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Items: 1 to 50 of 206

1.

Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study.

Pinchuk I, Weber D, Kochlik B, Stuetz W, Toussaint O, Debacq-Chainiaux F, Dollé MET, Jansen EHJM, Gonos ES, Sikora E, Breusing N, Gradinaru D, Sindlinger T, Moreno-Villanueva M, Bürkle A, Grune T, Lichtenberg D.

Redox Biol. 2019 Jun;24:101204. doi: 10.1016/j.redox.2019.101204. Epub 2019 Apr 15.

2.

Interactions of p53 with poly(ADP-ribose) and DNA induce distinct changes in protein structure as revealed by ATR-FTIR spectroscopy.

Krüger A, Stier A, Fischbach A, Bürkle A, Hauser K, Mangerich A.

Nucleic Acids Res. 2019 May 21;47(9):4843-4858. doi: 10.1093/nar/gkz175.

3.

Synergistic Effects of Weightlessness, Isoproterenol, and Radiation on DNA Damage Response and Cytokine Production in Immune Cells.

Moreno-Villanueva M, Feiveson AH, Krieger S, Kay Brinda A, von Scheven G, Bürkle A, Crucian B, Wu H.

Int J Mol Sci. 2018 Nov 21;19(11). pii: E3689. doi: 10.3390/ijms19113689.

4.

Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

De Francesco D, Wit FW, Bürkle A, Oehlke S, Kootstra NA, Winston A, Franceschi C, Garagnani P, Pirazzini C, Libert C, Grune T, Weber D, Jansen EHJM, Sabin CA, Reiss P; the Co-morBidity in Relation to AIDS (COBRA) Collaboration.

AIDS. 2019 Feb 1;33(2):259-268. doi: 10.1097/QAD.0000000000002063.

5.

A mass spectrometric platform for the quantitation of sulfur mustard-induced nucleic acid adducts as mechanistically relevant biomarkers of exposure.

Zubel T, Hochgesand S, John H, Steinritz D, Schmidt A, Bürkle A, Mangerich A.

Arch Toxicol. 2019 Jan;93(1):61-79. doi: 10.1007/s00204-018-2324-7. Epub 2018 Oct 15.

PMID:
30324314
6.

Transient DNA damage following exposure to gold nanoparticles.

May S, Hirsch C, Rippl A, Bohmer N, Kaiser JP, Diener L, Wichser A, Bürkle A, Wick P.

Nanoscale. 2018 Aug 23;10(33):15723-15735. doi: 10.1039/c8nr03612h.

PMID:
30094453
7.

Epigenetic and redox biomarkers: Novel insights from the MARK-AGE study.

Moreno-Villanueva M, Bürkle A.

Mech Ageing Dev. 2019 Jan;177:128-134. doi: 10.1016/j.mad.2018.06.006. Epub 2018 Jun 30. Review.

PMID:
29969595
8.

The Role of Norepinephrine and α-Adrenergic Receptors in Acute Stress-Induced Changes in Granulocytes and Monocytes.

Beis D, von Känel R, Heimgartner N, Zuccarella-Hackl C, Bürkle A, Ehlert U, Wirtz PH.

Psychosom Med. 2018 Sep;80(7):649-658. doi: 10.1097/PSY.0000000000000620.

9.

Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study.

Rietman ML, Spijkerman AMW, Wong A, van Steeg H, Bürkle A, Moreno-Villanueva M, Sindlinger T, Franceschi C, Grubeck-Loebenstein B, Bernhardt J, Slagboom PE, Toussaint O, Debacq-Chainiaux F, Sikora E, Gonos ES, Breusing N, Stuetz W, Weber D, Grune T, Basso A, Piacenza F, Malavolta M, Collino S, Jansen EHJM, Verschuren WMM, Dollé MET.

Mech Ageing Dev. 2019 Jan;177:135-143. doi: 10.1016/j.mad.2018.04.007. Epub 2018 Apr 30.

PMID:
29719199
10.

The degree of radiation-induced DNA strand breaks is altered by acute sleep deprivation and psychological stress and is associated with cognitive performance in humans.

Moreno-Villanueva M, von Scheven G, Feiveson A, Bürkle A, Wu H, Goel N.

Sleep. 2018 Jul 1;41(7). doi: 10.1093/sleep/zsy067.

PMID:
29596659
11.

The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics.

