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Items: 1 to 50 of 60

1.

Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity.

Carmona M, de Cubas L, Bautista E, Moral-Blanch M, Medraño-Fernández I, Sitia R, Boronat S, Ayté J, Hidalgo E.

Nat Commun. 2019 Oct 4;10(1):4526. doi: 10.1038/s41467-019-12475-0.

2.

Identification of ubiquitin-proteasome system components affecting the degradation of the transcription factor Pap1.

Marte L, Boronat S, García-Santamarina S, Ayté J, Kitamura K, Hidalgo E.

Redox Biol. 2019 Aug 20;28:101305. doi: 10.1016/j.redox.2019.101305. [Epub ahead of print]

3.

Gcn5-mediated acetylation at MBF-regulated promoters induces the G1/S transcriptional wave.

González-Medina A, Hidalgo E, Ayté J.

Nucleic Acids Res. 2019 Sep 19;47(16):8439-8451. doi: 10.1093/nar/gkz561.

PMID:
31260531
4.

The INO80 complex activates the transcription of S-phase genes in a cell cycle-regulated manner.

Knezevic I, González-Medina A, Gaspa L, Hidalgo E, Ayté J.

FEBS J. 2018 Oct;285(20):3870-3881. doi: 10.1111/febs.14640. Epub 2018 Sep 6.

5.

Using in vivo oxidation status of one- and two-component redox relays to determine H2O2 levels linked to signaling and toxicity.

Domènech A, Ayté J, Antunes F, Hidalgo E.

BMC Biol. 2018 Jun 1;16(1):61. doi: 10.1186/s12915-018-0523-6.

6.

Phospho-mimicking Atf1 mutants bypass the transcription activating function of the MAP kinase Sty1 of fission yeast.

Sánchez-Mir L, Salat-Canela C, Paulo E, Carmona M, Ayté J, Oliva B, Hidalgo E.

Curr Genet. 2018 Feb;64(1):97-102. doi: 10.1007/s00294-017-0730-7. Epub 2017 Aug 10. Review.

PMID:
28799013
7.

Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation.

Salat-Canela C, Paulo E, Sánchez-Mir L, Carmona M, Ayté J, Oliva B, Hidalgo E.

J Biol Chem. 2017 Aug 18;292(33):13635-13644. doi: 10.1074/jbc.M117.794339. Epub 2017 Jun 26.

8.

Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase.

Boronat S, Domènech A, Carmona M, García-Santamarina S, Bañó MC, Ayté J, Hidalgo E.

PLoS Genet. 2017 Jun 22;13(6):e1006858. doi: 10.1371/journal.pgen.1006858. eCollection 2017 Jun.

9.

A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave.

Gaspa L, González-Medina A, Hidalgo E, Ayté J.

Cell Cycle. 2016;15(5):720-9. doi: 10.1080/15384101.2016.1148839.

10.

Spatiotemporal Control of Forkhead Binding to DNA Regulates the Meiotic Gene Expression Program.

Alves-Rodrigues I, Ferreira PG, Moldón A, Vivancos AP, Hidalgo E, Guigó R, Ayté J.

Cell Rep. 2016 Feb 2;14(4):885-895. doi: 10.1016/j.celrep.2015.12.074. Epub 2016 Jan 21.

11.

Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation.

Eckert D, Andrée N, Razanau A, Zock-Emmenthal S, Lützelberger M, Plath S, Schmidt H, Guerra-Moreno A, Cozzuto L, Ayté J, Käufer NF.

PLoS Genet. 2016 Jan 5;12(1):e1005768. doi: 10.1371/journal.pgen.1005768. eCollection 2016 Jan.

12.

Genome-wide Screening of Regulators of Catalase Expression: ROLE OF A TRANSCRIPTION COMPLEX AND HISTONE AND tRNA MODIFICATION COMPLEXES ON ADAPTATION TO STRESS.

García P, Encinar Del Dedo J, Ayté J, Hidalgo E.

