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Items: 1 to 50 of 96

1.

Neutrophil/lymphocyte ratio elevation in renal dysfunction is caused by distortion of leukocyte hematopoiesis in bone marrow.

Ito S, Ohno Y, Tanaka T, Kobuchi S, Ayajiki K, Manabe E, Masuyama T, Jun-Ichi S, Tsujino T.

Ren Fail. 2019 Nov;41(1):284-293. doi: 10.1080/0886022X.2019.1597736.

2.

Nitric oxide modulation of endothelium-derived hyperpolarizing factor in agonist-induced depressor responses in anesthetized rats.

Kobuchi S, Miura K, Iwao H, Ayajiki K.

Eur J Pharmacol. 2015 Sep 5;762:26-34. doi: 10.1016/j.ejphar.2015.04.053. Epub 2015 May 8.

PMID:
25962662
3.

Mechanisms underlying the renoprotective effect of GABA against ischaemia/reperfusion-induced renal injury in rats.

Kobuchi S, Tanaka R, Shintani T, Suzuki R, Tsutsui H, Ohkita M, Matsumura Y, Ayajiki K.

Clin Exp Pharmacol Physiol. 2015 Mar;42(3):278-86. doi: 10.1111/1440-1681.12350.

PMID:
25482107
4.
5.

Involvement of renal sympathetic nerve overactivation in the progression of chronic kidney disease in rats.

Kobuchi S, Tanaka R, Funai A, Suzuki R, Yazawa M, Tsutsui H, Ohkita M, Ayajiki K, Matsumura Y.

J Cardiovasc Pharmacol. 2014 Jan;63(1):9-15. doi: 10.1097/FJC.0000000000000016.

PMID:
24084211
6.

Neurogenic and endothelial nitric oxide regulates blood circulation in lingual and other oral tissues.

Toda N, Ayajiki K, Okamura T.

J Cardiovasc Pharmacol. 2012 Jul;60(1):100-8. doi: 10.1097/FJC.0b013e318252452a. Review.

PMID:
22407338
7.

Nitrergic nerves derived from the pterygopalatine ganglion innervate arteries irrigating the cerebrum but not the cerebellum and brain stem in monkeys.

Ayajiki K, Kobuchi S, Tawa M, Okamura T.

Hypertens Res. 2012 Jan;35(1):88-92. doi: 10.1038/hr.2011.163. Epub 2011 Oct 6.

PMID:
21975516
8.

Mechanisms underlying the renoprotective effect of GABA against ischemia/reperfusion-induced renal injury in rats.

Kobuchi S, Tanaka R, Shintani T, Suzuki R, Tsutsui H, Ohkita M, Ayajiki K, Matsumura Y.

J Pharmacol Exp Ther. 2011 Sep;338(3):767-74. doi: 10.1124/jpet.111.180174. Epub 2011 Jun 1. Retraction in: J Pharmacol Exp Ther. 2014 May;349(2):347.

PMID:
21632868
9.

Impairment by hypoxia or hypoxia/reoxygenation of nitric oxide-mediated relaxation in isolated monkey coronary artery: the role of intracellular superoxide.

Tawa M, Yamamizu K, Geddawy A, Shimosato T, Imamura T, Ayajiki K, Okamura T.

J Pharmacol Sci. 2011;116(2):188-96. Epub 2011 May 19.

10.

Contribution of nitric oxide in big endothelin-1-induced cardioprotective effects on ischemia/reperfusion injury in rat hearts.

Tawa M, Fukumoto T, Ohkita M, Yamashita N, Geddawy A, Imamura T, Ayajiki K, Okamura T, Matsumura Y.

J Cardiovasc Pharmacol. 2011 May;57(5):575-8. doi: 10.1097/FJC.0b013e31821325ad.

PMID:
21326108
11.

Effects of exogenous big endothelin-1 on postischemic cardiac dysfunction and norepinephrine overflow in rat hearts.

Tawa M, Fukumoto T, Ohkita M, Yamashita N, Geddawy A, Imamura T, Ayajiki K, Okamura T, Matsumura Y.

Hypertens Res. 2011 Feb;34(2):218-24. doi: 10.1038/hr.2010.213. Epub 2010 Nov 4.

PMID:
21048781
12.

Effect of nitric oxide synthase inhibitor on increase in nasal mucosal blood flow induced by sensory and parasympathetic nerve stimulation in rats.

Ogawa F, Hanamitsu M, Ayajiki K, Aimi Y, Okamura T, Shimizu T.

Ann Otol Rhinol Laryngol. 2010 Jun;119(6):424-30.

PMID:
20583742
13.

Vascular actions of nitric oxide as affected by exposure to alcohol.

Toda N, Ayajiki K.

Alcohol Alcohol. 2010 Jul-Aug;45(4):347-55. doi: 10.1093/alcalc/agq028. Epub 2010 Jun 2. Review.

PMID:
20522422
14.

Alzheimer's disease, cerebral blood flow, and nitric oxide.

Toda N, Ayajiki K.

