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Casposons: mobile genetic elements that gave rise to the CRISPR-Cas adaptation machinery. Krupovic M et al. Curr Opin Microbiol. (2017)

Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016. et al. Hum Genomics. (2016)

The biological degradation of cellulose. Béguin P et al. FEMS Microbiol Rev. (1994)

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Items: 1 to 50 of 146


Sequence motifs recognized by the casposon integrase of Aciduliprofundum boonei.

Béguin P, Chekli Y, Sezonov G, Forterre P, Krupovic M.

Nucleic Acids Res. 2019 Jul 9;47(12):6386-6395. doi: 10.1093/nar/gkz447.


Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases.

Raia P, Carroni M, Henry E, Pehau-Arnaudet G, Brûlé S, Béguin P, Henneke G, Lindahl E, Delarue M, Sauguet L.

PLoS Biol. 2019 Jan 18;17(1):e3000122. doi: 10.1371/journal.pbio.3000122. eCollection 2019 Jan.


The work activity as an interface among different logics: The case of distributing food in a university restaurant.

Lipovaya V, Duarte F, Béguin P.

Work. 2018;61(4):647-660. doi: 10.3233/WOR-182832.


Work of community health agents in the Family Health Strategy: meta-synthesis.

Alonso CMDC, Béguin PD, Duarte FJCM.

Rev Saude Publica. 2018;52:14. doi: 10.11606/s1518-8787.2018052000395. Epub 2018 Feb 26. Review. Portuguese, English.


From the past to the future: Integrating work experience into the design process.

Bittencourt JM, Duarte F, Béguin P.

Work. 2017;57(3):379-387. doi: 10.3233/WOR-172567.


Innovation, systemic appropriation and prevention in the granite mining sector: The case of humidification.

Mendes RWB, Pueyo V, Béguin P, Duarte FJCM.

Work. 2017;57(3):351-361. doi: 10.3233/WOR-172566.


Professional transitions towards sustainable farming systems: The development of farmers' professional worlds.

Coquil X, Dedieu B, Béguin P.

Work. 2017;57(3):325-337. doi: 10.3233/WOR-172565.


Casposons: mobile genetic elements that gave rise to the CRISPR-Cas adaptation machinery.

Krupovic M, Béguin P, Koonin EV.

Curr Opin Microbiol. 2017 Aug;38:36-43. doi: 10.1016/j.mib.2017.04.004. Epub 2017 May 1. Review.


Casposon integration shows strong target site preference and recapitulates protospacer integration by CRISPR-Cas systems.

Béguin P, Charpin N, Koonin EV, Forterre P, Krupovic M.

Nucleic Acids Res. 2016 Dec 1;44(21):10367-10376. Epub 2016 Sep 20.


Normoxic Recovery Reverses Intermittent Hypoxia-Induced Systemic and Vascular Inflammation.

Arnaud C, Béguin P, Lévy P, Pépin JL.

Chest. 2016 Aug;150(2):471-3. doi: 10.1016/j.chest.2016.05.031. No abstract available.


Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair.

Gouge J, Rosario S, Romain F, Poitevin F, Béguin P, Delarue M.

EMBO J. 2015 Apr 15;34(8):1126-42. doi: 10.15252/embj.201489643. Epub 2015 Mar 11.


Synergistic template-free synthesis of dsDNA by Thermococcus nautili primase PolpTN2, DNA polymerase PolB, and pTN2 helicase.

Béguin P, Gill S, Charpin N, Forterre P.

Extremophiles. 2015 Jan;19(1):69-76. doi: 10.1007/s00792-014-0706-1. Epub 2014 Nov 25.


Digital expression profiling of the compartmentalized translatome of Purkinje neurons.

Kratz A, Beguin P, Kaneko M, Chimura T, Suzuki AM, Matsunaga A, Kato S, Bertin N, Lassmann T, Vigot R, Carninci P, Plessy C, Launey T.

Genome Res. 2014 Aug;24(8):1396-410. doi: 10.1101/gr.164095.113. Epub 2014 Jun 5.


The SF1 helicase encoded by the archaeal plasmid pTN2 of Thermococcus nautili.

Béguin P, Baron B, Gill S, Charpin N, Forterre P.

