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Items: 41


Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases.

Balasubramaniam M, Ayyadevara S, Ganne A, Kakraba S, Penthala NR, Du X, Crooks PA, Griffin ST, Shmookler Reis RJ.

iScience. 2019 Oct 25;20:248-264. doi: 10.1016/j.isci.2019.09.026. Epub 2019 Sep 21.


A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories.

Tarkhov AE, Alla R, Ayyadevara S, Pyatnitskiy M, Menshikov LI, Shmookler Reis RJ, Fedichev PO.

Sci Rep. 2019 May 14;9(1):7368. doi: 10.1038/s41598-019-43075-z.


Functional assessments through novel proteomics approaches: Application to insulin/IGF signaling in neurodegenerative disease'.

Ayyadevara S, Ganne A, Hendrix RD, Balasubramaniam M, Shmookler Reis RJ, Barger SW.

J Neurosci Methods. 2019 May 1;319:40-46. doi: 10.1016/j.jneumeth.2018.11.005. Epub 2018 Nov 6.


Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2.

Balasubramaniam M, Ayyadevara S, Shmookler Reis RJ.

Sci Rep. 2018 Oct 5;8(1):14891. doi: 10.1038/s41598-018-33143-1.


Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs.

Parcon PA, Balasubramaniam M, Ayyadevara S, Jones RA, Liu L, Shmookler Reis RJ, Barger SW, Mrak RE, Griffin WST.

Alzheimers Dement. 2018 Feb;14(2):230-242. doi: 10.1016/j.jalz.2017.07.754. Epub 2017 Sep 22.


Involvement of tRNAs in replication of human mitochondrial DNA and modifying effects of telomerase.

Balasubramaniam M, Reis RJS, Ayyadevara S, Wang X, Ganne A, Khaidakov M.

Mech Ageing Dev. 2017 Sep;166:55-63. doi: 10.1016/j.mad.2017.07.004. Epub 2017 Jul 29.


Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation.

Ayyadevara S, Balasubramaniam M, Kakraba S, Alla R, Mehta JL, Shmookler Reis RJ.

Antioxid Redox Signal. 2017 Dec 10;27(17):1383-1396. doi: 10.1089/ars.2016.6978. Epub 2017 Jun 28.


Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis.

Xavier S, Sahu RK, Landes SG, Yu J, Taylor RP, Ayyadevara S, Megyesi J, Stallcup WB, Duffield JS, Reis ES, Lambris JD, Portilla D.

Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F516-F532. doi: 10.1152/ajprenal.00604.2016. Epub 2017 Jan 4.


Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans.

Ayyadevara S, Balasubramaniam M, Suri P, Mackintosh SG, Tackett AJ, Sullivan DH, Shmookler Reis RJ, Dennis RA.

Aging (Albany NY). 2016 Dec 15;8(12):3486-3497. doi: 10.18632/aging.101141.


Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls.

Ayyadevara S, Balasubramaniam M, Parcon PA, Barger SW, Griffin WS, Alla R, Tackett AJ, Mackintosh SG, Petricoin E, Zhou W, Shmookler Reis RJ.

Aging Cell. 2016 Oct;15(5):924-39. doi: 10.1111/acel.12501. Epub 2016 Jul 23.


PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans.

Ayyadevara S, Balasubramaniam M, Johnson J, Alla R, Mackintosh SG, Shmookler Reis RJ.

Oncotarget. 2016 Aug 2;7(31):48870-48886. doi: 10.18632/oncotarget.10549.


Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles.

Ayyadevara S, Mercanti F, Wang X, Mackintosh SG, Tackett AJ, Prayaga SV, Romeo F, Shmookler Reis RJ, Mehta JL.

Hypertension. 2016 May;67(5):1006-13. doi: 10.1161/HYPERTENSIONAHA.115.06849. Epub 2016 Mar 14.


A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition.

Alagpulinsa DA, Ayyadevara S, Yaccoby S, Shmookler Reis RJ.

