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Items: 19

1.

Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis.

Gausachs M, Borras E, Chang K, Gonzalez S, Azuara D, Delgado Amador A, Lopez-Doriga A, San Lucas FA, Sanjuan X, Paules MJ, Taggart MW, Davies GE, Ehli EA, Fowler J, Moreno V, Pineda M, You YN, Lynch PM, Lazaro C, Navin NE, Scheet PA, Hawk ET, Capella G, Vilar E.

Clin Cancer Res. 2017 Oct 1;23(19):5936-5947. doi: 10.1158/1078-0432.CCR-17-0821. Epub 2017 Jun 23.

PMID:
28645942
2.

Optimization of RAS/BRAF Mutational Analysis Confirms Improvement in Patient Selection for Clinical Benefit to Anti-EGFR Treatment in Metastatic Colorectal Cancer.

Santos C, Azuara D, Garcia-Carbonero R, Alfonso PG, Carrato A, Elez ME, Gomez A, Losa F, Montagut C, Massuti B, Navarro V, Varela M, Lopez-Doriga A, Moreno V, Valladares M, Manzano JL, Vieitez JM, Aranda E, Sanjuan X, Tabernero J, Capella G, Salazar R.

Mol Cancer Ther. 2017 Sep;16(9):1999-2007. doi: 10.1158/1535-7163.MCT-17-0153. Epub 2017 Jun 16.

PMID:
28626084
3.

Concordance of blood- and tumor-based detection of RAS mutations to guide anti-EGFR therapy in metastatic colorectal cancer.

Grasselli J, Elez E, Caratù G, Matito J, Santos C, Macarulla T, Vidal J, Garcia M, Viéitez JM, Paéz D, Falcó E, Lopez Lopez C, Aranda E, Jones F, Sikri V, Nuciforo P, Fasani R, Tabernero J, Montagut C, Azuara D, Dienstmann R, Salazar R, Vivancos A.

Ann Oncol. 2017 Jun 1;28(6):1294-1301. doi: 10.1093/annonc/mdx112.

4.

Candidate predisposing germline copy number variants in early onset colorectal cancer patients.

Brea-Fernandez AJ, Fernandez-Rozadilla C, Alvarez-Barona M, Azuara D, Ginesta MM, Clofent J, de Castro L, Gonzalez D, Andreu M, Bessa X, Llor X, Xicola R, Jover R, Castells A, Castellvi-Bel S, Capella G, Carracedo A, Ruiz-Ponte C.

Clin Transl Oncol. 2017 May;19(5):625-632. doi: 10.1007/s12094-016-1576-z. Epub 2016 Nov 25.

PMID:
27888432
5.

Nanofluidic Digital PCR and Extended Genotyping of RAS and BRAF for Improved Selection of Metastatic Colorectal Cancer Patients for Anti-EGFR Therapies.

Azuara D, Santos C, Lopez-Doriga A, Grasselli J, Nadal M, Sanjuan X, Marin F, Vidal J, Montal R, Moreno V, Bellosillo B, Argiles G, Elez E, Dienstmann R, Montagut C, Tabernero J, Capellá G, Salazar R.

Mol Cancer Ther. 2016 May;15(5):1106-12. doi: 10.1158/1535-7163.MCT-15-0820. Epub 2016 Apr 1.

6.

Quantification of unmethylated Alu (QUAlu): a tool to assess global hypomethylation in routine clinical samples.

Buj R, Mallona I, Díez-Villanueva A, Barrera V, Mauricio D, Puig-Domingo M, Reverter JL, Matias-Guiu X, Azuara D, Ramírez JL, Alonso S, Rosell R, Capellà G, Perucho M, Robledo M, Peinado MA, Jordà M.

Oncotarget. 2016 Mar 1;7(9):10536-46. doi: 10.18632/oncotarget.7233.

7.

Relationship between methylation and colonic inflammation in inflammatory bowel disease.

Lobatón T, Azuara D, Rodríguez-Moranta F, Loayza C, Sanjuan X, de Oca J, Fernández-Robles A, Guardiola J, Capellá G.

World J Gastroenterol. 2014 Aug 14;20(30):10591-8. doi: 10.3748/wjg.v20.i30.10591.

8.