J Biol Chem. 2016 Jan 8;291(2):790-9. doi: 10.1074/jbc.M115.696658. Epub 2015 Nov 13.

13.

A cascade of iron-containing proteins governs the genetic iron starvation response to promote iron uptake and inhibit iron storage in fission yeast.

Encinar del Dedo J, Gabrielli N, Carmona M, Ayté J, Hidalgo E.

PLoS Genet. 2015 Mar 25;11(3):e1005106. doi: 10.1371/journal.pgen.1005106. eCollection 2015 Mar.

14.

Binding of the transcription factor Atf1 to promoters serves as a barrier to phase nucleosome arrays and avoid cryptic transcription.

García P, Paulo E, Gao J, Wahls WP, Ayté J, Lowy E, Hidalgo E.

Nucleic Acids Res. 2014;42(16):10351-9. doi: 10.1093/nar/gku704. Epub 2014 Aug 13.

15.

Monitoring in vivo reversible cysteine oxidation in proteins using ICAT and mass spectrometry.

García-Santamarina S, Boronat S, Domènech A, Ayté J, Molina H, Hidalgo E.

Nat Protoc. 2014 May;9(5):1131-45. doi: 10.1038/nprot.2014.065. Epub 2014 Apr 17.

PMID:
24743420
16.

A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase.

Paulo E, García-Santamarina S, Calvo IA, Carmona M, Boronat S, Domènech A, Ayté J, Hidalgo E.

Mol Microbiol. 2014 Apr;92(2):246-57. doi: 10.1111/mmi.12548. Epub 2014 Mar 6.

17.

Dissection of a redox relay: H2O2-dependent activation of the transcription factor Pap1 through the peroxidatic Tpx1-thioredoxin cycle.

Calvo IA, Boronat S, Domènech A, García-Santamarina S, Ayté J, Hidalgo E.

Cell Rep. 2013 Dec 12;5(5):1413-24. doi: 10.1016/j.celrep.2013.11.027. Epub 2013 Dec 5.

18.

Methionine sulphoxide reductases revisited: free methionine as a primary target of H₂O₂stress in auxotrophic fission yeast.

García-Santamarina S, Boronat S, Ayté J, Hidalgo E.

Mol Microbiol. 2013 Dec;90(5):1113-24. doi: 10.1111/mmi.12420. Epub 2013 Oct 29.

19.

The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor.

Ivanova T, Alves-Rodrigues I, Gómez-Escoda B, Dutta C, DeCaprio JA, Rhind N, Hidalgo E, Ayté J.

Mol Biol Cell. 2013 Nov;24(21):3350-7. doi: 10.1091/mbc.E13-05-0257. Epub 2013 Sep 4.

20.

Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs.

Fernández-Vázquez J, Vargas-Pérez I, Sansó M, Buhne K, Carmona M, Paulo E, Hermand D, Rodríguez-Gabriel M, Ayté J, Leidel S, Hidalgo E.

PLoS Genet. 2013;9(7):e1003647. doi: 10.1371/journal.pgen.1003647. Epub 2013 Jul 18.

21.

Reversible thiol oxidation in the H2O2-dependent activation of the transcription factor Pap1.

Calvo IA, Ayté J, Hidalgo E.

J Cell Sci. 2013 May 15;126(Pt 10):2279-84. doi: 10.1242/jcs.124370. Epub 2013 Mar 22.

22.

Is oxidized thioredoxin a major trigger for cysteine oxidation? Clues from a redox proteomics approach.

García-Santamarina S, Boronat S, Calvo IA, Rodríguez-Gabriel M, Ayté J, Molina H, Hidalgo E.

Antioxid Redox Signal. 2013 May 1;18(13):1549-56. doi: 10.1089/ars.2012.5037. Epub 2012 Dec 10.

23.

Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.

Gabrielli N, Ayté J, Hidalgo E.

J Biol Chem. 2012 Dec 14;287(51):43042-51. doi: 10.1074/jbc.M112.421735. Epub 2012 Oct 31.

