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Items: 1 to 20 of 241

1.

Use of busulfan in conditioning for allogeneic hematopoietic stem cell transplantation in adults: a survey by the Transplant Complications Working Party of the EBMT.

Ruutu T, van der Werf S, van Biezen A, Backman JT, Peczynski C, Kröger N, Mohty M, Nagler A, Montoto S, Langebrake C, Niederwieser D, Peric Z, Koenecke C, Duarte RF, Basak G.

Bone Marrow Transplant. 2019 Jun 3. doi: 10.1038/s41409-019-0579-0. [Epub ahead of print]

PMID:
31160806
2.

Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs.

Lilius TO, Blomqvist K, Hauglund NL, Liu G, Stæger FF, Bærentzen S, Du T, Ahlström F, Backman JT, Kalso EA, Rauhala PV, Nedergaard M.

J Control Release. 2019 Jun 28;304:29-38. doi: 10.1016/j.jconrel.2019.05.005. Epub 2019 May 5.

3.

Fluoroquinolone-related adverse events resulting in health service use and costs: A systematic review.

Kuula LSM, Viljemaa KM, Backman JT, Blom M.

PLoS One. 2019 Apr 26;14(4):e0216029. doi: 10.1371/journal.pone.0216029. eCollection 2019.

4.

Enantiospecific Pharmacogenomics of Fluvastatin.

Hirvensalo P, Tornio A, Neuvonen M, Kiander W, Kidron H, Paile-Hyvärinen M, Tapaninen T, Backman JT, Niemi M.

Clin Pharmacol Ther. 2019 Sep;106(3):668-680. doi: 10.1002/cpt.1463. Epub 2019 May 14.

PMID:
30989645
5.

Clinical Studies on Drug-Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation.

Tornio A, Filppula AM, Niemi M, Backman JT.

Clin Pharmacol Ther. 2019 Jun;105(6):1345-1361. doi: 10.1002/cpt.1435. Epub 2019 Apr 20.

6.

Photochemical degradation affects the light absorption of water-soluble brown carbon in the South Asian outflow.

Dasari S, Andersson A, Bikkina S, Holmstrand H, Budhavant K, Satheesh S, Asmi E, Kesti J, Backman J, Salam A, Bisht DS, Tiwari S, Hameed Z, Gustafsson Ö.

Sci Adv. 2019 Jan 30;5(1):eaau8066. doi: 10.1126/sciadv.aau8066. eCollection 2019 Jan.

7.

Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8.

Kahma H, Filppula AM, Launiainen T, Viinamäki J, Neuvonen M, Evangelista EA, Totah RA, Backman JT.

Drug Metab Dispos. 2019 Apr;47(4):436-443. doi: 10.1124/dmd.118.085498. Epub 2019 Feb 1.

PMID:
30709838
8.

Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans.

Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2019 Apr;47(4):377-385. doi: 10.1124/dmd.118.084665. Epub 2019 Jan 10.

PMID:
30630815
9.

Response to "Interaction of Dasabuvir With Clopidogrel: Did Predictions by Physiologically Based Pharmacokinetics Modeling Pass the Test?"

Itkonen MK, Tornio A, Lapatto-Reiniluoto O, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2019 Feb;105(2):322. doi: 10.1002/cpt.1195. Epub 2018 Sep 17. No abstract available.

PMID:
30226021
10.

Ecology of animal migration.

Alerstam T, Bäckman J.

Curr Biol. 2018 Sep 10;28(17):R968-R972. doi: 10.1016/j.cub.2018.04.043.

PMID:
30205072
11.

Voriconazole greatly increases the exposure to oral buprenorphine.

Fihlman M, Hemmilä T, Hagelberg NM, Backman JT, Laitila J, Laine K, Neuvonen PJ, Olkkola KT, Saari TI.

Eur J Clin Pharmacol. 2018 Dec;74(12):1615-1622. doi: 10.1007/s00228-018-2548-8. Epub 2018 Aug 30.

PMID:
30167757
12.

Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.

