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Items: 1 to 50 of 491

1.

Immune adjuvant therapy using Bacillus Calmette-Guérin cell wall skeleton (BCG-CWS) in advanced malignancies: A phase 1 study of safety and immunogenicity assessments.

Nishida S, Tsuboi A, Tanemura A, Ito T, Nakajima H, Shirakata T, Morimoto S, Fujiki F, Hosen N, Oji Y, Kumanogoh A, Kawase I, Oka Y, Azuma I, Morita S, Sugiyama H.

Medicine (Baltimore). 2019 Aug;98(33):e16771. doi: 10.1097/MD.0000000000016771.

2.

Indirect activation of constitutive androstane receptor in three-dimensionally cultured HepG2 cells.

Yokobori K, Azuma I, Chiba K, Akita H, Furihata T, Kobayashi K.

Biochem Pharmacol. 2019 Oct;168:26-37. doi: 10.1016/j.bcp.2019.06.011. Epub 2019 Jun 13.

PMID:
31202736
3.

Intracellular localization of pregnane X receptor in HepG2 cells cultured by the hanging drop method.

Yokobori K, Kobayashi K, Azuma I, Akita H, Chiba K.

Drug Metab Pharmacokinet. 2017 Oct;32(5):265-272. doi: 10.1016/j.dmpk.2017.08.001. Epub 2017 Aug 26.

PMID:
28942083
4.

Assessment of noninvasive, percutaneous hemoglobin measurement in pregnant and early postpartum women.

Yoshida A, Saito K, Ishii K, Azuma I, Sasa H, Furuya K.

Med Devices (Auckl). 2014 Jan 15;7:11-6. doi: 10.2147/MDER.S54696. eCollection 2014.

5.

Vaccination with WT-1 (Wilms' tumor gene-1) peptide and BCG-CWS in melanoma.

Nishioka M, Tanemura A, Nishida S, Nakano A, Tsuboi A, Oji Y, Oka Y, Azuma I, Sugiyama H, Katayama I.

Eur J Dermatol. 2012 Mar-Apr;22(2):258-9. doi: 10.1684/ejd.2011.1619. No abstract available.

PMID:
22240317
6.

Phagocytosis plays a dual role in activating dendritic cells; digestive production of active Toll-like receptor ligands and cooperation with Toll-like receptor signaling.

Miyauchi M, Murata M, Shibuya K, Koga-Yamakawa E, Yanagawa Y, Azuma I, Kashiwazaki Y.

Drug Discov Ther. 2010 Apr;4(2):135-43.

7.

Zinc suppresses Th17 development via inhibition of STAT3 activation.

Kitabayashi C, Fukada T, Kanamoto M, Ohashi W, Hojyo S, Atsumi T, Ueda N, Azuma I, Hirota H, Murakami M, Hirano T.

Int Immunol. 2010 May;22(5):375-86. doi: 10.1093/intimm/dxq017. Epub 2010 Mar 9.

PMID:
20215335
8.

Bacillus Calmette-Guérin cell-wall skeleton enhances the killing activity of cytotoxic lymphocyte-activated human dendritic cells transduced with the prostate-specific antigen gene.

Fujii R, Iwahashi M, Kikkawa K, Inagaki T, Kohjimoto Y, Ojima T, Mori T, Kuramoto T, Nishizawa S, Azuma I, Yamaue H, Shinka T, Hara I.

BJU Int. 2009 Dec;104(11):1766-73.

9.

The additive effects on intraocular pressure of combining nipradilol 0.25% and latanoprost 0.005% ophthalmic solutions: a prospective, randomized, multicenter study.

Tsuru T, Kitazawa Y, Usui M, Ueno S, Azuma I, Masuda K.

Jpn J Ophthalmol. 2008 Sep-Oct;52(5):368-373. doi: 10.1007/s10384-008-0571-5. Epub 2008 Nov 11.

PMID:
18991037
10.

Immune response against cell-wall skeleton of Mycobacterium bovis BCG at the inoculation site and peripheral lymphoid organs.

Kashiwazaki Y, Murata M, Fujii T, Nakagawa M, Fukushima A, Chiba N, Azuma I, Yamaoka T.

Drug Discov Ther. 2008 Jun;2(3):178-87.

11.

Injection of cell-wall skeleton of Mycobacterium bovis BCG draining to a sentinel lymph node eliminates both lymph node metastases and the primary transplanted tumor.

