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Onydecalins, Fungal Polyketides with Anti- Histoplasma and Anti-TRP Activity.

Lin Z, Phadke S, Lu Z, Beyhan S, Abdel Aziz MH, Reilly C, Schmidt EW.

J Nat Prod. 2018 Dec 3. doi: 10.1021/acs.jnatprod.7b01067. [Epub ahead of print]


Case report: two confirmed cases of human Seoul virus infections in Indonesia.

Lie KC, Aziz MH, Kosasih H, Neal A, Halim CL, Wulan WN, Karyana M, Hadi U.

BMC Infect Dis. 2018 Nov 16;18(1):578. doi: 10.1186/s12879-018-3482-1.


Infections by multidrug-resistant Gram-negative Bacteria: what's new in our arsenal and what's in the pipeline?

Koulenti D, Song A, Ellingboe A, Abdul-Aziz MH, Harris P, Gavey E, Lipman J.

Int J Antimicrob Agents. 2018 Oct 27. pii: S0924-8579(18)30303-0. doi: 10.1016/j.ijantimicag.2018.10.011. [Epub ahead of print] Review.


Grading the loss of sensation in diabetic patients: A psychometric evaluation of the rotterdam diabetic foot study test battery.

Rinkel WD, Rizopoulos D, Aziz MH, Van Neck JW, Cabezas MC, Coert JH.

Muscle Nerve. 2018 Oct;58(4):559-565. doi: 10.1002/mus.26192. Epub 2018 Aug 22.


In Vitro Cytotoxicity and Morphological Assessments of GO-ZnO against the MCF-7 Cells: Determination of Singlet Oxygen by Chemical Trapping.

Shaheen F, Aziz MH, Fatima M, Khan MA, Ahmed F, Ahmad R, Ahmad MA, Alkhuraiji TS, Akram MW, Raza R, Ali SM.

Nanomaterials (Basel). 2018 Jul 18;8(7). pii: E539. doi: 10.3390/nano8070539.



Aziz MH, Ramphul K.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-.
2018 Oct 27.


New paradigm for rapid achievement of appropriate therapy in special populations: coupling antibiotic dose optimization rapid microbiological methods.

Abdul-Aziz MH, Driver E, Lipman J, Roberts JA.

Expert Opin Drug Metab Toxicol. 2018 Jul;14(7):693-708. doi: 10.1080/17425255.2018.1484452. Epub 2018 Jun 14. Review.


Optimising drug dosing in patients receiving extracorporeal membrane oxygenation.

Cheng V, Abdul-Aziz MH, Roberts JA, Shekar K.

J Thorac Dis. 2018 Mar;10(Suppl 5):S629-S641. doi: 10.21037/jtd.2017.09.154. Review.


Novel heparin mimetics reveal cooperativity between exosite 2 and sodium-binding site of thrombin.

Abdel Aziz MH, Desai UR.

Thromb Res. 2018 May;165:61-67. doi: 10.1016/j.thromres.2018.03.013. Epub 2018 Mar 17.


Assessment of Blend PVDF Membranes, and the Effect of Polymer Concentration and Blend Composition.

Ali I, Bamaga OA, Gzara L, Bassyouni M, Abdel-Aziz MH, Soliman MF, Drioli E, Albeirutty M.

Membranes (Basel). 2018 Mar 5;8(1). pii: E13. doi: 10.3390/membranes8010013.


The Systemic-Immune-Inflammation Index Independently Predicts Survival and Recurrence in Resectable Pancreatic Cancer and its Prognostic Value Depends on Bilirubin Levels: A Retrospective Multicenter Cohort Study.

Aziz MH, Sideras K, Aziz NA, Mauff K, Haen R, Roos D, Saida L, Suker M, van der Harst E, Mieog JS, Bonsing BA, Klaver Y, Koerkamp BG, van Eijck CH.

Ann Surg. 2018 Jan 12. doi: 10.1097/SLA.0000000000002660. [Epub ahead of print]


Identifying "at-risk" patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections.

Abdul-Aziz MH, Lipman J, Roberts JA.

Crit Care. 2017 Nov 21;21(1):283. doi: 10.1186/s13054-017-1871-2. No abstract available.


Prolonged Infusion Piperacillin-Tazobactam Decreases Mortality and Improves Outcomes in Severely Ill Patients: Results of a Systematic Review and Meta-Analysis.

