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Items: 1 to 50 of 271

1.

Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations.

Akbergenov R, Duscha S, Fritz AK, Juskeviciene R, Oishi N, Schmitt K, Shcherbakov D, Teo Y, Boukari H, Freihofer P, Isnard-Petit P, Oettinghaus B, Frank S, Thiam K, Rehrauer H, Westhof E, Schacht J, Eckert A, Wolfer D, Böttger EC.

EMBO Rep. 2018 Sep 20. pii: e46193. doi: 10.15252/embr.201846193. [Epub ahead of print]

2.

Combining forecast probabilities with graphical visualization for improved reporting of antimicrobial susceptibility testing.

Mancini S, Marchesi M, Blöchliger N, Schmid M, Courvalin P, Keller PM, Böttger EC.

J Antimicrob Chemother. 2018 Aug 1;73(8):2266-2268. doi: 10.1093/jac/dky138. No abstract available.

3.

Effects of the 1- N-(4-Amino-2 S-hydroxybutyryl) and 6'- N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity, and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics.

Sonousi A, Sarpe VA, Brilkova M, Schacht J, Vasella A, Böttger EC, Crich D.

ACS Infect Dis. 2018 Jul 13;4(7):1114-1120. doi: 10.1021/acsinfecdis.8b00052. Epub 2018 May 10.

PMID:
29708331
4.

Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement.

van Ingen J, Aksamit T, Andrejak C, Böttger EC, Cambau E, Daley CL, Griffith DE, Guglielmetti L, Holland SM, Huitt GA, Koh WJ, Lange C, Leitman P, Marras TK, Morimoto K, Olivier KN, Santin M, Stout JE, Thomson R, Tortoli E, Wallace RJ Jr, Winthrop KL, Wagner D; for NTM-NET.

Eur Respir J. 2018 Mar 22;51(3). pii: 1800170. doi: 10.1183/13993003.00170-2018. Print 2018 Mar. No abstract available.

PMID:
29567726
5.

A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study.

Walker TM, Merker M, Knoblauch AM, Helbling P, Schoch OD, van der Werf MJ, Kranzer K, Fiebig L, Kröger S, Haas W, Hoffmann H, Indra A, Egli A, Cirillo DM, Robert J, Rogers TR, Groenheit R, Mengshoel AT, Mathys V, Haanperä M, Soolingen DV, Niemann S, Böttger EC, Keller PM; MDR-TB Cluster Consortium.

Lancet Infect Dis. 2018 Apr;18(4):431-440. doi: 10.1016/S1473-3099(18)30004-5. Epub 2018 Jan 8. Erratum in: Lancet Infect Dis. 2018 Jan 10;:.

6.

Rapid disc diffusion antibiotic susceptibility testing for Pseudomonas aeruginosa, Acinetobacter baumannii and Enterococcus spp.

Hombach M, Jetter M, Blöchliger N, Kolesnik-Goldmann N, Keller PM, Böttger EC.

J Antimicrob Chemother. 2018 Feb 1;73(2):385-391. doi: 10.1093/jac/dkx404.

7.

Rapid detection of ESBL, carbapenemases, MRSA and other important resistance phenotypes within 6-8 h by automated disc diffusion antibiotic susceptibility testing.

Hombach M, Jetter M, Keller PM, Blöchliger N, Kolesnik-Goldmann N, Böttger EC.

J Antimicrob Chemother. 2017 Nov 1;72(11):3063-3069. doi: 10.1093/jac/dkx256.

PMID:
28962001
8.

Structure-Based Design and Synthesis of Apramycin-Paromomycin Analogues: Importance of the Configuration at the 6'-Position and Differences between the 6'-Amino and Hydroxy Series.

Mandhapati AR, Yang G, Kato T, Shcherbakov D, Hobbie SN, Vasella A, Böttger EC, Crich D.

J Am Chem Soc. 2017 Oct 18;139(41):14611-14619. doi: 10.1021/jacs.7b07754. Epub 2017 Oct 9.

PMID:
28892368
9.

MASTER: a model to improve and standardize clinical breakpoints for antimicrobial susceptibility testing using forecast probabilities.

Blöchliger N, Keller PM, Böttger EC, Hombach M.

J Antimicrob Chemother. 2017 Sep 1;72(9):2553-2561. doi: 10.1093/jac/dkx196.

PMID:
28859448
10.

