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Items: 1 to 50 of 88

1.

CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments.

Girão H, Okada N, Rodrigues TA, Silva AO, Figueiredo AC, Garcia Z, Moutinho-Santos T, Hayashi I, Azevedo JE, Macedo-Ribeiro S, Maiato H.

J Cell Biol. 2020 Feb 3;219(2). pii: e201905080. doi: 10.1083/jcb.201905080.

PMID:
31757788
2.

A Mechanistic Perspective on PEX1 and PEX6, Two AAA+ Proteins of the Peroxisomal Protein Import Machinery.

Pedrosa AG, Francisco T, Ferreira MJ, Rodrigues TA, Barros-Barbosa A, Azevedo JE.

Int J Mol Sci. 2019 Oct 23;20(21). pii: E5246. doi: 10.3390/ijms20215246. Review.

3.

The intrinsically disordered nature of the peroxisomal protein translocation machinery.

Barros-Barbosa A, Rodrigues TA, Ferreira MJ, Pedrosa AG, Teixeira NR, Francisco T, Azevedo JE.

FEBS J. 2019 Jan;286(1):24-38. doi: 10.1111/febs.14704. Epub 2018 Dec 1. Review.

4.

Membrane topologies of PEX13 and PEX14 provide new insights on the mechanism of protein import into peroxisomes.

Barros-Barbosa A, Ferreira MJ, Rodrigues TA, Pedrosa AG, Grou CP, Pinto MP, Fransen M, Francisco T, Azevedo JE.

FEBS J. 2019 Jan;286(1):205-222. doi: 10.1111/febs.14697. Epub 2018 Nov 28.

5.

Chemically monoubiquitinated PEX5 binds to the components of the peroxisomal docking and export machinery.

Hagmann V, Sommer S, Fabian P, Bierlmeier J, van Treel N, Mootz HD, Schwarzer D, Azevedo JE, Dodt G.

Sci Rep. 2018 Oct 30;8(1):16014. doi: 10.1038/s41598-018-34200-5.

6.

Arabidopsis thaliana SPF1 and SPF2 are nuclear-located ULP2-like SUMO proteases that act downstream of SIZ1 in plant development.

Castro PH, Santos MÂ, Freitas S, Cana-Quijada P, Lourenço T, Rodrigues MAA, Fonseca F, Ruiz-Albert J, Azevedo JE, Tavares RM, Castillo AG, Bejarano ER, Azevedo H.

J Exp Bot. 2018 Aug 31;69(19):4633-4649. doi: 10.1093/jxb/ery265.

7.

Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol.

Pedrosa AG, Francisco T, Bicho D, Dias AF, Barros-Barbosa A, Hagmann V, Dodt G, Rodrigues TA, Azevedo JE.

J Biol Chem. 2018 Jul 20;293(29):11553-11563. doi: 10.1074/jbc.RA118.003669. Epub 2018 Jun 8.

8.

PEX13 Enters the RING, Lives Fast, Dies Young.

Rodrigues TA, Francisco T, Azevedo JE.

J Mol Biol. 2018 May 25;430(11):1559-1561. doi: 10.1016/j.jmb.2018.04.005. Epub 2018 Apr 12. No abstract available.

PMID:
29655985
9.

Protein transport into peroxisomes: Knowns and unknowns.

Francisco T, Rodrigues TA, Dias AF, Barros-Barbosa A, Bicho D, Azevedo JE.

Bioessays. 2017 Oct;39(10). doi: 10.1002/bies.201700047. Epub 2017 Aug 8. Review.

PMID:
28787099
10.

The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo.

Dias AF, Rodrigues TA, Pedrosa AG, Barros-Barbosa A, Francisco T, Azevedo JE.

J Biol Chem. 2017 Sep 15;292(37):15287-15300. doi: 10.1074/jbc.M117.805044. Epub 2017 Aug 1.

11.

Determining the Topology of Peroxisomal Proteins Using Protease Protection Assays.

Francisco T, Dias AF, Pedrosa AG, Grou CP, Rodrigues TA, Azevedo JE.

Methods Mol Biol. 2017;1595:27-35. doi: 10.1007/978-1-4939-6937-1_3.

PMID:
28409448
12.

A cell-free organelle-based in vitro system for studying the peroxisomal protein import machinery.

Rodrigues TA, Francisco T, Dias AF, Pedrosa AG, Grou CP, Azevedo JE.

