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Items: 34

1.

Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms.

Hansen J, Galatioto J, Caescu CI, Arnaud P, Calizo RC, Spronck B, Murtada SI, Borkar R, Weinberg A, Azeloglu EU, Bintanel-Morcillo M, Gallo JM, Humphrey JD, Jondeau G, Boileau C, Ramirez F, Iyengar R.

JCI Insight. 2019 Jun 6;4(11). pii: 127652. doi: 10.1172/jci.insight.127652. eCollection 2019 Jun 6.

2.

Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity.

Calizo RC, Bhattacharya S, van Hasselt JGC, Wei C, Wong JS, Wiener RJ, Ge X, Wong NJ, Lee JJ, Cuttitta CM, Jayaraman G, Au VH, Janssen W, Liu T, Li H, Salem F, Jaimes EA, Murphy B, Campbell KN, Azeloglu EU.

Nat Commun. 2019 May 3;10(1):2061. doi: 10.1038/s41467-019-09936-x.

3.

Validating Antibodies for Quantitative Western Blot Measurements with Microwestern Array.

Koch RJ, Barrette AM, Stern AD, Hu B, Bouhaddou M, Azeloglu EU, Iyengar R, Birtwistle MR.

Sci Rep. 2018 Jul 27;8(1):11329. doi: 10.1038/s41598-018-29436-0.

4.

Dehomogenized Elastic Properties of Heterogeneous Layered Materials in AFM Indentation Experiments.

Lee JJ, Rao S, Kaushik G, Azeloglu EU, Costa KD.

Biophys J. 2018 Jun 5;114(11):2717-2731. doi: 10.1016/j.bpj.2018.04.036.

5.

Protein S Protects against Podocyte Injury in Diabetic Nephropathy.

Zhong F, Chen H, Xie Y, Azeloglu EU, Wei C, Zhang W, Li Z, Chuang PY, Jim B, Li H, Elmastour F, Riyad JM, Weber T, Chen H, Wang Y, Zhang A, Jia W, Lee K, He JC.

J Am Soc Nephrol. 2018 May;29(5):1397-1410. doi: 10.1681/ASN.2017030234. Epub 2018 Mar 6.

6.

Cell shape information is transduced through tension-independent mechanisms.

Ron A, Azeloglu EU, Calizo RC, Hu M, Bhattacharya S, Chen Y, Jayaraman G, Lee S, Neves-Zaph SR, Li H, Gordon RE, He JC, Hone JC, Iyengar R.

Nat Commun. 2017 Dec 15;8(1):2145. doi: 10.1038/s41467-017-02218-4.

7.

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.

Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, Lachmann A, Kuleshov MV, Ma'ayan A, Stathias V, Terryn R, Cooper D, Forlin M, Koleti A, Vidovic D, Chung C, Schürer SC, Vasiliauskas J, Pilarczyk M, Shamsaei B, Fazel M, Ren Y, Niu W, Clark NA, White S, Mahi N, Zhang L, Kouril M, Reichard JF, Sivaganesan S, Medvedovic M, Meller J, Koch RJ, Birtwistle MR, Iyengar R, Sobie EA, Azeloglu EU, Kaye J, Osterloh J, Haston K, Kalra J, Finkbiener S, Li J, Milani P, Adam M, Escalante-Chong R, Sachs K, Lenail A, Ramamoorthy D, Fraenkel E, Daigle G, Hussain U, Coye A, Rothstein J, Sareen D, Ornelas L, Banuelos M, Mandefro B, Ho R, Svendsen CN, Lim RG, Stocksdale J, Casale MS, Thompson TG, Wu J, Thompson LM, Dardov V, Venkatraman V, Matlock A, Van Eyk JE, Jaffe JD, Papanastasiou M, Subramanian A, Golub TR, Erickson SD, Fallahi-Sichani M, Hafner M, Gray NS, Lin JR, Mills CE, Muhlich JL, Niepel M, Shamu CE, Williams EH, Wrobel D, Sorger PK, Heiser LM, Gray JW, Korkola JE, Mills GB, LaBarge M, Feiler HS, Dane MA, Bucher E, Nederlof M, Sudar D, Gross S, Kilburn DF, Smith R, Devlin K, Margolis R, Derr L, Lee A, Pillai A.

Cell Syst. 2018 Jan 24;6(1):13-24. doi: 10.1016/j.cels.2017.11.001. Epub 2017 Nov 29. Review.

8.

A Comparison of mRNA Sequencing with Random Primed and 3'-Directed Libraries.

Xiong Y, Soumillon M, Wu J, Hansen J, Hu B, van Hasselt JGC, Jayaraman G, Lim R, Bouhaddou M, Ornelas L, Bochicchio J, Lenaeus L, Stocksdale J, Shim J, Gomez E, Sareen D, Svendsen C, Thompson LM, Mahajan M, Iyengar R, Sobie EA, Azeloglu EU, Birtwistle MR.

