Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 86

1.

Direct targeting of Gαq and Gα11 oncoproteins in cancer cells.

Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, Pfeil EM, Cervantes-Villagrana RD, Inoue A, Häberlein F, Slodczyk T, Reher R, Kehraus S, Monteleone S, Schrage R, Heycke N, Rick U, Engel S, Pfeifer A, Kolb P, König G, Bünemann M, Tüting T, Vázquez-Prado J, Gutkind JS, Gaffal E, Kostenis E.

Sci Signal. 2019 Mar 19;12(573). pii: eaau5948. doi: 10.1126/scisignal.aau5948.

PMID:
30890659
2.

Potentiation of the activation of cholinergic receptors by multivalent presentation of ligands supported on gold nanoparticles.

Mattern A, Machka F, Wickleder MS, Ilyaskina OS, Bünemann M, Diener M, Pouokam E.

Org Biomol Chem. 2018 Sep 19;16(36):6680-6687. doi: 10.1039/c8ob01686k.

PMID:
30177977
3.

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization.

Miess E, Gondin AB, Yousuf A, Steinborn R, Mösslein N, Yang Y, Göldner M, Ruland JG, Bünemann M, Krasel C, Christie MJ, Halls ML, Schulz S, Canals M.

Sci Signal. 2018 Jul 17;11(539). pii: eaas9609. doi: 10.1126/scisignal.aas9609.

PMID:
30018083
4.

Lifetime of muscarinic receptor-G-protein complexes determines coupling efficiency and G-protein subtype selectivity.

Ilyaskina OS, Lemoine H, Bünemann M.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):5016-5021. doi: 10.1073/pnas.1715751115. Epub 2018 Apr 23.

5.

Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gαs upon receptor activation.

Andressen KW, Ulsund AH, Krobert KA, Lohse MJ, Bünemann M, Levy FO.

FASEB J. 2018 Feb;32(2):1059-1069. doi: 10.1096/fj.201700486R. Epub 2018 Jan 3.

PMID:
29079700
6.

The allosteric site regulates the voltage sensitivity of muscarinic receptors.

Hoppe A, Marti-Solano M, Drabek M, Bünemann M, Kolb P, Rinne A.

Cell Signal. 2018 Jan;42:114-126. doi: 10.1016/j.cellsig.2017.10.011. Epub 2017 Oct 19.

PMID:
29056499
7.

Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels.

Dembla S, Behrendt M, Mohr F, Goecke C, Sondermann J, Schneider FM, Schmidt M, Stab J, Enzeroth R, Leitner MG, Nuñez-Badinez P, Schwenk J, Nürnberg B, Cohen A, Philipp SE, Greffrath W, Bünemann M, Oliver D, Zakharian E, Schmidt M, Oberwinkler J.

Elife. 2017 Aug 15;6. pii: e26280. doi: 10.7554/eLife.26280.

8.

Potentiation of receptor responses induced by prolonged binding of Gα13 and leukemia-associated RhoGEF.

Bodmann EL, Krett AL, Bünemann M.

FASEB J. 2017 Aug;31(8):3663-3676. doi: 10.1096/fj.201700026R. Epub 2017 May 2.

9.

SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake.

Honrath B, Matschke L, Meyer T, Magerhans L, Perocchi F, Ganjam GK, Zischka H, Krasel C, Gerding A, Bakker BM, Bünemann M, Strack S, Decher N, Culmsee C, Dolga AM.

Cell Death Differ. 2017 May;24(5):761-773. doi: 10.1038/cdd.2017.2. Epub 2017 Mar 10.

10.

A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib.

Sun T, Yang L, Kaur H, Pestel J, Looso M, Nolte H, Krasel C, Heil D, Krishnan RK, Santoni MJ, Borg JP, Bünemann M, Offermanns S, Swiercz JM, Worzfeld T.

J Cell Biol. 2017 Jan 2;216(1):199-215. doi: 10.1083/jcb.201602002. Epub 2016 Dec 22.

11.

Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signaling.

Zindel D, Engel S, Bottrill AR, Pin JP, Prézeau L, Tobin AB, Bünemann M, Krasel C, Butcher AJ.

Biochem J. 2016 Nov 15;473(22):4173-4192. Epub 2016 Sep 13.

