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Multifunctional scaffolds for facile implantation, spontaneous fixation, and accelerated long bone regeneration in rodents.

Zhang B, Skelly JD, Maalouf JR, Ayers DC, Song J.

Sci Transl Med. 2019 Jul 24;11(502). pii: eaau7411. doi: 10.1126/scitranslmed.aau7411.


Significant Suppression of Staphylococcus aureus Colonization on Intramedullary Ti6Al4V Implants Surface-Grafted with Vancomycin-Bearing Polymer Brushes.

Zhang B, Braun BM, Skelly JD, Ayers DC, Song J.

ACS Appl Mater Interfaces. 2019 Aug 14;11(32):28641-28647. doi: 10.1021/acsami.9b07648. Epub 2019 Jul 30.


Modulating Viscoelasticity, Stiffness, and Degradation of Synthetic Cellular Niches via Stoichiometric Tuning of Covalent versus Dynamic Noncovalent Cross-Linking.

Tan Y, Huang H, Ayers DC, Song J.

ACS Cent Sci. 2018 Aug 22;4(8):971-981. doi: 10.1021/acscentsci.8b00170. Epub 2018 Jul 20.


The Case for Comanagement and Care Pathways for Osteoporotic Patients with a Hip Fracture.

Swart E, Kates S, McGee S, Ayers DC.

J Bone Joint Surg Am. 2018 Aug 1;100(15):1343-1350. doi: 10.2106/JBJS.17.01288. No abstract available.


A Web-Based Treatment Decision Support Tool for Patients With Advanced Knee Arthritis: Evaluation of User Interface and Content Design.

Zheng H, Rosal MC, Li W, Borg A, Yang W, Ayers DC, Franklin PD.

JMIR Hum Factors. 2018 Apr 30;5(2):e17. doi: 10.2196/humanfactors.8568.


Functional Gain and Pain Relief After Total Joint Replacement According to Obesity Status.

Li W, Ayers DC, Lewis CG, Bowen TR, Allison JJ, Franklin PD.

J Bone Joint Surg Am. 2017 Jul 19;99(14):1183-1189. doi: 10.2106/JBJS.16.00960.


Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue.

Filion TM, Skelly JD, Huang H, Greiner DL, Ayers DC, Song J.

Stem Cell Res Ther. 2017 Mar 11;8(1):65. doi: 10.1186/s13287-017-0521-6.


Important patient characteristics differ prior to total knee arthroplasty and total hip arthroplasty between Switzerland and the United States.

Franklin PD, Miozzari H, Christofilopoulos P, Hoffmeyer P, Ayers DC, Lübbeke A.

BMC Musculoskelet Disord. 2017 Jan 11;18(1):14. doi: 10.1186/s12891-016-1372-5.


Implementation of Patient-reported Outcome Measures in Total Knee Arthroplasty.

Ayers DC.

J Am Acad Orthop Surg. 2017 Feb;25 Suppl 1:S48-S50. doi: 10.5435/JAAOS-D-16-00631.


Preoperative Pain and Function: Profiles of Patients Selected for Total Knee Arthroplasty.

Nguyen UD, Ayers DC, Li W, Harrold LR, Franklin PD.

J Arthroplasty. 2016 Nov;31(11):2402-2407.e2. doi: 10.1016/j.arth.2016.04.015. Epub 2016 Apr 27.


Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes.

Huang H, Veien ES, Zhang H, Ayers DC, Song J.

PLoS One. 2016 Jan 27;11(1):e0148088. doi: 10.1371/journal.pone.0148088. eCollection 2016.


Editorial Comment: Symposium: Psychosocial Aspects of Musculoskeletal Illness.

Ring D, Ayers DC.

Clin Orthop Relat Res. 2015 Nov;473(11):3468-9. doi: 10.1007/s11999-015-4544-y. No abstract available.


A Novel Method for Assessment of Polyethylene Liner Wear in Radiopaque Tantalum Acetabular Cups: Clinical Validation in Patients Enrolled in a Randomized Controlled Trial.

Troelsen A, Greene ME, Ayers DC, Bragdon CR, Malchau H.

J Arthroplasty. 2015 Dec;30(12):2354-9. doi: 10.1016/j.arth.2015.06.050. Epub 2015 Jul 2.


Using joint registry data from FORCE-TJR to improve the accuracy of risk-adjustment prediction models for thirty-day readmission after total hip replacement and total knee replacement.

Ayers DC, Fehring TK, Odum SM, Franklin PD.

J Bone Joint Surg Am. 2015 Apr 15;97(8):668-71. doi: 10.2106/JBJS.N.00889. Review. No abstract available.


Templated repair of long bone defects in rats with bioactive spiral-wrapped electrospun amphiphilic polymer/hydroxyapatite scaffolds.

