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Items: 1 to 50 of 249

1.

Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents.

Eldehna WM, Hassan GS, Al-Rashood ST, Al-Warhi T, Altyar AE, Alkahtani HM, Almehizia AA, Abdel-Aziz HA.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):322-332. doi: 10.1080/14756366.2018.1547286.

2.

Synthesis and biological evaluation of some novel thiobenzimidazole derivatives as anti-renal cancer agents through inhibition of c-MET kinase.

Ibrahim HS, Albakri ME, Mahmoud WR, Allam HA, Reda AM, Abdel-Aziz HA.

Bioorg Chem. 2019 Jan 8;85:337-348. doi: 10.1016/j.bioorg.2019.01.006. [Epub ahead of print]

PMID:
30658233
3.

Evidence-based review of trauma center care and routine palliative care processes for geriatric trauma patients; a collaboration from the American Association for the Surgery of Trauma (AAST) Patient Assessment Committee, the AAST Geriatric Trauma Committee, and the Eastern Association for the Surgery of Trauma Guidelines Committee.

Aziz HA, Lunde J, Barraco R, Como JJ, Cooper Z, Hayward T 3rd, Hwang F, Lottenberg L, Mentzer C, Mosenthal A, Mukherjee K, Nash J, Robinson B, Staudenmayer K, Wright R, Yon J, Crandall M.

J Trauma Acute Care Surg. 2018 Dec 6. doi: 10.1097/TA.0000000000002155. [Epub ahead of print]

PMID:
30531333
4.

One-pot synthesis of spiro(indoline-3,4'-pyrazolo[3,4-b]pyridine)-5'-carbonitriles as p53-MDM2 interaction inhibitors.

Ibrahim HS, Eldehna WM, Fallacara AL, Ahmed ER, Ghabbour HA, Elaasser MM, Botta M, Abou-Seri SM, Abdel-Aziz HA.

Future Med Chem. 2018 Dec;10(24):2771-2789. doi: 10.4155/fmc-2018-0288. Epub 2018 Dec 10.

PMID:
30526032
5.

SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX.

Eldehna WM, Abo-Ashour MF, Berrino E, Vullo D, Ghabbour HA, Al-Rashood ST, Hassan GS, Alkahtani HM, Almehizia AA, Alharbi A, Abdel-Aziz HA, Supuran CT.

Bioorg Chem. 2019 Mar;83:549-558. doi: 10.1016/j.bioorg.2018.11.014. Epub 2018 Nov 14.

PMID:
30471577
6.

Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents.

Eldehna WM, Abo-Ashour MF, Nocentini A, El-Haggar RS, Bua S, Bonardi A, Al-Rashood ST, Hassan GS, Gratteri P, Abdel-Aziz HA, Supuran CT.

Eur J Med Chem. 2019 Jan 15;162:147-160. doi: 10.1016/j.ejmech.2018.10.068. Epub 2018 Nov 2.

PMID:
30445264
7.

New benzimidazothiazole derivatives as anti-inflammatory, antitumor active agents: Synthesis, in-vitro and in-vivo screening and molecular modeling studies.

El-Kerdawy MM, Ghaly MA, Darwish SA, Abdel-Aziz HA, Elsheakh AR, Abdelrahman RS, Hassan GS.

Bioorg Chem. 2019 Mar;83:250-261. doi: 10.1016/j.bioorg.2018.10.048. Epub 2018 Oct 24.

PMID:
30391698
8.

No correlation between lower extremity deep vein thrombosis and pulmonary embolism proportions in trauma: a systematic literature review.

Aziz HA, Hileman BM, Chance EA.

Eur J Trauma Emerg Surg. 2018 Dec;44(6):843-850. doi: 10.1007/s00068-018-1043-3. Epub 2018 Nov 1. Review.

PMID:
30382316
9.

Synthesis and anti-proliferative activity of some new quinoline based 4,5-dihydropyrazoles and their thiazole hybrids as EGFR inhibitors.

George RF, Samir EM, Abdelhamed MN, Abdel-Aziz HA, Abbas SE.

Bioorg Chem. 2019 Mar;83:186-197. doi: 10.1016/j.bioorg.2018.10.038. Epub 2018 Oct 20.

PMID:
30380447
10.

Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer.

Eldehna WM, Nocentini A, Al-Rashood ST, Hassan GS, Alkahtani HM, Almehizia AA, Reda AM, Abdel-Aziz HA, Supuran CT.

Bioorg Chem. 2018 Dec;81:425-432. doi: 10.1016/j.bioorg.2018.09.007. Epub 2018 Sep 7.

PMID:
30219719
11.

Chemical Waste and Allied Products.

