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EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblasts, mimicking the hallmarks of mucopolysaccharidosis IIIB.

De Pasquale V, Pezone A, Sarogni P, Tramontano A, Schiattarella GG, Avvedimento VE, Paladino S, Pavone LM.

Cell Death Dis. 2018 Jan 18;9(2):40. doi: 10.1038/s41419-017-0187-0.


Tracking the evolution of epialleles during neural differentiation and brain development: D-Aspartate oxidase as a model gene.

Florio E, Keller S, Coretti L, Affinito O, Scala G, Errico F, Fico A, Boscia F, Sisalli MJ, Reccia MG, Miele G, Monticelli A, Scorziello A, Lembo F, Colucci-D'Amato L, Minchiotti G, Avvedimento VE, Usiello A, Cocozza S, Chiariotti L.

Epigenetics. 2017 Jan 2;12(1):41-54. doi: 10.1080/15592294.2016.1260211. Epub 2016 Nov 18.


Modeling DNA methylation by analyzing the individual configurations of single molecules.

Affinito O, Scala G, Palumbo D, Florio E, Monticelli A, Miele G, Avvedimento VE, Usiello A, Chiariotti L, Cocozza S.

Epigenetics. 2016 Dec;11(12):881-888. Epub 2016 Oct 17.


Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds.

Carrella D, Manni I, Tumaini B, Dattilo R, Papaccio F, Mutarelli M, Sirci F, Amoreo CA, Mottolese M, Iezzi M, Ciolli L, Aria V, Bosotti R, Isacchi A, Loreni F, Bardelli A, Avvedimento VE, di Bernardo D, Cardone L.

Oncotarget. 2016 Sep 13;7(37):58743-58758. doi: 10.18632/oncotarget.11318.


Cyclical DNA Methylation and Histone Changes Are Induced by LPS to Activate COX-2 in Human Intestinal Epithelial Cells.

Angrisano T, Pero R, Brancaccio M, Coretti L, Florio E, Pezone A, Calabrò V, Falco G, Keller S, Lembo F, Avvedimento VE, Chiariotti L.

PLoS One. 2016 Jun 2;11(6):e0156671. doi: 10.1371/journal.pone.0156671. eCollection 2016.


Dual oxidase 2 generated reactive oxygen species selectively mediate the induction of mucins by epidermal growth factor in enterocytes.

Damiano S, Morano A, Ucci V, Accetta R, Mondola P, Paternò R, Avvedimento VE, Santillo M.

Int J Biochem Cell Biol. 2015 Mar;60:8-18. doi: 10.1016/j.biocel.2014.12.014. Epub 2015 Jan 3.


Epigenetic control of type 2 and 3 deiodinases in myogenesis: role of Lysine-specific Demethylase enzyme and FoxO3.

Ambrosio R, Damiano V, Sibilio A, De Stefano MA, Avvedimento VE, Salvatore D, Dentice M.

Nucleic Acids Res. 2013 Apr 1;41(6):3551-62. doi: 10.1093/nar/gkt065. Epub 2013 Feb 8.


Activation of β-catenin by oncogenic PIK3CA and EGFR promotes resistance to glucose deprivation by inducing a strong antioxidant response.

Cardone L, Bardelli A, Avvedimento VE.

PLoS One. 2012;7(5):e37526. doi: 10.1371/journal.pone.0037526. Epub 2012 May 25.


Early and late events induced by polyQ-expanded proteins: identification of a common pathogenic property of polYQ-expanded proteins.

Bertoni A, Giuliano P, Galgani M, Rotoli D, Ulianich L, Adornetto A, Santillo MR, Porcellini A, Avvedimento VE.

J Biol Chem. 2011 Feb 11;286(6):4727-41. doi: 10.1074/jbc.M110.156521. Epub 2010 Nov 28.


Menin stimulates homology-directed DNA repair.

Gallo A, Agnese S, Esposito I, Galgani M, Avvedimento VE.

FEBS Lett. 2010 Nov 19;584(22):4531-6. doi: 10.1016/j.febslet.2010.10.032. Epub 2010 Oct 20.


Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells.

