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Progress and challenges in lung xenotransplantation: an update.

Burdorf L, Azimzadeh AM, Pierson RN 3rd.

Curr Opin Organ Transplant. 2018 Dec;23(6):621-627. doi: 10.1097/MOT.0000000000000582. Review.


Thromboxane and histamine mediate PVR elevation during xenogeneic pig lung perfusion with human blood.

Burdorf L, Harris D, Dahi S, Laird C, Zhang T, Ali F, Shah A, Thompson M, Braileanu G, Cheng X, Sievert E, Schwartz E, Sendil S, Parsell DM, Redding E, Phelps CJ, Ayares DL, Azimzadeh AM, Pierson RN 3rd.

Xenotransplantation. 2019 Mar;26(2):e12458. doi: 10.1111/xen.12458. Epub 2018 Sep 3.


Vascularized Thymosternal Composite Tissue Allo- and Xenotransplantation in Nonhuman Primates: Initial Experience.

Sendil S, Diaconu SC, O'Neill NA, Burdorf L, Tatarov I, Parsell DM, Azimzadeh AM, Pierson RN 3rd, Nam AJ.

Plast Reconstr Surg Glob Open. 2017 Dec 22;5(12):e1538. doi: 10.1097/GOX.0000000000001538. eCollection 2017 Dec.


Pilot Study of Delayed ICOS/ICOS-L Blockade With αCD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model.

O'Neill NA, Zhang T, Braileanu G, Cheng X, Hershfeld A, Sun W, Reimann KA, Dahi S, Kubicki N, Hassanein W, Laird C, Cimeno A, Azimzadeh AM, Pierson RN.

Transplant Direct. 2018 Feb 2;4(2):e344. doi: 10.1097/TXD.0000000000000761. eCollection 2018 Feb.


Interleukin-8 mediates neutrophil-endothelial interactions in pig-to-human xenogeneic models.

French BM, Sendil S, Sepuru KM, Ranek J, Burdorf L, Harris D, Redding E, Cheng X, Laird CT, Zhao Y, Cerel B, Rajarathnam K, Pierson RN 3rd, Azimzadeh AM.

Xenotransplantation. 2018 Mar;25(2):e12385. doi: 10.1111/xen.12385. Epub 2018 Feb 9.


P- and E-selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage.

Laird CT, Hassanein W, O'Neill NA, French BM, Cheng X, Fogler WE, Magnani JL, Parsell D, Cimeno A, Phelps CJ, Ayares D, Burdorf L, Azimzadeh AM, Pierson RN 3rd.

Xenotransplantation. 2018 Mar;25(2):e12381. doi: 10.1111/xen.12381. Epub 2018 Jan 23.


Selective CD28 Inhibition Modulates Alloimmunity and Cardiac Allograft Vasculopathy in Anti-CD154-Treated Monkeys.

Zhang T, Azimzadeh AM, Sun W, O'Neill NA, Sievert E, Bergbower E, Braileanu G, Burdorf L, Cheng X, Monahan T, Dahi S, Harris DG, Rybak E, Welty E, Kronfli A, Avon C, Pierson RN 3rd.

Transplantation. 2018 Mar;102(3):e90-e100. doi: 10.1097/TP.0000000000002044.


Synthetic liver function is detectable in transgenic porcine livers perfused with human blood.

Cimeno A, French BM, Powell JM, Phelps C, Ayares D, O'Neill NA, Laird CT, Pierson RN 3rd, Azimzadeh AM, Barth RN, LaMattina JC.

Xenotransplantation. 2018 Jan;25(1). doi: 10.1111/xen.12361. Epub 2017 Oct 25.


The role of sialic acids in the immune recognition of xenografts.

French BM, Sendil S, Pierson RN 3rd, Azimzadeh AM.

Xenotransplantation. 2017 Nov;24(6). doi: 10.1111/xen.12345. Epub 2017 Oct 22. Review.


N-glycolylneuraminic acid knockout reduces erythrocyte sequestration and thromboxane elaboration in an ex vivo pig-to-human xenoperfusion model.

Cimeno A, Hassanein W, French BM, Powell JM, Burdorf L, Goloubeva O, Cheng X, Parsell DM, Ramsoondar J, Kuravi K, Vaught T, Uluer MC, Redding E, O'Neill N, Laird C, Hershfeld A, Tatarov I, Thomas K, Ayares D, Azimzadeh AM, Pierson RN 3rd, Barth RN, LaMattina JC.

