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Mutation of key lysine residues in the Insert B region of the yeast dynamin Vps1 disrupts lipid binding and causes defects in endocytosis.

Smaczynska-de Rooij II, Marklew CJ, Palmer SE, Allwood EG, Ayscough KR.

PLoS One. 2019 Apr 22;14(4):e0215102. doi: 10.1371/journal.pone.0215102. eCollection 2019.


AP-2-Dependent Endocytic Recycling of the Chitin Synthase Chs3 Regulates Polarized Growth in Candida albicans.

Knafler HC, Smaczynska-de Rooij II, Walker LA, Lee KK, Gow NAR, Ayscough KR.

MBio. 2019 Mar 19;10(2). pii: e02421-18. doi: 10.1128/mBio.02421-18.


Yeast-model-based study identified myosin- and calcium-dependent calmodulin signalling as a potential target for drug intervention in chorea-acanthocytosis.

Soczewka P, Kolakowski D, Smaczynska-de Rooij I, Rzepnikowska W, Ayscough KR, Kaminska J, Zoladek T.

Dis Model Mech. 2019 Jan 28;12(1). pii: dmm036830. doi: 10.1242/dmm.036830.


Disruption of the plant-specific CFS1 gene impairs autophagosome turnover and triggers EDS1-dependent cell death.

Sutipatanasomboon A, Herberth S, Alwood EG, Häweker H, Müller B, Shahriari M, Zienert AY, Marin B, Robatzek S, Praefcke GJK, Ayscough KR, Hülskamp M, Schellmann S.

Sci Rep. 2017 Aug 17;7(1):8677. doi: 10.1038/s41598-017-08577-8.


Insights into dynamin-associated disorders through analysis of equivalent mutations in the yeast dynamin Vps1.

Moustaq L, Smaczynska-de Rooij II, Palmer SE, Marklew CJ, Ayscough KR.

Microb Cell. 2016 Mar 22;3(4):147-158. doi: 10.15698/mic2016.04.490.


Amino acid substitution equivalent to human chorea-acanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate.

Rzepnikowska W, Flis K, Kaminska J, Grynberg M, Urbanek A, Ayscough KR, Zoladek T.

Hum Mol Genet. 2017 Apr 15;26(8):1497-1510. doi: 10.1093/hmg/ddx054.


WASP family proteins, more than Arp2/3 activators.

Tyler JJ, Allwood EG, Ayscough KR.

Biochem Soc Trans. 2016 Oct 15;44(5):1339-1345. Review.


Elucidating Key Motifs Required for Arp2/3-Dependent and Independent Actin Nucleation by Las17/WASP.

Allwood EG, Tyler JJ, Urbanek AN, Smaczynska-de Rooij II, Ayscough KR.

PLoS One. 2016 Sep 16;11(9):e0163177. doi: 10.1371/journal.pone.0163177. eCollection 2016.


Phosphorylation Regulates the Endocytic Function of the Yeast Dynamin-Related Protein Vps1.

Smaczynska-de Rooij II, Marklew CJ, Allwood EG, Palmer SE, Booth WI, Mishra R, Goldberg MW, Ayscough KR.

Mol Cell Biol. 2015 Dec 28;36(5):742-55. doi: 10.1128/MCB.00833-15.


A Charge Swap mutation E461K in the yeast dynamin Vps1 reduces endocytic invagination.

Palmer SE, Smaczynska-de Rooij II, Marklew CJ, Allwood EG, Mishra R, Goldberg MW, Ayscough KR.

Commun Integr Biol. 2015 Aug 31;8(4):e1051274. doi: 10.1080/19420889.2015.1051274. eCollection 2015 Jul-Aug.


Distinct Actin and Lipid Binding Sites in Ysc84 Are Required during Early Stages of Yeast Endocytosis.

Urbanek AN, Allwood EG, Smith AP, Booth WI, Ayscough KR.

PLoS One. 2015 Aug 27;10(8):e0136732. doi: 10.1371/journal.pone.0136732. eCollection 2015.


A dynamin-actin interaction is required for vesicle scission during endocytosis in yeast.

Palmer SE, Smaczynska-de Rooij II, Marklew CJ, Allwood EG, Mishra R, Johnson S, Goldberg MW, Ayscough KR.

Curr Biol. 2015 Mar 30;25(7):868-78. doi: 10.1016/j.cub.2015.01.061. Epub 2015 Mar 12.


Function and interactions of the Ysc84/SH3yl1 family of actin- and lipid-binding proteins.

Urbanek AN, Chan R, Ayscough KR.

Biochem Soc Trans. 2015 Feb;43(1):111-6. doi: 10.1042/BST20140221. Review.