Mol Cancer Ther. 2016 Feb;15(2):241-50. doi: 10.1158/1535-7163.MCT-15-0660. Epub 2015 Dec 30.


A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment.

Alagpulinsa DA, Yaccoby S, Ayyadevara S, Shmookler Reis RJ.

Cancer Biol Ther. 2015;16(6):976-86. doi: 10.1080/15384047.2015.1040951. Epub 2015 May 21.


Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes.

Ayyadevara S, Balasubramaniam M, Gao Y, Yu LR, Alla R, Shmookler Reis R.

Aging Cell. 2015 Feb;14(1):35-48. doi: 10.1111/acel.12296. Epub 2014 Dec 16.


A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin.

Alagpulinsa DA, Ayyadevara S, Shmookler Reis RJ.

Front Oncol. 2014 Oct 30;4:289. doi: 10.3389/fonc.2014.00289. eCollection 2014.


Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in S. cerevisiae.

Ayyadevara S, Tazearslan C, Alla R, Jiang JC, Jazwinski SM, Shmookler Reis RJ.

Front Genet. 2014 Aug 4;5:211. doi: 10.3389/fgene.2014.00211. eCollection 2014.


Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants.

Bharill P, Ayyadevara S, Alla R, Shmookler Reis RJ.

Front Genet. 2013 Mar 28;4:34. doi: 10.3389/fgene.2013.00034. eCollection 2013.


Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans.

Ayyadevara S, Bharill P, Dandapat A, Hu C, Khaidakov M, Mitra S, Shmookler Reis RJ, Mehta JL.

Antioxid Redox Signal. 2013 Feb 10;18(5):481-90. doi: 10.1089/ars.2011.4151. Epub 2012 Sep 7.


Reduced kidney lipoprotein lipase and renal tubule triglyceride accumulation in cisplatin-mediated acute kidney injury.

Li S, Nagothu K, Ranganathan G, Ali SM, Shank B, Gokden N, Ayyadevara S, Megyesi J, Olivecrona G, Chugh SS, Kersten S, Portilla D.

Am J Physiol Renal Physiol. 2012 Aug 1;303(3):F437-48. doi: 10.1152/ajprenal.00111.2012. Epub 2012 May 23.


Photothermal confocal spectromicroscopy of multiple cellular chromophores and fluorophores.

Nedosekin DA, Galanzha EI, Ayyadevara S, Shmookler Reis RJ, Zharov VP.

Biophys J. 2012 Feb 8;102(3):672-81. doi: 10.1016/j.bpj.2011.12.035. Epub 2012 Feb 7. Erratum in: Biophys J. 2012 Mar 7;102(5):1235.


A narrow quantitative trait locus in C. elegans coordinately affects longevity, thermotolerance, and resistance to paraquat.

Vertino A, Ayyadevara S, Thaden JJ, Shmookler Reis RJ.

Front Genet. 2011 Sep 27;2:63. doi: 10.3389/fgene.2011.00063. eCollection 2011.


Gene categories differentially expressed in C. elegans age-1 mutants of extraordinary longevity: new insights from novel data-mining procedures.

Shmookler Reis RJ, Ayyadevara S, Crow WA, Lee T, Delongchamp RR.

J Gerontol A Biol Sci Med Sci. 2012 Apr;67(4):366-75. doi: 10.1093/gerona/glr186. Epub 2011 Oct 21.


Prior exposure to oxidized low-density lipoprotein limits apoptosis in subsequent generations of endothelial cells by altering promoter methylation.

Mitra S, Khaidakov M, Lu J, Ayyadevara S, Szwedo J, Wang XW, Chen C, Khaidakov S, Kasula SR, Stone A, Pogribny I, Mehta JL.

Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H506-13. doi: 10.1152/ajpheart.00252.2011. Epub 2011 May 20.


Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants.

