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Items: 1 to 50 of 63

1.

Catalase S-Glutathionylation by NOX2 and Mitochondrial-Derived ROS Adversely Affects Mice and Human Neutrophil Survival.

Nagarkoti S, Dubey M, Sadaf S, Awasthi D, Chandra T, Jagavelu K, Kumar S, Dikshit M.

Inflammation. 2019 Dec;42(6):2286-2296. doi: 10.1007/s10753-019-01093-z.

PMID:
31646444
2.

Glycolysis dependent lactate formation in neutrophils: A metabolic link between NOX-dependent and independent NETosis.

Awasthi D, Nagarkoti S, Sadaf S, Chandra T, Kumar S, Dikshit M.

Biochim Biophys Acta Mol Basis Dis. 2019 Dec 1;1865(12):165542. doi: 10.1016/j.bbadis.2019.165542. Epub 2019 Aug 29.

PMID:
31473341
3.

Novel T9 loop conformation of filamenting temperature-sensitive mutant Z from Mycobacterium tuberculosis.

Lazo EO, Jakoncic J, RoyChowdhury S, Awasthi D, Ojima I.

Acta Crystallogr F Struct Biol Commun. 2019 May 1;75(Pt 5):359-367. doi: 10.1107/S2053230X19004618. Epub 2019 Apr 24.

PMID:
31045565
4.

Augmentation of iNOS expression in myeloid progenitor cells expedites neutrophil differentiation.

Sadaf S, Singh AK, Awasthi D, Nagarkoti S, Agrahari AK, Srivastava RN, Jagavelu K, Kumar S, Barthwal MK, Dikshit M.

J Leukoc Biol. 2019 Aug;106(2):397-412. doi: 10.1002/JLB.1A0918-349RR. Epub 2019 Mar 12.

PMID:
30861597
5.

L-Arginine and tetrahydrobiopterin supported nitric oxide production is crucial for the microbicidal activity of neutrophils.

Nagarkoti S, Sadaf S, Awasthi D, Chandra T, Jagavelu K, Kumar S, Dikshit M.

Free Radic Res. 2019 Mar;53(3):281-292. doi: 10.1080/10715762.2019.1566605. Epub 2019 Feb 4.

PMID:
30621514
6.

Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA.

Kumar P, Capodagli GC, Awasthi D, Shrestha R, Maharaja K, Sukheja P, Li SG, Inoyama D, Zimmerman M, Ho Liang HP, Sarathy J, Mina M, Rasic G, Russo R, Perryman AL, Richmann T, Gupta A, Singleton E, Verma S, Husain S, Soteropoulos P, Wang Z, Morris R, Porter G, Agnihotri G, Salgame P, Ekins S, Rhee KY, Connell N, Dartois V, Neiditch MB, Freundlich JS, Alland D.

MBio. 2018 Dec 18;9(6). pii: e02101-17. doi: 10.1128/mBio.02101-17.

7.

High content, high-throughput screening for small molecule inducers of NF-κB translocation.

Njikan S, Manning AJ, Ovechkina Y, Awasthi D, Parish T.

PLoS One. 2018 Jun 28;13(6):e0199966. doi: 10.1371/journal.pone.0199966. eCollection 2018.

8.

Glucose and lipid metabolism alterations in liver and adipose tissue pre-dispose p47phox knockout mice to systemic insulin resistance.

Kanuri BN, Rebello SC, Pathak P, Agarwal H, Kanshana JS, Awasthi D, Gupta AP, Gayen JR, Jagavelu K, Dikshit M.

Free Radic Res. 2018 May;52(5):568-582. doi: 10.1080/10715762.2018.1453136. Epub 2018 Apr 3.

PMID:
29544378
9.

S-Glutathionylation of p47phox sustains superoxide generation in activated neutrophils.

Nagarkoti S, Dubey M, Awasthi D, Kumar V, Chandra T, Kumar S, Dikshit M.

Biochim Biophys Acta Mol Cell Res. 2018 Feb;1865(2):444-454. doi: 10.1016/j.bbamcr.2017.11.014. Epub 2017 Dec 2.

10.

Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB.

Chandrasekera NS, Berube BJ, Shetye G, Chettiar S, O'Malley T, Manning A, Flint L, Awasthi D, Ioerger TR, Sacchettini J, Masquelin T, Hipskind PA, Odingo J, Parish T.