12.

The mode of agonist binding to a G protein-coupled receptor switches the effect that voltage changes have on signaling.

Rinne A, Mobarec JC, Mahaut-Smith M, Kolb P, Bünemann M.

Sci Signal. 2015 Nov 3;8(401):ra110. doi: 10.1126/scisignal.aac7419.

PMID:
26535008
13.

Membrane Potential Controls the Efficacy of Catecholamine-induced β1-Adrenoceptor Activity.

Birk A, Rinne A, Bünemann M.

J Biol Chem. 2015 Nov 6;290(45):27311-20. doi: 10.1074/jbc.M115.665000. Epub 2015 Sep 25.

14.

Dynamics of G protein effector interactions and their impact on timing and sensitivity of G protein-mediated signal transduction.

Bodmann EL, Wolters V, Bünemann M.

Eur J Cell Biol. 2015 Jul-Sep;94(7-9):415-9. doi: 10.1016/j.ejcb.2015.06.004. Epub 2015 Jun 3. Review.

PMID:
26074197
15.

Adenylyl cyclases 5 and 6 underlie PIP3-dependent regulation.

Reddy GR, Subramanian H, Birk A, Milde M, Nikolaev VO, Bünemann M.

FASEB J. 2015 Aug;29(8):3458-71. doi: 10.1096/fj.14-268466. Epub 2015 Apr 30.

16.

Interhelical interaction and receptor phosphorylation regulate the activation kinetics of different human β1-adrenoceptor variants.

Ahles A, Rodewald F, Rochais F, Bünemann M, Engelhardt S.

J Biol Chem. 2015 Jan 16;290(3):1760-9. doi: 10.1074/jbc.M114.607333. Epub 2014 Dec 1.

17.

Engineered hyperphosphorylation of the β2-adrenoceptor prolongs arrestin-3 binding and induces arrestin internalization.

Zindel D, Butcher AJ, Al-Sabah S, Lanzerstorfer P, Weghuber J, Tobin AB, Bünemann M, Krasel C.

Mol Pharmacol. 2015 Feb;87(2):349-62. doi: 10.1124/mol.114.095422. Epub 2014 Nov 25.

18.

Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors.

Wilke BU, Lindner M, Greifenberg L, Albus A, Kronimus Y, Bünemann M, Leitner MG, Oliver D.

Nat Commun. 2014 Nov 25;5:5540. doi: 10.1038/ncomms6540.

PMID:
25420509
19.

Influence of gαq on the dynamics of m3-acetylcholine receptor-g-protein-coupled receptor kinase 2 interaction.

Wolters V, Krasel C, Brockmann J, Bünemann M.

Mol Pharmacol. 2015 Jan;87(1):9-17. doi: 10.1124/mol.114.094722. Epub 2014 Oct 14.

PMID:
25316767
20.

The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively.

Al-Sabah S, Al-Fulaij M, Shaaban G, Ahmed HA, Mann RJ, Donnelly D, Bünemann M, Krasel C.

PLoS One. 2014 Sep 5;9(9):e106890. doi: 10.1371/journal.pone.0106890. eCollection 2014.

21.

Dynamics of adenylate cyclase regulation via heterotrimeric G-proteins.

Milde M, Werthmann RC, von Hayn K, Bünemann M.

Biochem Soc Trans. 2014 Apr;42(2):239-43. doi: 10.1042/BST20130280.

PMID:
24646224
22.

Dynamics of Gαq-protein-p63RhoGEF interaction and its regulation by RGS2.

Bodmann EL, Rinne A, Brandt D, Lutz S, Wieland T, Grosse R, Bünemann M.

Biochem J. 2014 Feb 15;458(1):131-40. doi: 10.1042/BJ20130782.

PMID:
24299002
23.

Dynamics of Gαi1 interaction with type 5 adenylate cyclase reveal the molecular basis for high sensitivity of Gi-mediated inhibition of cAMP production.

Milde M, Rinne A, Wunder F, Engelhardt S, Bünemann M.

Biochem J. 2013 Sep 15;454(3):515-23. doi: 10.1042/BJ20130554.

PMID:
23841650
24.

Voltage regulates adrenergic receptor function.