De Francesco D, Wit FW, Cole JH, Kootstra NA, Winston A, Sabin CA, Underwood J, van Zoest RA, Schouten J, Kooij KW, Prins M, Guaraldi G, Caan MWA, Burger D, Franceschi C, Libert C, Bürkle A, Reiss P; COmorBidity in Relation to AIDS (COBRA) collaboration.

PLoS One. 2018 Mar 29;13(3):e0191791. doi: 10.1371/journal.pone.0191791. eCollection 2018.

12.

Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder.

Boeck C, Pfister S, Bürkle A, Vanhooren V, Libert C, Salinas-Manrique J, Dietrich DE, Kolassa IT, Karabatsiakis A.

J Affect Disord. 2018 Jul;234:139-147. doi: 10.1016/j.jad.2018.02.082. Epub 2018 Feb 27.

PMID:
29529546
13.

Impaired PARP activity in response to the β-adrenergic receptor agonist isoproterenol.

Thomas M, Palombo P, Schuhmacher T, von Scheven G, Bazylianska V, Salzwedel J, Schäfer N, Bürkle A, Moreno-Villanueva M.

Toxicol In Vitro. 2018 Aug;50:29-39. doi: 10.1016/j.tiv.2018.02.001. Epub 2018 Feb 10.

PMID:
29438734
14.

Mass spectrometric analysis of sulfur mustard-induced biomolecular adducts: Are DNA adducts suitable biomarkers of exposure?

Zubel T, Bürkle A, Mangerich A.

Toxicol Lett. 2018 Sep 1;293:21-30. doi: 10.1016/j.toxlet.2017.12.014. Epub 2017 Dec 23. Review.

PMID:
29277573
15.

The C-terminal domain of p53 orchestrates the interplay between non-covalent and covalent poly(ADP-ribosyl)ation of p53 by PARP1.

Fischbach A, Krüger A, Hampp S, Assmann G, Rank L, Hufnagel M, Stöckl MT, Fischer JMF, Veith S, Rossatti P, Ganz M, Ferrando-May E, Hartwig A, Hauser K, Wiesmüller L, Bürkle A, Mangerich A.

Nucleic Acids Res. 2018 Jan 25;46(2):804-822. doi: 10.1093/nar/gkx1205.

16.

PARP1 protects from benzo[a]pyrene diol epoxide-induced replication stress and mutagenicity.

Fischer JMF, Zubel T, Jander K, Fix J, Trussina IREA, Gebhard D, Bergemann J, Bürkle A, Mangerich A.

Arch Toxicol. 2018 Mar;92(3):1323-1340. doi: 10.1007/s00204-017-2115-6. Epub 2017 Dec 1.

17.

DNA Hydroxymethylation Levels Are Altered in Blood Cells From Down Syndrome Persons Enrolled in the MARK-AGE Project.

Ciccarone F, Valentini E, Malavolta M, Zampieri M, Bacalini MG, Calabrese R, Guastafierro T, Reale A, Franceschi C, Capri M, Breusing N, Grune T, Moreno-Villanueva M, Bürkle A, Caiafa P.

J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):737-744. doi: 10.1093/gerona/glx198.

18.

Zinc-Induced Metallothionein in Centenarian Offspring From a Large European Population: The MARK-AGE Project.

Giacconi R, Costarelli L, Piacenza F, Basso A, Bürkle A, Moreno-Villanueva M, Grune T, Weber D, Stuetz W, Gonos ES, Schön C, Grubeck-Loebenstein B, Sikora E, Toussaint O, Debacq-Chainiaux F, Franceschi C, Hervonen A, Slagboom E, Ciccarone F, Zampieri M, Caiafa P, Jansen E, Dollé MET, Breusing N, Mocchegiani E, Malavolta M.

J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):745-753. doi: 10.1093/gerona/glx192.

PMID:
29045571
19.

Protection against Tetanus and Diphtheria in Europe: The impact of age, gender and country of origin based on data from the MARK-AGE Study.

Weinberger B, Keller M, Putzer C, Breitenberger D, Koller B, Fiegl S, Moreno-Villanueva M, Bernhardt J, Franceschi C, Voutetakis K, Gonos ES, Hurme M, Sikora E, Toussaint O, Debacq-Chainiaux F, Grune T, Breusing N, Bürkle A, Grubeck-Loebenstein B.

Exp Gerontol. 2018 May;105:109-112. doi: 10.1016/j.exger.2017.08.037. Epub 2017 Oct 7.

PMID:
29017961
20.

Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.

Schuhwerk H, Bruhn C, Siniuk K, Min W, Erener S, Grigaravicius P, Krüger A, Ferrari E, Zubel T, Lazaro D, Monajembashi S, Kiesow K, Kroll T, Bürkle A, Mangerich A, Hottiger M, Wang ZQ.

Nucleic Acids Res. 2017 Nov 2;45(19):11174-11192. doi: 10.1093/nar/gkx717.

21.

Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project.

Weber D, Stuetz W, Toussaint O, Debacq-Chainiaux F, Dollé MET, Jansen E, Gonos ES, Franceschi C, Sikora E, Hervonen A, Breusing N, Sindlinger T, Moreno-Villanueva M, Bürkle A, Grune T.

Oxid Med Cell Longev. 2017;2017:1401452. doi: 10.1155/2017/1401452. Epub 2017 Jul 19.

22.

Quantitation of Poly(ADP-Ribose) by Isotope Dilution Mass Spectrometry.

Zubel T, Martello R, Bürkle A, Mangerich A.

Methods Mol Biol. 2017;1608:3-18. doi: 10.1007/978-1-4939-6993-7_1.

PMID:
28695499
23.

The NAD+ precursor nicotinic acid improves genomic integrity in human peripheral blood mononuclear cells after X-irradiation.

Weidele K, Beneke S, Bürkle A.

DNA Repair (Amst). 2017 Apr;52:12-23. doi: 10.1016/j.dnarep.2017.02.001. Epub 2017 Feb 13.

PMID:
28216063
24.

Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.

Berger NA, Besson VC, Boulares AH, Bürkle A, Chiarugi A, Clark RS, Curtin NJ, Cuzzocrea S, Dawson TM, Dawson VL, Haskó G, Liaudet L, Moroni F, Pacher P, Radermacher P, Salzman AL, Snyder SH, Soriano FG, Strosznajder RP, Sümegi B, Swanson RA, Szabo C.

Br J Pharmacol. 2018 Jan;175(2):192-222. doi: 10.1111/bph.13748. Epub 2017 Mar 26. Review.

25.

Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: A Cross-Sectional Study in Six European Countries.

Stuetz W, Weber D, Dollé ME, Jansen E, Grubeck-Loebenstein B, Fiegl S, Toussaint O, Bernhardt J, Gonos ES, Franceschi C, Sikora E, Moreno-Villanueva M, Breusing N, Grune T, Bürkle A.

Nutrients. 2016 Sep 30;8(10). pii: E614.

26.

Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells.

Rank L, Veith S, Gwosch EC, Demgenski J, Ganz M, Jongmans MC, Vogel C, Fischbach A, Buerger S, Fischer JM, Zubel T, Stier A, Renner C, Schmalz M, Beneke S, Groettrup M, Kuiper RP, Bürkle A, Ferrando-May E, Mangerich A.

Nucleic Acids Res. 2016 Dec 1;44(21):10386-10405. Epub 2016 Sep 29.

27.

Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study.

Valentini E, Zampieri M, Malavolta M, Bacalini MG, Calabrese R, Guastafierro T, Reale A, Franceschi C, Hervonen A, Koller B, Bernhardt J, Slagboom PE, Toussaint O, Sikora E, Gonos ES, Breusing N, Grune T, Jansen E, Dollé ME, Moreno-Villanueva M, Sindlinger T, Bürkle A, Ciccarone F, Caiafa P.

Aging (Albany NY). 2016 Aug 29;8(9):1896-1922. doi: 10.18632/aging.101022.

28.

Association Between Off-site Central Monitoring Using Standardized Cardiac Telemetry and Clinical Outcomes Among Non-Critically Ill Patients.

Cantillon DJ, Loy M, Burkle A, Pengel S, Brosovich D, Hamilton A, Khot UN, Lindsay BD.

JAMA. 2016 Aug 2;316(5):519-24. doi: 10.1001/jama.2016.10258.

PMID:
27483066
29.

Differential cytotoxicity induced by the Titanium(IV)Salan complex Tc52 in G2-phase independent of DNA damage.

Pesch T, Schuhwerk H, Wyrsch P, Immel T, Dirks W, Bürkle A, Huhn T, Beneke S.

BMC Cancer. 2016 Jul 13;16:469. doi: 10.1186/s12885-016-2538-0.

30.

Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study.

