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Items: 1 to 50 of 200

1.

Liver-specific deletion of IGF2 mRNA binding protein-2/IMP2 reduces hepatic fatty acid oxidation and increases hepatic triglyceride accumulation.

Regué L, Minichiello L, Avruch J, Dai N.

J Biol Chem. 2019 Aug 2;294(31):11944-11951. doi: 10.1074/jbc.RA119.008778. Epub 2019 Jun 17.

2.

Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk.

Greenwald WW, Chiou J, Yan J, Qiu Y, Dai N, Wang A, Nariai N, Aylward A, Han JY, Kadakia N, Regue L, Okino ML, Drees F, Kramer D, Vinckier N, Minichiello L, Gorkin D, Avruch J, Frazer KA, Sander M, Ren B, Gaulton KJ.

Nat Commun. 2019 May 7;10(1):2078. doi: 10.1038/s41467-019-09975-4.

3.

IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism.

Regué L, Ji F, Flicker D, Kramer D, Pierce W, Davidoff T, Widrick JJ, Houstis N, Minichiello L, Dai N, Avruch J.

Mol Cell Biol. 2019 Mar 19;39(7). pii: e00528-18. doi: 10.1128/MCB.00528-18. Print 2019 Apr 1.

4.

Cryo-EM insight into the structure of MTOR complex 1 and its interactions with Rheb and substrates.

Chao LH, Avruch J.

F1000Res. 2019 Jan 3;8. pii: F1000 Faculty Rev-14. doi: 10.12688/f1000research.16109.1. eCollection 2019. Review.

5.

The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development.

Alsufyani F, Mattoo H, Zhou D, Cariappa A, Van Buren D, Hock H, Avruch J, Pillai S.

Front Immunol. 2018 Oct 17;9:2393. doi: 10.3389/fimmu.2018.02393. eCollection 2018.

6.

A novel model for ex situ reperfusion of the human liver following subnormothermic machine perfusion.

Avruch JH, Bruinsma BG, Weeder PD, Sridharan GV, Porte RJ, Yeh H, Markmann JF, Uygun K.

Technology (Singap World Sci). 2017 Dec;5(4):196-200. doi: 10.1142/S2339547817500108. Epub 2017 Nov 10.

7.

IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1.

Dai N, Ji F, Wright J, Minichiello L, Sadreyev R, Avruch J.

Elife. 2017 Jul 28;6. pii: e27155. doi: 10.7554/eLife.27155.

8.

Peritransplant Energy Changes and Their Correlation to Outcome After Human Liver Transplantation.

Bruinsma BG, Avruch JH, Sridharan GV, Weeder PD, Jacobs ML, Crisalli K, Amundsen B, Porte RJ, Markmann JF, Uygun K, Yeh H.

Transplantation. 2017 Jul;101(7):1637-1644. doi: 10.1097/TP.0000000000001699.

9.

MST1/MST2 Protein Kinases: Regulation and Physiologic Roles.

Galan JA, Avruch J.

Biochemistry. 2016 Oct 4;55(39):5507-5519. Epub 2016 Sep 26. Review.

10.

Metabolic profiling during ex vivo machine perfusion of the human liver.

Bruinsma BG, Sridharan GV, Weeder PD, Avruch JH, Saeidi N, Özer S, Geerts S, Porte RJ, Heger M, van Gulik TM, Martins PN, Markmann JF, Yeh H, Uygun K.

Sci Rep. 2016 Mar 3;6:22415. doi: 10.1038/srep22415.

11.

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.

Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, Hong L, Xie C, Li X, Zhao H, Liu Q, Jiang M, Chen Q, Zhang J, Li Y, Song S, Wang HR, Zhou R, Johnson RL, Chien KY, Lin SC, Han J, Avruch J, Chen L, Zhou D.

Nat Immunol. 2015 Nov;16(11):1142-52. doi: 10.1038/ni.3268. Epub 2015 Sep 28.

12.

Functional human liver preservation and recovery by means of subnormothermic machine perfusion.

Bruinsma BG, Avruch JH, Weeder PD, Sridharan GV, Uygun BE, Karimian NG, Porte RJ, Markmann JF, Yeh H, Uygun K.

J Vis Exp. 2015 Apr 27;(98). doi: 10.3791/52777.

13.

IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins.

Dai N, Zhao L, Wrighting D, Krämer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J.

Cell Metab. 2015 Apr 7;21(4):609-21. doi: 10.1016/j.cmet.2015.03.006.

14.

Co-transplantation of autologous MSCs delays islet allograft rejection and generates a local immunoprivileged site.

Ben Nasr M, Vergani A, Avruch J, Liu L, Kefaloyianni E, D'Addio F, Tezza S, Corradi D, Bassi R, Valderrama-Vasquez A, Usuelli V, Kim J, Azzi J, El Essawy B, Markmann J, Abdi R, Fiorina P.