Hung YT, Aziz HA, Zainal SFFS, Yeh RY, Liu LH, Paul HH, Huhnke CR.

Water Environ Res. 2018 Oct 1;90(10):1021-1032. doi: 10.2175/106143018X15289915807137.

PMID:
30126475
12.

Poultry Slaughterhouse Wastewater Treatment Using Submerged Fibers in an Attached Growth Sequential Batch Reactor.

Aziz HA, Puat NNA, Alazaiza MYD, Hung YT.

Int J Environ Res Public Health. 2018 Aug 13;15(8). pii: E1734. doi: 10.3390/ijerph15081734.

13.

Kynurenine 3-Monooxygenase Gene Associated With Nicotine Initiation and Addiction: Analysis of Novel Regulatory Features at 5' and 3'-Regions.

Aziz HA, Abdel-Salam AG, Al-Obaide MAI, Alobydi HW, Al-Humaish S.

Front Genet. 2018 Jun 13;9:198. doi: 10.3389/fgene.2018.00198. eCollection 2018.

14.

Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation.

El-Naggar M, Almahli H, Ibrahim HS, Eldehna WM, Abdel-Aziz HA.

Molecules. 2018 Jun 15;23(6). pii: E1459. doi: 10.3390/molecules23061459.

15.

Evaluation and comparison the performance of titanium and zirconium(IV) tetrachloride in textile wastewater treatment.

Aziz HA, Razak MHA, Rahim MZA, Kamar WISW, Abu Amr SS, Hussain S, Van Leeuwen J.

Data Brief. 2018 Mar 28;18:920-927. doi: 10.1016/j.dib.2018.03.113. eCollection 2018 Jun.

16.

Novel Thiazolidinone/Thiazolo[3,2-a]Benzimidazolone-Isatin Conjugates as Apoptotic Anti-proliferative Agents Towards Breast Cancer: One-Pot Synthesis and In Vitro Biological Evaluation.

El-Naggar M, Eldehna WM, Almahli H, Elgez A, Fares M, Elaasser MM, Abdel-Aziz HA.

Molecules. 2018 Jun 12;23(6). pii: E1420. doi: 10.3390/molecules23061420.

17.

Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2-STAT3 pathway.

Al-Obeed O, Vaali-Mohammed MA, Eldehna WM, Al-Khayal K, Mahmood A, Abdel-Aziz HA, Zubaidi A, Alafeefy A, Abdulla M, Ahmad R.

Onco Targets Ther. 2018 Jun 5;11:3313-3322. doi: 10.2147/OTT.S148108. eCollection 2018.

18.

Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents.

Eldehna WM, Al-Wabli RI, Almutairi MS, Keeton AB, Piazza GA, Abdel-Aziz HA, Attia MI.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):867-878. doi: 10.1080/14756366.2018.1462802.

PMID:
29707975
19.

Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform.

Ibrahim HS, Allam HA, Mahmoud WR, Bonardi A, Nocentini A, Gratteri P, Ibrahim ES, Abdel-Aziz HA, Supuran CT.

Eur J Med Chem. 2018 May 25;152:1-9. doi: 10.1016/j.ejmech.2018.04.016. Epub 2018 Apr 10.

PMID:
29684705
20.

Mirtazapine.

Al-Majed A, Bakheit AH, Alharbi RM, Abdel Aziz HA.

Profiles Drug Subst Excip Relat Methodol. 2018;43:209-254. doi: 10.1016/bs.podrm.2018.01.002. Epub 2018 Mar 30. Review.

PMID:
29678261
21.

An improved synthesis of pyrido[2,3-d]pyrimidin-4(1H)-ones and their antimicrobial activity.

Fares M, Abd El Hadi SR, Eladwy RA, Shoun AA, Abdel-Aziz MM, Eldehna WM, Abdel-Aziz HA, Keller PA.

Org Biomol Chem. 2018 May 9;16(18):3389-3395. doi: 10.1039/c8ob00627j.

PMID:
29671455
22.

Tyrosine kinase inhibition effects of novel Pyrazolo[1,5-a]pyrimidines and Pyrido[2,3-d]pyrimidines ligand: Synthesis, biological screening and molecular modeling studies.

El Sayed MT, Hussein HAR, Elebiary NM, Hassan GS, Elmessery SM, Elsheakh AR, Nayel M, Abdel-Aziz HA.

Bioorg Chem. 2018 Aug;78:312-323. doi: 10.1016/j.bioorg.2018.03.009. Epub 2018 Mar 26.

PMID:
29625271
24.

Decreased severity of age-related macular degeneration in amblyopic eyes.

Storey PP, Aziz HA, O'Keefe GAD, Borchert M, Lam LA, Puliafito CA, Olmos de Koo LC.

