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Outcomes of Primary versus Multiple-Staged Repair in Hirschsprung's Disease in England.

Giuliani S, Honeyford K, Chang CY, Bottle A, Aylin P.

Eur J Pediatr Surg. 2020 Jan 7. doi: 10.1055/s-0039-3402712. [Epub ahead of print]


A retrospective impact analysis of the WannaCry cyberattack on the NHS.

Ghafur S, Kristensen S, Honeyford K, Martin G, Darzi A, Aylin P.

NPJ Digit Med. 2019 Oct 2;2:98. doi: 10.1038/s41746-019-0161-6. eCollection 2019.


What is the relationship between mortality alerts and other indicators of quality of care? A national cross-sectional study.

Cecil E, Bottle A, Esmail A, Vincent C, Aylin P.

J Health Serv Res Policy. 2020 Jan;25(1):13-21. doi: 10.1177/1355819619847689. Epub 2019 Sep 18. No abstract available.


Young adults' perceptions of using wearables, social media and other technologies to detect worsening mental health: A qualitative study.

Dewa LH, Lavelle M, Pickles K, Kalorkoti C, Jaques J, Pappa S, Aylin P.

PLoS One. 2019 Sep 18;14(9):e0222655. doi: 10.1371/journal.pone.0222655. eCollection 2019.


Route to heart failure diagnosis in English primary care: a retrospective cohort study of variation.

Kim D, Hayhoe B, Aylin P, Majeed A, Cowie MR, Bottle A.

Br J Gen Pract. 2019 Sep 26;69(687):e697-e705. doi: 10.3399/bjgp19X705485. Print 2019 Oct.


Colorectal cancer patients under the age of 50 experience delays in primary care leading to emergency diagnoses: a population-based study.

Arhi CS, Ziprin P, Bottle A, Burns EM, Aylin P, Darzi A.

Colorectal Dis. 2019 Nov;21(11):1270-1278. doi: 10.1111/codi.14734. Epub 2019 Aug 6.


Evaluating the impact of organisational digital maturity on clinical outcomes in secondary care in England.

Martin G, Clarke J, Liew F, Arora S, King D, Aylin P, Darzi A.

NPJ Digit Med. 2019 May 16;2:41. doi: 10.1038/s41746-019-0118-9. eCollection 2019.


Unscheduled hospital contacts after inpatient discharge: A national observational study of COPD and heart failure patients in England.

Honeyford K, Bell D, Chowdhury F, Quint J, Aylin P, Bottle A.

PLoS One. 2019 Jun 13;14(6):e0218128. doi: 10.1371/journal.pone.0218128. eCollection 2019.


One-year outcomes for congenital diaphragmatic hernia.

Wang Y, Honeyford K, Aylin P, Bottle A, Giuliani S.

BJS Open. 2019 Jan 31;3(3):305-313. doi: 10.1002/bjs5.50135. eCollection 2019 Jun.


Risk factors for early revision after total hip and knee arthroplasty: National observational study from a surgeon and population perspective.

Bottle A, Parikh S, Aylin P, Loeffler M.

PLoS One. 2019 Apr 9;14(4):e0214855. doi: 10.1371/journal.pone.0214855. eCollection 2019.


Regional variations in trajectories of long-term readmission rates among patients in England with heart failure.

Rao A, Kim D, Darzi A, Majeed A, Aylin P, Bottle A.

BMC Cardiovasc Disord. 2019 Apr 6;19(1):86. doi: 10.1186/s12872-019-1057-8.


Delays in referral from primary care are associated with a worse survival in patients with esophagogastric cancer.

Arhi CS, Markar S, Burns EM, Bouras G, Bottle A, Hanna G, Aylin P, Ziprin P, Darzi A.

Dis Esophagus. 2019 Dec 13;32(10):1-11. doi: 10.1093/dote/doy132.


Antibiotic management of urinary tract infection in elderly patients in primary care and its association with bloodstream infections and all cause mortality: population based cohort study.

