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Items: 49


Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of AAV Serotypes.

Rieser R, Penaud-Budloo M, Bouzelha M, Rossi A, Menzen T, Biel M, Büning H, Ayuso E, Winter G, Michalakis S.

J Pharm Sci. 2019 Oct 19. pii: S0022-3549(19)30668-9. doi: 10.1016/j.xphs.2019.10.031. [Epub ahead of print]


Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates.

Milani M, Annoni A, Moalli F, Liu T, Cesana D, Calabria A, Bartolaccini S, Biffi M, Russo F, Visigalli I, Raimondi A, Patarroyo-White S, Drager D, Cristofori P, Ayuso E, Montini E, Peters R, Iannacone M, Cantore A, Naldini L.

Sci Transl Med. 2019 May 22;11(493). pii: eaav7325. doi: 10.1126/scitranslmed.aav7325.


Stability of the adeno-associated virus 8 reference standard material.

Penaud-Budloo M, Broucque F, Harrouet K, Bouzelha M, Saleun S, Douthe S, D'Costa S, Ogram S, Adjali O, Blouin V, Lock M, Snyder RO, Ayuso E.

Gene Ther. 2019 May;26(5):211-215. doi: 10.1038/s41434-019-0072-9. Epub 2019 Mar 29.


Evaluation of worldwide clinical trials by gender: An FDA perspective.

Ayuso E, Geller RJ, Wang J, Whyte J, Jenkins M.

Contemp Clin Trials. 2019 May;80:16-21. doi: 10.1016/j.cct.2019.03.007. Epub 2019 Mar 16.


Single-Stranded DNA Virus Sequencing (SSV-Seq) for Characterization of Residual DNA and AAV Vector Genomes.

Lecomte E, Leger A, Penaud-Budloo M, Ayuso E.

Methods Mol Biol. 2019;1950:85-106. doi: 10.1007/978-1-4939-9139-6_5.


Accurate Titration of Infectious AAV Particles Requires Measurement of Biologically Active Vector Genomes and Suitable Controls.

François A, Bouzelha M, Lecomte E, Broucque F, Penaud-Budloo M, Adjali O, Moullier P, Blouin V, Ayuso E.

Mol Ther Methods Clin Dev. 2018 Jul 27;10:223-236. doi: 10.1016/j.omtm.2018.07.004. eCollection 2018 Sep 21.


Pharmacology of Recombinant Adeno-associated Virus Production.

Penaud-Budloo M, François A, Clément N, Ayuso E.

Mol Ther Methods Clin Dev. 2018 Jan 8;8:166-180. doi: 10.1016/j.omtm.2018.01.002. eCollection 2018 Mar 16. Review.


Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome.

Polex-Wolf J, Lam BY, Larder R, Tadross J, Rimmington D, Bosch F, Cenzano VJ, Ayuso E, Ma MK, Rainbow K, Coll AP, O'Rahilly S, Yeo GS.

J Clin Invest. 2018 Mar 1;128(3):960-969. doi: 10.1172/JCI97007. Epub 2018 Jan 29.


Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.

Larder R, Sim MFM, Gulati P, Antrobus R, Tung YCL, Rimmington D, Ayuso E, Polex-Wolf J, Lam BYH, Dias C, Logan DW, Virtue S, Bosch F, Yeo GSH, Saudek V, O'Rahilly S, Coll AP.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9421-9426. doi: 10.1073/pnas.1707310114. Epub 2017 Aug 15.


Relevance of Assembly-Activating Protein for Adeno-associated Virus Vector Production and Capsid Protein Stability in Mammalian and Insect Cells.

Grosse S, Penaud-Budloo M, Herrmann AK, Börner K, Fakhiri J, Laketa V, Krämer C, Wiedtke E, Gunkel M, Ménard L, Ayuso E, Grimm D.

J Virol. 2017 Sep 27;91(20). pii: e01198-17. doi: 10.1128/JVI.01198-17. Print 2017 Oct 15.


Long-Term Efficacy and Safety of Insulin and Glucokinase Gene Therapy for Diabetes: 8-Year Follow-Up in Dogs.

Jaén ML, Vilà L, Elias I, Jimenez V, Rodó J, Maggioni L, Ruiz-de Gopegui R, Garcia M, Muñoz S, Callejas D, Ayuso E, Ferré T, Grifoll I, Andaluz A, Ruberte J, Haurigot V, Bosch F.

Mol Ther Methods Clin Dev. 2017 Apr 5;6:1-7. doi: 10.1016/j.omtm.2017.03.008. eCollection 2017 Sep 15.


Accurate Identification and Quantification of DNA Species by Next-Generation Sequencing in Adeno-Associated Viral Vectors Produced in Insect Cells.