Br J Ophthalmol. 2018 Nov;102(11):1575-1578. doi: 10.1136/bjophthalmol-2017-311671. Epub 2018 Feb 6.

PMID:
29437581
25.

Floc behavior and removal mechanisms of cross-linked Durio zibethinus seed starch as a natural flocculant for landfill leachate coagulation-flocculation treatment.

Yusoff MS, Aziz HA, Zamri MFMA, Suja' F, Abdullah AZ, Basri NEA.

Waste Manag. 2018 Apr;74:362-372. doi: 10.1016/j.wasman.2018.01.016. Epub 2018 Jan 19.

PMID:
29370968
26.

One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells.

Eldehna WM, El-Naggar DH, Hamed AR, Ibrahim HS, Ghabbour HA, Abdel-Aziz HA.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):309-318. doi: 10.1080/14756366.2017.1417276.

27.

First study in Qatar to reveal high Legionella counts in cooling towers.

AbuOdeh RO, Aziz HA, Moussa H, Hussien S, Hadwan T, Nasrallah GK.

East Mediterr Health J. 2017 Dec 14;23(10):703-707. doi: 10.26719/2017.23.10.703.

PMID:
29270971
28.

Design, synthesis, anti-inflammatory antitumor activities, molecular modeling and molecular dynamics simulations of potential naprosyn® analogs as COX-1 and/or COX-2 inhibitors.

El Sayed MT, El-Sharief MAMS, Zarie ES, Morsy NM, Elsheakh AR, Nayel M, Voronkov A, Berishvili V, Sabry NM, Hassan GS, Abdel-Aziz HA.

Bioorg Chem. 2018 Feb;76:188-201. doi: 10.1016/j.bioorg.2017.11.002. Epub 2017 Nov 13.

PMID:
29182950
29.

Novel 6-Phenylnicotinohydrazide Derivatives: Design, Synthesis and Biological Evaluation as a Novel Class of Antitubercular and Antimicrobial Agents.

Soliman DH, Eldehna WM, Ghabbour HA, Kabil MM, Abdel-Aziz MM, Abdel-Aziz HA.

Biol Pharm Bull. 2017;40(11):1883-1893. doi: 10.1248/bpb.b17-00361.

30.

Chemical Waste and Allied Products.

Hung YT, Aziz HA, Zainal SFFS, Yeh RY, Liu LH, Paul HH, Huhnke CR.

Water Environ Res. 2017 Oct 1;89(10):1349-1359. doi: 10.2175/106143017X15023776270359. Review.

PMID:
28954664
31.

Uveal Melanoma Regression after Brachytherapy: Relationship with Chromosome 3 Monosomy Status.

Salvi SM, Aziz HA, Dar S, Singh N, Hayden-Loreck B, Singh AD.

Ocul Oncol Pathol. 2017 Jul;3(2):87-94. doi: 10.1159/000451001. Epub 2016 Oct 29.

32.

RETINAL DETACHMENT SURGERY IN A PEDIATRIC POPULATION: Visual and Anatomic Outcomes.

Read SP, Aziz HA, Kuriyan A, Kothari N, Davis JL, Smiddy WE, Flynn HW Jr, Murray TG, Berrocal A.

Retina. 2018 Jul;38(7):1393-1402. doi: 10.1097/IAE.0000000000001725.

PMID:
28858062
33.

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling.

Abdel-Aziz HA, Eldehna WM, Keeton AB, Piazza GA, Kadi AA, Attwa MW, Abdelhameed AS, Attia MI.

Drug Des Devel Ther. 2017 Aug 9;11:2333-2346. doi: 10.2147/DDDT.S140164. eCollection 2017.

34.

Ocular/adnexal lymphoma: dissimilar to systemic lymphoma.

Rubinstein TJ, Aziz HA, Bellerive C, Sires BS, Hing AW, Habermehl G, Hsi E, Singh AD.

Surv Ophthalmol. 2018 May - Jun;63(3):381-388. doi: 10.1016/j.survophthal.2017.08.005. Epub 2017 Aug 31. Review.

PMID:
28837797
35.

Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies.

Eldehna WM, Abo-Ashour MF, Nocentini A, Gratteri P, Eissa IH, Fares M, Ismael OE, Ghabbour HA, Elaasser MM, Abdel-Aziz HA, Supuran CT.

Eur J Med Chem. 2017 Oct 20;139:250-262. doi: 10.1016/j.ejmech.2017.07.073. Epub 2017 Aug 1.

PMID:
28802125
36.

Reply.

Bellerive C, Aziz HA, Bena J, Wilkinson A, Suh JH, Plesec T, Singh AD.