Global outbreak of severe Mycobacterium chimaera disease after cardiac surgery: a molecular epidemiological study.

van Ingen J, Kohl TA, Kranzer K, Hasse B, Keller PM, Katarzyna Szafrańska A, Hillemann D, Chand M, Schreiber PW, Sommerstein R, Berger C, Genoni M, Rüegg C, Troillet N, Widmer AF, Becker SL, Herrmann M, Eckmanns T, Haller S, Höller C, Debast SB, Wolfhagen MJ, Hopman J, Kluytmans J, Langelaar M, Notermans DW, Ten Oever J, van den Barselaar P, Vonk ABA, Vos MC, Ahmed N, Brown T, Crook D, Lamagni T, Phin N, Smith EG, Zambon M, Serr A, Götting T, Ebner W, Thürmer A, Utpatel C, Spröer C, Bunk B, Nübel U, Bloemberg GV, Böttger EC, Niemann S, Wagner D, Sax H.

Lancet Infect Dis. 2017 Oct;17(10):1033-1041. doi: 10.1016/S1473-3099(17)30324-9. Epub 2017 Jul 12.

PMID:
28711585
11.

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, Snavely T, Robertson GT, Rubin EJ, Ioerger TR, Sirgel FA, van der Merwe R, van Helden PD, Keller P, Böttger EC, Karakousis PC, Lenaerts AJ, Sacchettini JC.

Cell. 2017 Jul 13;170(2):249-259.e25. doi: 10.1016/j.cell.2017.06.025. Epub 2017 Jun 29.

12.

N6', N6''', and O4' Modifications to Neomycin Affect Ribosomal Selectivity without Compromising Antibacterial Activity.

Sati GC, Shcherbakov D, Hobbie SN, Vasella A, Böttger EC, Crich D.

ACS Infect Dis. 2017 May 12;3(5):368-377. doi: 10.1021/acsinfecdis.6b00214. Epub 2017 Apr 6.

13.

Fully automated disc diffusion for rapid antibiotic susceptibility test results: a proof-of-principle study.

Hombach M, Jetter M, Blöchliger N, Kolesnik-Goldmann N, Böttger EC.

J Antimicrob Chemother. 2017 Jun 1;72(6):1659-1668. doi: 10.1093/jac/dkx026.

PMID:
28333189
14.

Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions.

Liu J, Bruhn DF, Lee RB, Zheng Z, Janusic T, Scherbakov D, Scherman MS, Boshoff HI, Das S, Rakesh, Waidyarachchi SL, Brewer TA, Gracia B, Yang L, Bollinger J, Robertson GT, Meibohm B, Lenaerts AJ, Ainsa J, Böttger EC, Lee RE.

ACS Infect Dis. 2017 Jan 13;3(1):72-88. doi: 10.1021/acsinfecdis.6b00158. Epub 2016 Nov 11.

15.

Intrinsic rifamycin resistance of Mycobacterium abscessus is mediated by ADP-ribosyltransferase MAB_0591.

Rominski A, Roditscheff A, Selchow P, Böttger EC, Sander P.

J Antimicrob Chemother. 2017 Feb;72(2):376-384. doi: 10.1093/jac/dkw466. Epub 2016 Dec 20.

PMID:
27999011
16.

Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase.

Freihofer P, Akbergenov R, Teo Y, Juskeviciene R, Andersson DI, Böttger EC.

RNA. 2016 Dec;22(12):1836-1843. Epub 2016 Oct 3.

17.

Synthesis and Antiribosomal Activities of 4'-O-, 6'-O-, 4″-O-, 4',6'-O- and 4″,6″-O-Derivatives in the Kanamycin Series Indicate Differing Target Selectivity Patterns between the 4,5- and 4,6-Series of Disubstituted 2-Deoxystreptamine Aminoglycoside Antibiotics.

Kato T, Yang G, Teo Y, Juskeviciene R, Perez-Fernandez D, Shinde HM, Salian S, Bernet B, Vasella A, Böttger EC, Crich D.

ACS Infect Dis. 2015 Oct 9;1(10):479-86. doi: 10.1021/acsinfecdis.5b00069. Epub 2015 Aug 6.

PMID:
27623314
18.

Comment on: Delamanid susceptibility testing of Mycobacterium tuberculosis using the resazurin microtitre assay and the BACTEC™ MGIT™ 960 system.