Rinne A, Birk A, Bünemann M.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1536-41. doi: 10.1073/pnas.1212656110. Epub 2013 Jan 7.

25.

Comparison of the activation kinetics of the M3 acetylcholine receptor and a constitutively active mutant receptor in living cells.

Hoffmann C, Nuber S, Zabel U, Ziegler N, Winkler C, Hein P, Berlot CH, Bünemann M, Lohse MJ.

Mol Pharmacol. 2012 Aug;82(2):236-45. doi: 10.1124/mol.112.077578. Epub 2012 May 7.

PMID:
22564786
26.

A polymorphism-specific "memory" mechanism in the β(2)-adrenergic receptor.

Ahles A, Rochais F, Frambach T, Bünemann M, Engelhardt S.

Sci Signal. 2011 Aug 9;4(185):ra53. doi: 10.1126/scisignal.2001681.

27.

Temporally resolved cAMP monitoring in endothelial cells uncovers a thrombin-induced [cAMP] elevation mediated via the Ca²+-dependent production of prostacyclin.

Werthmann RC, Lohse MJ, Bünemann M.

J Physiol. 2011 Jan 1;589(Pt 1):181-93. doi: 10.1113/jphysiol.2010.200121. Epub 2010 Nov 8.

28.

G proteins in reverse mode: receptor-mediated GTP release inhibits G protein and effector function.

Hommers LG, Klenk C, Dees C, Bünemann M.

J Biol Chem. 2010 Mar 12;285(11):8227-33. doi: 10.1074/jbc.M109.015388. Epub 2010 Jan 14.

29.

Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells.

von Hayn K, Werthmann RC, Nikolaev VO, Hommers LG, Lohse MJ, Bünemann M.

Am J Physiol Cell Physiol. 2010 Feb;298(2):C324-32. doi: 10.1152/ajpcell.00197.2009. Epub 2009 Nov 4.

30.

Real-time monitoring of cAMP levels in living endothelial cells: thrombin transiently inhibits adenylyl cyclase 6.

Werthmann RC, von Hayn K, Nikolaev VO, Lohse MJ, Bünemann M.

J Physiol. 2009 Aug 15;587(Pt 16):4091-104. doi: 10.1113/jphysiol.2009.172957. Epub 2009 Jun 22.

31.

Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdown.

Baumer Y, Spindler V, Werthmann RC, Bünemann M, Waschke J.

J Cell Physiol. 2009 Sep;220(3):716-26. doi: 10.1002/jcp.21819.

PMID:
19472214
32.

Analysis of receptor oligomerization by FRAP microscopy.

Dorsch S, Klotz KN, Engelhardt S, Lohse MJ, Bünemann M.

Nat Methods. 2009 Mar;6(3):225-30. doi: 10.1038/nmeth.1304. Epub 2009 Feb 22.

PMID:
19234451
33.

GPCR and G proteins: drug efficacy and activation in live cells.

Vilardaga JP, Bünemann M, Feinstein TN, Lambert N, Nikolaev VO, Engelhardt S, Lohse MJ, Hoffmann C.

Mol Endocrinol. 2009 May;23(5):590-9. doi: 10.1210/me.2008-0204. Epub 2009 Feb 5. Review.

34.

Coupling mode of receptors and G proteins.

Hein P, Bünemann M.

Naunyn Schmiedebergs Arch Pharmacol. 2009 May;379(5):435-43. doi: 10.1007/s00210-008-0383-7. Epub 2008 Dec 2. Review.

PMID:
19048232
35.

Alternative splicing of the guanylyl cyclase-A receptor modulates atrial natriuretic peptide signaling.

Hartmann M, Skryabin BV, Müller T, Gazinski A, Schröter J, Gassner B, Nikolaev VO, Bünemann M, Kuhn M.

J Biol Chem. 2008 Oct 17;283(42):28313-20. doi: 10.1074/jbc.M805521200. Epub 2008 Aug 18.

36.

Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors.

Lohse MJ, Nikolaev VO, Hein P, Hoffmann C, Vilardaga JP, Bünemann M.

Trends Pharmacol Sci. 2008 Mar;29(3):159-65. doi: 10.1016/j.tips.2007.12.002. Epub 2008 Feb 11. Review.

