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c-Jun N-Terminal Kinase Inhibition Induces Mitochondrial Oxidative Stress and Decreases Survival in Human Neural Stem Progenitors.

Sharma N, Moore L, Chidambaram S, Colangelo NW, de Toledo SM, Azzam EI.

Dev Neurosci. 2018;40(4):312-324. doi: 10.1159/000493009. Epub 2018 Oct 18.


The Translationally Controlled Tumor Protein and the Cellular Response to Ionizing Radiation-Induced DNA Damage.

Zhang J, Shim G, de Toledo SM, Azzam EI.

Results Probl Cell Differ. 2017;64:227-253. doi: 10.1007/978-3-319-67591-6_12.


Effect of densely ionizing radiation on cardiomyocyte differentiation from human-induced pluripotent stem cells.

Baljinnyam E, Venkatesh S, Gordan R, Mareedu S, Zhang J, Xie LH, Azzam EI, Suzuki CK, Fraidenraich D.

Physiol Rep. 2017 Aug;5(15). pii: e13308. doi: 10.14814/phy2.13308.


Genomic instability induced in distant progeny of bystander cells depends on the connexins expressed in the irradiated cells.

de Toledo SM, Buonanno M, Harris AL, Azzam EI.

Int J Radiat Biol. 2017 Oct;93(10):1182-1194. doi: 10.1080/09553002.2017.1334980. Epub 2017 Jun 15.


Diffusible Factors Secreted by Glioblastoma and Medulloblastoma Cells Induce Oxidative Stress in Bystander Neural Stem Progenitors.

Sharma N, Colangelo NW, de Toledo SM, Azzam EI.

ASN Neuro. 2016 Aug 9;8(4). pii: 1759091416662808. doi: 10.1177/1759091416662808. Print 2016 Aug.


Delayed activation of human microglial cells by high dose ionizing radiation.

Chen H, Chong ZZ, De Toledo SM, Azzam EI, Elkabes S, Souayah N.

Brain Res. 2016 Sep 1;1646:193-198. doi: 10.1016/j.brainres.2016.06.002. Epub 2016 Jun 2.


Galactic cosmic ray simulation at the NASA Space Radiation Laboratory.

Norbury JW, Schimmerling W, Slaba TC, Azzam EI, Badavi FF, Baiocco G, Benton E, Bindi V, Blakely EA, Blattnig SR, Boothman DA, Borak TB, Britten RA, Curtis S, Dingfelder M, Durante M, Dynan WS, Eisch AJ, Robin Elgart S, Goodhead DT, Guida PM, Heilbronn LH, Hellweg CE, Huff JL, Kronenberg A, La Tessa C, Lowenstein DI, Miller J, Morita T, Narici L, Nelson GA, Norman RB, Ottolenghi A, Patel ZS, Reitz G, Rusek A, Schreurs AS, Scott-Carnell LA, Semones E, Shay JW, Shurshakov VA, Sihver L, Simonsen LC, Story MD, Turker MS, Uchihori Y, Williams J, Zeitlin CJ.

Life Sci Space Res (Amst). 2016 Feb;8:38-51. doi: 10.1016/j.lssr.2016.02.001. Epub 2016 Feb 17.


Is Ionizing Radiation Harmful at any Exposure? An Echo That Continues to Vibrate.

Azzam EI, Colangelo NW, Domogauer JD, Sharma N, de Toledo SM.

Health Phys. 2016 Mar;110(3):249-51. doi: 10.1097/HP.0000000000000450. Review.


High Levels of Dietary Supplement Vitamins A, C and E are Absorbed in the Small Intestine and Protect Nutrient Transport Against Chronic Gamma Irradiation.

Roche M, Neti PVSV, Kemp FW, Azzam EI, Ferraris RP, Howell RW.

Radiat Res. 2015 Nov;184(5):470-481. doi: 10.1667/RR14043.1. Epub 2015 Oct 20.


Ionizing Radiation Perturbs Cell Cycle Progression of Neural Precursors in the Subventricular Zone Without Affecting Their Long-Term Self-Renewal.

