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Best matches for Bérubé G[au]:

Review on the delivery of steroids by carrier proteins. Chanphai P et al. J Photochem Photobiol B. (2016)

Testosterone and its dimers alter tRNA morphology. Chanphai P et al. J Pharm Biomed Anal. (2017)

An overview of molecular hybrids in drug discovery. Bérubé G et al. Expert Opin Drug Discov. (2016)

Search results

Items: 1 to 50 of 84

1.

Complexation of cis-Pt and trans-Pt(NH3)2Cl2 with serum proteins: A potential application for drug delivery.

Chanphai P, Bariyanga J, Bérubé G, Tajmir-Riahi HA.

J Biomol Struct Dyn. 2019 Aug 22:1-7. doi: 10.1080/07391102.2019.1654408. [Epub ahead of print]

PMID:
31402755
2.

Second-generation testosterone-platinum(II) hybrids for site-specific treatment of androgen receptor positive prostate cancer: Design, synthesis and antiproliferative activity.

Ouellette V, Côté MF, Gaudreault RC, Tajmir-Riahi HA, Bérubé G.

Eur J Med Chem. 2019 Oct 1;179:660-666. doi: 10.1016/j.ejmech.2019.06.090. Epub 2019 Jun 29.

PMID:
31279298
3.

How to utilize academic research efforts in cancer drug discovery.

Bérubé G.

Expert Opin Drug Discov. 2019 Apr;14(4):331-334. doi: 10.1080/17460441.2019.1582637. Epub 2019 Feb 20. No abstract available.

PMID:
30784328
4.

Cloning and characterization of norbelladine synthase catalyzing the first committed reaction in Amaryllidaceae alkaloid biosynthesis.

Singh A, Massicotte MA, Garand A, Tousignant L, Ouellette V, Bérubé G, Desgagné-Penix I.

BMC Plant Biol. 2018 Dec 7;18(1):338. doi: 10.1186/s12870-018-1570-4.

5.

Location of multiple binding sites for testo and testo-Pt(II) with tRNA.

Chanphai P, Ouellette V, Mandal S, Mandal SK, Bérubé G, Tajmir-Riahi HA.

J Biomol Struct Dyn. 2019 Oct;37(16):4133-4139. doi: 10.1080/07391102.2018.1541142. Epub 2018 Dec 24.

PMID:
30417741
6.

Prevalence and natural history of scoliosis and associated congenital vertebral anomalies in patients operated for esophageal atresia with or without tracheoesophageal fistula.

Soliman HA, Faure C, Berubé G, Mac-Thiong JM, Barchi S, Parent S.

J Pediatr Surg. 2019 Jul;54(7):1308-1311. doi: 10.1016/j.jpedsurg.2018.08.049. Epub 2018 Sep 9.

PMID:
30301608
7.

Testo and testo-Pt(II) bind DNA at different locations.

Chanphai P, Ouellette V, Mandal SK, Bérubé G, Tajmir-Riahi HA.

Chem Biol Interact. 2018 Dec 25;296:179-184. doi: 10.1016/j.cbi.2018.09.008. Epub 2018 Sep 22.

PMID:
30253125
8.

Conjugation of testo and testo-Pt(II) with serum proteins: Loading efficacy and protein conformation.

Chanphai P, Ouellette V, Bérubé G, Tajmir-Riahi HA.

Int J Biol Macromol. 2018 Oct 15;118(Pt A):1112-1119. doi: 10.1016/j.ijbiomac.2018.06.186. Epub 2018 Jul 2.

PMID:
30001598
9.

Testosterone and its dimers alter tRNA morphology.

Chanphai P, Agudelo D, Vesper AR, Bérubé G, Tajmir-Riahi HA.

J Pharm Biomed Anal. 2017 Feb 5;134:269-274. doi: 10.1016/j.jpba.2016.11.053. Epub 2016 Nov 30.

PMID:
27930994
10.

Effect of testosterone and its aliphatic and aromatic dimers on DNA morphology.

Chanphai P, Agudelo D, Vesper AR, Bérubé G, Tajmir-Riahi HA.

Int J Biol Macromol. 2017 Feb;95:850-855. doi: 10.1016/j.ijbiomac.2016.09.090. Epub 2016 Sep 28.

PMID:
27693340
11.

Synthesis of novel C2-symmetric testosterone dimers and evaluation of antiproliferative activity on androgen-dependent and -independent prostate cancer cell lines.

Vesper AR, Lacroix J, C-Gaudreault R, Tajmir-Rihai HA, Bérubé G.

Steroids. 2016 Nov;115:98-104. doi: 10.1016/j.steroids.2016.08.012. Epub 2016 Aug 21.

PMID:
27553724
12.

