Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 71


MondoA drives muscle lipid accumulation and insulin resistance.

Ahn B, Wan S, Jaiswal N, Vega RB, Ayer DE, Titchenell PM, Han X, Won KJ, Kelly DP.

JCI Insight. 2019 Jul 9;5. pii: 129119. doi: 10.1172/jci.insight.129119.


Cellular acidosis triggers human MondoA transcriptional activity by driving mitochondrial ATP production.

Wilde BR, Ye Z, Lim TY, Ayer DE.

Elife. 2019 Feb 5;8. pii: e40199. doi: 10.7554/eLife.40199.


Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization.

Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR.

Cell. 2018 Sep 20;175(1):117-132.e21. doi: 10.1016/j.cell.2018.08.017. Epub 2018 Sep 6.


Ras Suppresses TXNIP Expression by Restricting Ribosome Translocation.

Ye Z, Ayer DE.

Mol Cell Biol. 2018 Sep 28;38(20). pii: e00178-18. doi: 10.1128/MCB.00178-18. Print 2018 Oct 15.


Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas.

Schaub FX, Dhankani V, Berger AC, Trivedi M, Richardson AB, Shaw R, Zhao W, Zhang X, Ventura A, Liu Y, Ayer DE, Hurlin PJ, Cherniack AD, Eisenman RN, Bernard B, Grandori C; Cancer Genome Atlas Network.

Cell Syst. 2018 Mar 28;6(3):282-300.e2. doi: 10.1016/j.cels.2018.03.003.


Interactions between Myc and MondoA transcription factors in metabolism and tumourigenesis.

Wilde BR, Ayer DE.

Br J Cancer. 2015 Dec 1;113(11):1529-33. doi: 10.1038/bjc.2015.360. Epub 2015 Oct 15. Review.


Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP.

Shen L, O'Shea JM, Kaadige MR, Cunha S, Wilde BR, Cohen AL, Welm AL, Ayer DE.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5425-30. doi: 10.1073/pnas.1501555112. Epub 2015 Apr 13.


Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis.

Carroll PA, Diolaiti D, McFerrin L, Gu H, Djukovic D, Du J, Cheng PF, Anderson S, Ulrich M, Hurley JB, Raftery D, Ayer DE, Eisenman RN.

Cancer Cell. 2015 Feb 9;27(2):271-85. doi: 10.1016/j.ccell.2014.11.024. Epub 2015 Jan 29.


Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs.

Bowman CJ, Ayer DE, Dynlacht BD.

Nat Cell Biol. 2014 Dec;16(12):1202-14. doi: 10.1038/ncb3062. Epub 2014 Nov 17.


MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction.

Kaadige MR, Yang J, Wilde BR, Ayer DE.

Mol Cell Biol. 2015 Jan;35(1):101-10. doi: 10.1128/MCB.00636-14. Epub 2014 Oct 20.


Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis.

Parmenter TJ, Kleinschmidt M, Kinross KM, Bond ST, Li J, Kaadige MR, Rao A, Sheppard KE, Hugo W, Pupo GM, Pearson RB, McGee SL, Long GV, Scolyer RA, Rizos H, Lo RS, Cullinane C, Ayer DE, Ribas A, Johnstone RW, Hicks RJ, McArthur GA.

Cancer Discov. 2014 Apr;4(4):423-33. doi: 10.1158/2159-8290.CD-13-0440. Epub 2014 Jan 27.


Coordination of nutrient availability and utilization by MAX- and MLX-centered transcription networks.

O'Shea JM, Ayer DE.

Cold Spring Harb Perspect Med. 2013 Sep 1;3(9):a014258. doi: 10.1101/cshperspect.a014258. Review.


MondoA senses adenine nucleotides: transcriptional induction of thioredoxin-interacting protein.

Han KS, Ayer DE.

Biochem J. 2013 Jul 15;453(2):209-18. doi: 10.1042/BJ20121126.


Adaptive metabolic response to 4 weeks of sugar-sweetened beverage consumption in healthy, lightly active individuals and chronic high glucose availability in primary human myotubes.

Sartor F, Jackson MJ, Squillace C, Shepherd A, Moore JP, Ayer DE, Kubis HP.

Eur J Nutr. 2013 Apr;52(3):937-48. doi: 10.1007/s00394-012-0401-x. Epub 2012 Jun 26.


MondoA senses non-glucose sugars: regulation of thioredoxin-interacting protein (TXNIP) and the hexose transport curb.

Stoltzman CA, Kaadige MR, Peterson CW, Ayer DE.

J Biol Chem. 2011 Nov 4;286(44):38027-34. doi: 10.1074/jbc.M111.275503. Epub 2011 Sep 9.


Transcriptional and Translational Downregulation of Thioredoxin Interacting Protein Is Required for Metabolic Reprogramming during G(1).

Elgort MG, O'Shea JM, Jiang Y, Ayer DE.

Genes Cancer. 2010 Sep;1(9):893-907. doi: 10.1177/1947601910389604.


An extended Myc network contributes to glucose homeostasis in cancer and diabetes.

Peterson CW, Ayer DE.

Front Biosci (Landmark Ed). 2011 Jun 1;16:2206-23. Review.


Coordination of glucose and glutamine utilization by an expanded Myc network.

Kaadige MR, Elgort MG, Ayer DE.

Transcription. 2010 Jul-Aug;1(1):36-40. doi: 10.4161/trns.1.1.12142.


Myc, mondo, and metabolism.

Sloan EJ, Ayer DE.