Imkamp F, Keller PM, Böttger EC.

J Antimicrob Chemother. 2016 Dec;71(12):3624. Epub 2016 Aug 15. No abstract available.

19.

Diagnostic Molecular Mycobacteriology in Regions With Low Tuberculosis Endemicity: Combining Real-time PCR Assays for Detection of Multiple Mycobacterial Pathogens With Line Probe Assays for Identification of Resistance Mutations.

Deggim-Messmer V, Bloemberg GV, Ritter C, Voit A, Hömke R, Keller PM, Böttger EC.

EBioMedicine. 2016 Jul;9:228-237. doi: 10.1016/j.ebiom.2016.06.016. Epub 2016 Jun 14.

20.

Standard Genotyping Overestimates Transmission of Mycobacterium tuberculosis among Immigrants in a Low-Incidence Country.

Stucki D, Ballif M, Egger M, Furrer H, Altpeter E, Battegay M, Droz S, Bruderer T, Coscolla M, Borrell S, Zürcher K, Janssens JP, Calmy A, Mazza Stalder J, Jaton K, Rieder HL, Pfyffer GE, Siegrist HH, Hoffmann M, Fehr J, Dolina M, Frei R, Schrenzel J, Böttger EC, Gagneux S, Fenner L.

J Clin Microbiol. 2016 Jul;54(7):1862-1870. doi: 10.1128/JCM.00126-16. Epub 2016 May 18.

21.

Performance of Copan WASP for Routine Urine Microbiology.

Quiblier C, Jetter M, Rominski M, Mouttet F, Böttger EC, Keller PM, Hombach M.

J Clin Microbiol. 2016 Mar;54(3):585-92. doi: 10.1128/JCM.02577-15. Epub 2015 Dec 16.

22.

Evaluation of the Bruker MALDI Biotyper for Identification of Fastidious Gram-Negative Rods.

Schulthess B, Bloemberg GV, Zbinden A, Mouttet F, Zbinden R, Böttger EC, Hombach M.

J Clin Microbiol. 2016 Mar;54(3):543-8. doi: 10.1128/JCM.03107-15. Epub 2015 Dec 9.

23.

Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis.

Bloemberg GV, Keller PM, Stucki D, Trauner A, Borrell S, Latshang T, Coscolla M, Rothe T, Hömke R, Ritter C, Feldmann J, Schulthess B, Gagneux S, Böttger EC.

N Engl J Med. 2015 Nov 12;373(20):1986-8. doi: 10.1056/NEJMc1505196. Erratum in: N Engl J Med. 2015 Dec 17;373(25):e29. Stuckia, David [corrected to Stucki, David].

24.

Standardization of Operator-Dependent Variables Affecting Precision and Accuracy of the Disk Diffusion Method for Antibiotic Susceptibility Testing.

Hombach M, Maurer FP, Pfiffner T, Böttger EC, Furrer R.

J Clin Microbiol. 2015 Dec;53(12):3864-9. doi: 10.1128/JCM.02351-15. Epub 2015 Oct 14.

25.

Relative contribution of biological variation and technical variables to zone diameter variations of disc diffusion susceptibility testing.

Hombach M, Ochoa C, Maurer FP, Pfiffner T, Böttger EC, Furrer R.

J Antimicrob Chemother. 2016 Jan;71(1):141-51. doi: 10.1093/jac/dkv309. Epub 2015 Oct 12.

PMID:
26462987
26.

In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics.

Bruhn DF, Scherman MS, Liu J, Scherbakov D, Meibohm B, Böttger EC, Lenaerts AJ, Lee RE.

Sci Rep. 2015 Sep 14;5:13985. doi: 10.1038/srep13985.

27.

Correction: The Rationale for Using Rifabutin in the Treatment of MDR and XDR Tuberculosis Outbreaks.

Sirgel FA, Warren RM, Böttger EC, Klopper M, Victor TC, van Helden PD.

PLoS One. 2015 Jul 21;10(7):e0134190. doi: 10.1371/journal.pone.0134190. eCollection 2015. No abstract available.

28.

Healthcare-associated prosthetic heart valve, aortic vascular graft, and disseminated Mycobacterium chimaera infections subsequent to open heart surgery.