Nihon Yakurigaku Zasshi. 2010 Jan;135(1):20-4. doi: 10.1254/fpj.135.20. Review. Japanese. No abstract available.

PMID:
20075566
15.

Postconditioning improves postischemic cardiac dysfunction independently of norepinephrine overflow after reperfusion in rat hearts: comparison with preconditioning.

Tawa M, Fukumoto T, Yamashita N, Ohkita M, Ayajiki K, Okamura T, Matsumura Y.

J Cardiovasc Pharmacol. 2010 Jan;55(1):6-13. doi: 10.1097/FJC.0b013e3181bfb1c1.

PMID:
19786893
16.

Cerebral blood flow regulation by nitric oxide in neurological disorders.

Toda N, Ayajiki K, Okamura T.

Can J Physiol Pharmacol. 2009 Aug;87(8):581-94. doi: 10.1139/y09-048. Review.

PMID:
19767882
17.

Renoprotective effects of gamma-aminobutyric acid on ischemia/reperfusion-induced renal injury in rats.

Kobuchi S, Shintani T, Sugiura T, Tanaka R, Suzuki R, Tsutsui H, Fujii T, Ohkita M, Ayajiki K, Matsumura Y.

Eur J Pharmacol. 2009 Nov 25;623(1-3):113-8. doi: 10.1016/j.ejphar.2009.09.023. Epub 2009 Sep 16.

PMID:
19765583
18.

Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase.

Toda N, Ayajiki K, Okamura T.

J Hypertens. 2009 Oct;27(10):1929-40. doi: 10.1097/HJH.0b013e32832e8ddf. Review.

PMID:
19587610
19.

Characterization of nitrergic function in monkey penile erection in vivo and in vitro.

Ayajiki K, Hayashida H, Tawa M, Okamura T, Toda N.

Hypertens Res. 2009 Aug;32(8):685-9. doi: 10.1038/hr.2009.84. Epub 2009 Jun 5.

PMID:
19498439
20.

Cerebral blood flow regulation by nitric oxide: recent advances.

Toda N, Ayajiki K, Okamura T.

Pharmacol Rev. 2009 Mar;61(1):62-97. doi: 10.1124/pr.108.000547. Epub 2009 Mar 16. Review.

PMID:
19293146
21.

Cilostazol's effect on the response to perivascular nerve stimulation in isolated dog cerebral and mesenteric arteries.

Ayajiki K, Ozeki Y, Wang C, Okamura T.

Hypertens Res. 2008 Jul;31(7):1425-33. doi: 10.1291/hypres.31.1425.

PMID:
18957814
22.
23.

Oral administration of both tetrahydrobiopterin and L-arginine prevents endothelial dysfunction in rats with chronic renal failure.

Yamamizu K, Shinozaki K, Ayajiki K, Gemba M, Okamura T.

J Cardiovasc Pharmacol. 2007 Mar;49(3):131-9.

PMID:
17414224
24.

Pitavastatin restores vascular dysfunction in insulin-resistant state by inhibiting NAD(P)H oxidase activity and uncoupled endothelial nitric oxide synthase-dependent superoxide production.

Shinozaki K, Nishio Y, Ayajiki K, Yoshida Y, Masada M, Kashiwagi A, Okamura T.

J Cardiovasc Pharmacol. 2007 Mar;49(3):122-30.

PMID:
17414223
25.

Interaction of endothelial nitric oxide and angiotensin in the circulation.

Toda N, Ayajiki K, Okamura T.

Pharmacol Rev. 2007 Mar;59(1):54-87. Review.

PMID:
17329548
26.

Phylogenesis of constitutively formed nitric oxide in non-mammals.

Toda N, Ayajiki K.

Rev Physiol Biochem Pharmacol. 2006;157:31-80. Review.

PMID:
17236649
27.

Supplement of tetrahydrobiopterin by a gene transfer of GTP cyclohydrolase I cDNA improves vascular dysfunction in insulin-resistant rats.

Shinozaki K, Nishio Y, Yoshida Y, Koya D, Ayajiki K, Masada M, Kashiwagi A, Okamura T.

J Cardiovasc Pharmacol. 2005 Oct;46(4):505-12.

PMID:
16160605
28.

Nitric oxide and penile erectile function.

Toda N, Ayajiki K, Okamura T.

Pharmacol Ther. 2005 May;106(2):233-66. Epub 2005 Mar 2. Review.

PMID:
15866322
29.
30.

Malfunction of vascular control in lifestyle-related diseases: mechanisms underlying endothelial dysfunction in the insulin-resistant state.

Shinozaki K, Ayajiki K, Kashiwagi A, Masada M, Okamura T.

J Pharmacol Sci. 2004 Dec;96(4):401-5. Epub 2004 Dec 15. Review.

31.

[Mechanisms of nitric oxide production].

Ayajiki K, Shinozaki K, Okamura T.

Nihon Rinsho. 2004 Sep;62 Suppl 9:446-50. Review. Japanese. No abstract available.

PMID:
15506424
32.

Increased BBB permeability by parasympathetic sphenopalatine ganglion stimulation in dogs.