Review on the delivery of steroids by carrier proteins.

Chanphai P, Vesper AR, Bariyanga J, Bérubé G, Tajmir-Riahi HA.

J Photochem Photobiol B. 2016 Aug;161:184-91. doi: 10.1016/j.jphotobiol.2016.05.015. Epub 2016 May 18. Review.

PMID:
27261699
13.

An overview on the delivery of antitumor drug doxorubicin by carrier proteins.

Agudelo D, Bérubé G, Tajmir-Riahi HA.

Int J Biol Macromol. 2016 Jul;88:354-60. doi: 10.1016/j.ijbiomac.2016.03.060. Epub 2016 Mar 30. Review.

PMID:
27037051
14.

Review on the binding of anticancer drug doxorubicin with DNA and tRNA: Structural models and antitumor activity.

Agudelo D, Bourassa P, Bérubé G, Tajmir-Riahi HA.

J Photochem Photobiol B. 2016 May;158:274-9. doi: 10.1016/j.jphotobiol.2016.02.032. Epub 2016 Mar 4. Review.

PMID:
26971631
15.

The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4.

Denisov IG, Mak PJ, Grinkova YV, Bastien D, Bérubé G, Sligar SG, Kincaid JR.

J Inorg Biochem. 2016 May;158:77-85. doi: 10.1016/j.jinorgbio.2015.12.019. Epub 2015 Dec 31.

16.

An overview of molecular hybrids in drug discovery.

Bérubé G.

Expert Opin Drug Discov. 2016;11(3):281-305. doi: 10.1517/17460441.2016.1135125. Epub 2016 Jan 12. Review.

PMID:
26727036
17.

Transporting testosterone and its dimers by serum proteins.

Chanphai P, Vesper AR, Bekale L, Bérubé G, Tajmir-Riahi HA.

J Photochem Photobiol B. 2015 Dec;153:173-83. doi: 10.1016/j.jphotobiol.2015.09.008. Epub 2015 Sep 12.

PMID:
26410041
18.

Exploring the synthesis and anticancer potential of L-tyrosine-platinum(II) hybrid molecules.

Descôteaux C, Brasseur K, Leblanc V, Asselin E, Bérubé G.

Med Chem. 2015;11(8):717-24.

PMID:
25938424
19.

Identification of an anti-inflammatory derivative with anti-cancer potential: The impact of each of its structural components on inflammatory responses in macrophages and bladder cancer cells.

Hamelin-Morrissette J, Cloutier S, Girouard J, Belgorosky D, Eiján AM, Legault J, Reyes-Moreno C, Bérubé G.

Eur J Med Chem. 2015;96:259-68. doi: 10.1016/j.ejmech.2015.04.026. Epub 2015 Apr 13.

PMID:
25890076
20.

Encapsulation of testosterone and its aliphatic and aromatic dimers by milk beta-lactoglobulin.

Chanphai P, Vesper AR, Bekale L, Bérubé G, Tajmir-Riahi HA.

Int J Biol Macromol. 2015 May;76:153-60. doi: 10.1016/j.ijbiomac.2015.02.028. Epub 2015 Feb 25.

PMID:
25725333
21.

The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts.

Ramdzan ZM, Pal R, Kaur S, Leduy L, Bérubé G, Davoudi S, Vadnais C, Nepveu A.

Oncotarget. 2015 Feb 28;6(6):3613-26.

22.

New testosterone derivatives as semi-synthetic anticancer agents against prostate cancer: synthesis and preliminary biological evaluation.

Morin N, Bruneau J, Fortin S, Brasseur K, Leblanc V, Asselin E, Berube G.

Med Chem. 2015;11(6):531-9.

PMID:
25675439
23.

Intercalation of antitumor drug doxorubicin and its analogue by DNA duplex: structural features and biological implications.

Agudelo D, Bourassa P, Bérubé G, Tajmir-Riahi HA.

Int J Biol Macromol. 2014 May;66:144-50. doi: 10.1016/j.ijbiomac.2014.02.028. Epub 2014 Feb 20.

PMID:
24560949
24.

New platinum(II) complexes conjugated at position 7α of 17β-acetyl-testosterone as new combi-molecules against prostate cancer: design, synthesis, structure-activity relationships and biological evaluation.

Fortin S, Brasseur K, Morin N, Asselin É, Bérubé G.

Eur J Med Chem. 2013 Oct;68:433-43. doi: 10.1016/j.ejmech.2013.08.011. Epub 2013 Aug 15.

PMID:
23994871
25.

tRNA binding to antitumor drug doxorubicin and its analogue.

Agudelo D, Bourassa P, Beauregard M, Bérubé G, Tajmir-Riahi HA.