ACS Infect Dis. 2017 Dec 8;3(12):898-916. doi: 10.1021/acsinfecdis.7b00112. Epub 2017 Oct 31.

11.

Metabolic engineering of Bacillus subtilis for production of D-lactic acid.

Awasthi D, Wang L, Rhee MS, Wang Q, Chauliac D, Ingram LO, Shanmugam KT.

Biotechnol Bioeng. 2018 Feb;115(2):453-463. doi: 10.1002/bit.26472. Epub 2017 Oct 30.

PMID:
28986980
12.

Antimycobacterial Metabolism: Illuminating Mycobacterium tuberculosis Biology and Drug Discovery.

Awasthi D, Freundlich JS.

Trends Microbiol. 2017 Sep;25(9):756-767. doi: 10.1016/j.tim.2017.05.007. Epub 2017 Jun 13. Review.

13.

Natural orifice transluminal endoscopic surgery (hybrid) cholecystectomy: The Dhillon technique.

Dhillon KS, Awasthi D, Dhillon AS.

J Minim Access Surg. 2017 Jul-Sep;13(3):176-181. doi: 10.4103/0972-9941.207838.

14.

Strategic incorporation of fluorine in the drug discovery of new-generation antitubercular agents targeting bacterial cell division protein FtsZ.

Ojima I, Awasthi D, Wei L, Haranahalli K.

J Fluor Chem. 2017 Apr;196:44-56. doi: 10.1016/j.jfluchem.2016.07.020. Epub 2016 Jul 29.

15.

Bacterial Siderophores Hijack Neutrophil Functions.

Saha P, Yeoh BS, Olvera RA, Xiao X, Singh V, Awasthi D, Subramanian BC, Chen Q, Dikshit M, Wang Y, Parent CA, Vijay-Kumar M.

J Immunol. 2017 Jun 1;198(11):4293-4303. doi: 10.4049/jimmunol.1700261. Epub 2017 Apr 21.

16.

A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells.

Sukheja P, Kumar P, Mittal N, Li SG, Singleton E, Russo R, Perryman AL, Shrestha R, Awasthi D, Husain S, Soteropoulos P, Brukh R, Connell N, Freundlich JS, Alland D.

MBio. 2017 Feb 14;8(1). pii: e02022-16. doi: 10.1128/mBio.02022-16.

17.

Nitric oxide-mediated apoptosis of neutrophils through caspase-8 and caspase-3-dependent mechanism.

Dubey M, Nagarkoti S, Awasthi D, Singh AK, Chandra T, Kumaravelu J, Barthwal MK, Dikshit M.

Cell Death Dis. 2016 Sep 1;7(9):e2348. doi: 10.1038/cddis.2016.248.

18.

Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis.

Singh V, Yeoh BS, Chassaing B, Zhang B, Saha P, Xiao X, Awasthi D, Shashidharamurthy R, Dikshit M, Gewirtz A, Vijay-Kumar M.

Cell Mol Gastroenterol Hepatol. 2016 Jul;2(4):482-498.e6.

19.

High oxidative stress adversely affects NFκB mediated induction of inducible nitric oxide synthase in human neutrophils: Implications in chronic myeloid leukemia.

Singh AK, Awasthi D, Dubey M, Nagarkoti S, Kumar A, Chandra T, Barthwal MK, Tripathi AK, Dikshit M.

Nitric Oxide. 2016 Aug 31;58:28-41. doi: 10.1016/j.niox.2016.06.002. Epub 2016 Jun 3.

PMID:
27264783
20.

Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation.

Awasthi D, Nagarkoti S, Kumar A, Dubey M, Singh AK, Pathak P, Chandra T, Barthwal MK, Dikshit M.

Free Radic Biol Med. 2016 Apr;93:190-203. doi: 10.1016/j.freeradbiomed.2016.01.004. Epub 2016 Jan 14.

PMID:
26774674
21.

Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model.

Knudson SE, Awasthi D, Kumar K, Carreau A, Goullieux L, Lagrange S, Vermet H, Ojima I, Slayden RA.

J Antimicrob Chemother. 2015 Nov;70(11):3070-3. doi: 10.1093/jac/dkv226. Epub 2015 Aug 5.

22.