Chen H, Goodus MT, de Toledo SM, Azzam EI, Levison SW, Souayah N.

ASN Neuro. 2015 Jun 8;7(3). pii: 1759091415578026. doi: 10.1177/1759091415578026. Print 2015 May-Jun.


Low-dose energetic protons induce adaptive and bystander effects that protect human cells against DNA damage caused by a subsequent exposure to energetic iron ions.

Buonanno M, De Toledo SM, Howell RW, Azzam EI.

J Radiat Res. 2015 May;56(3):502-8. doi: 10.1093/jrr/rrv005. Epub 2015 Mar 23.


Genetic changes in progeny of bystander human fibroblasts after microbeam irradiation with X-rays, protons or carbon ions: the relevance to cancer risk.

Autsavapromporn N, Plante I, Liu C, Konishi T, Usami N, Funayama T, Azzam EI, Murakami T, Suzuki M.

Int J Radiat Biol. 2015 Jan;91(1):62-70. doi: 10.3109/09553002.2014.950715.


Connexins and cyclooxygenase-2 crosstalk in the expression of radiation-induced bystander effects.

Zhao Y, de Toledo SM, Hu G, Hei TK, Azzam EI.

Br J Cancer. 2014 Jul 8;111(1):125-31. doi: 10.1038/bjc.2014.276. Epub 2014 May 27.


Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis.

Shim G, Ricoul M, Hempel WM, Azzam EI, Sabatier L.

Mutat Res Rev Mutat Res. 2014 Jan 31. pii: S1383-5742(14)00002-7. doi: 10.1016/j.mrrev.2014.01.001. [Epub ahead of print] Review.


Health risks of space exploration: targeted and nontargeted oxidative injury by high-charge and high-energy particles.

Li M, Gonon G, Buonanno M, Autsavapromporn N, de Toledo SM, Pain D, Azzam EI.

Antioxid Redox Signal. 2014 Mar 20;20(9):1501-23. doi: 10.1089/ars.2013.5649. Epub 2013 Dec 6. Review.


Gap junction communication and the propagation of bystander effects induced by microbeam irradiation in human fibroblast cultures: the impact of radiation quality.

Autsavapromporn N, Suzuki M, Funayama T, Usami N, Plante I, Yokota Y, Mutou Y, Ikeda H, Kobayashi K, Kobayashi Y, Uchihori Y, Hei TK, Azzam EI, Murakami T.

Radiat Res. 2013 Oct;180(4):367-75. doi: 10.1667/RR3111.1. Epub 2013 Aug 29.


Participation of gap junction communication in potentially lethal damage repair and DNA damage in human fibroblasts exposed to low- or high-LET radiation.

Autsavapromporn N, Suzuki M, Plante I, Liu C, Uchihori Y, Hei TK, Azzam EI, Murakami T.

Mutat Res. 2013 Aug 30;756(1-2):78-85. doi: 10.1016/j.mrgentox.2013.07.001. Epub 2013 Jul 15.


Human umbilical-cord-blood mononucleated cells enhance the survival of lethally irradiated mice: dosage and the window of time.

Kovalenko OA, Azzam EI, Ende N.

J Radiat Res. 2013 Nov 1;54(6):1010-4. doi: 10.1093/jrr/rrt062. Epub 2013 Jun 21.


Human cell responses to ionizing radiation are differentially affected by the expressed connexins.

Autsavapromporn N, De Toledo SM, Jay-Gerin JP, Harris AL, Azzam EI.

J Radiat Res. 2013 Mar 1;54(2):251-9. doi: 10.1093/jrr/rrs099. Epub 2012 Nov 8.


Induction of lethal bystander effects in human breast cancer cell cultures by DNA-incorporated Iodine-125 depends on phenotype.

Akudugu JM, Azzam EI, Howell RW.

Int J Radiat Biol. 2012 Dec;88(12):1028-38. doi: 10.3109/09553002.2012.683511. Epub 2012 May 16.


Role of the translationally controlled tumor protein in DNA damage sensing and repair.