Shmookler Reis RJ, Xu L, Lee H, Chae M, Thaden JJ, Bharill P, Tazearslan C, Siegel E, Alla R, Zimniak P, Ayyadevara S.

Aging (Albany NY). 2011 Feb;3(2):125-47.


Antiangiogenic and antimitotic effects of aspirin in hypoxia–reoxygenation modulation of the LOX-1-NADPH oxidase axis as a potential mechanism.

Khaidakov M, Szwedo J, Mitra S, Ayyadevara S, Dobretsov M, Lu J, Mehta JL.

J Cardiovasc Pharmacol. 2010 Dec;56(6):635-41. doi: 10.1097/FJC.0b013e3181f801e4.


Histoplasma capsulatum and Caenorhabditis elegans: a simple nematode model for an innate immune response to fungal infection.

Johnson CH, Ayyadevara S, McEwen JE, Shmookler Reis RJ.

Med Mycol. 2009 Dec;47(8):808-13. doi: 10.3109/13693780802660532.


Caenorhabditis elegans PI3K mutants reveal novel genes underlying exceptional stress resistance and lifespan.

Ayyadevara S, Tazearslan C, Bharill P, Alla R, Siegel E, Shmookler Reis RJ.

Aging Cell. 2009 Dec;8(6):706-25. doi: 10.1111/j.1474-9726.2009.00524.x. Epub 2009 Sep 17.


Extreme-longevity mutations orchestrate silencing of multiple signaling pathways.

Shmookler Reis RJ, Bharill P, Tazearslan C, Ayyadevara S.

Biochim Biophys Acta. 2009 Oct;1790(10):1075-83. doi: 10.1016/j.bbagen.2009.05.011. Epub 2009 May 22. Review.


Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance.

Tazearslan C, Ayyadevara S, Bharill P, Shmookler Reis RJ.

PLoS Genet. 2009 Apr;5(4):e1000452. doi: 10.1371/journal.pgen.1000452. Epub 2009 Apr 10.


Remarkable longevity and stress resistance of nematode PI3K-null mutants.

Ayyadevara S, Alla R, Thaden JJ, Shmookler Reis RJ.

Aging Cell. 2008 Jan;7(1):13-22. Epub 2007 Nov 7.


Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal.

Ayyadevara S, Dandapat A, Singh SP, Siegel ER, Shmookler Reis RJ, Zimniak L, Zimniak P.

Mech Ageing Dev. 2007 Feb;128(2):196-205. Epub 2006 Dec 8.


Quantitative trait loci define genes and pathways underlying genetic variation in longevity.

Shmookler Reis RJ, Kang P, Ayyadevara S.

Exp Gerontol. 2006 Oct;41(10):1046-54. Epub 2006 Aug 17. Review.


Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2.

Ayyadevara S, Dandapat A, Singh SP, Benes H, Zimniak L, Shmookler Reis RJ, Zimniak P.

Aging Cell. 2005 Dec;4(6):299-307.


Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal.

Ayyadevara S, Engle MR, Singh SP, Dandapat A, Lichti CF, Benes H, Shmookler Reis RJ, Liebau E, Zimniak P.

Aging Cell. 2005 Oct;4(5):257-71.


Genetic loci modulating fitness and life span in Caenorhabditis elegans: categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred worms.

Ayyadevara S, Ayyadevara R, Vertino A, Galecki A, Thaden JJ, Shmookler Reis RJ.

Genetics. 2003 Feb;163(2):557-70.


Discrimination of primer 3'-nucleotide mismatch by taq DNA polymerase during polymerase chain reaction.

Ayyadevara S, Thaden JJ, Shmookler Reis RJ.

Anal Biochem. 2000 Aug 15;284(1):11-8.


Evaluation of a single step extraction procedure for enzymatic assay of levamisole in calf serum.

Ayyadevara S, Mercer JW Jr, Snow LD.

Res Commun Chem Pathol Pharmacol. 1994 May;84(2):245-52.


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