Kashiwazaki Y, Murata M, Sato T, Miyauchi M, Nakagawa M, Fukushima A, Chiba N, Azuma I, Yamaoka T.

Drug Discov Ther. 2008 Jun;2(3):168-77.

12.

Efficient syntheses of a series of trehalose dimycolate (TDM)/trehalose dicorynomycolate (TDCM) analogues and their interleukin-6 level enhancement activity in mice sera.

Nishizawa M, Yamamoto H, Imagawa H, Barbier-Chassefière V, Petit E, Azuma I, Papy-Garcia D.

J Org Chem. 2007 Mar 2;72(5):1627-33. Epub 2007 Feb 8.

PMID:
17286434
13.

Phase III long-term study and comparative clinical study of nipradilol ophthalmic solution in patients with primary open-angle glaucoma and ocular hypertension. Part 2.

Kanno M, Araie M, Masuda K, Takase M, Kitazawa Y, Shiose Y, Azuma I, Ogawa N, Ohdo S.

Arzneimittelforschung. 2006;56(12):820-5. No abstract available.

PMID:
17260669
14.

Phase III long-term study and comparative clinical study of nipradilol ophthalmic solution in patients with primary open-angle glaucoma and ocular hypertension.

Kanno M, Araie M, Masuda K, Takase M, Kitazawa Y, Shiose Y, Azuma I, Ogawa N, Ohdo S.

Arzneimittelforschung. 2006;56(11):729-34.

PMID:
17220049
15.

Enhancement of immunologic tumor regression by intratumoral administration of dendritic cells in combination with cryoablative tumor pretreatment and Bacillus Calmette-Guerin cell wall skeleton stimulation.

Udagawa M, Kudo-Saito C, Hasegawa G, Yano K, Yamamoto A, Yaguchi M, Toda M, Azuma I, Iwai T, Kawakami Y.

Clin Cancer Res. 2006 Dec 15;12(24):7465-75.

16.

Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation.

Uehori J, Fukase K, Akazawa T, Uematsu S, Akira S, Funami K, Shingai M, Matsumoto M, Azuma I, Toyoshima K, Kusumoto S, Seya T.

J Immunol. 2005 Jun 1;174(11):7096-103.

17.

WT1 peptide vaccination combined with BCG-CWS is more efficient for tumor eradication than WT1 peptide vaccination alone.

Nakajima H, Kawasaki K, Oka Y, Tsuboi A, Kawakami M, Ikegame K, Hoshida Y, Fujiki F, Nakano A, Masuda T, Wu F, Taniguchi Y, Yoshihara S, Elisseeva OA, Oji Y, Ogawa H, Azuma I, Kawase I, Aozasa K, Sugiyama H.

Cancer Immunol Immunother. 2004 Jul;53(7):617-24. Epub 2004 Feb 7.

PMID:
15175906
18.

Adjuvant-mediated tumor regression and tumor-specific cytotoxic response are impaired in MyD88-deficient mice.

Akazawa T, Masuda H, Saeki Y, Matsumoto M, Takeda K, Tsujimura K, Kuzushima K, Takahashi T, Azuma I, Akira S, Toyoshima K, Seya T.

Cancer Res. 2004 Jan 15;64(2):757-64.

19.

Mycobacterium bovis BCG cell wall-specific differentially expressed genes identified by differential display and cDNA subtraction in human macrophages.

Begum NA, Ishii K, Kurita-Taniguchi M, Tanabe M, Kobayashi M, Moriwaki Y, Matsumoto M, Fukumori Y, Azuma I, Toyoshima K, Seya T.

Infect Immun. 2004 Feb;72(2):937-48.

20.

The efficacy and safety of dose escalation of dorzolamide used in combination with other topical antiglaucoma agents.

Araie M, Kitazawa Y, Azuma I, Shirato S, Hamanaka T, Tomita G, Origasa H.

J Ocul Pharmacol Ther. 2003 Dec;19(6):517-25.

PMID:
14733709
21.

Role of toll-like receptors and their adaptors in adjuvant immunotherapy for cancer.

Seya T, Akazawa T, Uehori J, Matsumoto M, Azuma I, Toyoshima K.

Anticancer Res. 2003 Nov-Dec;23(6a):4369-76. Review.

PMID:
14666723
22.
23.

Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan.

Uehori J, Matsumoto M, Tsuji S, Akazawa T, Takeuchi O, Akira S, Kawata T, Azuma I, Toyoshima K, Seya T.