Gharbi M, Drysdale JH, Lishman H, Goudie R, Molokhia M, Johnson AP, Holmes AH, Aylin P.

BMJ. 2019 Feb 27;364:l525. doi: 10.1136/bmj.l525.


Frailty and co-morbidity predict first hospitalisation after heart failure diagnosis in primary care: population-based observational study in England.

Bottle A, Kim D, Hayhoe B, Majeed A, Aylin P, Clegg A, Cowie MR.

Age Ageing. 2019 May 1;48(3):347-354. doi: 10.1093/ageing/afy194.


Impact of social deprivation on the outcome of major head and neck cancer surgery in England: A national analysis.

Mirza AH, Aylin P, Middleton S, King EV, Nouraei RAR, Repanos C.

Head Neck. 2019 Mar;41(3):692-700. doi: 10.1002/hed.25461. Epub 2018 Dec 28.


Complications after discharge and delays in adjuvant chemotherapy following colonic resection: a cohort study of linked primary and secondary care data.

Arhi CS, Burns EM, Bouras G, Aylin P, Ziprin P, Darzi A.

Colorectal Dis. 2019 Mar;21(3):307-314. doi: 10.1111/codi.14525. Epub 2019 Jan 31.


Adherence to guidelines in management of symptoms suggestive of heart failure in primary care.

Hayhoe B, Kim D, Aylin PP, Majeed FA, Cowie MR, Bottle A.

Heart. 2019 May;105(9):678-685. doi: 10.1136/heartjnl-2018-313971. Epub 2018 Dec 4.


Real-world presentation with heart failure in primary care: do patients selected to follow diagnostic and management guidelines have better outcomes?

Bottle A, Kim D, Aylin PP, Majeed FA, Cowie MR, Hayhoe B.

Open Heart. 2018 Nov 10;5(2):e000935. doi: 10.1136/openhrt-2018-000935. eCollection 2018.


Predictors of 30-Day Readmission After Total Knee Arthroplasty: Analysis of 566,323 Procedures in the United Kingdom.

Ali AM, Loeffler MD, Aylin P, Bottle A.

J Arthroplasty. 2019 Feb;34(2):242-248.e1. doi: 10.1016/j.arth.2018.10.026. Epub 2018 Nov 2.


The weekend effect: does hospital mortality differ by day of the week? A systematic review and meta-analysis.

Honeyford K, Cecil E, Lo M, Bottle A, Aylin P.

BMC Health Serv Res. 2018 Nov 20;18(1):870. doi: 10.1186/s12913-018-3688-3.


Trajectory Modelling to Assess Trends in Long-Term Readmission Rate among Abdominal Aortic Aneurysm Patients.

Rao A, Bottle A, Bicknell C, Darzi A, Aylin P.

Surg Res Pract. 2018 Oct 21;2018:4321986. doi: 10.1155/2018/4321986. eCollection 2018.


Factors that impact on the burden of Escherichia coli bacteraemia: multivariable regression analysis of 2011-2015 data from West London.

Blandy O, Honeyford K, Gharbi M, Thomas A, Ramzan F, Ellington MJ, Hope R, Holmes AH, Johnson AP, Aylin P, Woodford N, Sriskandan S.

J Hosp Infect. 2019 Feb;101(2):120-128. doi: 10.1016/j.jhin.2018.10.024. Epub 2018 Nov 4.


An Assessment of Potential Unintended Consequences Following a National Antimicrobial Stewardship Program in England: An Interrupted Time Series Analysis.

Balinskaite V, Bou-Antoun S, Johnson AP, Holmes A, Aylin P.

Clin Infect Dis. 2019 Jul 2;69(2):233-242. doi: 10.1093/cid/ciy904.


The Impact of a National Antimicrobial Stewardship Program on Antibiotic Prescribing in Primary Care: An Interrupted Time Series Analysis.

Balinskaite V, Johnson AP, Holmes A, Aylin P.