Kohler P, Kuster SP, Bloemberg G, Schulthess B, Frank M, Tanner FC, Rössle M, Böni C, Falk V, Wilhelm MJ, Sommerstein R, Achermann Y, Ten Oever J, Debast SB, Wolfhagen MJ, Brandon Bravo Bruinsma GJ, Vos MC, Bogers A, Serr A, Beyersdorf F, Sax H, Böttger EC, Weber R, van Ingen J, Wagner D, Hasse B.

Eur Heart J. 2015 Oct 21;36(40):2745-53. doi: 10.1093/eurheartj/ehv342. Epub 2015 Jul 17.

PMID:
26188001
29.

Influence of 4'-O-Glycoside Constitution and Configuration on Ribosomal Selectivity of Paromomycin.

Matsushita T, Chen W, Juskeviciene R, Teo Y, Shcherbakov D, Vasella A, Böttger EC, Crich D.

J Am Chem Soc. 2015 Jun 24;137(24):7706-17. doi: 10.1021/jacs.5b02248. Epub 2015 Jun 12.

PMID:
26024064
30.

Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections.

Bruhn DF, Waidyarachchi SL, Madhura DB, Shcherbakov D, Zheng Z, Liu J, Abdelrahman YM, Singh AP, Duscha S, Rathi C, Lee RB, Belland RJ, Meibohm B, Rosch JW, Böttger EC, Lee RE.

Sci Transl Med. 2015 May 20;7(288):288ra75. doi: 10.1126/scitranslmed.3010572.

31.

Determination of MIC distribution and epidemiological cutoff values for bedaquiline and delamanid in Mycobacterium tuberculosis using the MGIT 960 system equipped with TB eXiST.

Keller PM, Hömke R, Ritter C, Valsesia G, Bloemberg GV, Böttger EC.

Antimicrob Agents Chemother. 2015 Jul;59(7):4352-5. doi: 10.1128/AAC.00614-15. Epub 2015 May 4.

32.
33.

The Resistant-Population Cutoff (RCOFF): a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations.

Valsesia G, Hombach M, Maurer FP, Courvalin P, Roos M, Böttger EC.

J Clin Microbiol. 2015 Jun;53(6):1806-11. doi: 10.1128/JCM.03505-14. Epub 2015 Mar 11.

34.

Prolonged Outbreak of Mycobacterium chimaera Infection After Open-Chest Heart Surgery.

Sax H, Bloemberg G, Hasse B, Sommerstein R, Kohler P, Achermann Y, Rössle M, Falk V, Kuster SP, Böttger EC, Weber R.

Clin Infect Dis. 2015 Jul 1;61(1):67-75. doi: 10.1093/cid/civ198. Epub 2015 Mar 11.

35.

Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protection in a guinea pig model of tuberculosis.

Sander P, Clark S, Petrera A, Vilaplana C, Meuli M, Selchow P, Zelmer A, Mohanan D, Andreu N, Rayner E, Dal Molin M, Bancroft GJ, Johansen P, Cardona PJ, Williams A, Böttger EC.

Vaccine. 2015 Mar 10;33(11):1353-9. doi: 10.1016/j.vaccine.2015.01.058. Epub 2015 Feb 2.

PMID:
25657094
36.

Aminoglycoside-modifying enzymes determine the innate susceptibility to aminoglycoside antibiotics in rapidly growing mycobacteria.

Maurer FP, Bruderer VL, Castelberg C, Ritter C, Scherbakov D, Bloemberg GV, Böttger EC.

J Antimicrob Chemother. 2015 May;70(5):1412-9. doi: 10.1093/jac/dku550. Epub 2015 Jan 20.

37.

Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study.

Cambau E, Viveiros M, Machado D, Raskine L, Ritter C, Tortoli E, Matthys V, Hoffner S, Richter E, Perez Del Molino ML, Cirillo DM, van Soolingen D, Böttger EC.

J Antimicrob Chemother. 2015 Mar;70(3):686-96. doi: 10.1093/jac/dku438. Epub 2014 Nov 11.

38.

Fluorine-decoupled carbon spectroscopy for the determination of configuration at fully substituted, trifluoromethyl- and perfluoroalkyl-bearing carbons: comparison with 19F-1H heteronuclear Overhauser effect spectroscopy.

Mandhapati AR, Kato T, Matsushita T, Ksebati B, Vasella A, Böttger EC, Crich D.

J Org Chem. 2015 Feb 6;80(3):1754-63. doi: 10.1021/jo502677a. Epub 2015 Jan 20.

39.