Infect Immun. 2003 Aug;71(8):4238-49.

24.

Influence of topical betaxolol and timolol on visual field in Japanese open-angle glaucoma patients.

Araie M, Azuma I, Kitazawa Y.

Jpn J Ophthalmol. 2003 Mar-Apr;47(2):199-207.

PMID:
12738555
25.
26.

Structural-functional relationship of pathogen-associated molecular patterns: lessons from BCG cell wall skeleton and mycoplasma lipoprotein M161Ag.

Seya T, Matsumoto M, Tsuji S, Begum NA, Azuma I, Toyoshima K.

Microbes Infect. 2002 Jul;4(9):955-61. Review.

PMID:
12106788
27.

Long-term effect of topically applied isopropyl unoprostone on microcirculation in the human ocular fundus.

Makimoto Y, Sugiyama T, Kojima S, Azuma I.

Jpn J Ophthalmol. 2002 Jan-Feb;46(1):31-5.

PMID:
11853711
28.

Two receptor theory in innate immune activation: studies on the receptors for bacillus Culmet Guillen-cell wall skeleton.

Seya T, Matsumoto M, Tsuji S, Begum NA, Nomura M, Azuma I, Hayashi A, Toyoshima K.

Arch Immunol Ther Exp (Warsz). 2001;49 Suppl 1:S13-21. Review.

PMID:
11603865
29.

Interferon gamma-producing ability in blood lymphocytes of patients with lung cancer through activation of the innate immune system by BCG cell wall skeleton.

Matsumoto M, Seya T, Kikkawa S, Tsuji S, Shida K, Nomura M, Kurita-Taniguchi M, Ohigashi H, Yokouchi H, Takami K, Hayashi A, Azuma I, Masaoka T, Kodama K, Toyoshima K, Higashiyama M.

Int Immunopharmacol. 2001 Aug;1(8):1559-69. Erratum in: Int Immunopharmacol 2002 Apr;2(5):731. Takami, H [corrected to Takami, K].

PMID:
11515819
30.

Development of immunoadjuvants for immunotherapy of cancer.

Azuma I, Seya T.

Int Immunopharmacol. 2001 Jul;1(7):1249-59. Review.

PMID:
11460306
31.

Cellular and humoral adjuvant activity of lectins isolated from Korean mistletoe (Viscum album colaratum).

Yoon TJ, Yoo YC, Kang TB, Her E, Kim SH, Kim K, Azuma I, Kim JB.

Int Immunopharmacol. 2001 May;1(5):881-9.

PMID:
11379043
32.

Effect of Topically Applied Iganidipine Dihydrochloride, a Novel Ca(2+) Antagonist, on Optic Nerve Head Circulation in Rabbits.

Waki M, Sugiyama T, Watanabe N, Ogawa T, Shirahase H, Azuma I.

Jpn J Ophthalmol. 2001 Jan;45(1):114.

PMID:
11341901
33.

Effect of topically applied iganidipine dihydrochloride, a novel calcium antagonist, on optic nerve head circulation in rabbits.

Waki M, Sugiyama T, Watanabe N, Ogawa T, Shirahase H, Azuma I.

Jpn J Ophthalmol. 2001 Jan-Feb;45(1):76-83.

PMID:
11163049
34.

Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors.

Tsuji S, Matsumoto M, Takeuchi O, Akira S, Azuma I, Hayashi A, Toyoshima K, Seya T.

Infect Immun. 2000 Dec;68(12):6883-90.

35.

Novel mutations in the myocilin gene in Japanese glaucoma patients.

Kubota R, Mashima Y, Ohtake Y, Tanino T, Kimura T, Hotta Y, Kanai A, Tokuoka S, Azuma I, Tanihara H, Inatani M, Inoue Y, Kudoh J, Oguchi Y, Shimizu N.

Hum Mutat. 2000 Sep;16(3):270.

PMID:
10980537
36.

[Effect of topically applied iganidipine dihydrochloride, a novel Ca2+ antagonist, on optic nerve head circulation in rabbits].

Waki M, Sugiyama T, Watanabe N, Ogawa T, Shirahase H, Azuma I.

Nippon Ganka Gakkai Zasshi. 2000 Aug;104(8):541-6. Japanese.

PMID:
10979293
37.