Zhang J, de Toledo SM, Pandey BN, Guo G, Pain D, Li H, Azzam EI.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):E926-33. doi: 10.1073/pnas.1106300109. Epub 2012 Mar 26.


Micro RNA responses to chronic or acute exposures to low dose ionizing radiation.

Chaudhry MA, Omaruddin RA, Kreger B, de Toledo SM, Azzam EI.

Mol Biol Rep. 2012 Jul;39(7):7549-58. doi: 10.1007/s11033-012-1589-9. Epub 2012 Feb 25.


The necessity of the early use of antibiotics in treatment of mass casualties from ionizing radiation.

Ende N, Kovalenko OA, Azzam EI.

Int J Radiat Biol. 2012 Apr;88(4):381. doi: 10.3109/09553002.2012.644256. Epub 2011 Dec 20. No abstract available.


Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury.

Azzam EI, Jay-Gerin JP, Pain D.

Cancer Lett. 2012 Dec 31;327(1-2):48-60. doi: 10.1016/j.canlet.2011.12.012. Epub 2011 Dec 17. Review.


The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining.

Shamanna RA, Hoque M, Lewis-Antes A, Azzam EI, Lagunoff D, Pe'ery T, Mathews MB.

Mol Cell Biol. 2011 Dec;31(23):4832-43. doi: 10.1128/MCB.05849-11. Epub 2011 Oct 3.


Intercellular communication amplifies stressful effects in high-charge, high-energy (HZE) particle-irradiated human cells.

Autsavapromporn N, De Toledo SM, Buonanno M, Jay-Gerin JP, Harris AL, Azzam EI.

J Radiat Res. 2011;52(4):408-14. doi: 10.1269/jrr.10114. No abstract available.


Exposure to low level environmental agents: the induction of hormesis.

Azzam EI.

Mutat Res. 2011 Dec 24;726(2):89-90. doi: 10.1016/j.mrgentox.2011.07.008. Epub 2011 Jul 23. No abstract available.


Increased frequency of spontaneous neoplastic transformation in progeny of bystander cells from cultures exposed to densely ionizing radiation.

Buonanno M, de Toledo SM, Azzam EI.

PLoS One. 2011;6(6):e21540. doi: 10.1371/journal.pone.0021540. Epub 2011 Jun 28.


The impact of adaptive and non-targeted effects in the biological responses to low dose/low fluence ionizing radiation: the modulating effect of linear energy transfer.

de Toledo SM, Buonanno M, Li M, Asaad N, Qin Y, Gonon G, Shim G, Galdass M, Boateng Y, Zhang J, Azzam EI.

Health Phys. 2011 Mar;100(3):290-2. doi: 10.1097/HP.0b013e31820832d8. No abstract available.


The role of gap junction communication and oxidative stress in the propagation of toxic effects among high-dose α-particle-irradiated human cells.

Autsavapromporn N, de Toledo SM, Little JB, Jay-Gerin JP, Harris AL, Azzam EI.

Radiat Res. 2011 Mar;175(3):347-57. doi: 10.1667/RR2372.1. Epub 2011 Jan 10.


Long-term consequences of radiation-induced bystander effects depend on radiation quality and dose and correlate with oxidative stress.

Buonanno M, de Toledo SM, Pain D, Azzam EI.

Radiat Res. 2011 Apr;175(4):405-15. doi: 10.1667/RR2461.1. Epub 2011 Feb 14.


Consideration for the treatment of mass casualties based on pathology of the fatalities of Hiroshima and Nagasaki.

Ende N, Azzam EI.

Int J Radiat Biol. 2011 Apr;87(4):443-4. doi: 10.3109/09553002.2011.538129. Epub 2011 Jan 4. No abstract available.


In vivo space radiation-induced non-targeted responses: late effects on molecular signaling in mitochondria.

Jain MR, Li M, Chen W, Liu T, de Toledo SM, Pandey BN, Li H, Rabin BM, Azzam EI.

Curr Mol Pharmacol. 2011 Jun;4(2):106-14.


