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Items: 42

1.

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions.

Bueno C, Calero-Nieto FJ, Wang X, Valdés-Mas R, Gutiérrez-Agüera F, Roca-Ho H, Ayllon V, Real PJ, Arambilet D, Espinosa L, Torres-Ruiz R, Agraz-Doblas A, Varela I, de Boer J, Bigas A, Gottgens B, Marschalek R, Menendez P.

Haematologica. 2019 Jun;104(6):1189-1201. doi: 10.3324/haematol.2018.202044. Epub 2019 Jan 24.

2.

Correction: NG2 antigen is involved in leukemia invasiveness and central nervous system infiltration in MLL-rearranged infant B-ALL.

Prieto C, López-Millán B, Roca-Ho H, Stam RW, Romero-Moya D, Rodríguez-Baena FJ, Sanjuan-Pla A, Ayllón V, Ramírez M, Bardini M, De Lorenzo P, Valsecchi MG, Stanulla M, Iglesias M, Ballerini P, Carcaboso ÁM, Mora J, Locatelli F, Bertaina A, Padilla L, Rodríguez-Manzaneque JC, Bueno C, Menéndez P.

Leukemia. 2018 Oct;32(10):2306. doi: 10.1038/s41375-018-0236-4.

PMID:
30218009
3.

Hoxa9 and EGFP reporter expression in human Embryonic Stem Cells (hESC) as useful tools for studying human development.

Domingo-Reines J, López-Ornelas A, Montes R, Romero T, Rodriguez-Llamas JL, Lara-Rodarte R, González-Pozas F, Ayllon V, Menendez P, Velasco I, Ramos-Mejia V.

Stem Cell Res. 2017 Dec;25:286-290. doi: 10.1016/j.scr.2017.08.004. Epub 2017 Aug 5.

4.

Establishment of 2 control and 2 hPSC cell lines constitutively expressing the Notch ligand DLL4.

González-Pozas F, Montes R, Domingo-Reinés J, Ayllón V, Ramos-Mejía V.

Stem Cell Res. 2017 Dec;25:274-277. doi: 10.1016/j.scr.2017.07.008. Epub 2017 Jul 10.

5.

NG2 antigen is involved in leukemia invasiveness and central nervous system infiltration in MLL-rearranged infant B-ALL.

Prieto C, López-Millán B, Roca-Ho H, Stam RW, Romero-Moya D, Rodríguez-Baena FJ, Sanjuan-Pla A, Ayllón V, Ramírez M, Bardini M, De Lorenzo P, Valsecchi MG, Stanulla M, Iglesias M, Ballerini P, Carcaboso ÁM, Mora J, Locatelli F, Bertaina A, Padilla L, Rodríguez-Manzaneque JC, Bueno C, Menéndez P.

Leukemia. 2018 Mar;32(3):633-644. doi: 10.1038/leu.2017.294. Epub 2017 Sep 25. Erratum in: Leukemia. 2018 Oct;32(10):2306.

6.

RUNX1c Regulates Hematopoietic Differentiation of Human Pluripotent Stem Cells Possibly in Cooperation with Proinflammatory Signaling.

Navarro-Montero O, Ayllon V, Lamolda M, López-Onieva L, Montes R, Bueno C, Ng E, Guerrero-Carreno X, Romero T, Romero-Moya D, Stanley E, Elefanty A, Ramos-Mejia V, Menendez P, Real PJ.

Stem Cells. 2017 Nov;35(11):2253-2266. doi: 10.1002/stem.2700. Epub 2017 Sep 23.

7.

New hPSC-based human models to study pediatric Acute Megakaryoblastic Leukemia harboring the fusion oncogene RBM15-MKL1.

Ayllón V, Vogel-González M, González-Pozas F, Domingo-Reinés J, Montes R, Morales-Cacho L, Ramos-Mejía V.

Stem Cell Res. 2017 Mar;19:1-5. doi: 10.1016/j.scr.2016.12.019. Epub 2016 Dec 19.

8.

Engineered LINE-1 retrotransposition in nondividing human neurons.

