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Third WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials, Changsha, Hunan, China December 12-14, 2018: "The 2018 Changsha Communiqué" The 10-Year Anniversary of The International Consultation on Xenotransplantation.

Hawthorne WJ, Cowan PJ, Bühler LH, Yi S, Bottino R, Pierson RN 3rd, Ahn C, Azimzadeh A, Cozzi E, Gianello P, Lakey JRT, Luo M, Miyagawa S, Mohiuddin MM, Park CG, Schuurman HJ, Scobie L, Sykes M, Tector J, Tönjes RR, Wolf E, Nuñez JR, Wang W.

Xenotransplantation. 2019 Mar;26(2):e12513. doi: 10.1111/xen.12513. Epub 2019 Apr 13. No abstract available.


Progress and challenges in lung xenotransplantation: an update.

Burdorf L, Azimzadeh AM, Pierson RN 3rd.

Curr Opin Organ Transplant. 2018 Dec;23(6):621-627. doi: 10.1097/MOT.0000000000000582. Review.


Thromboxane and histamine mediate PVR elevation during xenogeneic pig lung perfusion with human blood.

Burdorf L, Harris D, Dahi S, Laird C, Zhang T, Ali F, Shah A, Thompson M, Braileanu G, Cheng X, Sievert E, Schwartz E, Sendil S, Parsell DM, Redding E, Phelps CJ, Ayares DL, Azimzadeh AM, Pierson RN 3rd.

Xenotransplantation. 2019 Mar;26(2):e12458. doi: 10.1111/xen.12458. Epub 2018 Sep 3.


Vascularized Thymosternal Composite Tissue Allo- and Xenotransplantation in Nonhuman Primates: Initial Experience.

Sendil S, Diaconu SC, O'Neill NA, Burdorf L, Tatarov I, Parsell DM, Azimzadeh AM, Pierson RN 3rd, Nam AJ.

Plast Reconstr Surg Glob Open. 2017 Dec 22;5(12):e1538. doi: 10.1097/GOX.0000000000001538. eCollection 2017 Dec.


Pilot Study of Delayed ICOS/ICOS-L Blockade With αCD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model.

O'Neill NA, Zhang T, Braileanu G, Cheng X, Hershfeld A, Sun W, Reimann KA, Dahi S, Kubicki N, Hassanein W, Laird C, Cimeno A, Azimzadeh AM, Pierson RN.

Transplant Direct. 2018 Feb 2;4(2):e344. doi: 10.1097/TXD.0000000000000761. eCollection 2018 Feb.


Interleukin-8 mediates neutrophil-endothelial interactions in pig-to-human xenogeneic models.

French BM, Sendil S, Sepuru KM, Ranek J, Burdorf L, Harris D, Redding E, Cheng X, Laird CT, Zhao Y, Cerel B, Rajarathnam K, Pierson RN 3rd, Azimzadeh AM.

Xenotransplantation. 2018 Mar;25(2):e12385. doi: 10.1111/xen.12385. Epub 2018 Feb 9.


P- and E-selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage.

Laird CT, Hassanein W, O'Neill NA, French BM, Cheng X, Fogler WE, Magnani JL, Parsell D, Cimeno A, Phelps CJ, Ayares D, Burdorf L, Azimzadeh AM, Pierson RN 3rd.

Xenotransplantation. 2018 Mar;25(2):e12381. doi: 10.1111/xen.12381. Epub 2018 Jan 23.


Selective CD28 Inhibition Modulates Alloimmunity and Cardiac Allograft Vasculopathy in Anti-CD154-Treated Monkeys.

Zhang T, Azimzadeh AM, Sun W, O'Neill NA, Sievert E, Bergbower E, Braileanu G, Burdorf L, Cheng X, Monahan T, Dahi S, Harris DG, Rybak E, Welty E, Kronfli A, Avon C, Pierson RN 3rd.

Transplantation. 2018 Mar;102(3):e90-e100. doi: 10.1097/TP.0000000000002044.


Synthetic liver function is detectable in transgenic porcine livers perfused with human blood.

Cimeno A, French BM, Powell JM, Phelps C, Ayares D, O'Neill NA, Laird CT, Pierson RN 3rd, Azimzadeh AM, Barth RN, LaMattina JC.