Kutikov AB, Skelly JD, Ayers DC, Song J.

ACS Appl Mater Interfaces. 2015 Mar 4;7(8):4890-901. doi: 10.1021/am508984y. Epub 2015 Feb 19.


Implementation of patient-reported outcome measures in U.S. Total joint replacement registries: rationale, status, and plans.

Franklin PD, Lewallen D, Bozic K, Hallstrom B, Jiranek W, Ayers DC.

J Bone Joint Surg Am. 2014 Dec 17;96 Suppl 1:104-9. doi: 10.2106/JBJS.N.00328.


Reply to the letter to the editor: preoperative pain and function profiles reflect consistent TKA patient selection among US surgeons.

Ayers DC, Li W, Harrold L, Allison J, Franklin PD.

Clin Orthop Relat Res. 2015 Jan;473(1):395-6. doi: 10.1007/s11999-014-4036-5. Epub 2014 Nov 4. No abstract available.


Joint replacement registries in the United States: a new paradigm.

Ayers DC, Franklin PD.

J Bone Joint Surg Am. 2014 Sep 17;96(18):1567-9. doi: 10.2106/JBJS.N.00641. No abstract available.


Vancomycin-bearing synthetic bone graft delivers rhBMP-2 and promotes healing of critical rat femoral segmental defects.

Skelly JD, Lange J, Filion TM, Li X, Ayers DC, Song J.

Clin Orthop Relat Res. 2014 Dec;472(12):4015-23. doi: 10.1007/s11999-014-3841-1. Epub 2014 Aug 7.


Runx1 Activities in Superficial Zone Chondrocytes, Osteoarthritic Chondrocyte Clones and Response to Mechanical Loading.

LeBlanc KT, Walcott ME, Gaur T, O'Connell SL, Basil K, Tadiri CP, Mason-Savas A, Silva JA, van Wijnen AJ, Stein JL, Stein GS, Ayers DC, Lian JB, Fanning PJ.

J Cell Physiol. 2015 Feb;230(2):440-8. doi: 10.1002/jcp.24727.


Preoperative pain and function profiles reflect consistent TKA patient selection among US surgeons.

Ayers DC, Li W, Harrold L, Allison J, Franklin PD.

Clin Orthop Relat Res. 2015 Jan;473(1):76-81. doi: 10.1007/s11999-014-3716-5.


Modification of Ti6Al4V substrates with well-defined zwitterionic polysulfobetaine brushes for improved surface mineralization.

Liu P, Domingue E, Ayers DC, Song J.

ACS Appl Mater Interfaces. 2014 May 28;6(10):7141-52. doi: 10.1021/am501967y. Epub 2014 May 14.


Variations in Delivery and Exercise Content of Physical Therapy Rehabilitation Following Total Knee Replacement Surgery: A Cross-Sectional Observation Study.

Oatis CA, Li W, DiRusso JM, Hoover MJ, Johnston KK, Butz MK, Phillips AL, Nanovic KM, Cummings EC, Rosal MC, Ayers DC, Franklin PD.

Int J Phys Med Rehabil. 2014;Suppl 5. pii: 002. Epub 2014 Apr 22.


Web-based Comparative Patient-reported Outcome Feedback to Support Quality Improvement and Comparative Effectiveness Research in Total Joint Replacement.

Zheng H, Li W, Harrold L, Ayers DC, Franklin PD.

EGEMS (Wash DC). 2014 Dec 19;2(1):1130. doi: 10.13063/2327-9214.1130. eCollection 2014.


The role of emotional health in functional outcomes after orthopaedic surgery: extending the biopsychosocial model to orthopaedics: AOA critical issues.

Ayers DC, Franklin PD, Ring DC.

J Bone Joint Surg Am. 2013 Nov 6;95(21):e165. doi: 10.2106/JBJS.L.00799. No abstract available.


The importance of outcome measurement in orthopaedics.

Ayers DC, Bozic KJ.

Clin Orthop Relat Res. 2013 Nov;471(11):3409-11. doi: 10.1007/s11999-013-3224-z. Epub 2013 Aug 10. No abstract available.


Integrating patient-reported outcomes into orthopaedic clinical practice: proof of concept from FORCE-TJR.

Ayers DC, Zheng H, Franklin PD.

Clin Orthop Relat Res. 2013 Nov;471(11):3419-25. doi: 10.1007/s11999-013-3143-z.


Incorporating patient-reported outcomes in total joint arthroplasty registries: challenges and opportunities.

Franklin PD, Harrold L, Ayers DC.

Clin Orthop Relat Res. 2013 Nov;471(11):3482-8. doi: 10.1007/s11999-013-3193-2. Review.


pHEMA-nHA encapsulation and delivery of vancomycin and rhBMP-2 enhances its role as a bone graft substitute.