A mutation associated with clofazimine and bedaquiline cross-resistance in MDR-TB following bedaquiline treatment.

Somoskovi A, Bruderer V, Hömke R, Bloemberg GV, Böttger EC.

Eur Respir J. 2015 Feb;45(2):554-7. doi: 10.1183/09031936.00142914. Epub 2014 Oct 30. No abstract available.

40.

Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.

Duscha S, Boukari H, Shcherbakov D, Salian S, Silva S, Kendall A, Kato T, Akbergenov R, Perez-Fernandez D, Bernet B, Vaddi S, Thommes P, Schacht J, Crich D, Vasella A, Böttger EC.

MBio. 2014 Sep 30;5(5):e01827-14. doi: 10.1128/mBio.01827-14.

41.

Postsurgical wound infections due to rapidly growing mycobacteria in Swiss medical tourists following cosmetic surgery in Latin America between 2012 and 2014.

Maurer F, Castelberg C, von Braun A, Wolfensberger A, Bloemberg G, Bottger E, Somoskovi A.

Euro Surveill. 2014 Sep 18;19(37). pii: 20905. No abstract available.

42.

In vivo efficacy of apramycin in murine infection models.

Meyer M, Freihofer P, Scherman M, Teague J, Lenaerts A, Böttger EC.

Antimicrob Agents Chemother. 2014 Nov;58(11):6938-41. doi: 10.1128/AAC.03239-14. Epub 2014 Aug 18.

43.

Integrating forecast probabilities in antibiograms: a way to guide antimicrobial prescriptions more reliably?

Maurer FP, Courvalin P, Böttger EC, Hombach M.

J Clin Microbiol. 2014 Oct;52(10):3674-84. doi: 10.1128/JCM.01645-14. Epub 2014 Aug 6.

44.

Importance of the 6'-hydroxy group and its configuration for apramycin activity.

Mandhapati AR, Shcherbakov D, Duscha S, Vasella A, Böttger EC, Crich D.

ChemMedChem. 2014 Sep;9(9):2074-83. doi: 10.1002/cmdc.201402146. Epub 2014 Jul 17.

PMID:
25045149
45.

Use of the Bruker MALDI Biotyper for identification of molds in the clinical mycology laboratory.

Schulthess B, Ledermann R, Mouttet F, Zbinden A, Bloemberg GV, Böttger EC, Hombach M.

J Clin Microbiol. 2014 Aug;52(8):2797-803. doi: 10.1128/JCM.00049-14. Epub 2014 May 21.

46.

Validation of antibiotic susceptibility testing guidelines in a routine clinical microbiology laboratory exemplifies general key challenges in setting clinical breakpoints.

Hombach M, Courvalin P, Böttger EC.

Antimicrob Agents Chemother. 2014 Jul;58(7):3921-6. doi: 10.1128/AAC.02489-13. Epub 2014 Apr 28.

47.

Lack of antimicrobial bactericidal activity in Mycobacterium abscessus.

Maurer FP, Bruderer VL, Ritter C, Castelberg C, Bloemberg GV, Böttger EC.

Antimicrob Agents Chemother. 2014 Jul;58(7):3828-36. doi: 10.1128/AAC.02448-14. Epub 2014 Apr 21.

48.

Transmission of multidrug-resistant tuberculosis in a low-incidence setting, Switzerland, 2006 to 2012.

Somoskovi A, Helbling P, Deggim V, Hömke R, Ritter C, Böttger EC.

Euro Surveill. 2014 Mar 20;19(11). pii: 20736.

49.

Erm(41)-dependent inducible resistance to azithromycin and clarithromycin in clinical isolates of Mycobacterium abscessus.

Maurer FP, Castelberg C, Quiblier C, Böttger EC, Somoskövi A.

J Antimicrob Chemother. 2014 Jun;69(6):1559-63. doi: 10.1093/jac/dku007. Epub 2014 Feb 4.

50.

4'-O-substitutions determine selectivity of aminoglycoside antibiotics.

Perez-Fernandez D, Shcherbakov D, Matt T, Leong NC, Kudyba I, Duscha S, Boukari H, Patak R, Dubbaka SR, Lang K, Meyer M, Akbergenov R, Freihofer P, Vaddi S, Thommes P, Ramakrishnan V, Vasella A, Böttger EC.

Nat Commun. 2014;5:3112. doi: 10.1038/ncomms4112.

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