An Abp1-dependent route of endocytosis functions when the classical endocytic pathway in yeast is inhibited.

Aghamohammadzadeh S, Smaczynska-de Rooij II, Ayscough KR.

PLoS One. 2014 Jul 29;9(7):e103311. doi: 10.1371/journal.pone.0103311. eCollection 2014.


Yeast endocytic adaptor AP-2 binds the stress sensor Mid2 and functions in polarized cell responses.

Chapa-y-Lazo B, Allwood EG, Smaczynska-de Rooij II, Snape ML, Ayscough KR.

Traffic. 2014 May;15(5):546-57. doi: 10.1111/tra.12155. Epub 2014 Feb 25.


A novel actin-binding motif in Las17/WASP nucleates actin filaments independently of Arp2/3.

Urbanek AN, Smith AP, Allwood EG, Booth WI, Ayscough KR.

Curr Biol. 2013 Feb 4;23(3):196-203. doi: 10.1016/j.cub.2012.12.024. Epub 2013 Jan 3.


Depletion of the actin bundling protein SM22/transgelin increases actin dynamics and enhances the tumourigenic phenotypes of cells.

Thompson O, Moghraby JS, Ayscough KR, Winder SJ.

BMC Cell Biol. 2012 Jan 18;13:1. doi: 10.1186/1471-2121-13-1.


Yeast dynamin Vps1 and amphiphysin Rvs167 function together during endocytosis.

Smaczynska-de Rooij II, Allwood EG, Mishra R, Booth WI, Aghamohammadzadeh S, Goldberg MW, Ayscough KR.

Traffic. 2012 Feb;13(2):317-28. doi: 10.1111/j.1600-0854.2011.01311.x. Epub 2011 Dec 6.


Expression of Vps1 I649K a self-assembly defective yeast dynamin, leads to formation of extended endocytic invaginations.

Mishra R, Smaczynska-de Rooij II, Goldberg MW, Ayscough KR.

Commun Integr Biol. 2011 Jan;4(1):115-7. doi: 10.4161/cib.4.1.14206.


A role for the dynamin-like protein Vps1 during endocytosis in yeast.

Smaczynska-de Rooij II, Allwood EG, Aghamohammadzadeh S, Hettema EH, Goldberg MW, Ayscough KR.

J Cell Sci. 2010 Oct 15;123(Pt 20):3496-506. doi: 10.1242/jcs.070508. Epub 2010 Sep 14.


Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan.

Thompson O, Moore CJ, Hussain SA, Kleino I, Peckham M, Hohenester E, Ayscough KR, Saksela K, Winder SJ.

J Cell Sci. 2010 Jan 1;123(Pt 1):118-27. doi: 10.1242/jcs.047902.


Membrane rafts are involved in intracellular miconazole accumulation in yeast cells.

François IE, Bink A, Vandercappellen J, Ayscough KR, Toulmay A, Schneiter R, van Gyseghem E, Van den Mooter G, Borgers M, Vandenbosch D, Coenye T, Cammue BP, Thevissen K.

J Biol Chem. 2009 Nov 20;284(47):32680-5. doi: 10.1074/jbc.M109.014571. Epub 2009 Sep 25.


Differential requirements for actin during yeast and mammalian endocytosis.

Aghamohammadzadeh S, Ayscough KR.

Nat Cell Biol. 2009 Aug;11(8):1039-42. doi: 10.1038/ncb1918. Epub 2009 Jul 13.


Functions of actin in endocytosis.

Robertson AS, Smythe E, Ayscough KR.

Cell Mol Life Sci. 2009 Jul;66(13):2049-65. doi: 10.1007/s00018-009-0001-y. Epub 2009 Mar 17. Review.


Methyl beta-cyclodextrin reduces accumulation of reactive oxygen species and cell death in yeast.

Du W, Ayscough KR.

Free Radic Biol Med. 2009 Jun 1;46(11):1478-87. doi: 10.1016/j.freeradbiomed.2009.02.032. Epub 2009 Mar 9.


Whi2p links nutritional sensing to actin-dependent Ras-cAMP-PKA regulation and apoptosis in yeast.

Leadsham JE, Miller K, Ayscough KR, Colombo S, Martegani E, Sudbery P, Gourlay CW.

J Cell Sci. 2009 Mar 1;122(Pt 5):706-15. doi: 10.1242/jcs.042424. Epub 2009 Feb 10.


The WASP homologue Las17 activates the novel actin-regulatory activity of Ysc84 to promote endocytosis in yeast.

Robertson AS, Allwood EG, Smith AP, Gardiner FC, Costa R, Winder SJ, Ayscough KR.