Xenotransplantation. 2017 Nov;24(6). doi: 10.1111/xen.12339. Epub 2017 Sep 22.


Regulation of Clinical Xenotransplantation-Time for a Reappraisal.

Cooper DKC, Pierson RN 3rd, Hering BJ, Mohiuddin MM, Fishman JA, Denner J, Ahn C, Azimzadeh AM, Buhler LH, Cowan PJ, Hawthorne WJ, Kobayashi T, Sachs DH.

Transplantation. 2017 Aug;101(8):1766-1769. doi: 10.1097/TP.0000000000001683. Review.


Comparative Evaluation of αCD40 (2C10R4) and αCD154 (5C8H1 and IDEC-131) in a Nonhuman Primate Cardiac Allotransplant Model.

OʼNeill NA, Zhang T, Braileanu G, Sun W, Cheng X, Hershfeld A, Laird CT, Kronfli A, Hock LA, Dahi S, Kubicki N, Sievert E, Hassanein W, Cimeno A, Pierson RN 3rd, Azimzadeh AM.

Transplantation. 2017 Sep;101(9):2038-2047. doi: 10.1097/TP.0000000000001836.


Clinical Trypanosoma cruzi Disease after Cardiac Transplantation in a Cynomolgus Macaque (Macaca fascicularis).

Rybak ER, Shipley S, Tatarov I, Zhang T, Sun W, Braileanu G, Burdorf L, Sievert E, Azimzadeh AM, DeTolla LJ, Pierson RN III.

Comp Med. 2016 Dec 1;66(6):494-498.


Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury.

Laird CT, Burdorf L, French BM, Kubicki N, Cheng X, Braileanu G, Sun W, O'Neill NA, Cimeno A, Parsell D, So E, Bähr A, Klymiuk N, Phelps CJ, Ayares D, Azimzadeh AM, Pierson RN.

Xenotransplantation. 2017 Mar;24(2). doi: 10.1111/xen.12294. Epub 2017 Mar 3.


Preemptive CD20+ B cell Depletion Attenuates Cardiac Allograft Vasculopathy in CD154-Treated Monkeys.

Azimzadeh AM, Zhang T, Wu G, Kelishadi SS, Stoddard T, OʼNeill N, Nguyen BN, Welty E, Avon C, Higuchi M, Mitchell SL, Hershfeld A, Cheng XF, Kronfli A, Rybak E, Burdorf L, Pierson RN 3rd.

Transplantation. 2017 Jan;101(1):63-73. doi: 10.1097/TP.0000000000001258.


Platelet sequestration and activation during GalTKO.hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and von Willebrand Factor.

Burdorf L, Riner A, Rybak E, Salles II, De Meyer SF, Shah A, Quinn KJ, Harris D, Zhang T, Parsell D, Ali F, Schwartz E, Kang E, Cheng X, Sievert E, Zhao Y, Braileanu G, Phelps CJ, Ayares DL, Deckmyn H, Pierson RN 3rd, Azimzadeh AM, Dandro A, Karavi K.

Xenotransplantation. 2016 May;23(3):222-236. doi: 10.1111/xen.12236. Epub 2016 May 18. Erratum in: Xenotransplantation. 2016 Sep;23(5):423.


Current status of pig lung xenotransplantation.

Kubicki N, Laird C, Burdorf L, Pierson RN 3rd, Azimzadeh AM.

Int J Surg. 2015 Nov;23(Pt B):247-254. doi: 10.1016/j.ijsu.2015.08.019. Epub 2015 Aug 13. Review.


Update on CD40 and CD154 blockade in transplant models.

Zhang T, Pierson RN 3rd, Azimzadeh AM.

Immunotherapy. 2015;7(8):899-911. doi: 10.2217/IMT.15.54. Epub 2015 Aug 13. Review.


Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein.

Azimzadeh AM, Kelishadi SS, Ezzelarab MB, Singh AK, Stoddard T, Iwase H, Zhang T, Burdorf L, Sievert E, Avon C, Cheng X, Ayares D, Horvath KA, Corcoran PC, Mohiuddin MM, Barth RN, Cooper DK, Pierson RN 3rd.

