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Items: 25

1.

Detection of TAR DNA-binding protein 43 (TDP-43) oligomers as initial intermediate species during aggregate formation.

French RL, Grese ZR, Aligireddy H, Dhavale DD, Reeb AN, Kedia N, Kotzbauer PT, Bieschke J, Ayala YM.

J Biol Chem. 2019 Apr 26;294(17):6696-6709. doi: 10.1074/jbc.RA118.005889. Epub 2019 Mar 1.

PMID:
30824544
2.

A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.

Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, Nourse A, Ramirez Montero D, Ryan VH, Rohatgi R, Shewmaker F, Naik MT, Mittag T, Ayala YM, Fawzi NL.

EMBO J. 2018 Mar 1;37(5). pii: e97452. doi: 10.15252/embj.201797452. Epub 2018 Feb 9.

3.

Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function.

Li W, Reeb AN, Lin B, Subramanian P, Fey EE, Knoverek CR, French RL, Bigio EH, Ayala YM.

J Biol Chem. 2017 Mar 24;292(12):5089-5100. doi: 10.1074/jbc.M116.753913. Epub 2017 Feb 6.

4.

TDP-43 regulates its mRNA levels through a negative feedback loop.

Ayala YM, De Conti L, Avendaño-Vázquez SE, Dhir A, Romano M, D'Ambrogio A, Tollervey J, Ule J, Baralle M, Buratti E, Baralle FE.

EMBO J. 2011 Jan 19;30(2):277-88. doi: 10.1038/emboj.2010.310. Epub 2010 Dec 3.

5.

Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo.

D'Ambrogio A, Buratti E, Stuani C, Guarnaccia C, Romano M, Ayala YM, Baralle FE.

Nucleic Acids Res. 2009 Jul;37(12):4116-26. doi: 10.1093/nar/gkp342. Epub 2009 May 8.

6.

Structural determinants of the cellular localization and shuttling of TDP-43.

Ayala YM, Zago P, D'Ambrogio A, Xu YF, Petrucelli L, Buratti E, Baralle FE.

J Cell Sci. 2008 Nov 15;121(Pt 22):3778-85. doi: 10.1242/jcs.038950. Epub 2008 Oct 28.

7.

Improving human interferon-beta production in mammalian cell lines by insertion of an intronic sequence within its naturally uninterrupted gene.

Zago P, Baralle M, Ayala YM, Skoko N, Zacchigna S, Buratti E, Tisminetzky S.

Biotechnol Appl Biochem. 2009 Mar;52(Pt 3):191-8. doi: 10.1042/BA20080046.

PMID:
18564058
8.

TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression.

Ayala YM, Misteli T, Baralle FE.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3785-9. doi: 10.1073/pnas.0800546105. Epub 2008 Feb 27.

9.

TDP43 depletion rescues aberrant CFTR exon 9 skipping.

Ayala YM, Pagani F, Baralle FE.

FEBS Lett. 2006 Feb 20;580(5):1339-44. Epub 2006 Jan 26.

10.

Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene.

Mercado PA, Ayala YM, Romano M, Buratti E, Baralle FE.

Nucleic Acids Res. 2005 Oct 27;33(18):6000-10. Print 2005.

11.
12.

Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function.

Ayala YM, Pantano S, D'Ambrogio A, Buratti E, Brindisi A, Marchetti C, Romano M, Baralle FE.

J Mol Biol. 2005 May 6;348(3):575-88.

PMID:
15826655
13.

hnRNP H binding at the 5' splice site correlates with the pathological effect of two intronic mutations in the NF-1 and TSHbeta genes.

Buratti E, Baralle M, De Conti L, Baralle D, Romano M, Ayala YM, Baralle FE.

Nucleic Acids Res. 2004 Aug 6;32(14):4224-36. Print 2004.

14.

Regulation of 3' splice site selection in the 844ins68 polymorphism of the cystathionine Beta -synthase gene.

Romano M, Marcucci R, Buratti E, Ayala YM, Sebastio G, Baralle FE.

J Biol Chem. 2002 Nov 15;277(46):43821-9. Epub 2002 Sep 12.

15.

Molecular mapping of thrombin-receptor interactions.

Ayala YM, Cantwell AM, Rose T, Bush LA, Arosio D, Di Cera E.

Proteins. 2001 Nov 1;45(2):107-16.

PMID:
11562940
16.

Mutation of W215 compromises thrombin cleavage of fibrinogen, but not of PAR1 or protein C.

Ayala YM, Arosio D, Di Cera E.

Ann N Y Acad Sci. 2001;936:456-8.

PMID:
11460501
18.

Mutation of W215 compromises thrombin cleavage of fibrinogen, but not of PAR-1 or protein C.

Arosio D, Ayala YM, Di Cera E.

Biochemistry. 2000 Jul 11;39(27):8095-101.

PMID:
10891092
19.

Role of residue Y99 in tissue plasminogen activator.

Vindigni A, Winfield M, Ayala YM, Di Cera E.

Protein Sci. 2000 Mar;9(3):619-22.

20.

Molecular mechanisms of thrombin function.

Di Cera E, Dang QD, Ayala YM.

Cell Mol Life Sci. 1997 Sep;53(9):701-30. Review.

PMID:
9368668
21.

Characterization of the bacterial sensor protein PhoQ. Evidence for distinct binding sites for Mg2+ and Ca2+.

Véscovi EG, Ayala YM, Di Cera E, Groisman EA.

J Biol Chem. 1997 Jan 17;272(3):1440-3.

22.

An unexpected 5' untranslated intron in the P. falciparum genes for histidine-rich proteins II and III.

Sullivan DJ Jr, Ayala YM, Goldberg DE.

Mol Biochem Parasitol. 1996 Dec 20;83(2):247-51. No abstract available.

PMID:
9027758
23.

Identification of residues linked to the slow-->fast transition of thrombin.

Guinto ER, Vindigni A, Ayala YM, Dang QD, Di Cera E.

Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11185-9.

24.
25.

The Na+ binding site of thrombin.

Di Cera E, Guinto ER, Vindigni A, Dang QD, Ayala YM, Wuyi M, Tulinsky A.

J Biol Chem. 1995 Sep 22;270(38):22089-92.

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