Clin Infect Dis. 2019 Jul 2;69(2):227-232. doi: 10.1093/cid/ciy902.


National hospital mortality surveillance system: a descriptive analysis.

Cecil E, Wilkinson S, Bottle A, Esmail A, Vincent C, Aylin PP.

BMJ Qual Saf. 2018 Dec;27(12):974-981. doi: 10.1136/bmjqs-2018-008364. Epub 2018 Oct 8.


Comparison of cancer diagnosis recording between the Clinical Practice Research Datalink, Cancer Registry and Hospital Episodes Statistics.

Arhi CS, Bottle A, Burns EM, Clarke JM, Aylin P, Ziprin P, Darzi A.

Cancer Epidemiol. 2018 Dec;57:148-157. doi: 10.1016/j.canep.2018.08.009. Epub 2018 Oct 2.


Exploring the relationship between primary care antibiotic prescribing for urinary tract infections, Escherichia coli bacteraemia incidence and antimicrobial resistance: an ecological study.

Lishman H, Costelloe C, Hopkins S, Johnson AP, Hope R, Guy R, Muller-Pebody B, Holmes A, Aylin P.

Int J Antimicrob Agents. 2018 Dec;52(6):790-798. doi: 10.1016/j.ijantimicag.2018.08.013. Epub 2018 Aug 24.


Indicators of deterioration in young adults with serious mental illness: a systematic review protocol.

Dewa LH, Cecil E, Eastwood L, Darzi A, Aylin P.

Syst Rev. 2018 Aug 16;7(1):123. doi: 10.1186/s13643-018-0781-y.


Common Sequences of Emergency Readmissions among High-Impact Users following AAA Repair.

Rao A, Bottle A, Bicknell C, Darzi A, Aylin P.

Surg Res Pract. 2018 Jul 3;2018:5468010. doi: 10.1155/2018/5468010. eCollection 2018.


Mapping national surveillance of surgical site infections in England: needs and priorities.

Troughton R, Birgand G, Johnson AP, Naylor N, Gharbi M, Aylin P, Hopkins S, Jaffer U, Holmes A.

J Hosp Infect. 2018 Dec;100(4):378-385. doi: 10.1016/j.jhin.2018.06.006. Epub 2018 Jun 12.


Investigating the association of alerts from a national mortality surveillance system with subsequent hospital mortality in England: an interrupted time series analysis.

Cecil E, Bottle A, Esmail A, Wilkinson S, Vincent C, Aylin PP.

BMJ Qual Saf. 2018 Dec;27(12):965-973. doi: 10.1136/bmjqs-2017-007495. Epub 2018 May 4.


Long-term trends of use of health service among heart failure patients.

Rao A, Kim D, Darzi A, Majeed A, Aylin P, Bottle A.

Eur Heart J Qual Care Clin Outcomes. 2018 Jul 1;4(3):220-231. doi: 10.1093/ehjqcco/qcy013.


Comparison of 3 Types of Readmission Rates for Measuring Hospital and Surgeon Performance After Primary Total Hip and Knee Arthroplasty.

Bottle A, Loeffler MD, Aylin P, Ali AM.

J Arthroplasty. 2018 Jul;33(7):2014-2019.e2. doi: 10.1016/j.arth.2018.02.064. Epub 2018 Feb 26.


National trends in emergency readmission rates: a longitudinal analysis of administrative data for England between 2006 and 2016.

Friebel R, Hauck K, Aylin P, Steventon A.

BMJ Open. 2018 Mar 12;8(3):e020325. doi: 10.1136/bmjopen-2017-020325.


Evaluation of a national surveillance system for mortality alerts: a mixed-methods study.

Aylin P, Bottle A, Burnett S, Cecil E, Charles KL, Dawson P, D’Lima D, Esmail A, Vincent C, Wilkinson S, Benn J.

Southampton (UK): NIHR Journals Library; 2018 Feb. No abstract available.