Rhodes NJ, Liu J, O'Donnell JN, Dulhunty JM, Abdul-Aziz MH, Berko PY, Nadler B, Lipman J, Roberts JA.

Crit Care Med. 2018 Feb;46(2):236-243. doi: 10.1097/CCM.0000000000002836.


Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation.

Sinnah F, Shekar K, Abdul-Aziz MH, Buscher H, Diab SD, Fisquet S, Fung YL, McDonald CI, Reynolds C, Rudham S, Wallis SC, Welch S, Xie J, Fraser JF, Roberts JA; ASAP ECMO investigators.

Crit Care Resusc. 2017 Oct;19(Suppl 1):8-14.


Sex determination from chest measurements in a sample of Egyptian adults using Multislice Computed Tomography.

Darwish RT, Abdel-Aziz MH, El Nekiedy AM, Sobh ZK.

J Forensic Leg Med. 2017 Nov;52:154-158. doi: 10.1016/j.jflm.2017.09.006. Epub 2017 Sep 11.


Protective molecular mechanisms of resveratrol in UVR-induced Skin carcinogenesis.

Aziz SW, Aziz MH.

Photodermatol Photoimmunol Photomed. 2018 Jan;34(1):35-41. doi: 10.1111/phpp.12336. Epub 2017 Aug 29. Review.


Pharmacokinetic/Pharmacodynamics-Optimized Antimicrobial Therapy in Patients with Hospital-Acquired Pneumonia/Ventilator-Associated Pneumonia.

Sulaiman H, Abdul-Aziz MH, Roberts JA.

Semin Respir Crit Care Med. 2017 Jun;38(3):271-286. doi: 10.1055/s-0037-1602716. Epub 2017 Jun 4. Review.


The Upregulation of Integrin αDβ2 (CD11d/CD18) on Inflammatory Macrophages Promotes Macrophage Retention in Vascular Lesions and Development of Atherosclerosis.

Aziz MH, Cui K, Das M, Brown KE, Ardell CL, Febbraio M, Pluskota E, Han J, Wu H, Ballantyne CM, Smith JD, Cathcart MK, Yakubenko VP.

J Immunol. 2017 Jun 15;198(12):4855-4867. doi: 10.4049/jimmunol.1602175. Epub 2017 May 12.


Antibiotic dosing for multidrug-resistant pathogen pneumonia.

Abdul-Aziz MH, Lipman J, Roberts JA.

Curr Opin Infect Dis. 2017 Apr;30(2):231-239. doi: 10.1097/QCO.0000000000000348. Review.


Normative data for cutaneous threshold and spatial discrimination in the feet.

Rinkel WD, Aziz MH, Van Deelen MJM, Willemsen SP, Castro Cabezas M, Van Neck JW, Coert JH.

Muscle Nerve. 2017 Sep;56(3):399-407. doi: 10.1002/mus.25512. Epub 2017 Apr 1.


Regression equations for sex and population detection using the lip print pattern among Egyptian and Malaysian adult.

Abdel Aziz MH, Badr El Dine FM, Saeed NM.

J Forensic Leg Med. 2016 Nov;44:103-110. doi: 10.1016/j.jflm.2016.10.003. Epub 2016 Oct 8.


Prolonged administration of β-lactam antibiotics - a comprehensive review and critical appraisal.

Osthoff M, Siegemund M, Balestra G, Abdul-Aziz MH, Roberts JA.

Swiss Med Wkly. 2016 Oct 10;146:w14368. doi: 10.4414/smw.2016.14368. eCollection 2016. Review.


Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials.

Roberts JA, Abdul-Aziz MH, Davis JS, Dulhunty JM, Cotta MO, Myburgh J, Bellomo R, Lipman J.

Am J Respir Crit Care Med. 2016 Sep 15;194(6):681-91. doi: 10.1164/rccm.201601-0024OC.


Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis.

Abdul-Aziz MH, Sulaiman H, Mat-Nor MB, Rai V, Wong KK, Hasan MS, Abd Rahman AN, Jamal JA, Wallis SC, Lipman J, Staatz CE, Roberts JA.

Intensive Care Med. 2016 Oct;42(10):1535-1545. doi: 10.1007/s00134-015-4188-0. Epub 2016 Jan 11.


What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients?

Alobaid AS, Brinkmann A, Frey OR, Roehr AC, Luque S, Grau S, Wong G, Abdul-Aziz MH, Roberts MS, Lipman J, Roberts JA.

J Antimicrob Chemother. 2016 Mar;71(3):696-702. doi: 10.1093/jac/dkv412. Epub 2015 Dec 24.


