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Items: 49

1.

Interleukin-37 Treatment of Mice with Metabolic Syndrome Improves Insulin Sensitivity and Reduces Pro-inflammatory Cytokine Production in Adipose Tissue.

Ballak DB, Li S, Cavalli G, Stahl JL, Tengesdal IW, van Diepen JA, Kluck V, Swartzwelter B, Azam T, Track CJ, Stienstra R, Mandrup-Poulsen T, Seals DR, Dinarello CA.

J Biol Chem. 2018 Jul 13. pii: jbc.RA118.003698. doi: 10.1074/jbc.RA118.003698. [Epub ahead of print]

PMID:
30006351
2.

Representation of Minorities and Elderly Patients in Multiple Myeloma Clinical Trials.

Duma N, Azam T, Riaz IB, Gonzalez-Velez M, Ailawadhi S, Go R.

Oncologist. 2018 Apr 26. pii: theoncologist.2017-0592. doi: 10.1634/theoncologist.2017-0592. [Epub ahead of print]

PMID:
29700207
3.

NALCN Dysfunction as a Cause of Disordered Respiratory Rhythm With Central Apnea.

Campbell J, FitzPatrick DR, Azam T, Gibson NA, Somerville L, Joss SK; Deciphering Developmental Disorders Study, Urquhart DS.

Pediatrics. 2018 Apr;141(Suppl 5):S485-S490. doi: 10.1542/peds.2017-0026.

PMID:
29610177
4.

Function and maturation of the Fe-S center in dihydroxyacid dehydratase from Arabidopsis.

Gao H, Azam T, Randeniya S, Couturier J, Rouhier N, Johnson MK.

J Biol Chem. 2018 Mar 23;293(12):4422-4433. doi: 10.1074/jbc.RA117.001592. Epub 2018 Feb 7.

PMID:
29425096
5.

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.

Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539. doi: 10.1073/pnas.1716095115. Epub 2018 Jan 29.

6.

Improved PCR based methods for detecting C9orf72 hexanucleotide repeat expansions.

Cleary EM, Pal S, Azam T, Moore DJ, Swingler R, Gorrie G, Stephenson L, Colville S, Chandran S, Porteous M, Warner JP.

Mol Cell Probes. 2016 Aug;30(4):218-224. doi: 10.1016/j.mcp.2016.06.001. Epub 2016 Jun 7.

7.

Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.

Henry CJ, Casás-Selves M, Kim J, Zaberezhnyy V, Aghili L, Daniel AE, Jimenez L, Azam T, McNamee EN, Clambey ET, Klawitter J, Serkova NJ, Tan AC, Dinarello CA, DeGregori J.

J Clin Invest. 2015 Dec;125(12):4666-80. doi: 10.1172/JCI83024. Epub 2015 Nov 9.

8.

Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1β and by the induction of endogenous IL-1Ra.

Joosten LA, Crişan TO, Azam T, Cleophas MC, Koenders MI, van de Veerdonk FL, Netea MG, Kim S, Dinarello CA.

Ann Rheum Dis. 2016 Jun;75(6):1219-27. doi: 10.1136/annrheumdis-2014-206966. Epub 2015 Jul 14.

PMID:
26174021
9.

IL-1 Receptor Antagonist Chimeric Protein: Context-Specific and Inflammation-Restricted Activation.

Rider P, Carmi Y, Yossef R, Guttman O, Eini H, Azam T, Dinarello CA, Lewis EC.

J Immunol. 2015 Aug 15;195(4):1705-12. doi: 10.4049/jimmunol.1501168. Epub 2015 Jul 8.

10.

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.

Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF.

Nat Immunol. 2015 Apr;16(4):354-65. doi: 10.1038/ni.3103. Epub 2015 Mar 2.

PMID:
25729923
11.

Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8.

Li S, Neff CP, Barber K, Hong J, Luo Y, Azam T, Palmer BE, Fujita M, Garlanda C, Mantovani A, Kim S, Dinarello CA.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2497-502. doi: 10.1073/pnas.1424626112. Epub 2015 Feb 5.

12.

Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo.

Li S, Fossati G, Marchetti C, Modena D, Pozzi P, Reznikov LL, Moras ML, Azam T, Abbate A, Mascagni P, Dinarello CA.

J Biol Chem. 2015 Jan 23;290(4):2368-78. doi: 10.1074/jbc.M114.618454. Epub 2014 Dec 1.

13.

IL-32 promotes angiogenesis.

Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF.

J Immunol. 2014 Jan 15;192(2):589-602. doi: 10.4049/jimmunol.1202802. Epub 2013 Dec 11.

14.

The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines.

Kim B, Lee Y, Kim E, Kwak A, Ryoo S, Bae SH, Azam T, Kim S, Dinarello CA.

Front Immunol. 2013 Nov 20;4:391. doi: 10.3389/fimmu.2013.00391. eCollection 2013.

15.

Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis.