Li X, Xu J, Filion TM, Ayers DC, Song J.

Clin Orthop Relat Res. 2013 Aug;471(8):2540-7. doi: 10.1007/s11999-012-2644-5.


Surface mineralization of Ti6Al4V substrates with calcium apatites for the retention and local delivery of recombinant human bone morphogenetic protein-2.

Liu P, Smits J, Ayers DC, Song J.

Acta Biomater. 2011 Sep;7(9):3488-95. doi: 10.1016/j.actbio.2011.05.025. Epub 2011 May 27.


Periprosthetic osteolysis: characterizing the innate immune response to titanium wear-particles.

St Pierre CA, Chan M, Iwakura Y, Ayers DC, Kurt-Jones EA, Finberg RW.

J Orthop Res. 2010 Nov;28(11):1418-24. doi: 10.1002/jor.21149. Erratum in: J Orthop Res. 2011 Jan;29(1):154.


A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes.

Jones MD, Liu JC, Barthel TK, Hussain S, Lovria E, Cheng D, Schoonmaker JA, Mulay S, Ayers DC, Bouxsein ML, Stein GS, Mukherjee S, Lian JB.

Clin Cancer Res. 2010 Oct 15;16(20):4978-89. doi: 10.1158/1078-0432.CCR-09-3293. Epub 2010 Sep 15.


Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats.

Filion TM, Li X, Mason-Savas A, Kreider JM, Goldstein SA, Ayers DC, Song J.

Tissue Eng Part A. 2011 Feb;17(3-4):503-11. doi: 10.1089/ten.TEA.2010.0274. Epub 2010 Oct 21.


Reduction in narcotic use after primary total knee arthroplasty and association with patient pain relief and satisfaction.

Franklin PD, Karbassi JA, Li W, Yang W, Ayers DC.

J Arthroplasty. 2010 Sep;25(6 Suppl):12-6. doi: 10.1016/j.arth.2010.05.003. Epub 2010 Jun 26.


Two-year radiostereometric analysis evaluation of femoral head penetration in a challenging population of young total hip arthroplasty patients.

Ayers DC, Hays PL, Drew JM, Eskander MS, Osuch D, Bragdon CR.

J Arthroplasty. 2009 Sep;24(6 Suppl):9-14. doi: 10.1016/j.arth.2009.05.027.


Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor.

Wixted JJ, Fanning PJ, Gaur T, O'Connell SL, Silva J, Mason-Savas A, Ayers DC, Stein GS, Lian JB.

J Cell Physiol. 2009 Oct;221(1):31-9. doi: 10.1002/jcp.21809.


Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute.

Xu J, Li X, Lian JB, Ayers DC, Song J.

J Orthop Res. 2009 Oct;27(10):1306-11. doi: 10.1002/jor.20890.


Secreted frizzled related protein 1 is a target to improve fracture healing.

Gaur T, Wixted JJ, Hussain S, O'Connell SL, Morgan EF, Ayers DC, Komm BS, Bodine PV, Stein GS, Lian JB.

J Cell Physiol. 2009 Jul;220(1):174-81. doi: 10.1002/jcp.21747.


The Chitranjan Ranawat Award: functional outcome after total knee replacement varies with patient attributes.

Franklin PD, Li W, Ayers DC.

Clin Orthop Relat Res. 2008 Nov;466(11):2597-604. doi: 10.1007/s11999-008-0428-8.


Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications.

Song J, Xu J, Filion T, Saiz E, Tomsia AP, Lian JB, Stein GS, Ayers DC, Bertozzi CR.

J Biomed Mater Res A. 2009 Jun 15;89(4):1098-107. doi: 10.1002/jbm.a.32110.


Dexamethasone modulates BMP-2 effects on mesenchymal stem cells in vitro.

Jäger M, Fischer J, Dohrn W, Li X, Ayers DC, Czibere A, Prall WC, Lensing-Höhn S, Krauspe R.

J Orthop Res. 2008 Nov;26(11):1440-8. doi: 10.1002/jor.20565.


Osteoblast differentiation onto different biometals with an endoprosthetic surface topography in vitro.

Jäger M, Urselmann F, Witte F, Zanger K, Li X, Ayers DC, Krauspe R.

J Biomed Mater Res A. 2008 Jul;86(1):61-75.


Pilot study of methods to document quantity and variation of independent patient exercise and activity after total knee arthroplasty.

Franklin PD, McLaughlin J, Boisvert CB, Li W, Ayers DC.

J Arthroplasty. 2006 Sep;21(6 Suppl 2):157-63.


Total knee replacement outcome and coexisting physical and emotional illness.

Ayers DC, Franklin PD, Ploutz-Snyder R, Boisvert CB.

Clin Orthop Relat Res. 2005 Nov;440:157-61.


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