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Items: 7

1.

1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction.

Ahmed S, Ayscough A, Barker GR, Canning HE, Davenport R, Downham R, Harrison D, Jenkins K, Kinsella N, Livermore DG, Wright S, Ivetac AD, Skene R, Wilkens SJ, Webster NA, Hendrick AG.

J Med Chem. 2017 Jul 13;60(13):5663-5672. doi: 10.1021/acs.jmedchem.7b00352. Epub 2017 Jun 24.

PMID:
28594552
2.

Assessing molecular scaffolds for CNS drug discovery.

Mayol-LlinĂ s J, Nelson A, Farnaby W, Ayscough A.

Drug Discov Today. 2017 Jul;22(7):965-969. doi: 10.1016/j.drudis.2017.01.008. Epub 2017 Jan 20.

3.

Peptidomimetic inhibitors of bacterial peptide deformylase.

East SP, Ayscough A, Toogood-Johnson I, Taylor S, Thomas W.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):4032-5. doi: 10.1016/j.bmcl.2011.04.132. Epub 2011 May 11.

PMID:
21621999
4.

CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells.

Krige D, Needham LA, Bawden LJ, Flores N, Farmer H, Miles LE, Stone E, Callaghan J, Chandler S, Clark VL, Kirwin-Jones P, Legris V, Owen J, Patel T, Wood S, Box G, Laber D, Odedra R, Wright A, Wood LM, Eccles SA, Bone EA, Ayscough A, Drummond AH.

Cancer Res. 2008 Aug 15;68(16):6669-79. doi: 10.1158/0008-5472.CAN-07-6627.

5.

Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy.

Chiang GC, Bond AD, Ayscough A, Pain G, Ducki S, Holmes AB.

Chem Commun (Camb). 2005 Apr 14;(14):1860-2. Epub 2005 Feb 11.

PMID:
15795767
6.

Structure--activity relationships of the peptide deformylase inhibitor BB-3497: modification of the P2' and P3' side chains.

Davies SJ, Ayscough AP, Beckett RP, Clements JM, Doel S, Pratt LM, Spavold ZM, Thomas SW, Whittaker M.

Bioorg Med Chem Lett. 2003 Aug 18;13(16):2715-8.

PMID:
12873500
7.

Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the methylene spacer and the P1' side chain.

Davies SJ, Ayscough AP, Beckett RP, Bragg RA, Clements JM, Doel S, Grew C, Launchbury SB, Perkins GM, Pratt LM, Smith HK, Spavold ZM, Thomas SW, Todd RS, Whittaker M.

Bioorg Med Chem Lett. 2003 Aug 18;13(16):2709-13.

PMID:
12873499

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