Penaud-Budloo M, Lecomte E, Guy-Duché A, Saleun S, Roulet A, Lopez-Roques C, Tournaire B, Cogné B, Léger A, Blouin V, Lindenbaum P, Moullier P, Ayuso E.

Hum Gene Ther Methods. 2017 Jun;28(3):148-162. doi: 10.1089/hgtb.2016.185. Epub 2017 Apr 21.


AAV-ID: A Rapid and Robust Assay for Batch-to-Batch Consistency Evaluation of AAV Preparations.

Pacouret S, Bouzelha M, Shelke R, Andres-Mateos E, Xiao R, Maurer A, Mevel M, Turunen H, Barungi T, Penaud-Budloo M, Broucque F, Blouin V, Moullier P, Ayuso E, Vandenberghe LH.

Mol Ther. 2017 Jun 7;25(6):1375-1386. doi: 10.1016/j.ymthe.2017.04.001. Epub 2017 Apr 17.


Twelfth Annual Meeting of the French Society of Cell and Gene Therapy.

Verhoeyen E, Gomez S, Galy A, Ayuso E, Midoux P, Pucéat M, Vassaux G, Cordelier P.

Hum Gene Ther. 2016 Jul;27(7):555-8. doi: 10.1089/hum.2016.29031.eve. No abstract available.


Practical utilization of recombinant AAV vector reference standards: focus on vector genomes titration by free ITR qPCR.

D'Costa S, Blouin V, Broucque F, Penaud-Budloo M, François A, Perez IC, Le Bec C, Moullier P, Snyder RO, Ayuso E.

Mol Ther Methods Clin Dev. 2016 Mar 30;5:16019. doi: 10.1038/mtm.2016.19. eCollection 2016.


Manufacturing of recombinant adeno-associated viral vectors: new technologies are welcome.

Ayuso E.

Mol Ther Methods Clin Dev. 2016 Jan 6;3:15049. doi: 10.1038/mtm.2015.49. eCollection 2016. No abstract available.


Identification of miRNAs Involved in Reprogramming Acinar Cells into Insulin Producing Cells.

Teichenne J, Morró M, Casellas A, Jimenez V, Tellez N, Leger A, Bosch F, Ayuso E.

PLoS One. 2015 Dec 21;10(12):e0145116. doi: 10.1371/journal.pone.0145116. eCollection 2015.


Contribution of Intronic miR-338-3p and Its Hosting Gene AATK to Compensatory β-Cell Mass Expansion.

Jacovetti C, Jimenez V, Ayuso E, Laybutt R, Peyot ML, Prentki M, Bosch F, Regazzi R.

Mol Endocrinol. 2015 May;29(5):693-702. doi: 10.1210/me.2014-1299. Epub 2015 Mar 9.


Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction.

Bär C, Bernardes de Jesus B, Serrano R, Tejera A, Ayuso E, Jimenez V, Formentini I, Bobadilla M, Mizrahi J, de Martino A, Gomez G, Pisano D, Mulero F, Wollert KC, Bosch F, Blasco MA.

Nat Commun. 2014 Dec 18;5:5863. doi: 10.1038/ncomms6863.


Manufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard material.

Ayuso E, Blouin V, Lock M, McGorray S, Leon X, Alvira MR, Auricchio A, Bucher S, Chtarto A, Clark KR, Darmon C, Doria M, Fountain W, Gao G, Gao K, Giacca M, Kleinschmidt J, Leuchs B, Melas C, Mizukami H, Müller M, Noordman Y, Bockstael O, Ozawa K, Pythoud C, Sumaroka M, Surosky R, Tenenbaum L, van der Linden I, Weins B, Wright JF, Zhang X, Zentilin L, Bosch F, Snyder RO, Moullier P.

Hum Gene Ther. 2014 Nov;25(11):977-87. doi: 10.1089/hum.2014.057.


Pancreatic transduction by helper-dependent adenoviral vectors via intraductal delivery.

Morró M, Teichenne J, Jimenez V, Kratzer R, Marletta S, Maggioni L, Mallol C, Ruberte J, Kochanek S, Bosch F, Ayuso E.

Hum Gene Ther. 2014 Sep;25(9):824-36. doi: 10.1089/hum.2013.182.


Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy.

Haurigot V, Marcó S, Ribera A, Garcia M, Ruzo A, Villacampa P, Ayuso E, Añor S, Andaluz A, Pineda M, García-Fructuoso G, Molas M, Maggioni L, Muñoz S, Motas S, Ruberte J, Mingozzi F, Pumarola M, Bosch F.

J Clin Invest. 2013 Jul 1. pii: 66778. doi: 10.1172/JCI66778. [Epub ahead of print]


Treatment of diabetes and long-term survival after insulin and glucokinase gene therapy.

