. Epub 2007 Oct 9.


Role of ABCC1 in export of sphingosine-1-phosphate from mast cells.

Mitra P, Oskeritzian CA, Payne SG, Beaven MA, Milstien S, Spiegel S.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16394-9. Epub 2006 Oct 18.


Phospholipase D2 acts as an essential adaptor protein in the activation of Syk in antigen-stimulated mast cells.

Lee JH, Kim YM, Kim NW, Kim JW, Her E, Kim BK, Kim JH, Ryu SH, Park JW, Seo DW, Han JW, Beaven MA, Choi WS.

Blood. 2006 Aug 1;108(3):956-64.


Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival.

Furumoto Y, Brooks S, Olivera A, Takagi Y, Miyagishi M, Taira K, Casellas R, Beaven MA, Gilfillan AM, Rivera J.

J Immunol. 2006 May 1;176(9):5167-71.


Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kit.

Iwaki S, Tkaczyk C, Satterthwaite AB, Halcomb K, Beaven MA, Metcalfe DD, Gilfillan AM.

J Biol Chem. 2005 Dec 2;280(48):40261-70. Epub 2005 Sep 21.


FcepsilonR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cells.

Qiao H, Andrade MV, Lisboa FA, Morgan K, Beaven MA.

Blood. 2006 Jan 15;107(2):610-8. Epub 2005 Sep 20.


Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr.

Choi WS, Hiragun T, Lee JH, Kim YM, Kim HP, Chahdi A, Her E, Han JW, Beaven MA.

Mol Cell Biol. 2004 Aug;24(16):6980-92.


Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells.

Hundley TR, Gilfillan AM, Tkaczyk C, Andrade MV, Metcalfe DD, Beaven MA.

Blood. 2004 Oct 15;104(8):2410-7. Epub 2004 Jun 24.


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