Suppressing NRIP1 inhibits growth of breast cancer cells in vitro and in vivo.

Aziz MH, Chen X, Zhang Q, DeFrain C, Osland J, Luo Y, Shi X, Yuan R.

Oncotarget. 2015 Nov 24;6(37):39714-24. doi: 10.18632/oncotarget.5356.


Population Pharmacokinetics of Doripenem in Critically Ill Patients with Sepsis in a Malaysian Intensive Care Unit.

Abdul-Aziz MH, Abd Rahman AN, Mat-Nor MB, Sulaiman H, Wallis SC, Lipman J, Roberts JA, Staatz CE.

Antimicrob Agents Chemother. 2015 Oct 19;60(1):206-14. doi: 10.1128/AAC.01543-15. Print 2016 Jan.


Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort.

Abdul-Aziz MH, Lipman J, Akova M, Bassetti M, De Waele JJ, Dimopoulos G, Dulhunty J, Kaukonen KM, Koulenti D, Martin C, Montravers P, Rello J, Rhodes A, Starr T, Wallis SC, Roberts JA; DALI Study Group.

J Antimicrob Chemother. 2016 Jan;71(1):196-207. doi: 10.1093/jac/dkv288. Epub 2015 Oct 3.


Applying pharmacokinetic/pharmacodynamic principles in critically ill patients: optimizing efficacy and reducing resistance development.

Abdul-Aziz MH, Lipman J, Mouton JW, Hope WW, Roberts JA.

Semin Respir Crit Care Med. 2015 Feb;36(1):136-53. doi: 10.1055/s-0034-1398490. Epub 2015 Feb 2. Review.


Oxazinin A, a pseudodimeric natural product of mixed biosynthetic origin from a filamentous fungus.

Lin Z, Koch M, Abdel Aziz MH, Galindo-Murillo R, Tianero MD, Cheatham TE, Barrows LR, Reilly CA, Schmidt EW.

Org Lett. 2014 Sep 19;16(18):4774-7. doi: 10.1021/ol502227x. Epub 2014 Sep 4.


Drofenine: A 2-APB Analogue with Greater Selectivity for Human TRPV3.

Deering-Rice CE, Mitchell VK, Romero EG, Abdel Aziz MH, Ryskamp DA, Križaj D, Gopal VR, Reilly CA.

Pharmacol Res Perspect. 2014 Oct;2(5):e00062.


Low flucloxacillin concentrations in a patient with central nervous system infection: the need for plasma and cerebrospinal fluid drug monitoring in the ICU.

Abdul-Aziz MH, McDonald C, McWhinney B, Ungerer JP, Lipman J, Roberts JA.

Ann Pharmacother. 2014 Oct;48(10):1380-4. doi: 10.1177/1060028014540610. Epub 2014 Jun 20.


Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions.

Roberts JA, Abdul-Aziz MH, Lipman J, Mouton JW, Vinks AA, Felton TW, Hope WW, Farkas A, Neely MN, Schentag JJ, Drusano G, Frey OR, Theuretzbacher U, Kuti JL; International Society of Anti-Infective Pharmacology and the Pharmacokinetics and Pharmacodynamics Study Group of the European Society of Clinical Microbiology and Infectious Diseases.

Lancet Infect Dis. 2014 Jun;14(6):498-509. doi: 10.1016/S1473-3099(14)70036-2. Epub 2014 Apr 24. Review.


Second cancer risk after 3D-CRT, IMRT and VMAT for breast cancer.

Abo-Madyan Y, Aziz MH, Aly MM, Schneider F, Sperk E, Clausen S, Giordano FA, Herskind C, Steil V, Wenz F, Glatting G.

Radiother Oncol. 2014 Mar;110(3):471-6. doi: 10.1016/j.radonc.2013.12.002. Epub 2014 Jan 17.


Designing allosteric regulators of thrombin. Exosite 2 features multiple subsites that can be targeted by sulfated small molecules for inducing inhibition.

Sidhu PS, Abdel Aziz MH, Sarkar A, Mehta AY, Zhou Q, Desai UR.

J Med Chem. 2013 Jun 27;56(12):5059-70. doi: 10.1021/jm400369q. Epub 2013 Jun 13.


Continuous beta-lactam infusion in critically ill patients: the clinical evidence.

Abdul-Aziz MH, Dulhunty JM, Bellomo R, Lipman J, Roberts JA.