24.

Chemical genetic induction of meiosis in Schizosaccharomyces pombe.

Guerra-Moreno A, Alves-Rodrigues I, Hidalgo E, Ayté J.

Cell Cycle. 2012 Apr 15;11(8):1621-5. doi: 10.4161/cc.20051. Epub 2012 Apr 15.

PMID:
22456336
25.

The transcription factors Pap1 and Prr1 collaborate to activate antioxidant, but not drug tolerance, genes in response to H2O2.

Calvo IA, García P, Ayté J, Hidalgo E.

Nucleic Acids Res. 2012 Jun;40(11):4816-24. doi: 10.1093/nar/gks141. Epub 2012 Feb 16.

26.

Nuclear roles and regulation of chromatin structure by the stress-dependent MAP kinase Sty1 of Schizosaccharomyces pombe.

Sansó M, Vargas-Pérez I, García P, Ayté J, Hidalgo E.

Mol Microbiol. 2011 Nov;82(3):542-54. doi: 10.1111/j.1365-2958.2011.07851.x. Epub 2011 Oct 13. Review.

27.

The oxidized thiol proteome in fission yeast--optimization of an ICAT-based method to identify H2O2-oxidized proteins.

García-Santamarina S, Boronat S, Espadas G, Ayté J, Molina H, Hidalgo E.

J Proteomics. 2011 Oct 19;74(11):2476-86. doi: 10.1016/j.jprot.2011.05.030. Epub 2011 Jun 6.

PMID:
21672643
28.

Gcn5 facilitates Pol II progression, rather than recruitment to nucleosome-depleted stress promoters, in Schizosaccharomyces pombe.

Sansó M, Vargas-Pérez I, Quintales L, Antequera F, Ayté J, Hidalgo E.

Nucleic Acids Res. 2011 Aug;39(15):6369-79. doi: 10.1093/nar/gkr255. Epub 2011 Apr 22.

29.

G1/S transcription and the DNA synthesis checkpoint: common regulatory mechanisms.

Ivanova T, Gómez-Escoda B, Hidalgo E, Ayté J.

Cell Cycle. 2011 Mar 15;10(6):912-5. Epub 2011 Mar 15.

PMID:
21325896
30.

Yox1 links MBF-dependent transcription to completion of DNA synthesis.

Gómez-Escoda B, Ivanova T, Calvo IA, Alves-Rodrigues I, Hidalgo E, Ayté J.

EMBO Rep. 2011 Jan;12(1):84-9. doi: 10.1038/embor.2010.187. Epub 2010 Dec 3.

31.

Living on the edge: stress and activation of stress responses promote lifespan extension.

Zuin A, Castellano-Esteve D, Ayté J, Hidalgo E.

Aging (Albany NY). 2010 Apr;2(4):231-7.

32.

Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway.

Zuin A, Carmona M, Morales-Ivorra I, Gabrielli N, Vivancos AP, Ayté J, Hidalgo E.

EMBO J. 2010 Mar 3;29(5):981-91. doi: 10.1038/emboj.2009.407. Epub 2010 Jan 14.

33.

Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Calvo IA, Gabrielli N, Iglesias-Baena I, García-Santamarina S, Hoe KL, Kim DU, Sansó M, Zuin A, Pérez P, Ayté J, Hidalgo E.

PLoS One. 2009 Aug 12;4(8):e6619. doi: 10.1371/journal.pone.0006619.

34.

At the (3') end, you'll turn to meiosis.

Moldón A, Ayté J.

Nat Struct Mol Biol. 2009 Apr;16(4):350-1. doi: 10.1038/nsmb0409-350. No abstract available.

PMID:
19343068
35.

Promoter-driven splicing regulation in fission yeast.

Moldón A, Malapeira J, Gabrielli N, Gogol M, Gómez-Escoda B, Ivanova T, Seidel C, Ayté J.