PMID:
18262662
37.

Kinetics of G-protein-coupled receptor signals in intact cells.

Lohse MJ, Hein P, Hoffmann C, Nikolaev VO, Vilardaga JP, Bünemann M.

Br J Pharmacol. 2008 Mar;153 Suppl 1:S125-32. doi: 10.1038/sj.bjp.0707656. Epub 2008 Jan 14. Review.

38.

Conformational changes in G-protein-coupled receptors-the quest for functionally selective conformations is open.

Hoffmann C, Zürn A, Bünemann M, Lohse MJ.

Br J Pharmacol. 2008 Mar;153 Suppl 1:S358-66. Epub 2007 Dec 3. Review.

39.

Monitoring receptor signaling by intramolecular FRET.

Lohse MJ, Bünemann M, Hoffmann C, Vilardaga JP, Nikolaev VO.

Curr Opin Pharmacol. 2007 Oct;7(5):547-53. Epub 2007 Oct 4. Review.

PMID:
17919975
40.

Kinetic analysis of G protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells.

Lohse MJ, Hoffmann C, Nikolaev VO, Vilardaga JP, Bünemann M.

Adv Protein Chem. 2007;74:167-88. Review.

PMID:
17854658
41.

Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors.

Nikolaev VO, Boettcher C, Dees C, Bünemann M, Lohse MJ, Zenk MH.

J Biol Chem. 2007 Sep 14;282(37):27126-32. Epub 2007 Jul 6.

42.

Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure.

Hullin R, Matthes J, von Vietinghoff S, Bodi I, Rubio M, D'Souza K, Friedrich Khan I, Rottländer D, Hoppe UC, Mohacsi P, Schmitteckert E, Gilsbach R, Bünemann M, Hein L, Schwartz A, Herzig S.

PLoS One. 2007 Mar 14;2(3):e292.

43.

Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol.

Rochais F, Vilardaga JP, Nikolaev VO, Bünemann M, Lohse MJ, Engelhardt S.

J Clin Invest. 2007 Jan;117(1):229-35.

44.

Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling.

Nikolaev VO, Bünemann M, Schmitteckert E, Lohse MJ, Engelhardt S.

Circ Res. 2006 Nov 10;99(10):1084-91. Epub 2006 Oct 12.

PMID:
17038640
45.

Gs activation is time-limiting in initiating receptor-mediated signaling.

Hein P, Rochais F, Hoffmann C, Dorsch S, Nikolaev VO, Engelhardt S, Berlot CH, Lohse MJ, Bünemann M.

J Biol Chem. 2006 Nov 3;281(44):33345-51. Epub 2006 Sep 8.

46.

Molecular basis of partial agonism at the neurotransmitter alpha2A-adrenergic receptor and Gi-protein heterotrimer.

Nikolaev VO, Hoffmann C, Bünemann M, Lohse MJ, Vilardaga JP.

J Biol Chem. 2006 Aug 25;281(34):24506-11. Epub 2006 Jun 20.

47.

G protein-coupled receptors serve as mechanosensors for fluid shear stress in neutrophils.

Makino A, Prossnitz ER, Bünemann M, Wang JM, Yao W, Schmid-Schönbein GW.

Am J Physiol Cell Physiol. 2006 Jun;290(6):C1633-9. Epub 2006 Jan 25.

48.

Dynamics of receptor/G protein coupling in living cells.

Hein P, Frank M, Hoffmann C, Lohse MJ, Bünemann M.

EMBO J. 2005 Dec 7;24(23):4106-14. Epub 2005 Nov 17.

49.

G Protein activation without subunit dissociation depends on a G{alpha}(i)-specific region.

Frank M, Thümer L, Lohse MJ, Bünemann M.

J Biol Chem. 2005 Jul 1;280(26):24584-90. Epub 2005 May 2.

50.

A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells.

Hoffmann C, Gaietta G, Bünemann M, Adams SR, Oberdorff-Maass S, Behr B, Vilardaga JP, Tsien RY, Ellisman MH, Lohse MJ.

Nat Methods. 2005 Mar;2(3):171-6. Epub 2005 Feb 17.

PMID:
15782185

Supplemental Content

Loading ...
Support Center