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Items: 11


Intraductal patient-derived xenografts of estrogen receptor α-positive breast cancer recapitulate the histopathological spectrum and metastatic potential of human lesions.

Fiche M, Scabia V, Aouad P, Battista L, Treboux A, Stravodimou A, Zaman K; RLS, Dormoy V, Ayyanan A, Sflomos G, Brisken C.

J Pathol. 2019 Mar;247(3):287-292. doi: 10.1002/path.5200. Epub 2018 Dec 27.


Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium.

Cagnet S, Ataca D, Sflomos G, Aouad P, Schuepbach-Mallepell S, Hugues H, Krust A, Ayyanan A, Scabia V, Brisken C.

Nat Commun. 2018 Nov 9;9(1):4723. doi: 10.1038/s41467-018-07175-0.


A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response.

Sflomos G, Dormoy V, Metsalu T, Jeitziner R, Battista L, Scabia V, Raffoul W, Delaloye JF, Treboux A, Fiche M, Vilo J, Ayyanan A, Brisken C.

Cancer Cell. 2016 Mar 14;29(3):407-422. doi: 10.1016/j.ccell.2016.02.002. Epub 2016 Mar 3.


Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk.

Rajaram RD, Buric D, Caikovski M, Ayyanan A, Rougemont J, Shan J, Vainio SJ, Yalcin-Ozuysal O, Brisken C.

EMBO J. 2015 Mar 4;34(5):641-52. doi: 10.15252/embj.201490434. Epub 2015 Jan 20.


Progesterone/RANKL is a major regulatory axis in the human breast.

Tanos T, Sflomos G, Echeverria PC, Ayyanan A, Gutierrez M, Delaloye JF, Raffoul W, Fiche M, Dougall W, Schneider P, Yalcin-Ozuysal O, Brisken C.

Sci Transl Med. 2013 Apr 24;5(182):182ra55. doi: 10.1126/scitranslmed.3005654.


Perinatal exposure to bisphenol a increases adult mammary gland progesterone response and cell number.

Ayyanan A, Laribi O, Schuepbach-Mallepell S, Schrick C, Gutierrez M, Tanos T, Lefebvre G, Rougemont J, Yalcin-Ozuysal O, Brisken C.

Mol Endocrinol. 2011 Nov;25(11):1915-23. doi: 10.1210/me.2011-1129. Epub 2011 Sep 8.


Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells.

Battula VL, Evans KW, Hollier BG, Shi Y, Marini FC, Ayyanan A, Wang RY, Brisken C, Guerra R, Andreeff M, Mani SA.

Stem Cells. 2010 Aug;28(8):1435-45. doi: 10.1002/stem.467.


Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland.

Beleut M, Rajaram RD, Caikovski M, Ayyanan A, Germano D, Choi Y, Schneider P, Brisken C.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2989-94. doi: 10.1073/pnas.0915148107. Epub 2010 Jan 28.


The epithelial-mesenchymal transition generates cells with properties of stem cells.

Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA.

Cell. 2008 May 16;133(4):704-15. doi: 10.1016/j.cell.2008.03.027.


Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism.

Ayyanan A, Civenni G, Ciarloni L, Morel C, Mueller N, Lefort K, Mandinova A, Raffoul W, Fiche M, Dotto GP, Brisken C.

Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3799-804. Epub 2006 Feb 24.


Prolactin signaling and Stat5: going their own separate ways?

Brisken C, Ayyanan A, Doppler W.

Breast Cancer Res. 2002;4(6):209-12. Epub 2002 Oct 3.

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