Nielsen JB, Thorolfsdottir RB, Fritsche LG, Zhou W, Skov MW, Graham SE, Herron TJ, McCarthy S, Schmidt EM, Sveinbjornsson G, Surakka I, Mathis MR, Yamazaki M, Crawford RD, Gabrielsen ME, Skogholt AH, Holmen OL, Lin M, Wolford BN, Dey R, Dalen H, Sulem P, Chung JH, Backman JD, Arnar DO, Thorsteinsdottir U, Baras A, O'Dushlaine C, Holst AG, Wen X, Hornsby W, Dewey FE, Boehnke M, Kheterpal S, Mukherjee B, Lee S, Kang HM, Holm H, Kitzman J, Shavit JA, Jalife J, Brummett CM, Teslovich TM, Carey DJ, Gudbjartsson DF, Stefansson K, Abecasis GR, Hveem K, Willer CJ.

Nat Genet. 2018 Sep;50(9):1234-1239. doi: 10.1038/s41588-018-0171-3. Epub 2018 Jul 30.

13.

CYP3A4*22 Impairs the Elimination of Ticagrelor, But Has No Significant Effect on the Bioactivation of Clopidogrel or Prasugrel.

Holmberg MT, Tornio A, Paile-Hyvärinen M, Tarkiainen EK, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Clin Pharmacol Ther. 2019 Feb;105(2):448-457. doi: 10.1002/cpt.1177. Epub 2018 Aug 20.

PMID:
29998574
14.

In Vitro Screening of Six Protein Kinase Inhibitors for Time-Dependent Inhibition of CYP2C8 and CYP3A4: Possible Implications with regard to Drug-Drug Interactions.

Filppula AM, Mustonen TM, Backman JT.

Basic Clin Pharmacol Toxicol. 2018 Dec;123(6):739-748. doi: 10.1111/bcpt.13088. Epub 2018 Aug 9.

PMID:
29956478
15.

Cytochrome P450 in Pharmacogenetics: An Update.

Tornio A, Backman JT.

Adv Pharmacol. 2018;83:3-32. doi: 10.1016/bs.apha.2018.04.007. Review.

PMID:
29801580
16.

Clopidogrel Increases Dasabuvir Exposure With or Without Ritonavir, and Ritonavir Inhibits the Bioactivation of Clopidogrel.

Itkonen MK, Tornio A, Lapatto-Reiniluoto O, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2019 Jan;105(1):219-228. doi: 10.1002/cpt.1099. Epub 2018 Aug 9.

17.

Pulmonary administration of a dry powder formulation of the antifibrotic drug tilorone reduces silica-induced lung fibrosis in mice.

Vartiainen V, Raula J, Bimbo LM, Viinamäki J, Backman JT, Ugur N, Kauppinen E, Sutinen E, Joensuu E, Koli K, Myllärniemi M.

Int J Pharm. 2018 Jun 10;544(1):121-128. doi: 10.1016/j.ijpharm.2018.04.019. Epub 2018 Apr 12.

PMID:
29655797
18.

Implications of intercorrelation between hepatic CYP3A4-CYP2C8 enzymes for the evaluation of drug-drug interactions: a case study with repaglinide.

Doki K, Darwich AS, Achour B, Tornio A, Backman JT, Rostami-Hodjegan A.

Br J Clin Pharmacol. 2018 May;84(5):972-986. doi: 10.1111/bcp.13533. Epub 2018 Mar 6.

19.

Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle.

Hulmi JJ, Nissinen TA, Räsänen M, Degerman J, Lautaoja JH, Hemanthakumar KA, Backman JT, Ritvos O, Silvennoinen M, Kivelä R.

J Cachexia Sarcopenia Muscle. 2018 Apr;9(2):417-432. doi: 10.1002/jcsm.12265. Epub 2017 Dec 11.

20.

Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study.

Brinkman DJ, Tichelaar J, Mokkink LB, Christiaens T, Likic R, Maciulaitis R, Costa J, Sanz EJ, Maxwell SR, Richir MC, van Agtmael MA; Education Working Group of the European Association for Clinical Pharmacology and Therapeutics (EACPT) and its affiliated Network of Teachers in Pharmacotherapy (NOTIP).

Clin Pharmacol Ther. 2018 Aug;104(2):317-325. doi: 10.1002/cpt.962. Epub 2018 Jan 30.

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