PLoS One. 2013 Jul 29;8(7):e69248. doi: 10.1371/journal.pone.0069248. Print 2013.

26.

Steroid-linked nitrogen mustards as potential anticancer therapeutics: a review.

Saha P, Debnath C, Bérubé G.

J Steroid Biochem Mol Biol. 2013 Sep;137:271-300. doi: 10.1016/j.jsbmb.2013.05.004. Epub 2013 May 18. Review.

PMID:
23692738
27.

ERα-targeted therapy in ovarian cancer cells by a novel estradiol-platinum(II) hybrid.

Brasseur K, Leblanc V, Fabi F, Parent S, Descôteaux C, Bérubé G, Asselin E.

Endocrinology. 2013 Jul;154(7):2281-95. doi: 10.1210/en.2013-1083. Epub 2013 May 15.

PMID:
23677930
28.

Synthesis and preliminary in vitro biological evaluation of 7α-testosterone-chlorambucil hybrid designed for the treatment of prostate cancer.

Bastien D, Hanna R, Leblanc V, Asselin É, Bérubé G.

Eur J Med Chem. 2013 Jun;64:442-7. doi: 10.1016/j.ejmech.2013.04.027. Epub 2013 Apr 19.

PMID:
23665800
29.

Advances in the development of hybrid anticancer drugs.

Fortin S, Bérubé G.

Expert Opin Drug Discov. 2013 Aug;8(8):1029-47. doi: 10.1517/17460441.2013.798296. Epub 2013 May 7. Review.

PMID:
23646979
30.

Long-range transcriptional regulation by the p110 CUX1 homeodomain protein on the ENCODE array.

Vadnais C, Awan AA, Harada R, Clermont PL, Leduy L, Bérubé G, Nepveu A.

BMC Genomics. 2013 Apr 16;14:258. doi: 10.1186/1471-2164-14-258.

31.

Antibiotic doxorubicin and its derivative bind milk β-lactoglobulin.

Agudelo D, Beauregard M, Bérubé G, Tajmir-Riahi HA.

J Photochem Photobiol B. 2012 Dec 5;117:185-92. doi: 10.1016/j.jphotobiol.2012.09.014. Epub 2012 Oct 23.

PMID:
23147200
32.

Probing the binding sites of antibiotic drugs doxorubicin and N-(trifluoroacetyl) doxorubicin with human and bovine serum albumins.

Agudelo D, Bourassa P, Bruneau J, Bérubé G, Asselin E, Tajmir-Riahi HA.

PLoS One. 2012;7(8):e43814. doi: 10.1371/journal.pone.0043814. Epub 2012 Aug 24.

33.

Design, synthesis, cytocidal activity and estrogen receptor α affinity of doxorubicin conjugates at 16α-position of estrogen for site-specific treatment of estrogen receptor positive breast cancer.

Saha P, Fortin S, Leblanc V, Parent S, Asselin É, Bérubé G.

Steroids. 2012 Sep;77(11):1113-22. doi: 10.1016/j.steroids.2012.06.004. Epub 2012 Jul 16.

PMID:
22801351
34.

Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines.

Descôteaux C, Brasseur K, Leblanc V, Parent S, Asselin E, Bérubé G.

Steroids. 2012 Apr;77(5):403-12. doi: 10.1016/j.steroids.2011.12.021. Epub 2011 Dec 29.

PMID:
22227028
35.

Synthesis, antiproliferative activity and estrogen receptor α affinity of novel estradiol-linked platinum(II) complex analogs to carboplatin and oxaliplatin. Potential vector complexes to target estrogen-dependent tissues.

Saha P, Descôteaux C, Brasseur K, Fortin S, Leblanc V, Parent S, Asselin E, Bérubé G.

Eur J Med Chem. 2012 Feb;48:385-90. doi: 10.1016/j.ejmech.2011.12.017. Epub 2011 Dec 17.

PMID:
22209414
36.

SAR study of tyrosine-chlorambucil hybrid regioisomers; synthesis and biological evaluation against breast cancer cell lines.

Descôteaux C, Brasseur K, Leblanc V, Parent S, Asselin E, Bérubé G.

Amino Acids. 2012 Aug;43(2):923-35. doi: 10.1007/s00726-011-1152-3. Epub 2011 Nov 20.

PMID:
22102055
37.

Synthesis of D- and L-tyrosine-chlorambucil analogs active against breast cancer cell lines.

Descôteaux C, Leblanc V, Brasseur K, Gupta A, Asselin E, Bérubé G.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7388-92. doi: 10.1016/j.bmcl.2010.10.039. Epub 2010 Oct 21.

PMID:
21051231
38.

Design, synthesis and biological evaluation of estradiol-PEG-linked platinum(II) hybrid molecules: comparative molecular modeling study of three distinct families of hybrids.