Extremophiles. 2014 Jul;18(4):779-87. doi: 10.1007/s00792-014-0658-5. Epub 2014 Jun 3.


BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis.

Béguin P, Nagashima K, Mahalakshmi RN, Vigot R, Matsunaga A, Miki T, Ng MY, Ng YJ, Lim CH, Tay HS, Hwang LA, Firsov D, Tang BL, Inagaki N, Mori Y, Seino S, Launey T, Hunziker W.

J Cell Biol. 2014 Apr 28;205(2):233-49. doi: 10.1083/jcb.201304101. Epub 2014 Apr 21.


A highly divergent archaeo-eukaryotic primase from the Thermococcus nautilus plasmid, pTN2.

Gill S, Krupovic M, Desnoues N, Béguin P, Sezonov G, Forterre P.

Nucleic Acids Res. 2014 Apr;42(6):3707-19. doi: 10.1093/nar/gkt1385. Epub 2014 Jan 20.


Polyunsaturated fatty acid metabolism in enterocyte models: T84 cell line vs. Caco-2 cell line.

Beguin P, Schneider AC, Mignolet E, Schneider YJ, Larondelle Y.

In Vitro Cell Dev Biol Anim. 2014 Feb;50(2):111-20. doi: 10.1007/s11626-013-9682-5. Epub 2013 Aug 27.


Structures of intermediates along the catalytic cycle of terminal deoxynucleotidyltransferase: dynamical aspects of the two-metal ion mechanism.

Gouge J, Rosario S, Romain F, Beguin P, Delarue M.

J Mol Biol. 2013 Nov 15;425(22):4334-52. doi: 10.1016/j.jmb.2013.07.009. Epub 2013 Jul 13.


Effect of polyunsaturated fatty acids on tight junctions in a model of the human intestinal epithelium under normal and inflammatory conditions.

Beguin P, Errachid A, Larondelle Y, Schneider YJ.

Food Funct. 2013 Jun;4(6):923-31. doi: 10.1039/c3fo60036j. Epub 2013 May 9.


Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway.

Botros HG, Legrand P, Pagan C, Bondet V, Weber P, Ben-Abdallah M, Lemière N, Huguet G, Bellalou J, Maronde E, Beguin P, Haouz A, Shepard W, Bourgeron T.

J Pineal Res. 2013 Jan;54(1):46-57. doi: 10.1111/j.1600-079X.2012.01020.x. Epub 2012 Jul 9.


Enhanced basophil reactivities during severe malaria and their relationship with the Plasmodium falciparum histamine-releasing factor translationally controlled tumor protein.

Pelleau S, Diop S, Dia Badiane M, Vitte J, Beguin P, Nato F, Diop BM, Bongrand P, Parzy D, Jambou R.

Infect Immun. 2012 Aug;80(8):2963-70. doi: 10.1128/IAI.00072-12. Epub 2012 Jul 2.


Conversion of t11t13 CLA into c9t11 CLA in Caco-2 cells and inhibition by sterculic oil.

Schneider AC, Beguin P, Bourez S, Perfield JW 2nd, Mignolet E, Debier C, Schneider YJ, Larondelle Y.

PLoS One. 2012;7(3):e32824. doi: 10.1371/journal.pone.0032824. Epub 2012 Mar 12.


Activity at work, innovation and sustainable development.

Béguin P, Duarte F, Lima F, Pueyo V.

Work. 2012;41 Suppl 1:89-94. doi: 10.3233/WOR-2012-0140-89.


The inflammatory preatherosclerotic remodeling induced by intermittent hypoxia is attenuated by RANTES/CCL5 inhibition.

Arnaud C, Beguin PC, Lantuejoul S, Pepin JL, Guillermet C, Pelli G, Burger F, Buatois V, Ribuot C, Baguet JP, Mach F, Levy P, Dematteis M.

Am J Respir Crit Care Med. 2011 Sep 15;184(6):724-31. doi: 10.1164/rccm.201012-2033OC. Epub 2011 Jun 16.


Post-translational modifications, a key process in CD36 function: lessons from the spontaneously hypertensive rat heart.

Lauzier B, Merlen C, Vaillant F, McDuff J, Bouchard B, Beguin PC, Dolinsky VW, Foisy S, Villeneuve LR, Labarthe F, Dyck JR, Allen BG, Charron G, Des Rosiers C.