Effect of the consumption of ethanol on the microcirculation of the human optic nerve head in the acute phase

Kojima S, Sugiyama T, Kojima M, Azuma I I, Ito S.

Jpn J Ophthalmol. 2000 May;44(3):318-9.

PMID:
10913661
38.

Immunological aspects of chitin and chitin derivatives administered to animals.

Tokura S, Tamura H, Azuma I.

EXS. 1999;87:279-92. Review.

PMID:
10906967
39.

Innate immune therapy for cancer. Screen for molecules capable of activating the innate immune system.

Seya T, Begum NA, Nomura M, Tsuji S, Matsumoto M, Hayashi A, Azuma I, Toyoshima K.

Adv Exp Med Biol. 2000;465:229-37. Review.

PMID:
10810630
40.

Evaluation of the circulation in the retina, peripapillary choroid and optic disk in normal-tension glaucoma.

Sugiyama T, Schwartz B, Takamoto T, Azuma I.

Ophthalmic Res. 2000 Mar-Jun;32(2-3):79-86.

PMID:
10754439
41.

Efficacy and safety of latanoprost eye drops for glaucoma treatment: a 1-year study in Japan.

Suzuki M, Mishima HK, Masuda K, Araie M, Kitazawa Y, Azuma I.

Jpn J Ophthalmol. 2000 Jan-Feb;44(1):33-8.

PMID:
10698023
42.

Effect of continuous intravenous infusion of carteolol chloride on tissue blood flow in rabbit optic nerve head.

Sugiyama T, Azuma I, Araie M, Fujisawa S, Urashima H, Nagasawa M.

Jpn J Ophthalmol. 1999 Nov-Dec;43(6):490-4.

PMID:
10672877
43.

[Long-term effect of topically applied isopropyl unoprostone on microcirculation in the choroid-retina].

Makimoto Y, Sugiyama T, Kojima S, Azuma I.

Nippon Ganka Gakkai Zasshi. 2000 Jan;104(1):39-43. Japanese.

PMID:
10659625
44.

[Effect of the consumption of ethanol on the microcirculation of the human optic nerve head in the acute phase].

Kojima S, Sugiyama T, Kojima M, Azuma I, Ito S.

Nippon Ganka Gakkai Zasshi. 1999 Nov;103(11):811-6. Japanese.

PMID:
10589240
45.

Experimental optic cup enlargement caused by endothelin-1-induced chronic optic nerve head ischemia.

Oku H, Sugiyama T, Kojima S, Watanabe T, Azuma I.

Surv Ophthalmol. 1999 Oct;44 Suppl 1:S74-84.

PMID:
10548119
46.

Effect of lomerizine, a new Ca(2+)channel blocker, on the microcirculation in the optic nerve head in conscious rabbits: a study using a laser speckle technique.

Shimazawa M, Sugiyama T, Azuma I, Araie M, Iwakura Y, Watari M, Sakai T, Hara H.

Exp Eye Res. 1999 Aug;69(2):185-93.

PMID:
10433855
47.

Lectins isolated from Korean mistletoe (Viscum album coloratum) induce apoptosis in tumor cells.

Yoon TJ, Yoo YC, Kang TB, Shimazaki K, Song SK, Lee KH, Kim SH, Park CH, Azuma I, Kim JB.

Cancer Lett. 1999 Feb 8;136(1):33-40.

PMID:
10211936
48.

Inhibitory effect of trehalose dimycolate (TDM) and its stereoisometric derivatives, trehalose dicorynomycolates (TDCMs), with low toxicity on lung metastasis of tumour cells in mice.

Watanabe R, Yoo YC, Hata K, Mitobe M, Koike Y, Nishizawa M, Garcia DM, Nobuchi Y, Imagawa H, Yamada H, Azuma I.

Vaccine. 1999 Mar 17;17(11-12):1484-92.

PMID:
10195785
49.

Mechanisms underlying the neurogenic relaxation of isolated porcine sphincter pupillae.

Toda M, Okamura T, Fujimiya M, Azuma I, Toda N.

Exp Eye Res. 1999 Apr;68(4):505-12.

PMID:
10192808
50.

Human MD-1 homologue is a BCG-regulated gene product in monocytes: its identification by differential display.

Begum NA, Tsuji S, Nomura M, Shida K, Azuma I, Hayashi A, Matsumoto M, Seya T, Toyoshima K.

Biochem Biophys Res Commun. 1999 Mar 16;256(2):325-9.

PMID:
10079183

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