Yarnitsky D, Gross Y, Lorian A, Shalev A, Shorer S, Tanaka T, Ayajiki K, Fujimiya M, Okamura T.

Brain Res. 2004 Aug 27;1018(2):236-40.

PMID:
15276883
33.

Mechanisms underlying endothelium-dependent flow increase in perfused rat mesenteric vascular bed.

Fujioka H, Ayajiki K, Shinozaki K, Okamura T.

Eur J Pharmacol. 2004 Feb 6;485(1-3):219-25.

PMID:
14757144
34.

Evidence for a causal role of the renin-angiotensin system in vascular dysfunction associated with insulin resistance.

Shinozaki K, Ayajiki K, Nishio Y, Sugaya T, Kashiwagi A, Okamura T.

Hypertension. 2004 Feb;43(2):255-62. Epub 2003 Dec 29.

PMID:
14698997
35.

Protection by hypothermia of hypoxia-induced inhibition of neurogenic vasodilation in porcine cerebral arteries.

Tanaka T, Ayajiki K, Fujioka H, Toda N, Okamura T.

J Pharmacol Sci. 2003 Jun;92(2):93-9.

36.

Mediation of arachidonic acid metabolite(s) produced by endothelial cytochrome P-450 3A4 in monkey arterial relaxation.

Ayajiki K, Fujioka H, Toda N, Okada S, Minamiyama Y, Imaoka S, Funae Y, Watanabe S, Nakamura A, Okamura T.

Hypertens Res. 2003 Mar;26(3):237-43.

37.

Mechanisms underlying endothelium-dependent, nitric oxide- and prostanoid-independent relaxation in monkey and dog coronary arteries.

Fujioka H, Ayajiki K, Shinozaki K, Toda N, Okamura T.

Naunyn Schmiedebergs Arch Pharmacol. 2002 Nov;366(5):488-95. Epub 2002 Aug 30.

PMID:
12382080
38.

Endothelial and neuronal functions in cerebral and temporal arteries from monkeys fed a high-cholesterol diet.

Ayajiki K, Fujioka H, Torii R, Toda N, Okamura T.

J Cardiovasc Pharmacol. 2002 Sep;40(3):456-66.

PMID:
12198332
39.

Functional study on nitroxidergic nerve in isolated dog pulmonary arteries and veins.

Ayajiki K, Okamura T, Noda K, Toda N.

Jpn J Pharmacol. 2002 Jun;89(2):197-200.

40.

Comparison of the responses to thrombin in monkey renal and uterine arteries.

Kimura T, Ayajiki K, Noda Y, Okamura T.

J Soc Gynecol Investig. 2002 May-Jun;9(3):146-51.

PMID:
12009388
41.

Effects of nipradilol on alpha-adrenoceptor function in ocular arteries.

Okamura T, Fujioka H, Ayajiki K.

Pharmacology. 2002 May;65(2):110-8.

PMID:
11937782
42.

Effects of calcium antagonists on the nitrergic nerve function in canine corpus cavernosum.

Okamura T, Fujioka H, Ayajiki K.

Jpn J Pharmacol. 2001 Nov;87(3):208-13.

43.

[Nitroxidergic (nitrergic) nerve and erectile dysfunction].

Ayajiki K, Toda N, Okamura T.

Nihon Yakurigaku Zasshi. 2002 Jan;119(1):21-8. Review. Japanese.

PMID:
11862753
44.

Neurogenic cerebral vasodilation mediated by nitric oxide.

Okamura T, Ayajiki K, Fujioka H, Shinozaki K, Toda N.

Jpn J Pharmacol. 2002 Jan;88(1):32-8. Review.

45.

Relatively selective neuronal nitric oxide synthase inhibition by 7-nitroindazole in monkey isolated cerebral arteries.

Ayajiki K, Fujioka H, Okamura T, Toda N.

Eur J Pharmacol. 2001 Jul 6;423(2-3):179-83.

PMID:
11448483
46.

Modifications by sumatriptan and acetylcholine of nitric oxide-mediated neurogenic dilatation in dog cerebral arteries.

Ayajiki K, Fujioka H, Noda K, Okamura T, Toda N.

Eur J Pharmacol. 2001 May 18;420(1):67-72.

PMID:
11412840
47.

Ginsenoside potentiates NO-mediated neurogenic vasodilatation of monkey cerebral arteries.

Toda N, Ayajiki K, Fujioka H, Okamura T.

J Ethnopharmacol. 2001 Jun;76(1):109-13.

PMID:
11378291
48.
49.

Mechanisms underlying endothelium-dependent, nitric oxide/prostacyclin-independent, acetylcholine-induced relaxation in canine corpus cavernosum.

Ayajiki K, Fujioka H, Okamura T.

Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):448-51.

PMID:
11111842
50.

Mechanisms underlying contraction and relaxation induced by nerve stimulation in monkey uterine arteries.

Okamura T, Ghoneim HA, Ayajiki K, Ammar ES, Toda N.

Pharmacology. 2000 Nov;61(4):251-6.

PMID:
11093077

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