J Mol Cell Cardiol. 2011 Jul;51(1):99-108. doi: 10.1016/j.yjmcc.2011.04.001. Epub 2011 Apr 13.


Nestin expression is lost in ventricular fibroblasts during postnatal development of the rat heart and re-expressed in scar myofibroblasts.

Béguin PC, Gosselin H, Mamarbachi M, Calderone A.

J Cell Physiol. 2012 Feb;227(2):813-20. doi: 10.1002/jcp.22794.


Delayed myocardial preconditioning induced by cobalt chloride in the rat: HIF-1α and iNOS involvement.

Belaidi E, Beguin PC, Levy P, Ribuot C, Godin-Ribuot D.

Fundam Clin Pharmacol. 2012 Aug;26(4):454-62. doi: 10.1111/j.1472-8206.2011.00940.x. Epub 2011 Apr 11.


Nestin (+) stem cells independently contribute to neural remodelling of the ischemic heart.

Béguin PC, El-Helou V, Gillis MA, Duquette N, Gosselin H, Brugada R, Villeneuve L, Lauzier D, Tanguay JF, Ribuot C, Calderone A.

J Cell Physiol. 2011 May;226(5):1157-65. doi: 10.1002/jcp.22441.


Production of soluble, active acetyl serotonin methyl transferase in Leishmania tarentolae.

Ben-Abdallah M, Bondet V, Fauchereau F, Béguin P, Goubran-Botros H, Pagan C, Bourgeron T, Bellalou J.

Protein Expr Purif. 2011 Jan;75(1):114-8. doi: 10.1016/j.pep.2010.07.011. Epub 2010 Aug 3.


Identification of conserved amino acid residues of the Salmonella sigmaS chaperone Crl involved in Crl-sigmaS interactions.

Monteil V, Kolb A, D'Alayer J, Beguin P, Norel F.

J Bacteriol. 2010 Feb;192(4):1075-87. doi: 10.1128/JB.01197-09. Epub 2009 Dec 11.


The phenotype and potential origin of nestin+ cardiac myocyte-like cells following infarction.

Béguin PC, El-Helou V, Assimakopoulos J, Clément R, Gosselin H, Brugada R, Villeneuve L, Rohlicek CV, Del Duca D, Lapointe N, Rouleau JL, Calderone A.

J Appl Physiol (1985). 2009 Oct;107(4):1241-8. doi: 10.1152/japplphysiol.00564.2009. Epub 2009 Aug 13.


The cardiac neural stem cell phenotype is compromised in streptozotocin-induced diabetic cardiomyopathy.

El-Helou V, Proulx C, Béguin P, Assimakopoulos J, Gosselin H, Clement R, Villeneuve L, Huot-Marchand JE, Deblois D, Lajoie C, Calderone A.

J Cell Physiol. 2009 Aug;220(2):440-9. doi: 10.1002/jcp.21785.


The rat heart contains a neural stem cell population; role in sympathetic sprouting and angiogenesis.

El-Helou V, Beguin PC, Assimakopoulos J, Clement R, Gosselin H, Brugada R, Aumont A, Biernaskie J, Villeneuve L, Leung TK, Fernandes KJ, Calderone A.

J Mol Cell Cardiol. 2008 Nov;45(5):694-702. doi: 10.1016/j.yjmcc.2008.07.013. Epub 2008 Jul 31.


Novel chloride channel mutations leading to mild myotonia among Chinese.

Burgunder JM, Huifang S, Beguin P, Baur R, Eng CS, Seet RC, Lim EC, Ong BK, Hunziker W, Sigel E.

Neuromuscul Disord. 2008 Aug;18(8):633-40. doi: 10.1016/j.nmd.2008.05.007. Epub 2008 Jun 24.


Prevention of HIF-1 activation and iNOS gene targeting by low-dose cadmium results in loss of myocardial hypoxic preconditioning in the rat.

Belaidi E, Beguin PC, Levy P, Ribuot C, Godin-Ribuot D.

Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H901-8. Epub 2007 Dec 14.


Nuclear transport of Kir/Gem requires specific signals and importin alpha5 and is regulated by calmodulin and predicted serine phosphorylations.

Mahalakshmi RN, Nagashima K, Ng MY, Inagaki N, Hunziker W, Béguin P.