Callejas D, Mann CJ, Ayuso E, Lage R, Grifoll I, Roca C, Andaluz A, Ruiz-de Gopegui R, Montané J, Muñoz S, Ferre T, Haurigot V, Zhou S, Ruberte J, Mingozzi F, High KA, Garcia F, Bosch F.

Diabetes. 2013 May;62(5):1718-29. doi: 10.2337/db12-1113. Epub 2013 Feb 1.


Intraductal delivery of adenoviruses targets pancreatic tumors in transgenic Ela-myc mice and orthotopic xenografts.

José A, Sobrevals L, Miguel Camacho-Sánchez J, Huch M, Andreu N, Ayuso E, Navarro P, Alemany R, Fillat C.

Oncotarget. 2013 Jan;4(1):94-105.


Proinsulin slows retinal degeneration and vision loss in the P23H rat model of retinitis pigmentosa.

Fernández-Sánchez L, Lax P, Isiegas C, Ayuso E, Ruiz JM, de la Villa P, Bosch F, de la Rosa EJ, Cuenca N.

Hum Gene Ther. 2012 Dec;23(12):1290-300. doi: 10.1089/hum.2012.067. Epub 2012 Nov 5.


Vascular endothelial growth factor-mediated islet hypervascularization and inflammation contribute to progressive reduction of β-cell mass.

Agudo J, Ayuso E, Jimenez V, Casellas A, Mallol C, Salavert A, Tafuro S, Obach M, Ruzo A, Moya M, Pujol A, Bosch F.

Diabetes. 2012 Nov;61(11):2851-61. doi: 10.2337/db12-0134. Epub 2012 Sep 6.


Correction of pathological accumulation of glycosaminoglycans in central nervous system and peripheral tissues of MPSIIIA mice through systemic AAV9 gene transfer.

Ruzo A, Marcó S, García M, Villacampa P, Ribera A, Ayuso E, Maggioni L, Mingozzi F, Haurigot V, Bosch F.

Hum Gene Ther. 2012 Dec;23(12):1237-46. doi: 10.1089/hum.2012.029. Epub 2012 Oct 17.


LRH-1-dependent glucose sensing determines intermediary metabolism in liver.

Oosterveer MH, Mataki C, Yamamoto H, Harach T, Moullan N, van Dijk TH, Ayuso E, Bosch F, Postic C, Groen AK, Auwerx J, Schoonjans K.

J Clin Invest. 2012 Aug;122(8):2817-26. doi: 10.1172/JCI62368. Epub 2012 Jul 9.


Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit.

Guegan T, Cutando L, Ayuso E, Santini E, Fisone G, Bosch F, Martinez A, Valjent E, Maldonado R, Martin M.

Eur Neuropsychopharmacol. 2013 Feb;23(2):146-59. doi: 10.1016/j.euroneuro.2012.04.004. Epub 2012 May 20.


Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer.

Bernardes de Jesus B, Vera E, Schneeberger K, Tejera AM, Ayuso E, Bosch F, Blasco MA.

EMBO Mol Med. 2012 Aug;4(8):691-704. doi: 10.1002/emmm.201200245. Epub 2012 May 15.


Liver production of sulfamidase reverses peripheral and ameliorates CNS pathology in mucopolysaccharidosis IIIA mice.

Ruzo A, Garcia M, Ribera A, Villacampa P, Haurigot V, Marcó S, Ayuso E, Anguela XM, Roca C, Agudo J, Ramos D, Ruberte J, Bosch F.

Mol Ther. 2012 Feb;20(2):254-66. doi: 10.1038/mt.2011.220. Epub 2011 Oct 18.


In vivo genetic engineering of murine pancreatic beta cells mediated by single-stranded adeno-associated viral vectors of serotypes 6, 8 and 9.

Jimenez V, Ayuso E, Mallol C, Agudo J, Casellas A, Obach M, Muñoz S, Salavert A, Bosch F.

Diabetologia. 2011 May;54(5):1075-86. doi: 10.1007/s00125-011-2070-3. Epub 2011 Feb 11.


Production, purification and characterization of adeno-associated vectors.

Ayuso E, Mingozzi F, Bosch F.

Curr Gene Ther. 2010 Dec;10(6):423-36. Review.


Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material.

Lock M, McGorray S, Auricchio A, Ayuso E, Beecham EJ, Blouin-Tavel V, Bosch F, Bose M, Byrne BJ, Caton T, Chiorini JA, Chtarto A, Clark KR, Conlon T, Darmon C, Doria M, Douar A, Flotte TR, Francis JD, Francois A, Giacca M, Korn MT, Korytov I, Leon X, Leuchs B, Lux G, Melas C, Mizukami H, Moullier P, Müller M, Ozawa K, Philipsberg T, Poulard K, Raupp C, Rivière C, Roosendaal SD, Samulski RJ, Soltys SM, Surosky R, Tenenbaum L, Thomas DL, van Montfort B, Veres G, Wright JF, Xu Y, Zelenaia O, Zentilin L, Snyder RO.