Mol Biol Cell. 2009 Mar;20(6):1618-28. doi: 10.1091/mbc.E08-09-0982. Epub 2009 Jan 21.


Interactions between the yeast SM22 homologue Scp1 and actin demonstrate the importance of actin bundling in endocytosis.

Gheorghe DM, Aghamohammadzadeh S, Smaczynska-de Rooij II, Allwood EG, Winder SJ, Ayscough KR.

J Biol Chem. 2008 May 30;283(22):15037-46. doi: 10.1074/jbc.M710332200. Epub 2008 Apr 8.


Yeast Arf3p modulates plasma membrane PtdIns(4,5)P2 levels to facilitate endocytosis.

Smaczynska-de Rooij II, Costa R, Ayscough KR.

Traffic. 2008 Apr;9(4):559-73. doi: 10.1111/j.1600-0854.2008.00708.x. Epub 2008 Jan 15.


Miconazole induces changes in actin cytoskeleton prior to reactive oxygen species induction in yeast.

Thevissen K, Ayscough KR, Aerts AM, Du W, De Brucker K, Meert EM, Ausma J, Borgers M, Cammue BP, François IE.

J Biol Chem. 2007 Jul 27;282(30):21592-7. Epub 2007 Jun 6.


Nucleocytoplasmic trafficking is required for functioning of the adaptor protein Sla1p in endocytosis.

Gardiner FC, Costa R, Ayscough KR.

Traffic. 2007 Apr;8(4):347-58. Epub 2007 Feb 7.


Actin regulation in endocytosis.

Smythe E, Ayscough KR.

J Cell Sci. 2006 Nov 15;119(Pt 22):4589-98. Review.


Apoptosis in yeast--mechanisms and benefits to a unicellular organism.

Gourlay CW, Du W, Ayscough KR.

Mol Microbiol. 2006 Dec;62(6):1515-21. Review.


Interactions between Sla1p, Lsb5p and Arf3p in yeast endocytosis.

Costa R, Ayscough KR.

Biochem Soc Trans. 2005 Dec;33(Pt 6):1273-5.


A role for actin in aging and apoptosis.

Gourlay CW, Ayscough KR.

Biochem Soc Trans. 2005 Dec;33(Pt 6):1260-4. Review.


Defining protein modules for endocytosis.

Ayscough KR.

Cell. 2005 Oct 21;123(2):188-90.


Coupling actin dynamics to the endocytic process in Saccharomyces cerevisiae.

Ayscough KR.

Protoplasma. 2005 Oct;226(1-2):81-8. Epub 2005 Oct 20. Review.


The actin cytoskeleton in ageing and apoptosis.

Gourlay CW, Ayscough KR.

FEMS Yeast Res. 2005 Dec;5(12):1193-8. Epub 2005 Aug 29. Review.


The actin cytoskeleton: a key regulator of apoptosis and ageing?

Gourlay CW, Ayscough KR.

Nat Rev Mol Cell Biol. 2005 Jul;6(7):583-9. Review.


Identification of an upstream regulatory pathway controlling actin-mediated apoptosis in yeast.

Gourlay CW, Ayscough KR.

J Cell Sci. 2005 May 15;118(Pt 10):2119-32. Epub 2005 Apr 26.


Actin-binding proteins.

Winder SJ, Ayscough KR.

J Cell Sci. 2005 Feb 15;118(Pt 4):651-4. Review. No abstract available.


Two billion years of actin. Meeting on cytoskeletal dynamics: from cell biology to developmental disease.

Ayscough KR, Winder SJ.

EMBO Rep. 2004 Oct;5(10):947-52. Epub 2004 Sep 24. No abstract available.


A role for the actin cytoskeleton in cell death and aging in yeast.

Gourlay CW, Carpp LN, Timpson P, Winder SJ, Ayscough KR.

J Cell Biol. 2004 Mar 15;164(6):803-9.


SCP1 encodes an actin-bundling protein in yeast.

Winder SJ, Jess T, Ayscough KR.

Biochem J. 2003 Oct 15;375(Pt 2):287-95.


An interaction between Sla1p and Sla2p plays a role in regulating actin dynamics and endocytosis in budding yeast.

Gourlay CW, Dewar H, Warren DT, Costa R, Satish N, Ayscough KR.

J Cell Sci. 2003 Jun 15;116(Pt 12):2551-64. Epub 2003 May 6.


Novel proteins linking the actin cytoskeleton to the endocytic machinery in Saccharomyces cerevisiae.

Dewar H, Warren DT, Gardiner FC, Gourlay CG, Satish N, Richardson MR, Andrews PD, Ayscough KR.

Mol Biol Cell. 2002 Oct;13(10):3646-61.

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