Macia A, Widmann TJ, Heras SR, Ayllon V, Sanchez L, Benkaddour-Boumzaouad M, Muñoz-Lopez M, Rubio A, Amador-Cubero S, Blanco-Jimenez E, Garcia-Castro J, Menendez P, Ng P, Muotri AR, Goodier JL, Garcia-Perez JL.

Genome Res. 2017 Mar;27(3):335-348. doi: 10.1101/gr.206805.116. Epub 2016 Dec 13.

9.

Corrigendum to "Generation of induced pluripotent stem cells (iPSCs) from a Bernard-Soulier syndrome patient carrying a W71R mutation in the GPIX gene" [Stem Cell Res. 16/3 (2016) 692-695].

Lopez-Onieva L, Montes R, Lamolda M, Romero T, Ayllon V, Lozano ML, Vicente V, Rivera J, Ramos-Mejía V, Real PJ.

Stem Cell Res. 2016 Sep;17(2):462. doi: 10.1016/j.scr.2016.07.008. Epub 2016 Aug 31. No abstract available.

10.

Generation of human pluripotent stem cell lines with suppressed expression of the Notch ligand DLL4 using short hairpin RNAs.

González-Pozas F, Montes R, López-Onieva L, Romero T, Domingo-Reinés J, Real PJ, Ramos-Mejía V, Ayllón V.

Stem Cell Res. 2016 May;16(3):735-9. doi: 10.1016/j.scr.2016.04.005. Epub 2016 Apr 16. No abstract available.

11.

Generation of induced pluripotent stem cells (iPSCs) from a Bernard-Soulier syndrome patient carrying a W71R mutation in the GPIX gene.

Lopez-Onieva L, Montes R, Lamolda M, Romero T, Ayllon V, Lozano ML, Vicente V, Rivera J, Ramos-Mejía V, Real PJ.

Stem Cell Res. 2016 May;16(3):692-5. doi: 10.1016/j.scr.2016.04.013. Epub 2016 Apr 15. Erratum in: Stem Cell Res. 2016 Sep;17 (2):462.

12.

Generation and characterization of the human iPSC line PBMC1-iPS4F1 from adult peripheral blood mononuclear cells.

Montes R, Romero T, Cabrera S, Ayllon V, Lopez-Escamez JA, Ramos-Mejia V, Real PJ.

Stem Cell Res. 2015 Nov;15(3):614-7. doi: 10.1016/j.scr.2015.10.009. Epub 2015 Oct 19.

13.

The Notch ligand DLL4 specifically marks human hematoendothelial progenitors and regulates their hematopoietic fate.

Ayllón V, Bueno C, Ramos-Mejía V, Navarro-Montero O, Prieto C, Real PJ, Romero T, García-León MJ, Toribio ML, Bigas A, Menendez P.

Leukemia. 2015 Aug;29(8):1741-53. doi: 10.1038/leu.2015.74. Epub 2015 Mar 17.

PMID:
25778099
14.

Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence.

Guiu J, Bergen DJ, De Pater E, Islam AB, Ayllón V, Gama-Norton L, Ruiz-Herguido C, González J, López-Bigas N, Menendez P, Dzierzak E, Espinosa L, Bigas A.

J Exp Med. 2014 Nov 17;211(12):2411-23. doi: 10.1084/jem.20131857. Epub 2014 Nov 10.

15.

SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells.

Toscano MG, Navarro-Montero O, Ayllon V, Ramos-Mejia V, Guerrero-Carreno X, Bueno C, Romero T, Lamolda M, Cobo M, Martin F, Menendez P, Real PJ.

Mol Ther. 2015 Jan;23(1):158-70. doi: 10.1038/mt.2014.196. Epub 2014 Oct 8.

16.

HOXA9 promotes hematopoietic commitment of human embryonic stem cells.

Ramos-Mejía V, Navarro-Montero O, Ayllón V, Bueno C, Romero T, Real PJ, Menendez P.

Blood. 2014 Nov 13;124(20):3065-75. doi: 10.1182/blood-2014-03-558825. Epub 2014 Sep 3.

