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Items: 15

1.

The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions.

Costa C, Germena G, Martin-Conte EL, Molineris I, Bosco E, Marengo S, Azzolino O, Altruda F, Ranieri VM, Hirsch E.

Blood. 2011 Jul 28;118(4):1099-108. doi: 10.1182/blood-2010-12-324756. Epub 2011 May 6.

2.

Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure.

Damilano F, Franco I, Perrino C, Schaefer K, Azzolino O, Carnevale D, Cifelli G, Carullo P, Ragona R, Ghigo A, Perino A, Lembo G, Hirsch E.

Circulation. 2011 Feb 1;123(4):391-9. doi: 10.1161/CIRCULATIONAHA.110.950543. Epub 2011 Jan 17.

PMID:
21242482
3.

Nonredundant role of CCRL2 in lung dendritic cell trafficking.

Otero K, Vecchi A, Hirsch E, Kearley J, Vermi W, Del Prete A, Gonzalvo-Feo S, Garlanda C, Azzolino O, Salogni L, Lloyd CM, Facchetti F, Mantovani A, Sozzani S.

Blood. 2010 Oct 21;116(16):2942-9. doi: 10.1182/blood-2009-12-259903. Epub 2010 Jul 6.

4.

Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues.

Roetto A, Di Cunto F, Pellegrino RM, Hirsch E, Azzolino O, Bondi A, Defilippi I, Carturan S, Miniscalco B, Riondato F, Cilloni D, Silengo L, Altruda F, Camaschella C, Saglio G.

Blood. 2010 Apr 22;115(16):3382-9. doi: 10.1182/blood-2009-09-240960. Epub 2010 Feb 23.

5.

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.

Ciraolo E, Iezzi M, Marone R, Marengo S, Curcio C, Costa C, Azzolino O, Gonella C, Rubinetto C, Wu H, Dastrù W, Martin EL, Silengo L, Altruda F, Turco E, Lanzetti L, Musiani P, Rückle T, Rommel C, Backer JM, Forni G, Wymann MP, Hirsch E.

Sci Signal. 2008 Sep 9;1(36):ra3. doi: 10.1126/scisignal.1161577.

6.

Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions.

Madeddu P, Kraenkel N, Barcelos LS, Siragusa M, Campagnolo P, Oikawa A, Caporali A, Herman A, Azzolino O, Barberis L, Perino A, Damilano F, Emanueli C, Hirsch E.

Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):68-76. Epub 2007 Oct 25.

7.

Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma.

Costa C, Barberis L, Ambrogio C, Manazza AD, Patrucco E, Azzolino O, Neilsen PO, Ciraolo E, Altruda F, Prestwich GD, Chiarle R, Wymann M, Ridley A, Hirsch E.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14354-9. Epub 2007 Aug 24.

8.

Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma.

Vecchione C, Patrucco E, Marino G, Barberis L, Poulet R, Aretini A, Maffei A, Gentile MT, Storto M, Azzolino O, Brancaccio M, Colussi GL, Bettarini U, Altruda F, Silengo L, Tarone G, Wymann MP, Hirsch E, Lembo G.

J Exp Med. 2005 Apr 18;201(8):1217-28. Epub 2005 Apr 11.

9.

Phosphoinositide 3-kinase gamma controls autonomic regulation of the mouse heart through Gi-independent downregulation of cAMP level.

Alloatti G, Marcantoni A, Levi R, Gallo MP, Del Sorbo L, Patrucco E, Barberis L, Malan D, Azzolino O, Wymann M, Hirsch E, Montrucchio G.

FEBS Lett. 2005 Jan 3;579(1):133-40.

10.

Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis.

Lupia E, Goffi A, De Giuli P, Azzolino O, Bosco O, Patrucco E, Vivaldo MC, Ricca M, Wymann MP, Hirsch E, Montrucchio G, Emanuelli G.

Am J Pathol. 2004 Dec;165(6):2003-11.

11.

PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.

Patrucco E, Notte A, Barberis L, Selvetella G, Maffei A, Brancaccio M, Marengo S, Russo G, Azzolino O, Rybalkin SD, Silengo L, Altruda F, Wetzker R, Wymann MP, Lembo G, Hirsch E.

Cell. 2004 Aug 6;118(3):375-87.

12.

Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility.

Alloatti G, Levi R, Malan D, Del Sorbo L, Bosco O, Barberis L, Marcantoni A, Bedendi I, Penna C, Azzolino O, Altruda F, Wymann M, Hirsch E, Montrucchio G.

Cardiovasc Res. 2003 Nov 1;60(2):242-9.

PMID:
14613853
13.

Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain.

Hirsch E, Barberis L, Brancaccio M, Azzolino O, Xu D, Kyriakis JM, Silengo L, Giancotti FG, Tarone G, Fässler R, Altruda F.

J Cell Biol. 2002 Apr 29;157(3):481-92. Epub 2002 Apr 29.

14.

Defective dendrite elongation but normal fertility in mice lacking the Rho-like GTPase activator Dbl.

Hirsch E, Pozzato M, Vercelli A, Barberis L, Azzolino O, Russo C, Vanni C, Silengo L, Eva A, Altruda F.

Mol Cell Biol. 2002 May;22(9):3140-8.

15.

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, Sozzani S, Mantovani A, Altruda F, Wymann MP.

Science. 2000 Feb 11;287(5455):1049-53.

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