Angrisano T, Sacchetti S, Natale F, Cerrato A, Pero R, Keller S, Peluso S, Perillo B, Avvedimento VE, Fusco A, Bruni CB, Lembo F, Santoro M, Chiariotti L.

Nucleic Acids Res. 2011 Mar;39(6):1993-2006. doi: 10.1093/nar/gkq864. Epub 2010 Oct 15.


AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress.

Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M.

Cardiovasc Res. 2010 Oct 1;88(1):101-10. doi: 10.1093/cvr/cvq155. Epub 2010 May 28.


DNA methylation in intron 1 of the frataxin gene is related to GAA repeat length and age of onset in Friedreich ataxia patients.

Castaldo I, Pinelli M, Monticelli A, Acquaviva F, Giacchetti M, Filla A, Sacchetti S, Keller S, Avvedimento VE, Chiariotti L, Cocozza S.

J Med Genet. 2008 Dec;45(12):808-12. doi: 10.1136/jmg.2008.058594. Epub 2008 Aug 12.


TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters.

Angrisano T, Lembo F, Pero R, Natale F, Fusco A, Avvedimento VE, Bruni CB, Chiariotti L.

Nucleic Acids Res. 2006 Jan 12;34(1):364-72. Print 2006. Erratum in: Nucleic Acids Res. 2014 Jan;42(2):1392.


An alternative model of H ferritin promoter transactivation by c-Jun.

Faniello MC, Chirico G, Quaresima B, Cuda G, Allevato G, Bevilacqua MA, Baudi F, Colantuoni V, Cimino F, Venuta S, Avvedimento VE, Costanzo F.

Biochem J. 2002 Apr 1;363(Pt 1):53-8.


Effects of glucocorticoids on activation of c-jun N-terminal, extracellular signal-regulated, and p38 MAP kinases in human pulmonary endothelial cells.

Pelaia G, Cuda G, Vatrella A, Grembiale RD, De Sarro G, Maselli R, Costanzo FS, Avvedimento VE, Rotiroti D, Marsico SA.

Biochem Pharmacol. 2001 Dec 15;62(12):1719-24.


Thyroid transcription factor 1 phosphorylation is not required for protein kinase A-dependent transcription of the thyroglobulin promoter.

Feliciello A, Allevato G, Musti AM, De Brasi D, Gallo A, Avvedimento VE, Gottesman ME.

Cell Growth Differ. 2000 Dec;11(12):649-54.


Screening of thyrotropin receptor mutations by fine-needle aspiration biopsy in autonomous functioning thyroid nodules in multinodular goiters.

Tassi V, Di Cerbo A, Porcellini A, Papini E, Cisternino C, Crescenzi A, Scillitani A, Pizzuti A, Ratti A, Trischitta V, Avvedimento VE, Fenzi G, De Filippis V.

Thyroid. 1999 Apr;9(4):353-7.


The B subunit of the CAAT-binding factor NFY binds the central segment of the Co-activator p300.

Faniello MC, Bevilacqua MA, Condorelli G, de Crombrugghe B, Maity SN, Avvedimento VE, Cimino F, Costanzo F.

J Biol Chem. 1999 Mar 19;274(12):7623-6.


Apolipoprotein A-I reverse transcriptase-polymerase chain reaction analysis for detection of hematogenous colon cancer dissemination.

Normanno N, De Luca A, Castaldo A, Casamassimi A, Di Popolo A, Zarrilli R, Porcellini A, Acquaviva AM, Avvedimento VE, Pignata S.

Int J Oncol. 1998 Sep;13(3):443-7.


p53 genes mutated in the DNA binding site or at a specific COOH-terminal site exert divergent effects on thyroid cell growth and differentiation.

Casamassimi A, Miano MG, Porcellini A, De Vita G, de Nigris F, Zannini M, Di Lauro R, Russo T, Avvedimento VE, Fusco A.

Cancer Res. 1998 Jul 1;58(13):2888-94.


A common mechanism underlying the E1A repression and the cAMP stimulation of the H ferritin transcription.

Bevilacqua MA, Faniello MC, Quaresima B, Tiano MT, Giuliano P, Feliciello A, Avvedimento VE, Cimino F, Costanzo F.

