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Items: 18

1.

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.

Hammerschmidt P, Ostkotte D, Nolte H, Gerl MJ, Jais A, Brunner HL, Sprenger HG, Awazawa M, Nicholls HT, Turpin-Nolan SM, Langer T, Krüger M, Brügger B, Brüning JC.

Cell. 2019 May 30;177(6):1536-1552.e23. doi: 10.1016/j.cell.2019.05.008.

PMID:
31150623
2.

CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance.

Turpin-Nolan SM, Hammerschmidt P, Chen W, Jais A, Timper K, Awazawa M, Brodesser S, Brüning JC.

Cell Rep. 2019 Jan 2;26(1):1-10.e7. doi: 10.1016/j.celrep.2018.12.031.

3.

Acquired partial lipoatrophy as graft-versus-host disease and treatment with metreleptin: two case reports.

Shibata Y, Nakatsuka A, Eguchi J, Miyamoto S, Masuda Y, Awazawa M, Takaki A, Yoshida R, Yagi T, Wada J.

J Med Case Rep. 2018 Dec 14;12(1):368. doi: 10.1186/s13256-018-1901-y.

4.

Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation.

Brandt C, Nolte H, Henschke S, Engström Ruud L, Awazawa M, Morgan DA, Gabel P, Sprenger HG, Hess ME, Günther S, Langer T, Rahmouni K, Fenselau H, Krüger M, Brüning JC.

Cell. 2018 Nov 15;175(5):1321-1335.e20. doi: 10.1016/j.cell.2018.10.015.

5.

LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat.

Schmidt E, Dhaouadi I, Gaziano I, Oliverio M, Klemm P, Awazawa M, Mitterer G, Fernandez-Rebollo E, Pradas-Juni M, Wagner W, Hammerschmidt P, Loureiro R, Kiefer C, Hansmeier NR, Khani S, Bergami M, Heine M, Ntini E, Frommolt P, Zentis P, Ørom UA, Heeren J, Blüher M, Bilban M, Kornfeld JW.

Nat Commun. 2018 Sep 6;9(1):3622. doi: 10.1038/s41467-018-05933-8.

6.

The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis.

Kobayashi M, Ohsugi M, Sasako T, Awazawa M, Umehara T, Iwane A, Kobayashi N, Okazaki Y, Kubota N, Suzuki R, Waki H, Horiuchi K, Hamakubo T, Kodama T, Aoe S, Tobe K, Kadowaki T, Ueki K.

Mol Cell Biol. 2018 Jul 30;38(16). pii: e00116-18. doi: 10.1128/MCB.00116-18. Print 2018 Aug 15.

7.

A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle.

Awazawa M, Gabel P, Tsaousidou E, Nolte H, Krüger M, Schmitz J, Ackermann PJ, Brandt C, Altmüller J, Motameny S, Wunderlich FT, Kornfeld JW, Blüher M, Brüning JC.

Nat Med. 2017 Dec;23(12):1466-1473. doi: 10.1038/nm.4420. Epub 2017 Nov 6.

PMID:
29106399
8.

Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss.

Schmitz J, Evers N, Awazawa M, Nicholls HT, Brönneke HS, Dietrich A, Mauer J, Blüher M, Brüning JC.

Mol Metab. 2016 Jan 11;5(5):328-339. doi: 10.1016/j.molmet.2015.12.001. eCollection 2016 May.

9.

Deregulation of pancreas-specific oxidoreductin ERO1β in the pathogenesis of diabetes mellitus.

Awazawa M, Futami T, Sakada M, Kaneko K, Ohsugi M, Nakaya K, Terai A, Suzuki R, Koike M, Uchiyama Y, Kadowaki T, Ueki K.

Mol Cell Biol. 2014 Apr;34(7):1290-9. doi: 10.1128/MCB.01647-13. Epub 2014 Jan 27.

10.

Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding.

Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, Brüning JC.

Cell. 2014 Jan 30;156(3):495-509. doi: 10.1016/j.cell.2014.01.008. Epub 2014 Jan 23.

11.

Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway.

Awazawa M, Ueki K, Inabe K, Yamauchi T, Kubota N, Kaneko K, Kobayashi M, Iwane A, Sasako T, Okazaki Y, Ohsugi M, Takamoto I, Yamashita S, Asahara H, Akira S, Kasuga M, Kadowaki T.

Cell Metab. 2011 Apr 6;13(4):401-412. doi: 10.1016/j.cmet.2011.02.010.

12.

Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance.

Kobayashi N, Ueki K, Okazaki Y, Iwane A, Kubota N, Ohsugi M, Awazawa M, Kobayashi M, Sasako T, Kaneko K, Suzuki M, Nishikawa Y, Hara K, Yoshimura K, Koshima I, Goyama S, Murakami K, Sasaki J, Nagai R, Kurokawa M, Sasaki T, Kadowaki T.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5753-8. doi: 10.1073/pnas.1016430108. Epub 2011 Mar 21.

13.

Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms.

Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkarni RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T.

Cell Metab. 2010 Dec 1;12(6):619-32. doi: 10.1016/j.cmet.2010.11.005.

14.

Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway.

Awazawa M, Ueki K, Inabe K, Yamauchi T, Kaneko K, Okazaki Y, Bardeesy N, Ohnishi S, Nagai R, Kadowaki T.

Biochem Biophys Res Commun. 2009 Apr 24;382(1):51-6. doi: 10.1016/j.bbrc.2009.02.131. Epub 2009 Feb 28.

PMID:
19254698
15.

Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways.

Watanabe T, Kubota N, Ohsugi M, Kubota T, Takamoto I, Iwabu M, Awazawa M, Katsuyama H, Hasegawa C, Tokuyama K, Moroi M, Sugi K, Yamauchi T, Noda T, Nagai R, Terauchi Y, Tobe K, Ueki K, Kadowaki T.

J Biol Chem. 2009 Jan 16;284(3):1803-12. doi: 10.1074/jbc.M807120200. Epub 2008 Nov 13.

16.

Molecular mechanism of moderate insulin resistance in adiponectin-knockout mice.

Yano W, Kubota N, Itoh S, Kubota T, Awazawa M, Moroi M, Sugi K, Takamoto I, Ogata H, Tokuyama K, Noda T, Terauchi Y, Ueki K, Kadowaki T.

Endocr J. 2008 Jul;55(3):515-22. Epub 2008 Apr 30.

17.

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.

Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, Okada-Iwabu M, Kawamoto S, Kubota N, Kubota T, Ito Y, Kamon J, Tsuchida A, Kumagai K, Kozono H, Hada Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Awazawa M, Takamoto I, Froguel P, Hara K, Tobe K, Nagai R, Ueki K, Kadowaki T.

Nat Med. 2007 Mar;13(3):332-9. Epub 2007 Feb 1.

PMID:
17268472
18.

[Not Available].

Awazawa M, Noda M, Kadowaki T.

Clin Calcium. 2003 Aug;13(8):1077-82. Japanese. No abstract available.

PMID:
15775189

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