Free Books & Documents

Retrospective analysis of the national impact of industrial action by English junior doctors in 2016.

Furnivall D, Bottle A, Aylin P.

BMJ Open. 2018 Feb 8;8(1):e019319. doi: 10.1136/bmjopen-2017-019319.


Centralisation of acute stroke services in London: Impact evaluation using two treatment groups.

Friebel R, Hauck K, Aylin P.

Health Econ. 2018 Apr;27(4):722-732. doi: 10.1002/hec.3630. Epub 2017 Dec 28.


Investigating the burden of antibiotic resistance in ethnic minority groups in high-income countries: protocol for a systematic review and meta-analysis.

Lishman H, Aylin P, Alividza V, Castro-Sanchez E, Chatterjee A, Mariano V, Johnson AP, Jeraj S, Costelloe C.

Syst Rev. 2017 Dec 11;6(1):251. doi: 10.1186/s13643-017-0654-9.


Reorganisation of stroke care and impact on mortality in patients admitted during weekends: a national descriptive study based on administrative data.

Balinskaite V, Bottle A, Shaw LJ, Majeed A, Aylin P.

BMJ Qual Saf. 2018 Aug;27(8):611-618. doi: 10.1136/bmjqs-2017-006681. Epub 2017 Oct 27.


Secondary analysis of hospital patient experience scores across England's National Health Service - How much has improved since 2005?

Honeyford K, Greaves F, Aylin P, Bottle A.

PLoS One. 2017 Oct 26;12(10):e0187012. doi: 10.1371/journal.pone.0187012. eCollection 2017.


Comparative epidemiology of Clostridium difficile infection: England and the USA.

King A, Mullish BH, Williams HRT, Aylin P.

Int J Qual Health Care. 2017 Oct 1;29(6):785-791. doi: 10.1093/intqhc/mzx120.


Routes to diagnosis of heart failure: observational study using linked data in England.

Bottle A, Kim D, Aylin P, Cowie MR, Majeed A, Hayhoe B.

Heart. 2018 Apr;104(7):600-605. doi: 10.1136/heartjnl-2017-312183. Epub 2017 Oct 5.


Factors Associated With 30-Day Readmission After Primary Total Hip Arthroplasty: Analysis of 514 455 Procedures in the UK National Health Service.

Ali AM, Loeffler MD, Aylin P, Bottle A.

JAMA Surg. 2017 Dec 20;152(12):e173949. doi: 10.1001/jamasurg.2017.3949. Epub 2017 Dec 20. Erratum in: JAMA Surg. 2017 Dec 1;152(12):1184.


Does early return to theatre add value to rates of revision at 3 years in assessing surgeon performance for elective hip and knee arthroplasty? National observational study.

Bottle A, Chase HE, Aylin PP, Loeffler M.

BMJ Qual Saf. 2018 May;27(5):373-379. doi: 10.1136/bmjqs-2017-006603. Epub 2017 Aug 1.


Regional variation in hospitalisation and mortality in heart failure: comparison of England and Lombardy using multistate modelling.

Bottle A, Ventura CM, Dharmarajan K, Aylin P, Ieva F, Paganoni AM.

Health Care Manag Sci. 2018 Jun;21(2):292-304. doi: 10.1007/s10729-017-9410-x. Epub 2017 Jul 28.


A retrospective cohort study of high-impact users among patients with cerebrovascular conditions.

Rao A, Jones A, Bottle A, Darzi A, Aylin P.

BMJ Open. 2017 Jun 24;7(6):e014618. doi: 10.1136/bmjopen-2016-014618.


Vocal palsy increases the risk of lower respiratory tract infection in low-risk, low-morbidity patients undergoing thyroidectomy for benign disease: A big data analysis.

Nouraei SAR, Allen J, Kaddour H, Middleton SE, Aylin P, Darzi A, Tolley NS.

Clin Otolaryngol. 2017 Dec;42(6):1259-1266. doi: 10.1111/coa.12913. Epub 2017 Jul 20.

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