J Biol Chem. 1997 Aug 15;272(33):20736-41.


The v-erbA oncogene selectively inhibits iodide uptake in rat thyroid cells.

Trapasso F, Martelli ML, Battaglia C, Angotti E, Mele E, Stella A, Samarut J, Avvedimento VE, Fusco A.

Oncogene. 1996 May 2;12(9):1879-88.


The differential response of protein kinase A to cyclic AMP in discrete brain areas correlates with the abundance of regulatory subunit II.

Ventra C, Porcellini A, Feliciello A, Gallo A, Paolillo M, Mele E, Avvedimento VE, Schettini G.

J Neurochem. 1996 Apr;66(4):1752-61.


Effects of tissue factor induced by oxygen free radicals on coronary flow during reperfusion.

Golino P, Ragni M, Cirillo P, Avvedimento VE, Feliciello A, Esposito N, Scognamiglio A, Trimarco B, Iaccarino G, Condorelli M, Chiariello M, Ambrosio G.

Nat Med. 1996 Jan;2(1):35-40.


Smooth muscle cell proliferation is proportional to the degree of balloon injury in a rat model of angioplasty.

Indolfi C, Esposito G, Di Lorenzo E, Rapacciuolo A, Feliciello A, Porcellini A, Avvedimento VE, Condorelli M, Chiariello M.

Circulation. 1995 Sep 1;92(5):1230-5.


Differential expression of the asialoglycoprotein receptor in discrete brain areas, in kidney and thyroid.

Pacifico F, Laviola L, Ulianich L, Porcellini A, Ventra C, Consiglio E, Avvedimento VE.

Biochem Biophys Res Commun. 1995 May 5;210(1):138-44.


Ki-ras oncogene interferes with the expression of cyclic AMP-dependent promoters.

Gallo A, Feliciello A, Varrone A, Cerillo R, Gottesman ME, Avvedimento VE.

Cell Growth Differ. 1995 Jan;6(1):91-5.


Novel mutations of thyrotropin receptor gene in thyroid hyperfunctioning adenomas. Rapid identification by fine needle aspiration biopsy.

Porcellini A, Ciullo I, Laviola L, Amabile G, Fenzi G, Avvedimento VE.

J Clin Endocrinol Metab. 1994 Aug;79(2):657-61.


Reversible inhibition of a thyroid-specific trans-acting factor by Ras.

Avvedimento VE, Musti AM, Ueffing M, Obici S, Gallo A, Sanchez M, DeBrasi D, Gottesman ME.

Genes Dev. 1991 Jan;5(1):22-8.


The polarized epithelial phenotype is dominant in hybrids between polarized and unpolarized rat thyroid cell lines.

Zurzolo C, Gentile R, Mascia A, Garbi C, Polistina C, Aloj L, Avvedimento VE, Nitsch L.

J Cell Sci. 1991 Jan;98 ( Pt 1):65-73.


Polymorphism at the 5' end flanking region of the insulin gene is associated with reduced insulin secretion in healthy individuals.

Cocozza S, Riccardi G, Monticelli A, Capaldo B, Genovese S, Krogh V, Celentano E, Farinaro E, Varrone S, Avvedimento VE.

Eur J Clin Invest. 1988 Dec;18(6):582-6.


Neoplastic transformation inactivates specific trans-acting factor(s) required for the expression of the thyroglobulin gene.

Avvedimento VE, Musti A, Fusco A, Bonapace MJ, Di Lauro R.

Proc Natl Acad Sci U S A. 1988 Mar;85(6):1744-8.


Changes in cellular gene expression in rat thyroid epithelial cells transformed by the Kirsten murine sarcoma virus.

de Franciscis V, Avvedimento VE, Colletta G, Zimarino V, Ursini VM, Ciliberto F, Vecchio G.

Exp Cell Res. 1987 Aug;171(2):483-91.


Increased level of thyroglobulin mRNA in a human familial goiter.

Monticelli A, Avvedimento VE, Mariano A, Marcocci C, Chiovato L, Fenzi GF, Pinchera A, Varrone S.

J Endocrinol Invest. 1987 Feb;10(1):59-63.