Xenotransplantation. 2015 Jul-Aug;22(4):310-6. doi: 10.1111/xen.12176. Epub 2015 Jul 14.


Early Microchimerism After Face Transplantation Detected by Quantitative Real-time Polymerase Chain Reaction of Insertion/Deletion Polymorphisms.

Schultz BD, Woodall JD, Brazio PS, Uluer MC, Kukuruga DL, Azimzadeh AM, Bojovic B, Rodriguez ED, Bartlett ST, Barth RN.

Transplantation. 2015 Jul;99(7):e44-5. doi: 10.1097/TP.0000000000000745. No abstract available.


Infused Bone Marrow Fails to Prevent Vascularized Composite Allograft Rejection in Nonhuman Primates.

Brazio PS, Woodall J, Panda A, Brown EN, Ha JS, Azimzadeh AM, Rodriguez ED, Bartlett ST, Bojovic B, Barth RN.

Am J Transplant. 2015 Jul;15(7):2011-2. doi: 10.1111/ajt.13268. Epub 2015 Apr 23. No abstract available.


Four-dimensional characterization of thrombosis in a live-cell, shear-flow assay: development and application to xenotransplantation.

Harris DG, Benipal PK, Cheng X, Burdorf L, Azimzadeh AM, Pierson RN 3rd.

PLoS One. 2015 Apr 1;10(4):e0123015. doi: 10.1371/journal.pone.0123015. eCollection 2015.


Meta-analysis of the independent and cumulative effects of multiple genetic modifications on pig lung xenograft performance during ex vivo perfusion with human blood.

Harris DG, Quinn KJ, French BM, Schwartz E, Kang E, Dahi S, Phelps CJ, Ayares DL, Burdorf L, Azimzadeh AM, Pierson RN 3rd.

Xenotransplantation. 2015 Mar-Apr;22(2):102-11. doi: 10.1111/xen.12149. Epub 2014 Dec 2.


Development of a consensus protocol to quantify primate anti-non-Gal xenoreactive antibodies using pig aortic endothelial cells.

Azimzadeh AM, Byrne GW, Ezzelarab M, Welty E, Braileanu G, Cheng X, Robson SC, McGregor CG, Cooper DK, Pierson RN 3rd.

Xenotransplantation. 2014 Nov-Dec;21(6):555-66. doi: 10.1111/xen.12125. Epub 2014 Sep 1.


Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection.

Byrne GW, Azimzadeh AM, Ezzelarab M, Tazelaar HD, Ekser B, Pierson RN, Robson SC, Cooper DK, McGregor CG.

Xenotransplantation. 2013 Sep-Oct;20(5):292-307. doi: 10.1111/xen.12050. Review.


Lung xenotransplantation: recent progress and current status.

Harris DG, Quinn KJ, Dahi S, Burdorf L, Azimzadeh AM, Pierson RN 3rd.

Xenotransplantation. 2014 Nov-Dec;21(6):496-506. doi: 10.1111/xen.12116. Epub 2014 Jul 5. Review.


Expression of human CD46 modulates inflammation associated with GalTKO lung xenograft injury.

Burdorf L, Stoddard T, Zhang T, Rybak E, Riner A, Avon C, Laaris A, Cheng X, Sievert E, Braileanu G, Newton A, Phelps CJ, Ayares D, Azimzadeh AM, Pierson RN 3rd.

Am J Transplant. 2014 May;14(5):1084-95. doi: 10.1111/ajt.12673. Epub 2014 Apr 2.


Pig-to-baboon liver xenoperfusion utilizing GalTKO.hCD46 pigs and glycoprotein Ib blockade.

LaMattina JC, Burdorf L, Zhang T, Rybak E, Cheng X, Munivenkatappa R, Salles II, Broos K, Sievert E, McCormick B, Decarlo M, Ayares D, Deckmyn H, Azimzadeh AM, Pierson RN 3rd, Barth RN.

Xenotransplantation. 2014 May-Jun;21(3):274-86. doi: 10.1111/xen.12093. Epub 2014 Mar 17.


Transplantation: Negative vaccination to modulate transplant immunity.

Azimzadeh AM, Bromberg JS.

Nat Rev Nephrol. 2013 Oct;9(10):557-9. doi: 10.1038/nrneph.2013.172. Epub 2013 Aug 27. No abstract available.