Acta Diabetol. 2015 Oct;52(5):917-27. doi: 10.1007/s00592-015-0735-y. Epub 2015 Mar 27.

15.

A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation.

Papageorgiou A, Rapley J, Mesirov JP, Tamayo P, Avruch J.

PLoS One. 2015 Mar 19;10(3):e0116096. doi: 10.1371/journal.pone.0116096. eCollection 2015.

16.

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression.

Fitamant J, Kottakis F, Benhamouche S, Tian HS, Chuvin N, Parachoniak CA, Nagle JM, Perera RM, Lapouge M, Deshpande V, Zhu AX, Lai A, Min B, Hoshida Y, Avruch J, Sia D, Campreciós G, McClatchey AI, Llovet JM, Morrissey D, Raj L, Bardeesy N.

Cell Rep. 2015 Mar 17;10(10):1692-1707. doi: 10.1016/j.celrep.2015.02.027. Epub 2015 Mar 12.

17.

Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment.

Matsumoto H, Murakami Y, Kataoka K, Lin H, Connor KM, Miller JW, Zhou D, Avruch J, Vavvas DG.

Cell Death Dis. 2014 May 29;5:e1269. doi: 10.1038/cddis.2014.218.

18.

Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.

Oshiro N, Rapley J, Avruch J.

J Biol Chem. 2014 Jan 31;289(5):2658-74. doi: 10.1074/jbc.M113.528505. Epub 2013 Dec 11.

19.

The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.

Wu H, Xiao Y, Zhang S, Ji S, Wei L, Fan F, Geng J, Tian J, Sun X, Qin F, Jin C, Lin J, Yin ZY, Zhang T, Luo L, Li Y, Song S, Lin SC, Deng X, Camargo F, Avruch J, Chen L, Zhou D.

Cell Rep. 2013 May 30;3(5):1663-77. doi: 10.1016/j.celrep.2013.04.020. Epub 2013 May 16.

20.

Hippo signaling regulates differentiation and maintenance in the exocrine pancreas.

Gao T, Zhou D, Yang C, Singh T, Penzo-Méndez A, Maddipati R, Tzatsos A, Bardeesy N, Avruch J, Stanger BZ.

Gastroenterology. 2013 Jun;144(7):1543-53, 1553.e1. doi: 10.1053/j.gastro.2013.02.037. Epub 2013 Feb 27.

22.

mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts.

Dai N, Christiansen J, Nielsen FC, Avruch J.

Genes Dev. 2013 Feb 1;27(3):301-12. doi: 10.1101/gad.209130.112.

23.

Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes.

Faustman DL, Wang L, Okubo Y, Burger D, Ban L, Man G, Zheng H, Schoenfeld D, Pompei R, Avruch J, Nathan DM.

PLoS One. 2012;7(8):e41756. doi: 10.1371/journal.pone.0041756. Epub 2012 Aug 8.

24.

Protein kinases of the Hippo pathway: regulation and substrates.

Avruch J, Zhou D, Fitamant J, Bardeesy N, Mou F, Barrufet LR.

Semin Cell Dev Biol. 2012 Sep;23(7):770-84. doi: 10.1016/j.semcdb.2012.07.002. Epub 2012 Aug 9. Review.

25.

Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.

Kyriakis JM, Avruch J.

Physiol Rev. 2012 Apr;92(2):689-737. doi: 10.1152/physrev.00028.2011. Review.

26.

Hippo pathway in intestinal homeostasis and tumorigenesis.

Chen L, Qin F, Deng X, Avruch J, Zhou D.

Protein Cell. 2012 Apr;3(4):305-10. doi: 10.1007/s13238-012-2913-9. Epub 2012 Apr 10. Review.

27.

The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.

Mou F, Praskova M, Xia F, Van Buren D, Hock H, Avruch J, Zhou D.

J Exp Med. 2012 Apr 9;209(4):741-59. doi: 10.1084/jem.20111692. Epub 2012 Mar 12.

28.

YAP oncogene overexpression supercharges colon cancer proliferation.

Avruch J, Zhou D, Bardeesy N.

Cell Cycle. 2012 Mar 15;11(6):1090-6. doi: 10.4161/cc.11.6.19453. Epub 2012 Mar 15. Review.

29.

A genome-wide RNAi screen for polypeptides that alter rpS6 phosphorylation.

Papageorgiou A, Avruch J.

Methods Mol Biol. 2012;821:187-214. doi: 10.1007/978-1-61779-430-8_11.

30.

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance.

Zhou D, Zhang Y, Wu H, Barry E, Yin Y, Lawrence E, Dawson D, Willis JE, Markowitz SD, Camargo FD, Avruch J.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):E1312-20. doi: 10.1073/pnas.1110428108. Epub 2011 Oct 31.

31.

The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling.

Rapley J, Oshiro N, Ortiz-Vega S, Avruch J.