Ann Intensive Care. 2012 Aug 16;2(1):37. doi: 10.1186/2110-5820-2-37.


Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition.

Abdel Aziz MH, Sidhu PS, Liang A, Kim JY, Mosier PD, Zhou Q, Farrell DH, Desai UR.

J Med Chem. 2012 Aug 9;55(15):6888-97. doi: 10.1021/jm300670q. Epub 2012 Jul 25.


Glucocorticoid receptor activation inhibits p53-induced apoptosis of MCF10Amyc cells via induction of protein kinase Cε.

Aziz MH, Shen H, Maki CG.

J Biol Chem. 2012 Aug 24;287(35):29825-36. doi: 10.1074/jbc.M112.393256. Epub 2012 Jul 6.


Can the risk of secondary cancer induction after breast conserving therapy be reduced using intraoperative radiotherapy (IORT) with low-energy x-rays?

Aziz MH, Schneider F, Clausen S, Blank E, Herskind C, Afzal M, Wenz F.

Radiat Oncol. 2011 Dec 16;6:174. doi: 10.1186/1748-717X-6-174.


Identification of the site of binding of sulfated, low molecular weight lignins on thrombin.

Abdel Aziz MH, Mosier PD, Desai UR.

Biochem Biophys Res Commun. 2011 Sep 23;413(2):348-52. doi: 10.1016/j.bbrc.2011.08.102. Epub 2011 Aug 27.


Rational design of potent, small, synthetic allosteric inhibitors of thrombin.

Sidhu PS, Liang A, Mehta AY, Abdel Aziz MH, Zhou Q, Desai UR.

J Med Chem. 2011 Aug 11;54(15):5522-31. doi: 10.1021/jm2005767. Epub 2011 Jul 18.


Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3.

Aziz MH, Shen H, Maki CG.

Oncogene. 2011 Nov 17;30(46):4678-86. doi: 10.1038/onc.2011.185. Epub 2011 Jun 6.


Ultraviolet radiation and 12-O-tetradecanoylphorbol-13-acetate-induced interaction of mouse epidermal protein kinase Cε with Stat3 involve integration with ERK1/2.

Sand JM, Bin Hafeez B, Aziz MH, Siebers EM, Dreckschmidt NE, Verma AK.

Mol Carcinog. 2012 Apr;51(4):291-302. doi: 10.1002/mc.20776. Epub 2011 Apr 7.


Effective of metronidazole to bacterial flora in vagina and the impact of microbes on live birth rate during intracytoplasmic sperm injection (ICSI).

Selim SA, El Alfy SM, Aziz MH, Mohamed HM, Alasbahi AA.

Arch Gynecol Obstet. 2011 Dec;284(6):1449-53. doi: 10.1007/s00404-011-1857-2. Epub 2011 Feb 18.


Protein kinase Cvarepsilon mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression, and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2, and ERK1/2).

Aziz MH, Hafeez BB, Sand JM, Pierce DB, Aziz SW, Dreckschmidt NE, Verma AK.

Oncogene. 2010 May 27;29(21):3100-9. doi: 10.1038/onc.2010.63. Epub 2010 Mar 15.


PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas.

Sand JM, Aziz MH, Dreckschmidt NE, Havighurst TC, Kim K, Oberley TD, Verma AK.

J Invest Dermatol. 2010 Jan;130(1):270-7. doi: 10.1038/jid.2009.212.


Protein kinase Cepsilon inhibits UVR-induced expression of FADD, an adaptor protein, linked to both Fas- and TNFR1-mediated apoptosis.

Aziz MH, Sundling KE, Dreckschmidt NE, Verma AK.

J Invest Dermatol. 2009 Aug;129(8):2011-21. doi: 10.1038/jid.2008.458. Epub 2009 Feb 5.


Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer.

Aziz MH, Dreckschmidt NE, Verma AK.

Cancer Res. 2008 Nov 1;68(21):9024-32. doi: 10.1158/0008-5472.CAN-08-2494.


Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer.

Aziz MH, Manoharan HT, Church DR, Dreckschmidt NE, Zhong W, Oberley TD, Wilding G, Verma AK.

Cancer Res. 2007 Sep 15;67(18):8828-38.


Protein kinase Cepsilon interacts with Stat3 and regulates its activation that is essential for the development of skin cancer.

Aziz MH, Manoharan HT, Sand JM, Verma AK.

Mol Carcinog. 2007 Aug;46(8):646-53. Review.


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