Traffic. 2007 Sep;8(9):1150-63. Epub 2007 Jul 1.


Nuclear localization of endogenous RGK proteins and modulation of cell shape remodeling by regulated nuclear transport.

Mahalakshmi RN, Ng MY, Guo K, Qi Z, Hunziker W, Béguin P.

Traffic. 2007 Sep;8(9):1164-78. Epub 2007 Jul 1.


Time- and temperature-dependent acetylation of the chemokine RANTES produced in recombinant Escherichia coli.

d'Alayer J, Expert-Bezançon N, Béguin P.

Protein Expr Purif. 2007 Sep;55(1):9-16. Epub 2007 May 10.


RGK small GTP-binding proteins interact with the nucleotide kinase domain of Ca2+-channel beta-subunits via an uncommon effector binding domain.

Béguin P, Ng YJ, Krause C, Mahalakshmi RN, Ng MY, Hunziker W.

J Biol Chem. 2007 Apr 13;282(15):11509-20. Epub 2007 Feb 15.


Intermittent hypoxia-induced delayed cardioprotection is mediated by PKC and triggered by p38 MAP kinase and Erk1/2.

Béguin PC, Belaidi E, Godin-Ribuot D, Lévy P, Ribuot C.

J Mol Cell Cardiol. 2007 Feb;42(2):343-51. Epub 2006 Dec 22.


[Hypoxic preconditioning: role of transcription factor HIF-1alpha].

Belaïdi E, Béguin PC, Ribuot C, Godin-Ribuot D.

Ann Cardiol Angeiol (Paris). 2006 Apr;55(2):70-3. Review. French.


Early pharmacological preconditioning by erythropoietin mediated by inducible NOS and mitochondrial ATP-dependent potassium channels in the rat heart.

Joyeux-Faure M, Ramond A, Béguin PC, Belaïdi E, Godin-Ribuot D, Ribuot C.

Fundam Clin Pharmacol. 2006 Feb;20(1):51-6.


Nuclear sequestration of beta-subunits by Rad and Rem is controlled by 14-3-3 and calmodulin and reveals a novel mechanism for Ca2+ channel regulation.

Béguin P, Mahalakshmi RN, Nagashima K, Cher DH, Ikeda H, Yamada Y, Seino Y, Hunziker W.

J Mol Biol. 2006 Jan 6;355(1):34-46. Epub 2005 Nov 8.


Acute intermittent hypoxia improves rat myocardium tolerance to ischemia.

Béguin PC, Joyeux-Faure M, Godin-Ribuot D, Lévy P, Ribuot C.

J Appl Physiol (1985). 2005 Sep;99(3):1064-9. Epub 2005 May 5.


Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G-protein Rem2.

Béguin P, Mahalakshmi RN, Nagashima K, Cher DH, Kuwamura N, Yamada Y, Seino Y, Hunziker W.

Biochem J. 2005 Aug 15;390(Pt 1):67-75. Erratum in: Biochem J. 2005 Nov 1;391(Pt 3):712.


14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity.

Béguin P, Mahalakshmi RN, Nagashima K, Cher DH, Takahashi A, Yamada Y, Seino Y, Hunziker W.

J Cell Sci. 2005 May 1;118(Pt 9):1923-34.


Chronic intermittent hypoxia increases infarction in the isolated rat heart.

Joyeux-Faure M, Stanke-Labesque F, Lefebvre B, Béguin P, Godin-Ribuot D, Ribuot C, Launois SH, Bessard G, Lévy P.

J Appl Physiol (1985). 2005 May;98(5):1691-6. Epub 2004 Dec 23.


Direct inhibition of the interaction between alpha-interaction domain and beta-interaction domain of voltage-dependent Ca2+ channels by Gem.

Sasaki T, Shibasaki T, Béguin P, Nagashima K, Miyazaki M, Seino S.

J Biol Chem. 2005 Mar 11;280(10):9308-12. Epub 2004 Dec 22.


Interaction between a type-II dockerin domain and a type-II cohesin domain from Clostridium thermocellum cellulosome.

Jindou S, Kajino T, Inagaki M, Karita S, Beguin P, Kimura T, Sakka K, Ohmiya K.

Biosci Biotechnol Biochem. 2004 Apr;68(4):924-6.

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