Epistaxis and Death by the Trigeminocardiac Reflex: A Cautionary Report.

Awasthi D, Roy TM, Byrd RP Jr.

Fed Pract. 2015 Jun;32(6):45-49.

23.

L-Plastin S-glutathionylation promotes reduced binding to β-actin and affects neutrophil functions.

Dubey M, Singh AK, Awasthi D, Nagarkoti S, Kumar S, Ali W, Chandra T, Kumar V, Barthwal MK, Jagavelu K, Sánchez-Gómez FJ, Lamas S, Dikshit M.

Free Radic Biol Med. 2015 Sep;86:1-15. doi: 10.1016/j.freeradbiomed.2015.04.008. Epub 2015 Apr 14.

24.

SB-RA-2001 inhibits bacterial proliferation by targeting FtsZ assembly.

Singh D, Bhattacharya A, Rai A, Dhaked HP, Awasthi D, Ojima I, Panda D.

Biochemistry. 2014 May 13;53(18):2979-92. doi: 10.1021/bi401356y. Epub 2014 May 1.

25.

In vitro-in vivo activity relationship of substituted benzimidazole cell division inhibitors with activity against Mycobacterium tuberculosis.

Knudson SE, Kumar K, Awasthi D, Ojima I, Slayden RA.

Tuberculosis (Edinb). 2014 May;94(3):271-6. doi: 10.1016/j.tube.2014.03.007. Epub 2014 Apr 1.

26.

A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis.

Knudson SE, Awasthi D, Kumar K, Carreau A, Goullieux L, Lagrange S, Vermet H, Ojima I, Slayden RA.

PLoS One. 2014 Apr 15;9(4):e93953. doi: 10.1371/journal.pone.0093953. eCollection 2014.

27.

Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents.

Park B, Awasthi D, Chowdhury SR, Melief EH, Kumar K, Knudson SE, Slayden RA, Ojima I.

Bioorg Med Chem. 2014 May 1;22(9):2602-12. doi: 10.1016/j.bmc.2014.03.035. Epub 2014 Apr 1.

28.

Drug discovery targeting cell division proteins, microtubules and FtsZ.

Ojima I, Kumar K, Awasthi D, Vineberg JG.

Bioorg Med Chem. 2014 Sep 15;22(18):5060-77. doi: 10.1016/j.bmc.2014.02.036. Epub 2014 Mar 5. Review.

29.

SAR studies on trisubstituted benzimidazoles as inhibitors of Mtb FtsZ for the development of novel antitubercular agents.

Awasthi D, Kumar K, Knudson SE, Slayden RA, Ojima I.

J Med Chem. 2013 Dec 12;56(23):9756-70. doi: 10.1021/jm401468w. Epub 2013 Nov 23.

30.

Benzimidazole-based antibacterial agents against Francisella tularensis.

Kumar K, Awasthi D, Lee SY, Cummings JE, Knudson SE, Slayden RA, Ojima I.

Bioorg Med Chem. 2013 Jun 1;21(11):3318-26. doi: 10.1016/j.bmc.2013.02.059. Epub 2013 Apr 3.

31.

Laparoscopic-assisted uterovaginal anastomosis in congenital atresia of uterine cervix: follow-up study.

Kriplani A, Kachhawa G, Awasthi D, Kulshrestha V.

J Minim Invasive Gynecol. 2012 Jul-Aug;19(4):477-84. doi: 10.1016/j.jmig.2012.03.017.

PMID:
22748953
32.

Ketotic hyperglycemia with movement disorder.

Awasthi D, Tiwari AK, Upadhyaya A, Singh B, Tomar GS.

J Emerg Trauma Shock. 2012 Jan;5(1):90-1. doi: 10.4103/0974-2700.93095.

33.

Human papillomavirus deoxyribonucleic acid testing in developed countries.

Bhatla N, Singla S, Awasthi D.

Best Pract Res Clin Obstet Gynaecol. 2012 Apr;26(2):209-20. doi: 10.1016/j.bpobgyn.2011.11.003. Epub 2011 Dec 6. Review.

PMID:
22154228
34.

Efficacy of the levonorgestrel-releasing intrauterine system in uterine leiomyoma.

Kriplani A, Awasthi D, Kulshrestha V, Agarwal N.