Expression of (NES-)hTERT in cancer cells delays cell cycle progression and increases sensitivity to genotoxic stress.

Kovalenko OA, Kaplunov J, Herbig U, Detoledo S, Azzam EI, Santos JH.

PLoS One. 2010 May 25;5(5):e10812. doi: 10.1371/journal.pone.0010812.


The effect of human cord blood therapy on the intestinal tract of lethally irradiated mice: possible use for mass casualties.

Azzam EI, Yang Z, Li M, Kim S, Kovalenko OA, Khorshidi M, Ende N.

Int J Radiat Biol. 2010 Jun;86(6):467-75. doi: 10.3109/09553000903567987.


Lack of evidence for low-LET radiation induced bystander response in normal human fibroblasts and colon carcinoma cells.

Sowa MB, Goetz W, Baulch JE, Pyles DN, Dziegielewski J, Yovino S, Snyder AR, de Toledo SM, Azzam EI, Morgan WF.

Int J Radiat Biol. 2010 Feb;86(2):102-13. doi: 10.3109/09553000903419957.


An adoptive transfer method to detect low-dose radiation-induced bystander effects in vivo.

Blyth BJ, Azzam EI, Howell RW, Ormsby RJ, Staudacher AH, Sykes PJ.

Radiat Res. 2010 Feb;173(2):125-37. doi: 10.1667/RR1899.1.


Radiation-induced reductions in transporter mRNA levels parallel reductions in intestinal sugar transport.

Roche M, Neti PV, Kemp FW, Agrawal A, Attanasio A, Douard V, Muduli A, Azzam EI, Norkus E, Brimacombe M, Howell RW, Ferraris RP.

Am J Physiol Regul Integr Comp Physiol. 2010 Jan;298(1):R173-82. doi: 10.1152/ajpregu.00612.2009. Epub 2009 Nov 11.


Propagation distance of the alpha-particle-induced bystander effect: the role of nuclear traversal and gap junction communication.

Gaillard S, Pusset D, de Toledo SM, Fromm M, Azzam EI.

Radiat Res. 2009 May;171(5):513-20. doi: 10.1667/RR1658.1.


Adaptive and bystander responses in human and rodent cell cultures exposed to low level ionizing radiation: the impact of linear energy transfer.

de Toledo SM, Azzam EI.

Dose Response. 2006 Nov 27;4(4):291-301. doi: 10.2203/ Toledo.


Regulation of normal cell cycle progression by flavin-containing oxidases.

Venkatachalam P, de Toledo SM, Pandey BN, Tephly LA, Carter AB, Little JB, Spitz DR, Azzam EI.

Oncogene. 2008 Jan 3;27(1):20-31. Epub 2007 Jul 16.


Challenges and progress in predicting biological responses to incorporated radioactivity.

Howell RW, Neti PV, Pinto M, Gerashchenko BI, Narra VR, Azzam EI.

Radiat Prot Dosimetry. 2006;122(1-4):521-7. Epub 2007 Feb 6. Review.


Bystander responses in three-dimensional cultures containing radiolabelled and unlabelled human cells.

Pinto M, Azzam EI, Howell RW.

Radiat Prot Dosimetry. 2006;122(1-4):252-5. Epub 2006 Dec 21.


Adaptive responses to low-dose/low-dose-rate gamma rays in normal human fibroblasts: the role of growth architecture and oxidative metabolism.

de Toledo SM, Asaad N, Venkatachalam P, Li L, Howell RW, Spitz DR, Azzam EI.

Radiat Res. 2006 Dec;166(6):849-57.


Normal human fibroblasts exposed to high- or low-dose ionizing radiation: differential effects on mitochondrial protein import and membrane potential.

Pandey BN, Gordon DM, De Toledo SM, Pain D, Azzam EI.

Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1253-61.


High-LET ion radiolysis of water: visualization of the formation and evolution of ion tracks and relevance to the radiation-induced bystander effect.

Muroya Y, Plante I, Azzam EI, Meesungnoen J, Katsumura Y, Jay-Gerin JP.

Radiat Res. 2006 Apr;165(4):485-91.


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