Clinical lung xenotransplantation--what donor genetic modifications may be necessary?

Cooper DK, Ekser B, Burlak C, Ezzelarab M, Hara H, Paris L, Tector AJ, Phelps C, Azimzadeh AM, Ayares D, Robson SC, Pierson RN 3rd.

Xenotransplantation. 2012 May-Jun;19(3):144-58. doi: 10.1111/j.1399-3089.2012.00708.x. Review.


Implication for transglutaminase 2-mediated activation of β-catenin signaling in neointimal vascular smooth muscle cells in chronic cardiac allograft rejection.

Beazley KE, Zhang T, Lima F, Pozharskaya T, Niger C, Tzitzikov E, Azimzadeh AM, Nurminskaya M.

J Heart Lung Transplant. 2012 Sep;31(9):1009-17. doi: 10.1016/j.healun.2012.04.009. Epub 2012 Jun 12.


Xenogeneic lung transplantation models.

Burdorf L, Azimzadeh AM, Pierson RN 3rd.

Methods Mol Biol. 2012;885:169-89. doi: 10.1007/978-1-61779-845-0_11.


Myeloid derived suppressor cells in transplantation.

Lees JR, Azimzadeh AM, Bromberg JS.

Curr Opin Immunol. 2011 Oct;23(5):692-7. doi: 10.1016/j.coi.2011.07.004. Epub 2011 Jul 28. Review.


Selective CD28 blockade attenuates acute and chronic rejection of murine cardiac allografts in a CTLA-4-dependent manner.

Zhang T, Fresnay S, Welty E, Sangrampurkar N, Rybak E, Zhou H, Cheng XF, Feng Q, Avon C, Laaris A, Whitters M, Nagelin AM, O'Hara RM Jr, Azimzadeh AM.

Am J Transplant. 2011 Aug;11(8):1599-609. doi: 10.1111/j.1600-6143.2011.03624.x. Epub 2011 Jul 12.


Immunobiology of transplantation: impact on targets for large and small molecules.

Azimzadeh AM, Lees JR, Ding Y, Bromberg JS.

Clin Pharmacol Ther. 2011 Aug;90(2):229-42. doi: 10.1038/clpt.2011.106. Review.


Absence of Gal epitope prolongs survival of swine lungs in an ex vivo model of hyperacute rejection.

Nguyen BN, Azimzadeh AM, Schroeder C, Buddensick T, Zhang T, Laaris A, Cochrane M, Schuurman HJ, Sachs DH, Allan JS, Pierson RN 3rd.

Xenotransplantation. 2011 Mar-Apr;18(2):94-107. doi: 10.1111/j.1399-3089.2011.00633.x. Erratum in: Xenotransplantation. 2011 Jul-Aug;18(4):267.


Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation.

Poirier N, Azimzadeh AM, Zhang T, Dilek N, Mary C, Nguyen B, Tillou X, Wu G, Reneaudin K, Hervouet J, Martinet B, Coulon F, Allain-Launay E, Karam G, Soulillou JP, Pierson RN 3rd, Blancho G, Vanhove B.

Sci Transl Med. 2010 Feb 3;2(17):17ra10. doi: 10.1126/scitranslmed.3000116.


Preemptive CD20+ B cell depletion attenuates cardiac allograft vasculopathy in cyclosporine-treated monkeys.

Kelishadi SS, Azimzadeh AM, Zhang T, Stoddard T, Welty E, Avon C, Higuchi M, Laaris A, Cheng XF, McMahon C, Pierson RN 3rd.

J Clin Invest. 2010 Apr;120(4):1275-84. doi: 10.1172/JCI41861. Epub 2010 Mar 24.


Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction.

Duda MK, O'Shea KM, Tintinu A, Xu W, Khairallah RJ, Barrows BR, Chess DJ, Azimzadeh AM, Harris WS, Sharov VG, Sabbah HN, Stanley WC.

Cardiovasc Res. 2009 Feb 1;81(2):319-27. doi: 10.1093/cvr/cvn310. Epub 2008 Nov 17.


The antioxidant tempol attenuates pressure overload-induced cardiac hypertrophy and contractile dysfunction in mice fed a high-fructose diet.