Collins CB, Aherne CM, Ehrentraut SF, Gerich ME, McNamee EN, McManus MC, Lebsack MD, Jedlicka P, Azam T, de Zoeten EF, Dinarello CA, Rivera-Nieves J.

Inflamm Bowel Dis. 2013 Aug;19(9):1964-73. doi: 10.1097/MIB.0b013e31829292aa.

16.

Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure.

Van Tassell BW, Arena RA, Toldo S, Mezzaroma E, Azam T, Seropian IM, Shah K, Canada J, Voelkel NF, Dinarello CA, Abbate A.

PLoS One. 2012;7(3):e33438. doi: 10.1371/journal.pone.0033438. Epub 2012 Mar 16.

17.

IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist.

van de Veerdonk FL, Stoeckman AK, Wu G, Boeckermann AN, Azam T, Netea MG, Joosten LA, van der Meer JW, Hao R, Kalabokis V, Dinarello CA.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3001-5. doi: 10.1073/pnas.1121534109. Epub 2012 Feb 6.

18.

Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation.

Tawara I, Sun Y, Lewis EC, Toubai T, Evers R, Nieves E, Azam T, Dinarello CA, Reddy P.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):564-9. doi: 10.1073/pnas.1117665109. Epub 2011 Dec 27.

19.

Differential expression of interleukin-32 in chronic rhinosinusitis with and without nasal polyps.

Keswani A, Chustz RT, Suh L, Carter R, Peters AT, Tan BK, Chandra R, Kim SH, Azam T, Dinarello CA, Kern RC, Schleimer RP, Kato A.

Allergy. 2012 Jan;67(1):25-32. doi: 10.1111/j.1398-9995.2011.02706.x. Epub 2011 Sep 7.

20.

Paradoxical effects of constitutive human IL-32{gamma} in transgenic mice during experimental colitis.

Choi J, Bae S, Hong J, Ryoo S, Jhun H, Hong K, Yoon D, Lee S, Her E, Choi W, Kim J, Azam T, Dinarello CA, Kim S.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21082-6. doi: 10.1073/pnas.1015418107. Epub 2010 Nov 15.

21.

IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages.

Bai X, Kim SH, Azam T, McGibney MT, Huang H, Dinarello CA, Chan ED.

J Immunol. 2010 Apr 1;184(7):3830-40. doi: 10.4049/jimmunol.0901913. Epub 2010 Feb 26.

22.

Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta.

Hong J, Bae S, Kang Y, Yoon D, Bai X, Chan ED, Azam T, Dinarello CA, Lee S, Her E, Rho G, Kim S.

Cytokine. 2010 Feb;49(2):171-6. doi: 10.1016/j.cyto.2009.10.003. Epub 2009 Oct 31.

PMID:
19880327
23.

Proteinase 3-processed form of the recombinant IL-32 separate domain.

Kim S, Lee S, Her E, Bae S, Choi J, Hong J, Jaekal J, Yoon D, Azam T, Dinarello CA, Kim S.

BMB Rep. 2008 Nov 30;41(11):814-9.

24.

Identification of the most active interleukin-32 isoform.

Choi JD, Bae SY, Hong JW, Azam T, Dinarello CA, Her E, Choi WS, Kim BK, Lee CK, Yoon DY, Kim SJ, Kim SH.

Immunology. 2009 Apr;126(4):535-42. doi: 10.1111/j.1365-2567.2008.02917.x. Epub 2008 Sep 2.

25.

Interleukin-32 induces the differentiation of monocytes into macrophage-like cells.

Netea MG, Lewis EC, Azam T, Joosten LA, Jaekal J, Bae SY, Dinarello CA, Kim SH.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3515-20. doi: 10.1073/pnas.0712381105. Epub 2008 Feb 22.

26.

Unique expression of a small IL-32 protein in the Jurkat leukemic T cell line.

Ko NY, Chang SH, Lee JH, Kim NW, Kim YM, Choi WS, Choi JD, Bae SY, Hong JW, Jaekal J, Azam T, Her E, Kim SH.

Cytokine. 2008 Apr;42(1):121-7. doi: 10.1016/j.cyto.2008.01.004. Epub 2008 Mar 4.

PMID:
18289868
27.

Molecular and clinical characterization of de novo and familial cases with microduplication 3q29: guidelines for copy number variation case reporting.

Goobie S, Knijnenburg J, Fitzpatrick D, Sharkey FH, Lionel AC, Marshall CR, Azam T, Shago M, Chong K, Mendoza-Londono R, den Hollander NS, Ruivenkamp C, Maher E, Tanke HJ, Szuhai K, Wintle RF, Scherer SW.

Cytogenet Genome Res. 2008;123(1-4):65-78. doi: 10.1159/000184693. Epub 2009 Mar 11.

28.

Individual LPS responsiveness depends on the variation of toll-like receptor (TLR) expression level.

Jaekal J, Abraham E, Azam T, Netea MG, Dinarello CA, Lim JS, Yang Y, Yoon DY, Kim SH.

J Microbiol Biotechnol. 2007 Nov;17(11):1862-7.

29.

Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors.

Netea MG, Azam T, Ferwerda G, Girardin SE, Kim SH, Dinarello CA.

J Leukoc Biol. 2006 Dec;80(6):1454-61. Epub 2006 Aug 29.

PMID:
16940328
30.

Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism.

Netea MG, Azam T, Lewis EC, Joosten LA, Wang M, Langenberg D, Meng X, Chan ED, Yoon DY, Ottenhoff T, Kim SH, Dinarello CA.

PLoS Med. 2006 Aug;3(8):e277.

31.

Lymphangioma circumscriptum: report of three cases from Saudi Arabia.

Samdani AJ, Bana SH, Azam T.

Int J Dermatol. 2006 Jul;45(7):840-2. No abstract available.

PMID:
16863522
32.

Peripheral blood neutrophil activation patterns are associated with pulmonary inflammatory responses to lipopolysaccharide in humans.

Abraham E, Nick JA, Azam T, Kim SH, Mira JP, Svetkauskaite D, He Q, Zamora M, Murphy J, Park JS, Overdier K, Dinarello CA.

J Immunol. 2006 Jun 15;176(12):7753-60.

33.

Proteinase 3 is an IL-32 binding protein.

Novick D, Rubinstein M, Azam T, Rabinkov A, Dinarello CA, Kim SH.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3316-21. Epub 2006 Feb 17.

34.

IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism.

Netea MG, Azam T, Ferwerda G, Girardin SE, Walsh M, Park JS, Abraham E, Kim JM, Yoon DY, Dinarello CA, Kim SH.

Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16309-14. Epub 2005 Oct 31.

35.

Menke's kinky hair syndrome--a rare medical condition.

Al-Bitar Y, Azam-Jah-Samdani, Azam T.

J Pak Med Assoc. 2005 Jan;55(1):40-2.

36.

Interleukin-32: a cytokine and inducer of TNFalpha.

Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA.

Immunity. 2005 Jan;22(1):131-42.

37.

Effect of advanced glycation end products on endotoxin-induced TNF-alpha, IL-1beta and IL-8 in human peripheral blood mononuclear cells.

Reznikov LL, Waksman J, Azam T, Kim SH, Bufler P, Niwa T, Werman A, Zhang X, Pischetsrieder M, Shaldon S, Dinarello CA.

Clin Nephrol. 2004 May;61(5):324-36.

PMID:
15182127
38.

Differences in signaling pathways by IL-1beta and IL-18.

Lee JK, Kim SH, Lewis EC, Azam T, Reznikov LL, Dinarello CA.

Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8815-20. Epub 2004 May 25.

39.
40.

Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex.

Azam T, Novick D, Bufler P, Yoon DY, Rubinstein M, Dinarello CA, Kim SH.

J Immunol. 2003 Dec 15;171(12):6574-80.

41.

Generation and characterization of mice transgenic for human IL-18-binding protein isoform a.

Fantuzzi G, Banda NK, Guthridge C, Vondracek A, Kim SH, Siegmund B, Azam T, Sennello JA, Dinarello CA, Arend WP.

J Leukoc Biol. 2003 Nov;74(5):889-96. Epub 2003 Aug 11.

PMID:
12960225
42.

A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity.

Bufler P, Azam T, Gamboni-Robertson F, Reznikov LL, Kumar S, Dinarello CA, Kim SH.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13723-8.

43.

Rat interleukin-18 binding protein: cloning, expression, and characterization.

Im SH, Kim SH, Azam T, Venkatesh N, Dinarello CA, Fuchs S, Souroujon MC.

J Interferon Cytokine Res. 2002 Mar;22(3):321-8.

PMID:
12034039
44.

The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines.

Leoni F, Zaliani A, Bertolini G, Porro G, Pagani P, Pozzi P, Donà G, Fossati G, Sozzani S, Azam T, Bufler P, Fantuzzi G, Goncharov I, Kim SH, Pomerantz BJ, Reznikov LL, Siegmund B, Dinarello CA, Mascagni P.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2995-3000. Epub 2002 Feb 26.

45.

Identification of amino acid residues critical for biological activity in human interleukin-18.

Kim SH, Azam T, Novick D, Yoon DY, Reznikov LL, Bufler P, Rubinstein M, Dinarello CA.

J Biol Chem. 2002 Mar 29;277(13):10998-1003. Epub 2002 Jan 14.

46.

Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein.

Kim SH, Azam T, Yoon DY, Reznikov LL, Novick D, Rubinstein M, Dinarello CA.

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3304-9.

47.

Two types of localization of the DNA-binding proteins within the Escherichia coli nucleoid.

Azam TA, Hiraga S, Ishihama A.

Genes Cells. 2000 Aug;5(8):613-26.

49.

Protein prenyl transferase activities of Plasmodium falciparum.

Chakrabarti D, Azam T, DelVecchio C, Qiu L, Park YI, Allen CM.

Mol Biochem Parasitol. 1998 Aug 1;94(2):175-84.

PMID:
9747968

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