Sci Rep. 2017 Nov 7;7(1):14626. doi: 10.1038/s41598-017-14892-x.

9.

The Hippo pathway regulator KIBRA promotes podocyte injury by inhibiting YAP signaling and disrupting actin cytoskeletal dynamics.

Meliambro K, Wong JS, Ray J, Calizo RC, Towne S, Cole B, El Salem F, Gordon RE, Kaufman L, He JC, Azeloglu EU, Campbell KN.

J Biol Chem. 2017 Dec 22;292(51):21137-21148. doi: 10.1074/jbc.M117.819029. Epub 2017 Oct 5.

10.

Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability.

Falkenberg CV, Azeloglu EU, Stothers M, Deerinck TJ, Chen Y, He JC, Ellisman MH, Hone JC, Iyengar R, Loew LM.

PLoS Comput Biol. 2017 Mar 16;13(3):e1005433. doi: 10.1371/journal.pcbi.1005433. eCollection 2017 Mar.

11.

A biomimetic gelatin-based platform elicits a pro-differentiation effect on podocytes through mechanotransduction.

Hu M, Azeloglu EU, Ron A, Tran-Ba KH, Calizo RC, Tavassoly I, Bhattacharya S, Jayaraman G, Chen Y, Rabinovich V, Iyengar R, Hone JC, He JC, Kaufman LJ.

Sci Rep. 2017 Mar 6;7:43934. doi: 10.1038/srep43934.

12.

Novel mutations in the inverted formin 2 gene of Chinese families contribute to focal segmental glomerulosclerosis.

Xie J, Hao X, Azeloglu EU, Ren H, Wang Z, Ma J, Liu J, Ma X, Wang W, Pan X, Zhang W, Zhong F, Li Y, Meng G, Kiryluk K, He JC, Gharavi AG, Chen N.

Kidney Int. 2015 Sep;88(3):593-604. doi: 10.1038/ki.2015.106. Epub 2015 Jun 3.

PMID:
26039629
13.

Good practices for building dynamical models in systems biology.

Azeloglu EU, Iyengar R.

Sci Signal. 2015 Apr 7;8(371):fs8. doi: 10.1126/scisignal.aab0880. Review.

PMID:
25852187
14.

Signaling networks: information flow, computation, and decision making.

Azeloglu EU, Iyengar R.

Cold Spring Harb Perspect Biol. 2015 Apr 1;7(4):a005934. doi: 10.1101/cshperspect.a005934. Review.

15.

Interconnected network motifs control podocyte morphology and kidney function.

Azeloglu EU, Hardy SV, Eungdamrong NJ, Chen Y, Jayaraman G, Chuang PY, Fang W, Xiong H, Neves SR, Jain MR, Li H, Ma'ayan A, Gordon RE, He JC, Iyengar R.

Sci Signal. 2014 Feb 4;7(311):ra12. doi: 10.1126/scisignal.2004621.

16.

Small molecule-mediated directed differentiation of human embryonic stem cells toward ventricular cardiomyocytes.

Karakikes I, Senyei GD, Hansen J, Kong CW, Azeloglu EU, Stillitano F, Lieu DK, Wang J, Ren L, Hulot JS, Iyengar R, Li RA, Hajjar RJ.

Stem Cells Transl Med. 2014 Jan;3(1):18-31. doi: 10.5966/sctm.2013-0110. Epub 2013 Dec 9.

17.

Systems pharmacology of adverse event mitigation by drug combinations.

Zhao S, Nishimura T, Chen Y, Azeloglu EU, Gottesman O, Giannarelli C, Zafar MU, Benard L, Badimon JJ, Hajjar RJ, Goldfarb J, Iyengar R.

Sci Transl Med. 2013 Oct 9;5(206):206ra140. doi: 10.1126/scitranslmed.3006548.

18.

Decoding information in cell shape.

Rangamani P, Lipshtat A, Azeloglu EU, Calizo RC, Hu M, Ghassemi S, Hone J, Scarlata S, Neves SR, Iyengar R.

Cell. 2013 Sep 12;154(6):1356-69. doi: 10.1016/j.cell.2013.08.026.

19.

The guidance of stem cell differentiation by substrate alignment and mechanical stimulation.

Subramony SD, Dargis BR, Castillo M, Azeloglu EU, Tracey MS, Su A, Lu HH.

Biomaterials. 2013 Mar;34(8):1942-53. doi: 10.1016/j.biomaterials.2012.11.012. Epub 2012 Dec 13.

20.