Am J Ophthalmol. 2017 Sep;181:179-180. doi: 10.1016/j.ajo.2017.06.029. Epub 2017 Jul 26. No abstract available.

PMID:
28755758
37.

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres.

Attia MI, Eldehna WM, Afifi SA, Keeton AB, Piazza GA, Abdel-Aziz HA.

PLoS One. 2017 Jul 25;12(7):e0181241. doi: 10.1371/journal.pone.0181241. eCollection 2017.

38.

Cancer stem cells CD133 inhibition and cytotoxicity of certain 3-phenylthiazolo[3,2-a]benzimidazoles: design, direct synthesis, crystal study and in vitro biological evaluation.

Al-Ansary GH, Eldehna WM, Ghabbour HA, Al-Rashood STA, Al-Rashood KA, Eladwy RA, Al-Dhfyan A, Kabil MM, Abdel-Aziz HA.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):986-991. doi: 10.1080/14756366.2017.1347166.

39.

Performance of modified anaerobic inclining-baffled reactor treating recycled paper mill effluent: effects of influent chemical oxygen demand concentration and hydraulic retention time.

Zwain HM, Aziz HA, Dahlan I.

Environ Technol. 2018 Jun;39(12):1557-1565. doi: 10.1080/09593330.2017.1332692. Epub 2017 Jun 1.

PMID:
28514902
40.

Clenbuterol Hydrochloride.

Al-Majed AA, Khalil NY, Khbrani I, Abdel-Aziz HA.

Profiles Drug Subst Excip Relat Methodol. 2017;42:91-123. doi: 10.1016/bs.podrm.2017.02.002. Epub 2017 Mar 31.

PMID:
28431781
41.

Propranolol.

Al-Majed AA, Bakheit AHH, Abdel Aziz HA, Alajmi FM, AlRabiah H.

Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338. doi: 10.1016/bs.podrm.2017.02.006. Epub 2017 Apr 6.

PMID:
28431779
42.

Olmesartan.

Al-Majed AA, Bakheit AHH, Abdel Aziz HA, Al-Jallal AAM.

Profiles Drug Subst Excip Relat Methodol. 2017;42:241-286. doi: 10.1016/bs.podrm.2017.02.005. Epub 2017 Mar 31.

PMID:
28431778
43.

Performance and microbial community analysis in a modified anaerobic inclining-baffled reactor treating recycled paper mill effluent.

Zwain HM, Aziz HA, Ng WJ, Dahlan I.

Environ Sci Pollut Res Int. 2017 May;24(14):13012-13024. doi: 10.1007/s11356-017-8804-0. Epub 2017 Apr 5.

PMID:
28378314
44.
45.

Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects.

Fares M, Eladwy RA, Nocentini A, El Hadi SRA, Ghabbour HA, Abdel-Megeed A, Eldehna WM, Abdel-Aziz HA, Supuran CT.

Bioorg Med Chem. 2017 Apr 1;25(7):2210-2217. doi: 10.1016/j.bmc.2017.02.037. Epub 2017 Feb 21.

PMID:
28256371
46.

Risk of metastasis and orbital recurrence in advanced retinoblastoma eyes treated with systemic chemoreduction versus primary enucleation.

Berry JL, Kogachi K, Aziz HA, McGovern K, Zolfaghari E, Murphree AL, Jubran R, Kim JW.

Pediatr Blood Cancer. 2017 Apr;64(4). doi: 10.1002/pbc.26270. Epub 2016 Nov 5.

PMID:
28221729
47.

Extranodal natural killer/T-cell lymphoma presenting as orbital cellulitis.

Zuhaimy H, Aziz HA, Vasudevan S, Hui Hui S.

GMS Ophthalmol Cases. 2017 Feb 6;7:Doc04. doi: 10.3205/oc000055. eCollection 2017.

48.

Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents.

Eldehna WM, Almahli H, Al-Ansary GH, Ghabbour HA, Aly MH, Ismael OE, Al-Dhfyan A, Abdel-Aziz HA.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):600-613. doi: 10.1080/14756366.2017.1279155.

49.

Local Failure After Episcleral Brachytherapy for Posterior Uveal Melanoma: Patterns, Risk Factors, and Management.

Bellerive C, Aziz HA, Bena J, Wilkinson A, Suh JH, Plesec T, Singh AD.

Am J Ophthalmol. 2017 May;177:9-16. doi: 10.1016/j.ajo.2017.01.024. Epub 2017 Feb 3.

PMID:
28163118
50.

Health Informatics Tools to Improve Utilization of Laboratory Tests.

Aziz HA, Alshekhabobakr HM.

Lab Med. 2017 May 1;48(2):e30-e35. doi: 10.1093/labmed/lmw066.

PMID:
28122937

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