Genes Cancer. 2010 Jun;1(6):587-96. doi: 10.1177/1947601910377489.


Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA.

Chen JL, Merl D, Peterson CW, Wu J, Liu PY, Yin H, Muoio DM, Ayer DE, West M, Chi JT.

PLoS Genet. 2010 Sep 2;6(9):e1001093. doi: 10.1371/journal.pgen.1001093.


Glucose controls nuclear accumulation, promoter binding, and transcriptional activity of the MondoA-Mlx heterodimer.

Peterson CW, Stoltzman CA, Sighinolfi MP, Han KS, Ayer DE.

Mol Cell Biol. 2010 Jun;30(12):2887-95. doi: 10.1128/MCB.01613-09. Epub 2010 Apr 12.


Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity.

Kaadige MR, Looper RE, Kamalanaadhan S, Ayer DE.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14878-83. doi: 10.1073/pnas.0901221106. Epub 2009 Aug 17.


Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cells.

Silveira AC, Hurst DR, Vaidya KS, Ayer DE, Welch DR.

Cancer Lett. 2009 Apr 8;276(1):32-7. doi: 10.1016/j.canlet.2008.10.024. Epub 2008 Dec 13.


Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.

Stoltzman CA, Peterson CW, Breen KT, Muoio DM, Billin AN, Ayer DE.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):6912-7. doi: 10.1073/pnas.0712199105. Epub 2008 May 5.


A C. elegans Myc-like network cooperates with semaphorin and Wnt signaling pathways to control cell migration.

Pickett CL, Breen KT, Ayer DE.

Dev Biol. 2007 Oct 15;310(2):226-39. Epub 2007 Aug 3.


MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis.

Sans CL, Satterwhite DJ, Stoltzman CA, Breen KT, Ayer DE.

Mol Cell Biol. 2006 Jul;26(13):4863-71.


ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.

Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T, Carney D, Peña P, Lan F, Kaadige MR, Lacoste N, Cayrou C, Davrazou F, Saha A, Cairns BR, Ayer DE, Kutateladze TG, Shi Y, Côté J, Chua KF, Gozani O.

Nature. 2006 Jul 6;442(7098):96-9. Epub 2006 May 21.


The Mlx network: evidence for a parallel Max-like transcriptional network that regulates energy metabolism.

Billin AN, Ayer DE.

Curr Top Microbiol Immunol. 2006;302:255-78. Review.


Identification and characterization of three new components of the mSin3A corepressor complex.

Fleischer TC, Yun UJ, Ayer DE.

Mol Cell Biol. 2003 May;23(10):3456-67.


A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex.

Eilers AL, Sundwall E, Lin M, Sullivan AA, Ayer DE.

Mol Cell Biol. 2002 Dec;22(24):8514-26.


Solution structure of the interacting domains of the Mad-Sin3 complex: implications for recruitment of a chromatin-modifying complex.

Brubaker K, Cowley SM, Huang K, Loo L, Yochum GS, Ayer DE, Eisenman RN, Radhakrishnan I.

Cell. 2000 Nov 10;103(4):655-65.


Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors.

Billin AN, Eilers AL, Queva C, Ayer DE.

J Biol Chem. 1999 Dec 17;274(51):36344-50.


The Mad protein family links transcriptional repression to cell differentiation.

McArthur GA, Laherty CD, Quéva C, Hurlin PJ, Loo L, James L, Grandori C, Gallant P, Shiio Y, Hokanson WC, Bush AC, Cheng PF, Lawrence QA, Pulverer B, Koskinen PJ, Foley KP, Ayer DE, Eisenman RN.

Cold Spring Harb Symp Quant Biol. 1998;63:423-33. Review. No abstract available.


Histone deacetylases: transcriptional repression with SINers and NuRDs.

Ayer DE.

Trends Cell Biol. 1999 May;9(5):193-8. Review.


SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.

Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN.

Mol Cell. 1998 Jul;2(1):33-42.


A role for histone deacetylase activity in HDAC1-mediated transcriptional repression.

Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE, Schreiber SL.

Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3519-24.


Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase.

Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM.

Cell. 1997 May 2;89(3):373-80.


Histone deacetylase activity is required for full transcriptional repression by mSin3A.

Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE.

Cell. 1997 May 2;89(3):341-7.


Mad proteins contain a dominant transcription repression domain.

Ayer DE, Laherty CD, Lawrence QA, Armstrong AP, Eisenman RN.

Mol Cell Biol. 1996 Oct;16(10):5772-81.


Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo.

Grandori C, Mac J, Siëbelt F, Ayer DE, Eisenman RN.

EMBO J. 1996 Aug 15;15(16):4344-57.


SIN3-dependent transcriptional repression by interaction with the Mad1 DNA-binding protein.

Kasten MM, Ayer DE, Stillman DJ.

Mol Cell Biol. 1996 Aug;16(8):4215-21.


Inhibition of cell proliferation by the Mad1 transcriptional repressor.

Roussel MF, Ashmun RA, Sherr CJ, Eisenman RN, Ayer DE.

Mol Cell Biol. 1996 Jun;16(6):2796-801.


Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.

Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN.

EMBO J. 1996 Apr 15;15(8):2030. No abstract available.


Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants.

Hall ED, Andrus PK, Smith SL, Oostveen JA, Scherch HM, Lutzke BS, Raub TJ, Sawada GA, Palmer JR, Banitt LS, Tustin JS, Belonga KL, Ayer DE, Bundy GL.

Acta Neurochir Suppl. 1996;66:107-13. Review.


Supplemental Content

Support Center