Atomic force microscopy in mechanobiology: measuring microelastic heterogeneity of living cells.

Azeloglu EU, Costa KD.

Methods Mol Biol. 2011;736:303-29. doi: 10.1007/978-1-61779-105-5_19. Review.

PMID:
21660735
21.

Cross-bridge cycling gives rise to spatiotemporal heterogeneity of dynamic subcellular mechanics in cardiac myocytes probed with atomic force microscopy.

Azeloglu EU, Costa KD.

Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H853-60. doi: 10.1152/ajpheart.00427.2009. Epub 2009 Dec 18.

22.

Dynamic AFM elastography reveals phase dependent mechanical heterogeneity of beating cardiac myocytes.

Azeloglu EU, Costa KD.

Conf Proc IEEE Eng Med Biol Soc. 2009;2009:7180-3. doi: 10.1109/IEMBS.2009.5335316.

PMID:
19965272
23.

Developing a hybrid computational model of AFM indentation for analysis of mechanically heterogeneous samples.

Azeloglu EU, Kaushik G, Costa KD.

Conf Proc IEEE Eng Med Biol Soc. 2009;2009:4273-6. doi: 10.1109/IEMBS.2009.5334043.

PMID:
19964629
24.

Continuum modeling of biological tissue growth by cell division, and alteration of intracellular osmolytes and extracellular fixed charge density.

Ateshian GA, Costa KD, Azeloglu EU, Morrison B 3rd, Hung CT.

J Biomech Eng. 2009 Oct;131(10):101001. doi: 10.1115/1.3192138.

25.

Microscale control of stiffness in a cell-adhesive substrate using microfluidics-based lithography.

Cheung YK, Azeloglu EU, Shiovitz DA, Costa KD, Seliktar D, Sia SK.

Angew Chem Int Ed Engl. 2009;48(39):7188-92. doi: 10.1002/anie.200900807. No abstract available.

PMID:
19479917
26.

Increased myocyte content and mechanical function within a tissue-engineered myocardial patch following implantation.

Kelly DJ, Rosen AB, Schuldt AJ, Kochupura PV, Doronin SV, Potapova IA, Azeloglu EU, Badylak SF, Brink PR, Cohen IS, Gaudette GR.

Tissue Eng Part A. 2009 Aug;15(8):2189-201. doi: 10.1089/ten.tea.2008.0430.

27.

Atomic force microscope elastography reveals phenotypic differences in alveolar cell stiffness.

Azeloglu EU, Bhattacharya J, Costa KD.

J Appl Physiol (1985). 2008 Aug;105(2):652-61. doi: 10.1152/japplphysiol.00958.2007. Epub 2008 Jun 5.

28.

Engineered cardiac organoid chambers: toward a functional biological model ventricle.

Lee EJ, Kim DE, Azeloglu EU, Costa KD.

Tissue Eng Part A. 2008 Feb;14(2):215-25. doi: 10.1089/tea.2007.0351.

PMID:
18333774
29.

Heterogeneous transmural proteoglycan distribution provides a mechanism for regulating residual stresses in the aorta.

Azeloglu EU, Albro MB, Thimmappa VA, Ateshian GA, Costa KD.

Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1197-205. Epub 2007 Dec 21.

30.

Mechanical heterogeneity of the rat hippocampus measured by atomic force microscope indentation.

Elkin BS, Azeloglu EU, Costa KD, Morrison B 3rd.

J Neurotrauma. 2007 May;24(5):812-22.

PMID:
17518536
31.

Accuracy and reproducibility of a subpixel extended phase correlation method to determine micron level displacements in the heart.

Kelly DJ, Azeloglu EU, Kochupura PV, Sharma GS, Gaudette GR.

Med Eng Phys. 2007 Jan;29(1):154-62. Epub 2006 Mar 13.

PMID:
16531092
32.

High resolution mechanical function in the intact porcine heart: mechanical effects of pacemaker location.

Azeloglu EU, Yun YH, Saltman AE, Krukenkamp IB, Chiang FP, Chen W, Gaudette GR.

J Biomech. 2006;39(4):717-25.

PMID:
16439241
33.

Tissue-engineered myocardial patch derived from extracellular matrix provides regional mechanical function.

Kochupura PV, Azeloglu EU, Kelly DJ, Doronin SV, Badylak SF, Krukenkamp IB, Cohen IS, Gaudette GR.

Circulation. 2005 Aug 30;112(9 Suppl):I144-9.

PMID:
16159807
34.

Effects of ischemia on epicardial deformation in the passive rabbit heart.

Gaudette GR, Krukenkamp IB, Azeloglu EU, Saltman AE, Lense M, Todaro J, Chiang FP.

J Biomech Eng. 2004 Feb;126(1):70-5.

PMID:
15171131

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