Chess DJ, Xu W, Khairallah R, O'Shea KM, Kop WJ, Azimzadeh AM, Stanley WC.

Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2223-30. doi: 10.1152/ajpheart.00563.2008. Epub 2008 Oct 17.


High-sugar diets increase cardiac dysfunction and mortality in hypertension compared to low-carbohydrate or high-starch diets.

Sharma N, Okere IC, Barrows BR, Lei B, Duda MK, Yuan CL, Previs SF, Sharov VG, Azimzadeh AM, Ernsberger P, Hoit BD, Sabbah H, Stanley WC.

J Hypertens. 2008 Jul;26(7):1402-10. doi: 10.1097/HJH.0b013e3283007dda.


Low-carbohydrate/high-fat diet attenuates pressure overload-induced ventricular remodeling and dysfunction.

Duda MK, O'Shea KM, Lei B, Barrows BR, Azimzadeh AM, McElfresh TE, Hoit BD, Kop WJ, Stanley WC.

J Card Fail. 2008 May;14(4):327-35. doi: 10.1016/j.cardfail.2007.11.003.


Effects of a high saturated fat diet on cardiac hypertrophy and dysfunction in response to pressure overload.

Chess DJ, Lei B, Hoit BD, Azimzadeh AM, Stanley WC.

J Card Fail. 2008 Feb;14(1):82-8. doi: 10.1016/j.cardfail.2007.09.004.


A heterotopic primate model for facial composite tissue transplantation.

Silverman RP, Banks ND, Detolla LJ, Shipley ST, Panda A, Sanchez RA, Azimzadeh AM, Pierson RN 3rd, Wang D, Rodriguez ED, Holton LH 3rd, Bartlett ST.

Ann Plast Surg. 2008 Feb;60(2):209-16. doi: 10.1097/SAP.0b013e318061b792.


CCR5 blockade modulates inflammation and alloimmunity in primates.

Schröder C, Pierson RN 3rd, Nguyen BN, Kawka DW, Peterson LB, Wu G, Zhang T, Springer MS, Siciliano SJ, Iliff S, Ayala JM, Lu M, Mudgett JS, Lyons K, Mills SG, Miller GG, Singer II, Azimzadeh AM, DeMartino JA.

J Immunol. 2007 Aug 15;179(4):2289-99.


Dietary supplementation with omega-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload.

Duda MK, O'Shea KM, Lei B, Barrows BR, Azimzadeh AM, McElfresh TE, Hoit BD, Kop WJ, Stanley WC.

Cardiovasc Res. 2007 Nov 1;76(2):303-10. Epub 2007 Jul 23.


Deleterious effects of sugar and protective effects of starch on cardiac remodeling, contractile dysfunction, and mortality in response to pressure overload.

Chess DJ, Lei B, Hoit BD, Azimzadeh AM, Stanley WC.

Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1853-60. Epub 2007 Jul 6.


Life-supporting function of genetically modified swine lungs in baboons.

Nguyen BN, Azimzadeh AM, Zhang T, Wu G, Schuurman HJ, Sachs DH, Ayares D, Allan JS, Pierson RN 3rd.

J Thorac Cardiovasc Surg. 2007 May;133(5):1354-63. Epub 2007 Apr 2. Erratum in: J Thorac Cardiovasc Surg. 2008 Aug;136(2):542. J Thorac Cardiovasc Surg. 2008 Jan;135(1):28A. Shuurman, Henk-Jan [corrected to Schuurman Henk-Jan].


Coagulation cascade activation triggers early failure of pig hearts expressing human complement regulatory genes.

Wu G, Pfeiffer S, Schröder C, Zhang T, Nguyen BN, Kelishadi S, Atkinson JB, Schuurman HJ, White DJ, Azimzadeh AM, Pierson RN 3rd.

Xenotransplantation. 2007 Jan;14(1):34-47.


Robust gene expression with amplified RNA from biopsy-sized human heart tissue.

Barrows BR, Azimzadeh AM, McCulle SL, Vives-Rodriguez G, Stark WN Jr, Ambulos N, Yin J, Chen H, Balke CW, Moravec CS, Pierson RN 3rd, Gottlieb SS, Bond M, Johnson FL.

J Mol Cell Cardiol. 2007 Jan;42(1):260-4. Epub 2006 Oct 27.


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