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A Tangled Web: Origins of Reproductive Parasitism.

Gillespie JJ, Driscoll TP, Verhoeve VI, Rahman MS, Macaluso KR, Azad AF.

Genome Biol Evol. 2018 Sep 1;10(9):2292-2309. doi: 10.1093/gbe/evy159.


Rickettsia Lipid A Biosynthesis Utilizes the Late Acyltransferase LpxJ for Secondary Fatty Acid Addition.

Guillotte ML, Gillespie JJ, Chandler CE, Rahman MS, Ernst RK, Azad AF.

J Bacteriol. 2018 Sep 10;200(19). pii: e00334-18. doi: 10.1128/JB.00334-18. Print 2018 Oct 1.


The Rickettsial Ankyrin Repeat Protein 2 Is a Type IV Secreted Effector That Associates with the Endoplasmic Reticulum.

Lehman SS, Noriea NF, Aistleitner K, Clark TR, Dooley CA, Nair V, Kaur SJ, Rahman MS, Gillespie JJ, Azad AF, Hackstadt T.

MBio. 2018 Jun 26;9(3). pii: e00975-18. doi: 10.1128/mBio.00975-18.


The Cat Flea (Ctenocephalides felis) Immune Deficiency Signaling Pathway Regulates Rickettsia typhi Infection.

Rennoll SA, Rennoll-Bankert KE, Guillotte ML, Lehman SS, Driscoll TP, Beier-Sexton M, Rahman MS, Gillespie JJ, Azad AF.

Infect Immun. 2017 Dec 19;86(1). pii: e00562-17. doi: 10.1128/IAI.00562-17. Print 2018 Jan.


Wholly Rickettsia! Reconstructed Metabolic Profile of the Quintessential Bacterial Parasite of Eukaryotic Cells.

Driscoll TP, Verhoeve VI, Guillotte ML, Lehman SS, Rennoll SA, Beier-Sexton M, Rahman MS, Azad AF, Gillespie JJ.

MBio. 2017 Sep 26;8(5). pii: e00859-17. doi: 10.1128/mBio.00859-17.


Comparative vertical transmission of Rickettsia by Dermacentor variabilis and Amblyomma maculatum.

Harris EK, Verhoeve VI, Banajee KH, Macaluso JA, Azad AF, Macaluso KR.

Ticks Tick Borne Dis. 2017 Jun;8(4):598-604. doi: 10.1016/j.ttbdis.2017.04.003. Epub 2017 Apr 6.


RalF-Mediated Activation of Arf6 Controls Rickettsia typhi Invasion by Co-Opting Phosphoinositol Metabolism.

Rennoll-Bankert KE, Rahman MS, Guillotte ML, Lehman SS, Beier-Sexton M, Gillespie JJ, Azad AF.

Infect Immun. 2016 Nov 18;84(12):3496-3506. Print 2016 Dec.


The Rickettsia type IV secretion system: unrealized complexity mired by gene family expansion.

Gillespie JJ, Phan IQ, Driscoll TP, Guillotte ML, Lehman SS, Rennoll-Bankert KE, Subramanian S, Beier-Sexton M, Myler PJ, Rahman MS, Azad AF.

Pathog Dis. 2016 Aug;74(6). pii: ftw058. doi: 10.1093/femspd/ftw058. Epub 2016 Jun 14.


Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems.

Gillespie JJ, Phan IQ, Scheib H, Subramanian S, Edwards TE, Lehman SS, Piitulainen H, Rahman MS, Rennoll-Bankert KE, Staker BL, Taira S, Stacy R, Myler PJ, Azad AF, Pulliainen AT.

MBio. 2015 Dec 8;6(6):e01867-15. doi: 10.1128/mBio.01867-15.


Which Way In? The RalF Arf-GEF Orchestrates Rickettsia Host Cell Invasion.

Rennoll-Bankert KE, Rahman MS, Gillespie JJ, Guillotte ML, Kaur SJ, Lehman SS, Beier-Sexton M, Azad AF.

PLoS Pathog. 2015 Aug 20;11(8):e1005115. doi: 10.1371/journal.ppat.1005115. eCollection 2015 Aug.


Genomic diversification in strains of Rickettsia felis Isolated from different arthropods.