Nat Protoc. 2016 Dec;11(12):2454-2469. doi: 10.1038/nprot.2016.147. Epub 2016 Nov 10.

PMID:
27831570
13.

Evaluation of the activity and substrate specificity of the human SENP family of SUMO proteases.

Mendes AV, Grou CP, Azevedo JE, Pinto MP.

Biochim Biophys Acta. 2016 Jan;1863(1):139-47. doi: 10.1016/j.bbamcr.2015.10.020. Epub 2015 Oct 30.

14.

The first minutes in the life of a peroxisomal matrix protein.

Dias AF, Francisco T, Rodrigues TA, Grou CP, Azevedo JE.

Biochim Biophys Acta. 2016 May;1863(5):814-20. doi: 10.1016/j.bbamcr.2015.09.025. Epub 2015 Sep 25. Review.

15.

The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors.

Grou CP, Pinto MP, Mendes AV, Domingues P, Azevedo JE.

Sci Rep. 2015 Aug 3;5:12836. doi: 10.1038/srep12836.

16.

Revisiting the intraperoxisomal pathway of mammalian PEX7.

Rodrigues TA, Grou CP, Azevedo JE.

Sci Rep. 2015 Jul 3;5:11806. doi: 10.1038/srep11806.

17.

Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts.

Nordgren M, Francisco T, Lismont C, Hennebel L, Brees C, Wang B, Van Veldhoven PP, Azevedo JE, Fransen M.

Autophagy. 2015;11(8):1326-40. doi: 10.1080/15548627.2015.1061846.

18.

The peroxisomal protein import machinery displays a preference for monomeric substrates.

Freitas MO, Francisco T, Rodrigues TA, Lismont C, Domingues P, Pinto MP, Grou CP, Fransen M, Azevedo JE.

Open Biol. 2015 Apr;5(4):140236. doi: 10.1098/rsob.140236.

19.

Intracellular trafficking of AIP56, an NF-κB-cleaving toxin from Photobacterium damselae subsp. piscicida.

Pereira LM, Pinto RD, Silva DS, Moreira AR, Beitzinger C, Oliveira P, Sampaio P, Benz R, Azevedo JE, dos Santos NM, do Vale A.

Infect Immun. 2014 Dec;82(12):5270-85. doi: 10.1128/IAI.02623-14. Epub 2014 Oct 6.

20.

A PEX7-centered perspective on the peroxisomal targeting signal type 2-mediated protein import pathway.

Rodrigues TA, Alencastre IS, Francisco T, Brites P, Fransen M, Grou CP, Azevedo JE.

Mol Cell Biol. 2014 Aug;34(15):2917-28. doi: 10.1128/MCB.01727-13. Epub 2014 May 27.

21.

PEX5, the shuttling import receptor for peroxisomal matrix proteins, is a redox-sensitive protein.

Apanasets O, Grou CP, Van Veldhoven PP, Brees C, Wang B, Nordgren M, Dodt G, Azevedo JE, Fransen M.

Traffic. 2014 Jan;15(1):94-103. doi: 10.1111/tra.12129. Epub 2013 Oct 31.

22.

A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway.

Francisco T, Rodrigues TA, Freitas MO, Grou CP, Carvalho AF, Sá-Miranda C, Pinto MP, Azevedo JE.

J Biol Chem. 2013 Oct 4;288(40):29151-9. doi: 10.1074/jbc.M113.487140. Epub 2013 Aug 20.

23.

Ubiquitin in the peroxisomal protein import pathway.

Francisco T, Rodrigues TA, Pinto MP, Carvalho AF, Azevedo JE, Grou CP.

Biochimie. 2014 Mar;98:29-35. doi: 10.1016/j.biochi.2013.08.003. Epub 2013 Aug 14. Review.

PMID:
23954799
24.

The apoptogenic toxin AIP56 is a metalloprotease A-B toxin that cleaves NF-κb P65.

Silva DS, Pereira LM, Moreira AR, Ferreira-da-Silva F, Brito RM, Faria TQ, Zornetta I, Montecucco C, Oliveira P, Azevedo JE, Pereira PJ, Macedo-Ribeiro S, do Vale A, dos Santos NM.

PLoS Pathog. 2013 Feb;9(2):e1003128. doi: 10.1371/journal.ppat.1003128. Epub 2013 Feb 28.

25.

Caspase-1 and IL-1β processing in a teleost fish.

Reis MI, do Vale A, Pereira PJ, Azevedo JE, Dos Santos NM.