Provencher-Mandeville J, Debnath C, Mandal SK, Leblanc V, Parent S, Asselin E, Bérubé G.

Steroids. 2011 Jan;76(1-2):94-103. doi: 10.1016/j.steroids.2010.09.004. Epub 2010 Oct 30.

PMID:
20869376
39.

Evaluation of in vivo biological activities of tetrapyrrole ethanolamides as novel anticancer agents.

Weagle G, Gupta A, Bérubé G, Chapados C.

J Photochem Photobiol B. 2010 Jul 2;100(1):44-50. doi: 10.1016/j.jphotobiol.2010.04.009. Epub 2010 May 8.

PMID:
20580888
40.

First synthesis of separable isomeric testosterone dimers showing differential activities on prostate cancer cells.

Bastien D, Leblanc V, Asselin E, Bérubé G.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2078-81. doi: 10.1016/j.bmcl.2010.02.077. Epub 2010 Feb 23.

PMID:
20226660
41.

Design, synthesis and biological evaluation of estradiol-chlorambucil hybrids as anticancer agents.

Gupta A, Saha P, Descôteaux C, Leblanc V, Asselin E, Bérubé G.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1614-8. doi: 10.1016/j.bmcl.2010.01.053. Epub 2010 Jan 20.

PMID:
20137939
42.

VP-128, a novel oestradiol-platinum(II) hybrid with selective anti-tumour activity towards hormone-dependent breast cancer cells in vivo.

Van Themsche C, Parent S, Leblanc V, Descôteaux C, Simard AM, Bérubé G, Asselin E.

Endocr Relat Cancer. 2009 Dec;16(4):1185-95. doi: 10.1677/ERC-09-0113. Epub 2009 Aug 6.

PMID:
19661132
43.

Study of DNA interactions with steroidal and nonsteroidal estrogen-platinum (II)-based anticancer drugs.

Froehlich E, Gupta A, Provencher-Mandeville J, Asselin E, Bariyanga J, Bérubé G, Tajmir-Riahi HA.

DNA Cell Biol. 2009 Jan;28(1):31-9. doi: 10.1089/dna.2008.0804.

PMID:
18928379
44.

Improved synthesis of unique estradiol-linked platinum(II) complexes showing potent cytocidal activity and affinity for the estrogen receptor alpha and beta.

Descôteaux C, Leblanc V, Bélanger G, Parent S, Asselin E, Bérubé G.

Steroids. 2008 Oct;73(11):1077-89. doi: 10.1016/j.steroids.2008.04.009. Epub 2008 Apr 25.

PMID:
18572212
45.

Synthesis and cytotoxic activity of benzopyran-based platinum(II) complexes.

Gupta A, Mandal SK, Leblanc V, Descôteaux C, Asselin E, Bérubé G.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):3982-7. doi: 10.1016/j.bmcl.2008.06.013. Epub 2008 Jun 10.

PMID:
18571403
46.

Transfer RNA bindings to antitumor estradiol-platinum(II) hybrid and cisplatin.

N'soukpoé-Kossi CN, Descôteaux C, Asselin E, Bariyanga J, Tajmir-Riahi HA, Bérubé G.

DNA Cell Biol. 2008 Jun;27(6):337-43. doi: 10.1089/dna.2008.0727.

PMID:
18447754
47.

Synthesis of 17beta-estradiol-platinum(II) hybrid molecules showing cytotoxic activity on breast cancer cell lines.

Provencher-Mandeville J, Descôteaux C, Mandal SK, Leblanc V, Asselin E, Bérubé G.

Bioorg Med Chem Lett. 2008 Apr 1;18(7):2282-7. doi: 10.1016/j.bmcl.2008.03.005. Epub 2008 Mar 6.

PMID:
18356047
48.

Genome-wide location analysis and expression studies reveal a role for p110 CUX1 in the activation of DNA replication genes.

Harada R, Vadnais C, Sansregret L, Leduy L, Bérubé G, Robert F, Nepveu A.

Nucleic Acids Res. 2008 Jan;36(1):189-202. Epub 2007 Nov 14.

49.

Preparation and in vitro biological evaluation of tetrapyrrole ethanolamide derivatives as potential anticancer agents.

Girard D, Weagle G, Gupta A, Bérubé G, Chapados C.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):360-5. Epub 2007 Oct 24.

PMID:
17993275
50.

DNA interaction with novel antitumor estradiol-platinum(II) hybrid molecule: a comparative study with cisplatin drug.

N'soukpoé-Kossi CN, Descôteaux C, Asselin E, Tajmir-Riahi HA, Bérubé G.

DNA Cell Biol. 2008 Feb;27(2):101-7.

PMID:
17970617

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