Differential expression of thyroglobulin gene in normal and transformed thyroid cells.

Avvedimento VE, Monticelli A, Tramontano D, Polistina C, Nitsch L, Di Lauro R.

Eur J Biochem. 1985 Jun 18;149(3):467-72.


The sequence of 967 amino acids at the carboxyl-end of rat thyroglobulin. Location and surroundings of two thyroxine-forming sites.

Di Lauro R, Obici S, Condliffe D, Ursini VM, Musti A, Moscatelli C, Avvedimento VE.

Eur J Biochem. 1985 Apr 1;148(1):7-11.


Mapping of human thyroglobulin gene on the long arm of chromosome 8 by in situ hybridization.

Avvedimento VE, Di Lauro R, Monticelli A, Bernardi F, Patracchini P, Calzolari E, Martini G, Varrone S.

Hum Genet. 1985;71(2):163-6.


The level of thyroglobulin mRNA is regulated by TSH both in vitro and in vivo.

Avvedimento VE, Tramontano D, Ursini MV, Monticelli A, Di Lauro R.

Biochem Biophys Res Commun. 1984 Jul 18;122(1):472-7.


Structural organization of the 3' half of the rat thyroglobulin gene.

Avvedimento VE, Musti AM, Obici S, Cocozza S, Di Lauro R.

Nucleic Acids Res. 1984 Apr 25;12(8):3461-72.


Dissociation between transformed and differentiated phenotype in rat thyroid epithelial cells after transformation with a temperature-sensitive mutant of the Kirsten murine sarcoma virus.

Colletta G, Pinto A, Di Fiore PP, Fusco A, Ferrentino M, Avvedimento VE, Tsuchida N, Vecchio G.

Mol Cell Biol. 1983 Nov;3(11):2099-109.


A repetitive structure in the chick alpha 2-collagen gene.

Vogeli G, Ohkubo H, Avvedimento VE, Sullivan M, Yamada Y, Mudryj M, Pastan I, de Crombrugghe B.

Cold Spring Harb Symp Quant Biol. 1981;45 Pt 2:777-83. No abstract available.


The collagen gene: evidence for its evolutinary assembly by amplification of a DNA segment containing an exon of 54 bp.

Yamada Y, Avvedimento VE, Mudryj M, Ohkubo H, Vogeli G, Irani M, Pastan I, de Crombrugghe B.

Cell. 1980 Dec;22(3):887-92.


Isolation and characterization of overlapping genomic clones covering the chicken alpha 2 (type I) collagen gene.

Ohkubo H, Vogeli G, Mudryj M, Avvedimento VE, Sullivan M, Pastan I, de Crombrugghe B.

Proc Natl Acad Sci U S A. 1980 Dec;77(12):7059-63.


Correlation between splicing sites within an intron and their sequence complementarity with U1 RNA.

Avvedimento VE, Vogeli G, Yamada Y, Maizel JV Jr, Pastan I, de Crombrugghe B.

Cell. 1980 Oct;21(3):689-96.


Construction of a recombinant bacterial plasmid containing pro-alpha 1(I) collagen DNA sequences.

Yamamoto T, Sobel ME, Adams SL, Avvedimento VE, DiLauro R, Pastan I, de Crombrugghe B, Showalter A, Pesciotta D, Fietzek P, Olsen B.

J Biol Chem. 1980 Mar 25;255(6):2612-5.


Construction of a recombinant bacterial plasmid containing a chick pro-alpha2 collagen gene sequence.

Sobel ME, Yamamoto T, Adams SL, DiLauro R, Avvedimento VE, de Crombrugghe B, Pastan I.

Proc Natl Acad Sci U S A. 1978 Dec;75(12):5846-50.


[In vitro expression of the thyroid gland genome. Difference between chromatin and DNA].

Acquaviva AM, Avvedimento VE, Varrone S.

C R Seances Soc Biol Fil. 1978;172(6):1085-93. French.


Repetitive and non-repetitive sequences in the transcript in vitro of porcine thyroid chromatin.

Avvedimento VE, Acquaviva AM, Varrone S.

Eur J Biochem. 1977 Aug 15;78(1):1-10.

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