Ciccarone F, Malavolta M, Calabrese R, Guastafierro T, Bacalini MG, Reale A, Franceschi C, Capri M, Hervonen A, Hurme M, Grubeck-Loebenstein B, Koller B, Bernhardt J, Schӧn C, Slagboom PE, Toussaint O, Sikora E, Gonos ES, Breusing N, Grune T, Jansen E, Dollé M, Moreno-Villanueva M, Sindlinger T, Bürkle A, Zampieri M, Caiafa P.

Aging Cell. 2016 Aug;15(4):755-65. doi: 10.1111/acel.12485. Epub 2016 May 11.

31.

Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants.

Hirsch C, Striegl B, Mathes S, Adlhart C, Edelmann M, Bono E, Gaan S, Salmeia KA, Hoelting L, Krebs A, Nyffeler J, Pape R, Bürkle A, Leist M, Wick P, Schildknecht S.

Arch Toxicol. 2017 Jan;91(1):407-425. doi: 10.1007/s00204-016-1680-4. Epub 2016 Feb 29.

32.

Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients.

Maynard S, Hejl AM, Dinh TS, Keijzers G, Hansen ÅM, Desler C, Moreno-Villanueva M, Bürkle A, Rasmussen LJ, Waldemar G, Bohr VA.

Aging (Albany NY). 2015 Oct;7(10):793-815.

33.

Stress Hormone-Mediated DNA Damage Response--Implications for Cellular Senescence and Tumour Progression.

Moreno-Villanueva M, Bürkle A.

Curr Drug Targets. 2016;17(4):398-404. Review.

PMID:
26424387
34.

Immunochemical analysis of poly(ADP-ribosyl)ation in HaCaT keratinocytes induced by the mono-alkylating agent 2-chloroethyl ethyl sulfide (CEES): Impact of experimental conditions.

Debiak M, Lex K, Ponath V, Burckhardt-Boer W, Thiermann H, Steinritz D, Schmidt A, Mangerich A, Bürkle A.

Toxicol Lett. 2016 Feb 26;244:72-80. doi: 10.1016/j.toxlet.2015.09.009. Epub 2015 Sep 14.

PMID:
26383632
35.

Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences.

Mangerich A, Debiak M, Birtel M, Ponath V, Balszuweit F, Lex K, Martello R, Burckhardt-Boer W, Strobelt R, Siegert M, Thiermann H, Steinritz D, Schmidt A, Bürkle A.

Toxicol Lett. 2016 Feb 26;244:56-71. doi: 10.1016/j.toxlet.2015.09.010. Epub 2015 Sep 14.

PMID:
26383629
36.

Editorial.

Bürkle A, Grune T, Gonos ES, Bohr VA.

Mech Ageing Dev. 2015 Nov;151:1. doi: 10.1016/j.mad.2015.08.008. Epub 2015 Sep 14. No abstract available.

37.

Toxicology: a discipline in need of academic anchoring--the point of view of the German Society of Toxicology.

Gundert-Remy U, Barth H, Bürkle A, Degen GH, Landsiedel R.

Arch Toxicol. 2015 Oct;89(10):1881-93. doi: 10.1007/s00204-015-1577-7. Epub 2015 Aug 28.

38.

Statistical strategies and stochastic predictive models for the MARK-AGE data.

Giampieri E, Remondini D, Bacalini MG, Garagnani P, Pirazzini C, Yani SL, Giuliani C, Menichetti G, Zironi I, Sala C, Capri M, Franceschi C, Bürkle A, Castellani G.

Mech Ageing Dev. 2015 Nov;151:45-53. doi: 10.1016/j.mad.2015.07.001. Epub 2015 Jul 21.

39.

Antibiotics and sweeteners in the aquatic environment: biodegradability, formation of phototransformation products, and in vitro toxicity.

Bergheim M, Gminski R, Spangenberg B, Debiak M, Bürkle A, Mersch-Sundermann V, Kümmerer K, Gieré R.

Environ Sci Pollut Res Int. 2015 Nov;22(22):18017-30. doi: 10.1007/s11356-015-4831-x. Epub 2015 Jul 15.

PMID:
26169816
40.

Quality control data of physiological and immunological biomarkers measured in serum and plasma.

Jansen E, Beekhof P, Cremers J, Weinberger B, Fiegl S, Toussaint O, Bernhard J, Gonos E, Capri M, Franceschi C, Sikora E, Moreno-Villanueva M, Breusing N, Grune T, Bürkle A, Dollé ME.