Nature. 2008 Oct 16;455(7215):997-1000. doi: 10.1038/nature07325. Epub 2008 Sep 24.

PMID:
18815595
36.

Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

Zuin A, Gabrielli N, Calvo IA, García-Santamarina S, Hoe KL, Kim DU, Park HO, Hayles J, Ayté J, Hidalgo E.

PLoS One. 2008 Jul 30;3(7):e2842. doi: 10.1371/journal.pone.0002842.

37.

Transcription factors Pcr1 and Atf1 have distinct roles in stress- and Sty1-dependent gene regulation.

Sansó M, Gogol M, Ayté J, Seidel C, Hidalgo E.

Eukaryot Cell. 2008 May;7(5):826-35. doi: 10.1128/EC.00465-07. Epub 2008 Mar 28.

38.

The glycolytic metabolite methylglyoxal activates Pap1 and Sty1 stress responses in Schizosaccharomyces pombe.

Zuin A, Vivancos AP, Sansó M, Takatsume Y, Ayté J, Inoue Y, Hidalgo E.

J Biol Chem. 2005 Nov 4;280(44):36708-13. Epub 2005 Sep 1.

39.

A meiosis-specific cyclin regulated by splicing is required for proper progression through meiosis.

Malapeira J, Moldón A, Hidalgo E, Smith GR, Nurse P, Ayté J.

Mol Cell Biol. 2005 Aug;25(15):6330-7.

40.

A cysteine-sulfinic acid in peroxiredoxin regulates H2O2-sensing by the antioxidant Pap1 pathway.

Vivancos AP, Castillo EA, Biteau B, Nicot C, Ayté J, Toledano MB, Hidalgo E.

Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8875-80. Epub 2005 Jun 13.

41.

Activation of the redox sensor Pap1 by hydrogen peroxide requires modulation of the intracellular oxidant concentration.

Vivancos AP, Castillo EA, Jones N, Ayté J, Hidalgo E.

Mol Microbiol. 2004 Jun;52(5):1427-35.

42.

Schizosaccharomyces pombe cells lacking the Ran-binding protein Hba1 show a multidrug resistance phenotype due to constitutive nuclear accumulation of Pap1.

Castillo EA, Vivancos AP, Jones N, Ayte J, Hidalgo E.

J Biol Chem. 2003 Oct 17;278(42):40565-72. Epub 2003 Aug 1.

43.

Diethylmaleate activates the transcription factor Pap1 by covalent modification of critical cysteine residues.

Castillo EA, Ayté J, Chiva C, Moldón A, Carrascal M, Abián J, Jones N, Hidalgo E.

Mol Microbiol. 2002 Jul;45(1):243-54.

44.

The G1/S cyclin Cig2p during meiosis in fission yeast.

Borgne A, Murakami H, Ayté J, Nurse P.

Mol Biol Cell. 2002 Jun;13(6):2080-90.

45.

Feedback regulation of the MBF transcription factor by cyclin Cig2.

Ayté J, Schweitzer C, Zarzov P, Nurse P, DeCaprio JA.

Nat Cell Biol. 2001 Dec;3(12):1043-50.

PMID:
11781565
46.
47.

The Schizosaccharomyces pombe MBF complex requires heterodimerization for entry into S phase.

Ayté J, Leis JF, Herrera A, Tang E, Yang H, DeCaprio JA.

Mol Cell Biol. 1995 May;15(5):2589-99.

48.

Immunolocalization of mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase in rat liver.

Royo T, Pedragosa MJ, Ayté J, Gil-Gómez G, Vilaró S, Hegardt FG.

J Cell Physiol. 1995 Jan;162(1):103-9.

PMID:
7814442
49.

Gene expression of enzymes regulating ketogenesis and fatty acid metabolism in regenerating rat liver.

Asins G, Rosa JL, Serra D, Gil-Gómez G, Ayté J, Bartrons R, Tauler A, Hegardt FG.

Biochem J. 1994 Apr 1;299 ( Pt 1):65-9.

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