DNA methylation biomarkers for noninvasive diagnosis of colorectal cancer.

Carmona FJ, Azuara D, Berenguer-Llergo A, Fernández AF, Biondo S, de Oca J, Rodriguez-Moranta F, Salazar R, Villanueva A, Fraga MF, Guardiola J, Capellá G, Esteller M, Moreno V.

Cancer Prev Res (Phila). 2013 Jul;6(7):656-65. doi: 10.1158/1940-6207.CAPR-12-0501. Epub 2013 May 21.

9.

Deep hypothermia protects against acute hypoxia in vivo in rats: a mechanism related to the attenuation of oxidative stress.

Alva N, Azuara D, Palomeque J, Carbonell T.

Exp Physiol. 2013 Jun;98(6):1115-24. doi: 10.1113/expphysiol.2012.071365. Epub 2013 Jan 25.

10.

Nanofluidic digital PCR for KRAS mutation detection and quantification in gastrointestinal cancer.

Azuara D, Ginesta MM, Gausachs M, Rodriguez-Moranta F, Fabregat J, Busquets J, Pelaez N, Boadas J, Galter S, Moreno V, Costa J, de Oca J, Capellá G.

Clin Chem. 2012 Sep;58(9):1332-41. doi: 10.1373/clinchem.2012.186577. Epub 2012 Jun 27.

11.

Novel methylation panel for the early detection of neoplasia in high-risk ulcerative colitis and Crohn's colitis patients.

Azuara D, Rodriguez-Moranta F, de Oca J, Sanjuan X, Guardiola J, Lobaton T, Wang A, Boadas J, Piqueras M, Monfort D, Galter S, Esteller M, Moreno V, Capellá G.

Inflamm Bowel Dis. 2013 Jan;19(1):165-73. doi: 10.1002/ibd.22994.

PMID:
22532293
12.

Novel methylation panel for the early detection of colorectal tumors in stool DNA.

Azuara D, Rodriguez-Moranta F, de Oca J, Soriano-Izquierdo A, Mora J, Guardiola J, Biondo S, Blanco I, Peinado MA, Moreno V, Esteller M, Capellá G.

Clin Colorectal Cancer. 2010 Jul;9(3):168-76. doi: 10.3816/CCC.2010.n.023.

PMID:
20643622
13.

Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease.

Mayor R, Casadomé L, Azuara D, Moreno V, Clark SJ, Capellà G, Peinado MA.

Br J Cancer. 2009 May 19;100(10):1534-9. doi: 10.1038/sj.bjc.6605045. Epub 2009 Apr 21.

14.

Time course of necrosis/apoptosis and neovascularization during experimental gastric conditioning.

Lamas S, Azuara D, de Oca J, Sans M, Farran L, Alba E, Escalante E, Rafecas A.

Dis Esophagus. 2008;21(4):370-6. doi: 10.1111/j.1442-2050.2007.00772.x.

PMID:
18477261
15.

Caspase-3 activity, response to chemotherapy and clinical outcome in patients with colon cancer.

de Oca J, Azuara D, Sanchez-Santos R, Navarro M, Capella G, Moreno V, Sola A, Hotter G, Biondo S, Osorio A, Martí-Ragué J, Rafecas A.

Int J Colorectal Dis. 2008 Jan;23(1):21-7. Epub 2007 Sep 4.

PMID:
17805550
16.

Apoptosis inhibition during preservation by fructose-1,6-diphosphate and theophylline in rat intestinal transplantation.

Genescà M, Sola A, Azuara D, De Oca J, Hotter G.

Crit Care Med. 2005 Apr;33(4):827-34.

PMID:
15818112
17.
18.

Administration of nitric oxide with caspase inhibitors minimizes bacterial translocation in experimental intestinal transplantation.

Azuara D, Sola A, Hotter G, Calatayud L, Jaurrieta E, de Oca J.

Transplantation. 2004 Jan 27;77(2):177-83.

PMID:
14742977
19.

Role of nitric oxide in apoptosis and cell necrosis for intestinal transplantation.

Azuara D, Sola A, Hotter G, Calatayud L, Jaurrieta E, de Oca J.

Transplant Proc. 2003 Aug;35(5):1931-2.

PMID:
12962853

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