PMID:
25185710
17.

Ligand-independent FLT3 activation does not cooperate with MLL-AF4 to immortalize/transform cord blood CD34+ cells.

Montes R, Ayllón V, Prieto C, Bursen A, Prelle C, Romero-Moya D, Real PJ, Navarro-Montero O, Chillón C, Marschalek R, Bueno C, Menendez P.

Leukemia. 2014 Mar;28(3):666-74. doi: 10.1038/leu.2013.346. Epub 2013 Nov 18.

PMID:
24240202
18.

PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome.

Bowe RA, Cox OT, Ayllón V, Tresse E, Healy NC, Edmunds SJ, Huigsloot M, O'Connor R.

Mol Biol Cell. 2014 Jan;25(1):184-95. doi: 10.1091/mbc.E13-06-0306. Epub 2013 Nov 6.

19.

HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H(+) ATPase.

Fogarty FM, O'Keeffe J, Zhadanov A, Papkovsky D, Ayllon V, O'Connor R.

Oncogene. 2014 Sep 18;33(38):4653-63. doi: 10.1038/onc.2013.403. Epub 2013 Oct 21.

PMID:
24141772
20.

The role of RUNX1 isoforms in hematopoietic commitment of human pluripotent stem cells.

Real PJ, Navarro-Montero O, Ramos-Mejía V, Ayllón V, Bueno C, Menéndez P.

Blood. 2013 Jun 27;121(26):5250-2. doi: 10.1182/blood-2013-03-487587. No abstract available.

PMID:
23813937
21.

FLT3 activation cooperates with MLL-AF4 fusion protein to abrogate the hematopoietic specification of human ESCs.

Bueno C, Ayllón V, Montes R, Navarro-Montero O, Ramos-Mejia V, Real PJ, Romero-Moya D, Araúzo-Bravo MJ, Menendez P.

Blood. 2013 May 9;121(19):3867-78, S1-3. doi: 10.1182/blood-2012-11-470146. Epub 2013 Mar 11.

PMID:
23479570
22.

Expression profile of telomere-associated genes in multiple myeloma.

Díaz de la Guardia R, Catalina P, Panero J, Elosua C, Pulgarin A, López MB, Ayllón V, Ligero G, Slavutsky I, Leone PE.

J Cell Mol Med. 2012 Dec;16(12):3009-21. doi: 10.1111/j.1582-4934.2012.01628.x.

23.

Residual expression of the reprogramming factors prevents differentiation of iPSC generated from human fibroblasts and cord blood CD34+ progenitors.

Ramos-Mejía V, Montes R, Bueno C, Ayllón V, Real PJ, Rodríguez R, Menendez P.

PLoS One. 2012;7(4):e35824. doi: 10.1371/journal.pone.0035824. Epub 2012 Apr 24.

24.

SCL/TAL1 regulates hematopoietic specification from human embryonic stem cells.

Real PJ, Ligero G, Ayllon V, Ramos-Mejia V, Bueno C, Gutierrez-Aranda I, Navarro-Montero O, Lako M, Menendez P.

Mol Ther. 2012 Jul;20(7):1443-53. doi: 10.1038/mt.2012.49. Epub 2012 Apr 10.

25.

A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification.

Bueno C, Montes R, Melen GJ, Ramos-Mejia V, Real PJ, Ayllón V, Sanchez L, Ligero G, Gutierrez-Aranda I, Fernández AF, Fraga MF, Moreno-Gimeno I, Burks D, Plaza-Calonge Mdel C, Rodríguez-Manzaneque JC, Menendez P.

Cell Res. 2012 Jun;22(6):986-1002. doi: 10.1038/cr.2012.4. Epub 2012 Jan 3.

26.

Maintenance of human embryonic stem cells in media conditioned by human mesenchymal stem cells obviates the requirement of exogenous basic fibroblast growth factor supplementation.

Sánchez L, Gutierrez-Aranda I, Ligero G, Martín M, Ayllón V, Real PJ, Ramos-Mejía V, Bueno C, Menendez P.