Gillespie JJ, Driscoll TP, Verhoeve VI, Utsuki T, Husseneder C, Chouljenko VN, Azad AF, Macaluso KR.

Genome Biol Evol. 2014 Dec 4;7(1):35-56. doi: 10.1093/gbe/evu262.


Secretome of obligate intracellular Rickettsia.

Gillespie JJ, Kaur SJ, Rahman MS, Rennoll-Bankert K, Sears KT, Beier-Sexton M, Azad AF.

FEMS Microbiol Rev. 2015 Jan;39(1):47-80. doi: 10.1111/1574-6976.12084. Epub 2014 Dec 4. Review.


Molecular and functional characterization of vacuolar-ATPase from the American dog tick Dermacentor variabilis.

Petchampai N, Sunyakumthorn P, Guillotte ML, Thepparit C, Kearney MT, Mulenga A, Azad AF, Macaluso KR.

Insect Mol Biol. 2014 Feb;23(1):42-51. doi: 10.1111/imb.12059. Epub 2013 Oct 25.


Rickettsia typhi possesses phospholipase A2 enzymes that are involved in infection of host cells.

Rahman MS, Gillespie JJ, Kaur SJ, Sears KT, Ceraul SM, Beier-Sexton M, Azad AF.

PLoS Pathog. 2013;9(6):e1003399. doi: 10.1371/journal.ppat.1003399. Epub 2013 Jun 20.


Bacterial DNA sifted from the Trichoplax adhaerens (Animalia: Placozoa) genome project reveals a putative rickettsial endosymbiont.

Driscoll T, Gillespie JJ, Nordberg EK, Azad AF, Sobral BW.

Genome Biol Evol. 2013;5(4):621-45. doi: 10.1093/gbe/evt036.


Surface proteome analysis and characterization of surface cell antigen (Sca) or autotransporter family of Rickettsia typhi.

Sears KT, Ceraul SM, Gillespie JJ, Allen ED Jr, Popov VL, Ammerman NC, Rahman MS, Azad AF.

PLoS Pathog. 2012;8(8):e1002856. doi: 10.1371/journal.ppat.1002856. Epub 2012 Aug 9.


TolC-dependent secretion of an ankyrin repeat-containing protein of Rickettsia typhi.

Kaur SJ, Rahman MS, Ammerman NC, Beier-Sexton M, Ceraul SM, Gillespie JJ, Azad AF.

J Bacteriol. 2012 Sep;194(18):4920-32. doi: 10.1128/JB.00793-12. Epub 2012 Jul 6.


A Rickettsia genome overrun by mobile genetic elements provides insight into the acquisition of genes characteristic of an obligate intracellular lifestyle.

Gillespie JJ, Joardar V, Williams KP, Driscoll T, Hostetler JB, Nordberg E, Shukla M, Walenz B, Hill CA, Nene VM, Azad AF, Sobral BW, Caler E.

J Bacteriol. 2012 Jan;194(2):376-94. doi: 10.1128/JB.06244-11. Epub 2011 Nov 4.


A Kunitz protease inhibitor from Dermacentor variabilis, a vector for spotted fever group rickettsiae, limits Rickettsia montanensis invasion.

Ceraul SM, Chung A, Sears KT, Popov VL, Beier-Sexton M, Rahman MS, Azad AF.

Infect Immun. 2011 Jan;79(1):321-9. doi: 10.1128/IAI.00362-10. Epub 2010 Oct 18.


Functional characterization of a phospholipase A(2) homolog from Rickettsia typhi.

Rahman MS, Ammerman NC, Sears KT, Ceraul SM, Azad AF.

J Bacteriol. 2010 Jul;192(13):3294-303. doi: 10.1128/JB.00155-10. Epub 2010 Apr 30.


Transcriptional analysis of the pre-erythrocytic stages of the rodent malaria parasite, Plasmodium yoelii.

Williams CT, Azad AF.

PLoS One. 2010 Apr 21;5(4):e10267. doi: 10.1371/journal.pone.0010267.


Phylogenomics reveals a diverse Rickettsiales type IV secretion system.

Gillespie JJ, Brayton KA, Williams KP, Diaz MA, Brown WC, Azad AF, Sobral BW.

Infect Immun. 2010 May;78(5):1809-23. doi: 10.1128/IAI.01384-09. Epub 2010 Feb 22. Review.