Xenotransplantation. 2018 Jan;25(1). doi: 10.1111/xen.12361. Epub 2017 Oct 25.


The role of sialic acids in the immune recognition of xenografts.

French BM, Sendil S, Pierson RN 3rd, Azimzadeh AM.

Xenotransplantation. 2017 Nov;24(6). doi: 10.1111/xen.12345. Epub 2017 Oct 22. Review.


N-glycolylneuraminic acid knockout reduces erythrocyte sequestration and thromboxane elaboration in an ex vivo pig-to-human xenoperfusion model.

Cimeno A, Hassanein W, French BM, Powell JM, Burdorf L, Goloubeva O, Cheng X, Parsell DM, Ramsoondar J, Kuravi K, Vaught T, Uluer MC, Redding E, O'Neill N, Laird C, Hershfeld A, Tatarov I, Thomas K, Ayares D, Azimzadeh AM, Pierson RN 3rd, Barth RN, LaMattina JC.

Xenotransplantation. 2017 Nov;24(6). doi: 10.1111/xen.12339. Epub 2017 Sep 22.


David J. G. White, PhD, FRCPath.

Cozzi E, Pierson RN 3rd, Wallwork J, Cooper DKC, Friend PJ, Azimzadeh A, Buhler L, Cowan P.

Xenotransplantation. 2017 Sep;24(5). doi: 10.1111/xen.12346. No abstract available.


Regulation of Clinical Xenotransplantation-Time for a Reappraisal.

Cooper DKC, Pierson RN 3rd, Hering BJ, Mohiuddin MM, Fishman JA, Denner J, Ahn C, Azimzadeh AM, Buhler LH, Cowan PJ, Hawthorne WJ, Kobayashi T, Sachs DH.

Transplantation. 2017 Aug;101(8):1766-1769. doi: 10.1097/TP.0000000000001683. Review.


Comparative Evaluation of αCD40 (2C10R4) and αCD154 (5C8H1 and IDEC-131) in a Nonhuman Primate Cardiac Allotransplant Model.

OʼNeill NA, Zhang T, Braileanu G, Sun W, Cheng X, Hershfeld A, Laird CT, Kronfli A, Hock LA, Dahi S, Kubicki N, Sievert E, Hassanein W, Cimeno A, Pierson RN 3rd, Azimzadeh AM.

Transplantation. 2017 Sep;101(9):2038-2047. doi: 10.1097/TP.0000000000001836.


Clinical Trypanosoma cruzi Disease after Cardiac Transplantation in a Cynomolgus Macaque (Macaca fascicularis).

Rybak ER, Shipley S, Tatarov I, Zhang T, Sun W, Braileanu G, Burdorf L, Sievert E, Azimzadeh AM, DeTolla LJ, Pierson RN III.

Comp Med. 2016 Dec 1;66(6):494-498.


Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury.

Laird CT, Burdorf L, French BM, Kubicki N, Cheng X, Braileanu G, Sun W, O'Neill NA, Cimeno A, Parsell D, So E, Bähr A, Klymiuk N, Phelps CJ, Ayares D, Azimzadeh AM, Pierson RN.

Xenotransplantation. 2017 Mar;24(2). doi: 10.1111/xen.12294. Epub 2017 Mar 3.


Anterior segment optical coherence tomography changes with introduction and discontinuation of tamsulosin.

Al-Kharashi A, Azimzadeh AA, Leung J, Radomski S, Radomski L, Lam WC.

Saudi J Ophthalmol. 2016 Jul-Sep;30(3):150-156. doi: 10.1016/j.sjopt.2016.07.005. Epub 2016 Jul 30.


Preemptive CD20+ B cell Depletion Attenuates Cardiac Allograft Vasculopathy in CD154-Treated Monkeys.

Azimzadeh AM, Zhang T, Wu G, Kelishadi SS, Stoddard T, OʼNeill N, Nguyen BN, Welty E, Avon C, Higuchi M, Mitchell SL, Hershfeld A, Cheng XF, Kronfli A, Rybak E, Burdorf L, Pierson RN 3rd.

Transplantation. 2017 Jan;101(1):63-73. doi: 10.1097/TP.0000000000001258.


Platelet sequestration and activation during GalTKO.hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and von Willebrand Factor.