Mech Ageing Dev. 2015 Nov;151:54-9. doi: 10.1016/j.mad.2015.06.004. Epub 2015 Jul 9.

41.

MARK-AGE data management: Cleaning, exploration and visualization of data.

Baur J, Moreno-Villanueva M, Kötter T, Sindlinger T, Bürkle A, Berthold MR, Junk M.

Mech Ageing Dev. 2015 Nov;151:38-44. doi: 10.1016/j.mad.2015.05.007. Epub 2015 May 21.

42.

The MARK-AGE extended database: data integration and pre-processing.

Baur J, Kötter T, Moreno-Villanueva M, Sindlinger T, Berthold MR, Bürkle A, Junk M.

Mech Ageing Dev. 2015 Nov;151:31-7. doi: 10.1016/j.mad.2015.05.006. Epub 2015 May 21.

43.

Prevention of the degeneration of human dopaminergic neurons in an astrocyte co-culture system allowing endogenous drug metabolism.

Efremova L, Schildknecht S, Adam M, Pape R, Gutbier S, Hanf B, Bürkle A, Leist M.

Br J Pharmacol. 2015 Aug;172(16):4119-32. doi: 10.1111/bph.13193. Epub 2015 Jun 26.

44.

MARK-AGE population: From the human model to new insights.

Capri M, Moreno-Villanueva M, Cevenini E, Pini E, Scurti M, Borelli V, Palmas MG, Zoli M, Schön C, Siepelmeyer A, Bernhardt J, Fiegl S, Zondag G, de Craen AJ, Hervonen A, Hurme M, Sikora E, Gonos ES, Voutetakis K, Toussaint O, Debacq-Chainiaux F, Grubeck-Loebenstein B, Bürkle A, Franceschi C.

Mech Ageing Dev. 2015 Nov;151:13-7. doi: 10.1016/j.mad.2015.03.010. Epub 2015 Apr 2. Review. No abstract available.

45.

MARK-AGE biomarkers of ageing.

Bürkle A, Moreno-Villanueva M, Bernhard J, Blasco M, Zondag G, Hoeijmakers JH, Toussaint O, Grubeck-Loebenstein B, Mocchegiani E, Collino S, Gonos ES, Sikora E, Gradinaru D, Dollé M, Salmon M, Kristensen P, Griffiths HR, Libert C, Grune T, Breusing N, Simm A, Franceschi C, Capri M, Talbot D, Caiafa P, Friguet B, Slagboom PE, Hervonen A, Hurme M, Aspinall R.

Mech Ageing Dev. 2015 Nov;151:2-12. doi: 10.1016/j.mad.2015.03.006. Epub 2015 Mar 24. Review.

46.

MARK-AGE standard operating procedures (SOPs): A successful effort.

Moreno-Villanueva M, Capri M, Breusing N, Siepelmeyer A, Sevini F, Ghezzo A, de Craen AJ, Hervonen A, Hurme M, Schön C, Grune T, Franceschi C, Bürkle A.

Mech Ageing Dev. 2015 Nov;151:18-25. doi: 10.1016/j.mad.2015.03.007. Epub 2015 Mar 26.

47.

The MARK-AGE phenotypic database: Structure and strategy.

Moreno-Villanueva M, Kötter T, Sindlinger T, Baur J, Oehlke S, Bürkle A, Berthold MR.

Mech Ageing Dev. 2015 Nov;151:26-30. doi: 10.1016/j.mad.2015.03.005. Epub 2015 Mar 27.

48.

Reconfiguration of DNA methylation in aging.

Zampieri M, Ciccarone F, Calabrese R, Franceschi C, Bürkle A, Caiafa P.

Mech Ageing Dev. 2015 Nov;151:60-70. doi: 10.1016/j.mad.2015.02.002. Epub 2015 Feb 20. Review.

49.

Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors.

Kalfalah F, Seggewiß S, Walter R, Tigges J, Moreno-Villanueva M, Bürkle A, Ohse S, Busch H, Boerries M, Hildebrandt B, Royer-Pokora B, Boege F.

Aging (Albany NY). 2015 Feb;7(2):110-22.

50.

Differences in alarm events between disposable and reusable electrocardiography lead wires.

Albert NM, Murray T, Bena JF, Slifcak E, Roach JD, Spence J, Burkle A.

Am J Crit Care. 2015 Jan;24(1):67-73; quiz 74. doi: 10.4037/ajcc2015663.

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