Analysis of Rickettsia typhi-infected and uninfected cat flea (Ctenocephalides felis) midgut cDNA libraries: deciphering molecular pathways involved in host response to R. typhi infection.

Dreher-Lesnick SM, Ceraul SM, Lesnick SC, Gillespie JJ, Anderson JM, Jochim RC, Valenzuela JG, Azad AF.

Insect Mol Biol. 2010 Apr;19(2):229-41. doi: 10.1111/j.1365-2583.2009.00978.x. Epub 2009 Dec 15.


A typhus group-specific protease defies reductive evolution in rickettsiae.

Ammerman NC, Gillespie JJ, Neuwald AF, Sobral BW, Azad AF.

J Bacteriol. 2009 Dec;191(24):7609-13. doi: 10.1128/JB.01077-09. Epub 2009 Oct 9.


An anomalous type IV secretion system in Rickettsia is evolutionarily conserved.

Gillespie JJ, Ammerman NC, Dreher-Lesnick SM, Rahman MS, Worley MJ, Setubal JC, Sobral BS, Azad AF.

PLoS One. 2009;4(3):e4833. doi: 10.1371/journal.pone.0004833. Epub 2009 Mar 12.


Rickettsia phylogenomics: unwinding the intricacies of obligate intracellular life.

Gillespie JJ, Williams K, Shukla M, Snyder EE, Nordberg EK, Ceraul SM, Dharmanolla C, Rainey D, Soneja J, Shallom JM, Vishnubhat ND, Wattam R, Purkayastha A, Czar M, Crasta O, Setubal JC, Azad AF, Sobral BS.

PLoS One. 2008;3(4):e2018. doi: 10.1371/journal.pone.0002018. Epub 2008 Apr 16.


Louse- and flea-borne rickettsioses: biological and genomic analyses.

Gillespie JJ, Ammerman NC, Beier-Sexton M, Sobral BS, Azad AF.

Vet Res. 2009 Mar-Apr;40(2):12. doi: 10.1051/vetres:2008050. Epub 2008 Nov 28. Review.


Laboratory maintenance of Rickettsia rickettsii.

Ammerman NC, Beier-Sexton M, Azad AF.

Curr Protoc Microbiol. 2008 Nov;Chapter 3:Unit 3A.5. doi: 10.1002/9780471729259.mc03a05s11.


Growth and maintenance of Vero cell lines.

Ammerman NC, Beier-Sexton M, Azad AF.

Curr Protoc Microbiol. 2008 Nov;Appendix 4:Appendix 4E. doi: 10.1002/9780471729259.mca04es11.


Functional characterization and novel rickettsiostatic effects of a Kunitz-type serine protease inhibitor from the tick Dermacentor variabilis.

Ceraul SM, Dreher-Lesnick SM, Mulenga A, Rahman MS, Azad AF.

Infect Immun. 2008 Nov;76(11):5429-35. doi: 10.1128/IAI.00866-08. Epub 2008 Sep 8.


Characterization of Sec-translocon-dependent extracytoplasmic proteins of Rickettsia typhi.

Ammerman NC, Rahman MS, Azad AF.

J Bacteriol. 2008 Sep;190(18):6234-42. doi: 10.1128/JB.00794-08. Epub 2008 Jul 18.


Genome-wide screen for temperature-regulated genes of the obligate intracellular bacterium, Rickettsia typhi.

Dreher-Lesnick SM, Ceraul SM, Rahman MS, Azad AF.

BMC Microbiol. 2008 Apr 15;8:61. doi: 10.1186/1471-2180-8-61.


An aquaporin-like protein from the ovaries and gut of American dog tick (Acari: Ixodidae).

Holmes SP, Li D, Ceraul SM, Azad AF.

J Med Entomol. 2008 Jan;45(1):68-74.


Propagation of arthropod-borne Rickettsia spp. in two mosquito cell lines.

Sakamoto JM, Azad AF.

Appl Environ Microbiol. 2007 Oct;73(20):6637-43. Epub 2007 Aug 31.


Pathogenic rickettsiae as bioterrorism agents.

Azad AF.

Clin Infect Dis. 2007 Jul 15;45 Suppl 1:S52-5.


Plasmids and rickettsial evolution: insight from Rickettsia felis.