Burdorf L, Riner A, Rybak E, Salles II, De Meyer SF, Shah A, Quinn KJ, Harris D, Zhang T, Parsell D, Ali F, Schwartz E, Kang E, Cheng X, Sievert E, Zhao Y, Braileanu G, Phelps CJ, Ayares DL, Deckmyn H, Pierson RN 3rd, Azimzadeh AM, Dandro A, Karavi K.

Xenotransplantation. 2016 May;23(3):222-236. doi: 10.1111/xen.12236. Epub 2016 May 18. Erratum in: Xenotransplantation. 2016 Sep;23(5):423.


Current status of pig lung xenotransplantation.

Kubicki N, Laird C, Burdorf L, Pierson RN 3rd, Azimzadeh AM.

Int J Surg. 2015 Nov;23(Pt B):247-254. doi: 10.1016/j.ijsu.2015.08.019. Epub 2015 Aug 13. Review.


Update on CD40 and CD154 blockade in transplant models.

Zhang T, Pierson RN 3rd, Azimzadeh AM.

Immunotherapy. 2015;7(8):899-911. doi: 10.2217/IMT.15.54. Epub 2015 Aug 13. Review.


Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein.

Azimzadeh AM, Kelishadi SS, Ezzelarab MB, Singh AK, Stoddard T, Iwase H, Zhang T, Burdorf L, Sievert E, Avon C, Cheng X, Ayares D, Horvath KA, Corcoran PC, Mohiuddin MM, Barth RN, Cooper DK, Pierson RN 3rd.

Xenotransplantation. 2015 Jul-Aug;22(4):310-6. doi: 10.1111/xen.12176. Epub 2015 Jul 14.


Early Microchimerism After Face Transplantation Detected by Quantitative Real-time Polymerase Chain Reaction of Insertion/Deletion Polymorphisms.

Schultz BD, Woodall JD, Brazio PS, Uluer MC, Kukuruga DL, Azimzadeh AM, Bojovic B, Rodriguez ED, Bartlett ST, Barth RN.

Transplantation. 2015 Jul;99(7):e44-5. doi: 10.1097/TP.0000000000000745. No abstract available.


Infused Bone Marrow Fails to Prevent Vascularized Composite Allograft Rejection in Nonhuman Primates.

Brazio PS, Woodall J, Panda A, Brown EN, Ha JS, Azimzadeh AM, Rodriguez ED, Bartlett ST, Bojovic B, Barth RN.

Am J Transplant. 2015 Jul;15(7):2011-2. doi: 10.1111/ajt.13268. Epub 2015 Apr 23. No abstract available.


Four-dimensional characterization of thrombosis in a live-cell, shear-flow assay: development and application to xenotransplantation.

Harris DG, Benipal PK, Cheng X, Burdorf L, Azimzadeh AM, Pierson RN 3rd.

PLoS One. 2015 Apr 1;10(4):e0123015. doi: 10.1371/journal.pone.0123015. eCollection 2015.


Meta-analysis of the independent and cumulative effects of multiple genetic modifications on pig lung xenograft performance during ex vivo perfusion with human blood.

Harris DG, Quinn KJ, French BM, Schwartz E, Kang E, Dahi S, Phelps CJ, Ayares DL, Burdorf L, Azimzadeh AM, Pierson RN 3rd.

Xenotransplantation. 2015 Mar-Apr;22(2):102-11. doi: 10.1111/xen.12149. Epub 2014 Dec 2.


Systemic inflammation in xenograft recipients precedes activation of coagulation.

Ezzelarab MB, Ekser B, Azimzadeh A, Lin CC, Zhao Y, Rodriguez R, Echeverri GJ, Iwase H, Long C, Hara H, Ayares D, Pierson RN, Thomson AW, Cooper DK.

Xenotransplantation. 2015 Jan-Feb;22(1):32-47. doi: 10.1111/xen.12133. Epub 2014 Sep 11.


Development of a consensus protocol to quantify primate anti-non-Gal xenoreactive antibodies using pig aortic endothelial cells.

Azimzadeh AM, Byrne GW, Ezzelarab M, Welty E, Braileanu G, Cheng X, Robson SC, McGregor CG, Cooper DK, Pierson RN 3rd.