Int J Gynaecol Obstet. 2012 Jan;116(1):35-8. doi: 10.1016/j.ijgo.2011.07.031. Epub 2011 Sep 28.

PMID:
21959070
35.

Therapeutic potential of FtsZ inhibition: a patent perspective.

Awasthi D, Kumar K, Ojima I.

Expert Opin Ther Pat. 2011 May;21(5):657-79. doi: 10.1517/13543776.2011.568483. Epub 2011 Mar 18. Review.

PMID:
21413908
36.

Discovery of anti-TB agents that target the cell-division protein FtsZ.

Kumar K, Awasthi D, Berger WT, Tonge PJ, Slayden RA, Ojima I.

Future Med Chem. 2010 Aug;2(8):1305-23. doi: 10.4155/fmc.10.220. Review.

37.

Allergy to lactated ringer solution-an unusual case presentation.

Tiwari AK, Tayal S, Awasthi D, Valson G.

Am J Ther. 2011 May;18(3):e86-8. doi: 10.1097/MJT.0b013e3181fafb30.

PMID:
21326085
38.

Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.

Kumar K, Awasthi D, Lee SY, Zanardi I, Ruzsicska B, Knudson S, Tonge PJ, Slayden RA, Ojima I.

J Med Chem. 2011 Jan 13;54(1):374-81. doi: 10.1021/jm1012006. Epub 2010 Dec 2.

39.

Alstrom syndrome: A rare genetic disorder and its anaesthetic significance.

Tiwari A, Awasthi D, Tayal S, Ganguly S.

Indian J Anaesth. 2010 Mar;54(2):154-6. doi: 10.4103/0019-5049.63628.

40.

Combined use of modified Alvarado score and USG in decreasing negative appendicectomy rate.

Nautiyal H, Ahmad S, Keshwani NK, Awasthi DN.

Indian J Surg. 2010 Feb;72(1):42-8. doi: 10.1007/s12262-010-0008-5. Epub 2010 Feb 5.

41.

Spontaneous cervical spinal epidural hematoma in a 12-year-old girl: case report and review of the literature.

Tender GC, Awasthi D.

J La State Med Soc. 2004 Jul-Aug;156(4):196-8. Review.

PMID:
15366348
42.

Concanavalin A induced activity change in yeast PM-bound NADH-HCF(III) oxidoreductase.

Awasthi D, Awasthi V, Misra PC.

Biochim Biophys Acta. 2004 Apr 7;1672(1):21-6.

PMID:
15056489
43.

Risk stratification in mild head injury patients: the head injury predictive index.

Tender GC, Awasthi D.

J La State Med Soc. 2003 Nov-Dec;155(6):338-42.

PMID:
14750754
44.

Cocaine use as a predictor of outcome in aneurysmal subarachnoid hemorrhage.

Howington JU, Kutz SC, Wilding GE, Awasthi D.

J Neurosurg. 2003 Aug;99(2):271-5.

PMID:
12924699
45.

Early gene expression in the rat cortex after experimental traumatic brain injury and hypotension.

Awasthi D, Kutz SC, Beuerman R, Nguyen D, Carey ME, Zeiller S.

Neurosci Lett. 2003 Jul 10;345(1):29-32.

PMID:
12809981
46.

Vascularized temporalis muscle flap for the treatment of otorrhea. Technical note.

Tender GC, Kutz S, Awasthi D, Rigby P.

J Neurosurg. 2003 May;98(5):1128-32.

PMID:
12744378
47.

Skull-base trauma: neurosurgical perspective.

Kruse JJ, Awasthi D.

J Craniomaxillofac Trauma. 1998 Summer;4(2):8-14; discussion 7.

PMID:
11951432
48.

Anatomic considerations of superior laryngeal nerve during anterior cervical spine procedures.

Melamed H, Harris MB, Awasthi D.

Spine (Phila Pa 1976). 2002 Feb 15;27(4):E83-6.

PMID:
11840114
49.

Gunshot wounds to the neck.

Tender GC, Ratliff J, Awasthi D, Buechter K.

South Med J. 2001 Aug;94(8):830-2.

PMID:
11549197
50.

Surgical anatomy of the C-2 pedicle.

Howington JU, Kruse JJ, Awasthi D.

J Neurosurg. 2001 Jul;95(1 Suppl):88-92.

PMID:
11453437

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