Gillespie JJ, Beier MS, Rahman MS, Ammerman NC, Shallom JM, Purkayastha A, Sobral BS, Azad AF.

PLoS One. 2007 Mar 7;2(3):e266. Review.


New tick defensin isoform and antimicrobial gene expression in response to Rickettsia montanensis challenge.

Ceraul SM, Dreher-Lesnick SM, Gillespie JJ, Rahman MS, Azad AF.

Infect Immun. 2007 Apr;75(4):1973-83. Epub 2007 Jan 29.


PATRIC: the VBI PathoSystems Resource Integration Center.

Snyder EE, Kampanya N, Lu J, Nordberg EK, Karur HR, Shukla M, Soneja J, Tian Y, Xue T, Yoo H, Zhang F, Dharmanolla C, Dongre NV, Gillespie JJ, Hamelius J, Hance M, Huntington KI, Jukneliene D, Koziski J, Mackasmiel L, Mane SP, Nguyen V, Purkayastha A, Shallom J, Yu G, Guo Y, Gabbard J, Hix D, Azad AF, Baker SC, Boyle SM, Khudyakov Y, Meng XJ, Rupprecht C, Vinje J, Crasta OR, Czar MJ, Dickerman A, Eckart JD, Kenyon R, Will R, Setubal JC, Sobral BW.

Nucleic Acids Res. 2007 Jan;35(Database issue):D401-6. Epub 2006 Nov 16.


Characterization of Dermacentor variabilis molecules associated with Rickettsial infection.

Macaluso KR, Mulenga A, Simser JA, Azad AF.

Ann N Y Acad Sci. 2006 Oct;1078:384-8.


The lspA gene, encoding the type II signal peptidase of Rickettsia typhi: transcriptional and functional analysis.

Rahman MS, Ceraul SM, Dreher-Lesnick SM, Beier MS, Azad AF.

J Bacteriol. 2007 Jan;189(2):336-41. Epub 2006 Nov 10.


Differential expression of two glutathione S-transferases identified from the American dog tick, Dermacentor variabilis.

Dreher-Lesnick SM, Mulenga A, Simser JA, Azad AF.

Insect Mol Biol. 2006 Aug;15(4):445-53.


Development of quantitative real-time PCR assays to detect Rickettsia typhi and Rickettsia felis, the causative agents of murine typhus and flea-borne spotted fever.

Henry KM, Jiang J, Rozmajzl PJ, Azad AF, Macaluso KR, Richards AL.

Mol Cell Probes. 2007 Feb;21(1):17-23. Epub 2006 Jul 1.


Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers.

Sacci JB Jr, Alam U, Douglas D, Lewis J, Tyrrell DL, Azad AF, Kneteman NM.

Int J Parasitol. 2006 Mar;36(3):353-60.


The molecular and biological analysis of ixodid ticks histamine release factors.

Mulenga A, Azad AF.

Exp Appl Acarol. 2005;37(3-4):215-29.


Plasmodium yoelii: axenic development of the parasite mosquito stages.

Porter-Kelley JM, Dinglasan RR, Alam U, Ndeta GA, Sacci JB Jr, Azad AF.

Exp Parasitol. 2006 Feb;112(2):99-108. Epub 2005 Nov 14.


Transcriptional analysis of in vivo Plasmodium yoelii liver stage gene expression.

Sacci JB Jr, Ribeiro JM, Huang F, Alam U, Russell JA, Blair PL, Witney A, Carucci DJ, Azad AF, Aguiar JC.

Mol Biochem Parasitol. 2005 Aug;142(2):177-83. Epub 2005 Apr 26.


Peptide mimics as surrogate immunogens of mosquito midgut carbohydrate malaria transmission blocking targets.

Dinglasan RR, Porter-Kelley JM, Alam U, Azad AF.

Vaccine. 2005 Apr 15;23(21):2717-24.


Functional analysis of secA homologues from rickettsiae.

Rahman MS, Simser JA, Macaluso KR, Azad AF.

Microbiology. 2005 Feb;151(Pt 2):589-96.


Sugar epitopes as potential universal disease transmission blocking targets.

Dinglasan RR, Valenzuela JG, Azad AF.

Insect Biochem Mol Biol. 2005 Jan;35(1):1-10.


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