Xenotransplantation. 2014 Nov-Dec;21(6):555-66. doi: 10.1111/xen.12125. Epub 2014 Sep 1.


Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection.

Byrne GW, Azimzadeh AM, Ezzelarab M, Tazelaar HD, Ekser B, Pierson RN, Robson SC, Cooper DK, McGregor CG.

Xenotransplantation. 2013 Sep-Oct;20(5):292-307. doi: 10.1111/xen.12050. Review.


Lung xenotransplantation: recent progress and current status.

Harris DG, Quinn KJ, Dahi S, Burdorf L, Azimzadeh AM, Pierson RN 3rd.

Xenotransplantation. 2014 Nov-Dec;21(6):496-506. doi: 10.1111/xen.12116. Epub 2014 Jul 5. Review.


Expression of human CD46 modulates inflammation associated with GalTKO lung xenograft injury.

Burdorf L, Stoddard T, Zhang T, Rybak E, Riner A, Avon C, Laaris A, Cheng X, Sievert E, Braileanu G, Newton A, Phelps CJ, Ayares D, Azimzadeh AM, Pierson RN 3rd.

Am J Transplant. 2014 May;14(5):1084-95. doi: 10.1111/ajt.12673. Epub 2014 Apr 2.


Pig-to-baboon liver xenoperfusion utilizing GalTKO.hCD46 pigs and glycoprotein Ib blockade.

LaMattina JC, Burdorf L, Zhang T, Rybak E, Cheng X, Munivenkatappa R, Salles II, Broos K, Sievert E, McCormick B, Decarlo M, Ayares D, Deckmyn H, Azimzadeh AM, Pierson RN 3rd, Barth RN.

Xenotransplantation. 2014 May-Jun;21(3):274-86. doi: 10.1111/xen.12093. Epub 2014 Mar 17.


Transplantation: Negative vaccination to modulate transplant immunity.

Azimzadeh AM, Bromberg JS.

Nat Rev Nephrol. 2013 Oct;9(10):557-9. doi: 10.1038/nrneph.2013.172. Epub 2013 Aug 27. No abstract available.


Reply to "Biologics in organ transplantation".

Vanhove B, Azimzadeh A.

Transpl Int. 2013 Apr;26(4):e25. doi: 10.1111/tri.12009. Epub 2012 Nov 12. No abstract available.


Efficacy of Microwave and Infrared Radiation in the Treatment of the Skin Lesions Caused by Leishmania major in an Animal Model.

Eskandari S, Azimzadeh A, Bahar M, Naraghi ZS, Javadi A, Khamesipour A, Mohamadi AM.

Iran J Public Health. 2012;41(8):80-3. Epub 2012 Aug 31.


Changing indications and surgical techniques for corneal transplantation between 2004 and 2009 at a tertiary referral center.

Zare M, Javadi MA, Einollahi B, Karimian F, Rafie AR, Feizi S, Azimzadeh A.

Middle East Afr J Ophthalmol. 2012 Jul-Sep;19(3):323-9. doi: 10.4103/0974-9233.97941.


Clinical lung xenotransplantation--what donor genetic modifications may be necessary?

Cooper DK, Ekser B, Burlak C, Ezzelarab M, Hara H, Paris L, Tector AJ, Phelps C, Azimzadeh AM, Ayares D, Robson SC, Pierson RN 3rd.

Xenotransplantation. 2012 May-Jun;19(3):144-58. doi: 10.1111/j.1399-3089.2012.00708.x. Review.


Implication for transglutaminase 2-mediated activation of β-catenin signaling in neointimal vascular smooth muscle cells in chronic cardiac allograft rejection.

Beazley KE, Zhang T, Lima F, Pozharskaya T, Niger C, Tzitzikov E, Azimzadeh AM, Nurminskaya M.

J Heart Lung Transplant. 2012 Sep;31(9):1009-17. doi: 10.1016/j.healun.2012.04.009. Epub 2012 Jun 12.


Effect of photorefractive keratectomy with mitomycin-C on corneal biomechanical features.

Zare M, Feizi S, Azimzadeh A, Esfandiari H.

Curr Eye Res. 2012 Jun;37(6):457-62. doi: 10.3109/02713683.2012.660594.