Hum Gene Ther. 2010 Oct;21(10):1273-85. doi: 10.1089/hum.2009.223.


Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.

Tung YC, Ayuso E, Shan X, Bosch F, O'Rahilly S, Coll AP, Yeo GS.

PLoS One. 2010 Jan 19;5(1):e8771. doi: 10.1371/journal.pone.0008771.


Skeletal muscle metabolism in the pathology and treatment of type 1 diabetes.

Mann CJ, Ayuso E, Anguela XM, Bosch F.

Curr Pharm Des. 2010;16(8):1002-20. Review.


High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency.

Ayuso E, Mingozzi F, Montane J, Leon X, Anguela XM, Haurigot V, Edmonson SA, Africa L, Zhou S, High KA, Bosch F, Wright JF.

Gene Ther. 2010 Apr;17(4):503-10. doi: 10.1038/gt.2009.157. Epub 2009 Dec 3.


Endothelial cell transduction in primary cultures from regressing mesonephros.

Nacher V, Carretero A, Navarro M, Ayuso E, Ramos D, Luppo M, Rodríguez A, Mendes L, Herrero-Fresneda I, Ruberte J.

Cells Tissues Organs. 2010;191(2):84-95. doi: 10.1159/000231478. Epub 2009 Jul 28.


Increased intraocular insulin-like growth factor-I triggers blood-retinal barrier breakdown.

Haurigot V, Villacampa P, Ribera A, Llombart C, Bosch A, Nacher V, Ramos D, Ayuso E, Segovia JC, Bueren JA, Ruberte J, Bosch F.

J Biol Chem. 2009 Aug 21;284(34):22961-9. doi: 10.1074/jbc.M109.014787. Epub 2009 May 27.


Inducible adeno-associated virus vectors promote functional angiogenesis in adult organisms via regulated vascular endothelial growth factor expression.

Tafuro S, Ayuso E, Zacchigna S, Zentilin L, Moimas S, Dore F, Giacca M.

Cardiovasc Res. 2009 Sep 1;83(4):663-71. doi: 10.1093/cvr/cvp152. Epub 2009 May 14.


IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice.

Agudo J, Ayuso E, Jimenez V, Salavert A, Casellas A, Tafuro S, Haurigot V, Ruberte J, Segovia JC, Bueren J, Bosch F.

Diabetologia. 2008 Oct;51(10):1862-72. doi: 10.1007/s00125-008-1087-8. Epub 2008 Jul 29.


Expression of IGF-I in pancreatic islets prevents lymphocytic infiltration and protects mice from type 1 diabetes.

Casellas A, Salavert A, Agudo J, Ayuso E, Jimenez V, Moya M, Muñoz S, Franckhauser S, Bosch F.

Diabetes. 2006 Dec;55(12):3246-55.


The quail mesonephros: a new model for renal senescence?

Nacher V, Carretero A, Navarro M, Armengol C, Llombart C, Rodríguez A, Herrero-Fresneda I, Ayuso E, Ruberte J.

J Vasc Res. 2006;43(6):581-6. Epub 2006 Oct 6.


In vivo gene transfer to healthy and diabetic canine pancreas.

Ayuso E, Chillón M, García F, Agudo J, Andaluz A, Carretero A, Monfar M, Moya M, Montané J, Otaegui PJ, Bosch F.

Mol Ther. 2006 Apr;13(4):747-55. Epub 2005 Dec 5.


In vivo gene transfer to pancreatic beta cells by systemic delivery of adenoviral vectors.

Ayuso E, Chillón M, Agudo J, Haurigot V, Bosch A, Carretero A, Otaegui PJ, Bosch F.

Hum Gene Ther. 2004 Aug;15(8):805-12.


Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease.

Ruberte J, Ayuso E, Navarro M, Carretero A, Nacher V, Haurigot V, George M, Llombart C, Casellas A, Costa C, Bosch A, Bosch F.

J Clin Invest. 2004 Apr;113(8):1149-57.


Beta cell expression of IGF-I leads to recovery from type 1 diabetes.

George M, Ayuso E, Casellas A, Costa C, Devedjian JC, Bosch F.

J Clin Invest. 2002 May;109(9):1153-63.


Vasculogenesis and angiogenesis in the subcardinal venous plexus of quail mesonephros: spatial and temporal morphological analysis.

Arcalís T, Carretero A, Navarro M, Ayuso E, Ruberte J.

Anat Embryol (Berl). 2002 Jan;205(1):19-28.


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