Tissue Eng Part C Methods. 2012 May;18(5):387-96. doi: 10.1089/ten.TEC.2011.0546. Epub 2012 Jan 26.

PMID:
22136131
27.

Maintenance of human embryonic stem cells in mesenchymal stem cell-conditioned media augments hematopoietic specification.

Ramos-Mejía V, Fernández AF, Ayllón V, Real PJ, Bueno C, Anderson P, Martín F, Fraga MF, Menendez P.

Stem Cells Dev. 2012 Jun 10;21(9):1549-58. doi: 10.1089/scd.2011.0400. Epub 2011 Oct 27.

PMID:
21936705
28.

Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia.

Montes R, Ayllón V, Gutierrez-Aranda I, Prat I, Hernández-Lamas MC, Ponce L, Bresolin S, Te Kronnie G, Greaves M, Bueno C, Menendez P.

Blood. 2011 May 5;117(18):4746-58. doi: 10.1182/blood-2010-12-322230. Epub 2011 Mar 9.

PMID:
21389315
29.

Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.

McMahon M, Ayllón V, Panov KI, O'Connor R.

J Biol Chem. 2010 Jun 11;285(24):18309-18. doi: 10.1074/jbc.M110.108555. Epub 2010 Apr 14.

30.

Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.

O'Callaghan KM, Ayllon V, O'Keeffe J, Wang Y, Cox OT, Loughran G, Forgac M, O'Connor R.

J Biol Chem. 2010 Jan 1;285(1):381-91. doi: 10.1074/jbc.M109.063248. Epub 2009 Oct 29.

31.

PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response.

Ayllón V, O'connor R.

Oncogene. 2007 May 24;26(24):3451-61. Epub 2006 Dec 11.

PMID:
17160018
32.

Gene expression profiles in cells transformed by overexpression of the IGF-I receptor.

Loughran G, Huigsloot M, Kiely PA, Smith LM, Floyd S, Ayllon V, O'Connor R.

Oncogene. 2005 Sep 8;24(40):6185-93.

PMID:
15940254
33.

BH3-only proteins: the lords of death.

Fleischer A, Rebollo A, Ayllón V.

Arch Immunol Ther Exp (Warsz). 2003;51(1):9-17. Review.

PMID:
12691300
34.

ITM2BS regulates apoptosis by inducing loss of mitochondrial membrane potential.

Fleischer A, Ayllon V, Rebollo A.

Eur J Immunol. 2002 Dec;32(12):3498-505.

35.

The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad.

Ayllón V, Cayla X, García A, Fleischer A, Rebollo A.

Eur J Immunol. 2002 Jul;32(7):1847-55.

36.

Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2.

Fleischer A, Ayllón V, Dumoutier L, Renauld JC, Rebollo A.

Oncogene. 2002 May 9;21(20):3181-9.

37.

Segregation of Bad from lipid rafts is implicated in the induction of apoptosis.

Ayllón V, Fleischer A, Cayla X, García A, Rebollo A.

J Immunol. 2002 Apr 1;168(7):3387-93.

38.

The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis.

Rebollo A, Ayllón V, Fleischer A, Martínez CA, Zaballos A.

J Immunol. 2001 Dec 1;167(11):6366-73.

39.

Bcl-2 targets protein phosphatase 1 alpha to Bad.

Ayllón V, Cayla X, García A, Roncal F, Fernández R, Albar JP, Martínez C, Rebollo A.

J Immunol. 2001 Jun 15;166(12):7345-52.

40.

Ras-induced cellular events (review).

Ayllón V, Rebollo A.

Mol Membr Biol. 2000 Apr-Jun;17(2):65-73. Review.

PMID:
10989457
41.

Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis.

Ayllón V, Martínez-A C, García A, Cayla X, Rebollo A.

EMBO J. 2000 May 15;19(10):2237-46.

42.

Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors.

Rebollo A, Dumoutier L, Renauld JC, Zaballos A, Ayllón V, Martínez-A C.

Mol Cell Biol. 2000 May;20(10):3407-16.

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