J Biol Chem. 2011 Nov 4;286(44):38043-53. doi: 10.1074/jbc.M111.245449. Epub 2011 Sep 13.

32.

Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.

Bertran MT, Sdelci S, Regué L, Avruch J, Caelles C, Roig J.

EMBO J. 2011 Jun 3;30(13):2634-47. doi: 10.1038/emboj.2011.179.

33.

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.

Dai N, Rapley J, Angel M, Yanik MF, Blower MD, Avruch J.

Genes Dev. 2011 Jun 1;25(11):1159-72. doi: 10.1101/gad.2042311. Epub 2011 May 16.

34.

Yap1 acts downstream of α-catenin to control epidermal proliferation.

Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, Camargo FD.

Cell. 2011 Mar 4;144(5):782-95. doi: 10.1016/j.cell.2011.02.031.

35.

Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development.

Avruch J, Zhou D, Fitamant J, Bardeesy N.

Br J Cancer. 2011 Jan 4;104(1):24-32. doi: 10.1038/sj.bjc.6606011. Epub 2010 Nov 23. Review.

36.

Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis.

Park J, Kang SI, Lee SY, Zhang XF, Kim MS, Beers LF, Lim DS, Avruch J, Kim HS, Lee SB.

J Biol Chem. 2010 Nov 5;285(45):35029-38. doi: 10.1074/jbc.M110.165506. Epub 2010 Sep 1.

37.

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.

Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, Bardeesy N.

Cancer Cell. 2009 Nov 6;16(5):425-38. doi: 10.1016/j.ccr.2009.09.026.

38.

pTOM, a vector for expressing two proteins in mammalian cells.

Lin Y, Avruch J.

Anal Biochem. 2009 May 15;388(2):353-5. doi: 10.1016/j.ab.2009.03.015. Epub 2009 Mar 19.

39.

Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor.

Avruch J, Long X, Lin Y, Ortiz-Vega S, Rapley J, Papageorgiou A, Oshiro N, Kikkawa U.

Biochem Soc Trans. 2009 Feb;37(Pt 1):223-6. doi: 10.1042/BST0370223. Review.

PMID:
19143636
40.

Rassf family of tumor suppressor polypeptides.

Avruch J, Xavier R, Bardeesy N, Zhang XF, Praskova M, Zhou D, Xia F.

J Biol Chem. 2009 Apr 24;284(17):11001-5. doi: 10.1074/jbc.R800073200. Epub 2008 Dec 17. Review.

41.

The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.

Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20321-6. doi: 10.1073/pnas.0810773105. Epub 2008 Dec 10.

42.

The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.

Patursky-Polischuk I, Stolovich-Rain M, Hausner-Hanochi M, Kasir J, Cybulski N, Avruch J, Rüegg MA, Hall MN, Meyuhas O.

Mol Cell Biol. 2009 Feb;29(3):640-9. doi: 10.1128/MCB.00980-08. Epub 2008 Dec 1. Erratum in: Mol Cell Biol. 2009 Mar;29(6):1670.

43.

The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation.

Rapley J, Nicolàs M, Groen A, Regué L, Bertran MT, Caelles C, Avruch J, Roig J.

J Cell Sci. 2008 Dec 1;121(Pt 23):3912-21. doi: 10.1242/jcs.035360. Epub 2008 Nov 11.

44.

Characterization of two Mst1-deficient mouse models.

Anguera MC, Liu M, Avruch J, Lee JT.

Dev Dyn. 2008 Nov;237(11):3424-34. doi: 10.1002/dvdy.21764.

45.

Amino acid regulation of TOR complex 1.

Avruch J, Long X, Ortiz-Vega S, Rapley J, Papageorgiou A, Dai N.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E592-602. doi: 10.1152/ajpendo.90645.2008. Epub 2008 Sep 2. Review.

46.

A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.

Hagan GN, Lin Y, Magnuson MA, Avruch J, Czech MP.

Mol Cell Biol. 2008 Jul;28(13):4215-26. doi: 10.1128/MCB.00867-07. Epub 2008 Apr 21.

47.

MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.

Praskova M, Xia F, Avruch J.

Curr Biol. 2008 Mar 11;18(5):311-21. doi: 10.1016/j.cub.2008.02.006.

48.

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.

Oshiro N, Takahashi R, Yoshino K, Tanimura K, Nakashima A, Eguchi S, Miyamoto T, Hara K, Takehana K, Avruch J, Kikkawa U, Yonezawa K.

J Biol Chem. 2007 Jul 13;282(28):20329-39. Epub 2007 May 21.

49.

The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.

Long X, Lin Y, Ortiz-Vega S, Busch S, Avruch J.

J Biol Chem. 2007 Jun 22;282(25):18542-51. Epub 2007 Apr 30.

50.

MAP kinase pathways: the first twenty years.

Avruch J.

Biochim Biophys Acta. 2007 Aug;1773(8):1150-60. Epub 2006 Nov 15. Review.

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