PLoS One. 2012;7(11):e50450. doi: 10.1371/journal.pone.0050450. Epub 2012 Nov 30.

26.

Heat shock induces a massive but differential inactivation of SUMO-specific proteases.

Pinto MP, Carvalho AF, Grou CP, Rodríguez-Borges JE, Sá-Miranda C, Azevedo JE.

Biochim Biophys Acta. 2012 Oct;1823(10):1958-66. doi: 10.1016/j.bbamcr.2012.07.010. Epub 2012 Jul 31.

27.

Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate.

Grou CP, Francisco T, Rodrigues TA, Freitas MO, Pinto MP, Carvalho AF, Domingues P, Wood SA, Rodríguez-Borges JE, Sá-Miranda C, Fransen M, Azevedo JE.

J Biol Chem. 2012 Apr 13;287(16):12815-27. doi: 10.1074/jbc.M112.340158. Epub 2012 Feb 27.

28.

High-yield expression in Escherichia coli and purification of mouse ubiquitin-activating enzyme E1.

Carvalho AF, Pinto MP, Grou CP, Vitorino R, Domingues P, Yamao F, Sá-Miranda C, Azevedo JE.

Mol Biotechnol. 2012 Jul;51(3):254-61. doi: 10.1007/s12033-011-9463-x.

PMID:
22012022
29.

PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14.

Freitas MO, Francisco T, Rodrigues TA, Alencastre IS, Pinto MP, Grou CP, Carvalho AF, Fransen M, Sá-Miranda C, Azevedo JE.

J Biol Chem. 2011 Nov 25;286(47):40509-19. doi: 10.1074/jbc.M111.287201. Epub 2011 Oct 5.

30.

The cytosolic domain of PEX3, a protein involved in the biogenesis of peroxisomes, binds membrane lipids.

Pinto MP, Grou CP, Fransen M, Sá-Miranda C, Azevedo JE.

Biochim Biophys Acta. 2009 Nov;1793(11):1669-75. doi: 10.1016/j.bbamcr.2009.08.007. Epub 2009 Aug 26.

31.

Mapping the cargo protein membrane translocation step into the PEX5 cycling pathway.

Alencastre IS, Rodrigues TA, Grou CP, Fransen M, Sá-Miranda C, Azevedo JE.

J Biol Chem. 2009 Oct 2;284(40):27243-51. doi: 10.1074/jbc.M109.032565. Epub 2009 Jul 23.

32.

Properties of the ubiquitin-pex5p thiol ester conjugate.

Grou CP, Carvalho AF, Pinto MP, Huybrechts SJ, Sá-Miranda C, Fransen M, Azevedo JE.

J Biol Chem. 2009 Apr 17;284(16):10504-13. doi: 10.1074/jbc.M808978200. Epub 2009 Feb 10.

33.

The peroxisomal protein import machinery--a case report of transient ubiquitination with a new flavor.

Grou CP, Carvalho AF, Pinto MP, Alencastre IS, Rodrigues TA, Freitas MO, Francisco T, Sá-Miranda C, Azevedo JE.

Cell Mol Life Sci. 2009 Jan;66(2):254-62. doi: 10.1007/s00018-008-8415-5. Review.

PMID:
18810320
34.

A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome.

Balreira A, Gaspar P, Caiola D, Chaves J, Beirão I, Lima JL, Azevedo JE, Miranda MC.

Hum Mol Genet. 2008 Jul 15;17(14):2238-43. doi: 10.1093/hmg/ddn124. Epub 2008 Apr 17.

PMID:
18424452
35.

Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor.

Grou CP, Carvalho AF, Pinto MP, Wiese S, Piechura H, Meyer HE, Warscheid B, Sá-Miranda C, Azevedo JE.

J Biol Chem. 2008 May 23;283(21):14190-7. doi: 10.1074/jbc.M800402200. Epub 2008 Mar 22.

36.

Proteomics characterization of mouse kidney peroxisomes by tandem mass spectrometry and protein correlation profiling.

Wiese S, Gronemeyer T, Ofman R, Kunze M, Grou CP, Almeida JA, Eisenacher M, Stephan C, Hayen H, Schollenberger L, Korosec T, Waterham HR, Schliebs W, Erdmann R, Berger J, Meyer HE, Just W, Azevedo JE, Wanders RJ, Warscheid B.

Mol Cell Proteomics. 2007 Dec;6(12):2045-57. Epub 2007 Sep 2.

37.