Xenogeneic lung transplantation models.

Burdorf L, Azimzadeh AM, Pierson RN 3rd.

Methods Mol Biol. 2012;885:169-89. doi: 10.1007/978-1-61779-845-0_11.


Alternative immunomodulatory strategies for xenotransplantation: CD40/154 pathway-sparing regimens promote xenograft survival.

Thompson P, Badell IR, Lowe M, Turner A, Cano J, Avila J, Azimzadeh A, Cheng X, Pierson RN 3rd, Johnson B, Robertson J, Song M, Leopardi F, Strobert E, Korbutt G, Rayat G, Rajotte R, Larsen CP, Kirk AD.

Am J Transplant. 2012 Jul;12(7):1765-75. doi: 10.1111/j.1600-6143.2012.04031.x. Epub 2012 Mar 28.


B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months.

Mohiuddin MM, Corcoran PC, Singh AK, Azimzadeh A, Hoyt RF Jr, Thomas ML, Eckhaus MA, Seavey C, Ayares D, Pierson RN 3rd, Horvath KA.

Am J Transplant. 2012 Mar;12(3):763-71. doi: 10.1111/j.1600-6143.2011.03846.x. Epub 2011 Nov 9.


Myeloid derived suppressor cells in transplantation.

Lees JR, Azimzadeh AM, Bromberg JS.

Curr Opin Immunol. 2011 Oct;23(5):692-7. doi: 10.1016/j.coi.2011.07.004. Epub 2011 Jul 28. Review.


Selective CD28 blockade attenuates acute and chronic rejection of murine cardiac allografts in a CTLA-4-dependent manner.

Zhang T, Fresnay S, Welty E, Sangrampurkar N, Rybak E, Zhou H, Cheng XF, Feng Q, Avon C, Laaris A, Whitters M, Nagelin AM, O'Hara RM Jr, Azimzadeh AM.

Am J Transplant. 2011 Aug;11(8):1599-609. doi: 10.1111/j.1600-6143.2011.03624.x. Epub 2011 Jul 12.


Immunobiology of transplantation: impact on targets for large and small molecules.

Azimzadeh AM, Lees JR, Ding Y, Bromberg JS.

Clin Pharmacol Ther. 2011 Aug;90(2):229-42. doi: 10.1038/clpt.2011.106. Review.


Absence of Gal epitope prolongs survival of swine lungs in an ex vivo model of hyperacute rejection.

Nguyen BN, Azimzadeh AM, Schroeder C, Buddensick T, Zhang T, Laaris A, Cochrane M, Schuurman HJ, Sachs DH, Allan JS, Pierson RN 3rd.

Xenotransplantation. 2011 Mar-Apr;18(2):94-107. doi: 10.1111/j.1399-3089.2011.00633.x. Erratum in: Xenotransplantation. 2011 Jul-Aug;18(4):267.


Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis.

Soheilian M, Ramezani A, Azimzadeh A, Sadoughi MM, Dehghan MH, Shahghadami R, Yaseri M, Peyman GA.

Ophthalmology. 2011 Jan;118(1):134-41. doi: 10.1016/j.ophtha.2010.04.020. Epub 2010 Aug 12.


Transplantation tolerance: one --- step towards the holy grail.

Scott DW, Azimzadeh A.

Clin Immunol. 2010 Aug;136(2):161. No abstract available.


Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation.

Poirier N, Azimzadeh AM, Zhang T, Dilek N, Mary C, Nguyen B, Tillou X, Wu G, Reneaudin K, Hervouet J, Martinet B, Coulon F, Allain-Launay E, Karam G, Soulillou JP, Pierson RN 3rd, Blancho G, Vanhove B.

Sci Transl Med. 2010 Feb 3;2(17):17ra10. doi: 10.1126/scitranslmed.3000116.


Preemptive CD20+ B cell depletion attenuates cardiac allograft vasculopathy in cyclosporine-treated monkeys.

Kelishadi SS, Azimzadeh AM, Zhang T, Stoddard T, Welty E, Avon C, Higuchi M, Laaris A, Cheng XF, McMahon C, Pierson RN 3rd.

J Clin Invest. 2010 Apr;120(4):1275-84. doi: 10.1172/JCI41861. Epub 2010 Mar 24.

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