Ubiquitination of mammalian Pex5p, the peroxisomal import receptor.

Carvalho AF, Pinto MP, Grou CP, Alencastre IS, Fransen M, Sá-Miranda C, Azevedo JE.

J Biol Chem. 2007 Oct 26;282(43):31267-72. Epub 2007 Aug 28.

38.

Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation.

de Almeida SF, Picarote G, Fleming JV, Carmo-Fonseca M, Azevedo JE, de Sousa M.

J Biol Chem. 2007 Sep 21;282(38):27905-12. Epub 2007 Jul 11.

39.

Functional characterization of two missense mutations in Pex5p - C11S and N526K.

Carvalho AF, Grou CP, Pinto MP, Alencastre IS, Costa-Rodrigues J, Fransen M, Sá-Miranda C, Azevedo JE.

Biochim Biophys Acta. 2007 Jul;1773(7):1141-8. Epub 2007 Apr 29.

40.

Stimulation of an unfolded protein response impairs MHC class I expression.

de Almeida SF, Fleming JV, Azevedo JE, Carmo-Fonseca M, de Sousa M.

J Immunol. 2007 Mar 15;178(6):3612-9.

41.

Pex14p, more than just a docking protein.

Azevedo JE, Schliebs W.

Biochim Biophys Acta. 2006 Dec;1763(12):1574-84. Epub 2006 Sep 14. Review.

42.

The import competence of a peroxisomal membrane protein is determined by Pex19p before the docking step.

Pinto MP, Grou CP, Alencastre IS, Oliveira ME, Sá-Miranda C, Fransen M, Azevedo JE.

J Biol Chem. 2006 Nov 10;281(45):34492-502. Epub 2006 Sep 15.

43.

The N-terminal half of the peroxisomal cycling receptor Pex5p is a natively unfolded domain.

Carvalho AF, Costa-Rodrigues J, Correia I, Costa Pessoa J, Faria TQ, Martins CL, Fransen M, Sá-Miranda C, Azevedo JE.

J Mol Biol. 2006 Mar 3;356(4):864-75. Epub 2005 Dec 19.

PMID:
16403517
44.

AIP56, a novel plasmid-encoded virulence factor of Photobacterium damselae subsp. piscicida with apoptogenic activity against sea bass macrophages and neutrophils.

do Vale A, Silva MT, dos Santos NM, Nascimento DS, Reis-Rodrigues P, Costa-Ramos C, Ellis AE, Azevedo JE.

Mol Microbiol. 2005 Nov;58(4):1025-38.

45.

Pex5p, the peroxisomal cycling receptor, is a monomeric non-globular protein.

Costa-Rodrigues J, Carvalho AF, Fransen M, Hambruch E, Schliebs W, Sá-Miranda C, Azevedo JE.

J Biol Chem. 2005 Jul 1;280(26):24404-11. Epub 2005 May 2.

46.

HFE cross-talks with the MHC class I antigen presentation pathway.

de Almeida SF, Carvalho IF, Cardoso CS, Cordeiro JV, Azevedo JE, Neefjes J, de Sousa M.

Blood. 2005 Aug 1;106(3):971-7. Epub 2005 Apr 19.

PMID:
15840699
47.

Probing substrate-induced conformational alterations in adrenoleukodystrophy protein by proteolysis.

Guimarães CP, Sá-Miranda C, Azevedo JE.

J Hum Genet. 2005;50(2):99-105. Epub 2005 Jan 29.

PMID:
15682271
48.

Protein translocation across the peroxisomal membrane.

Azevedo JE, Costa-Rodrigues J, Guimarães CP, Oliveira ME, Sã-Miranda C.

Cell Biochem Biophys. 2004;41(3):451-68. Review.

PMID:
15509892
49.

The N terminus of the peroxisomal cycling receptor, Pex5p, is required for redirecting the peroxisome-associated peroxin back to the cytosol.

Costa-Rodrigues J, Carvalho AF, Gouveia AM, Fransen M, Sá-Miranda C, Azevedo JE.

J Biol Chem. 2004 Nov 5;279(45):46573-9. Epub 2004 Aug 24.

50.

Mouse liver PMP70 and ALDP: homomeric interactions prevail in vivo.

Guimarães CP, Domingues P, Aubourg P, Fouquet F, Pujol A, Jimenez-Sanchez G, Sá-Miranda C, Azevedo JE.

Biochim Biophys Acta. 2004 Aug 4;1689(3):235-43.

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