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Items: 42


The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts.

Baur J, Otto C, Steger U, Klein-Hessling S, Muhammad K, Pusch T, Murti K, Wismer R, Germer CT, Klein I, Müller N, Serfling E, Avots A.

Front Immunol. 2018 Jun 12;9:1338. doi: 10.3389/fimmu.2018.01338. eCollection 2018.


NFATc1 controls the cytotoxicity of CD8+ T cells.

Klein-Hessling S, Muhammad K, Klein M, Pusch T, Rudolf R, Flöter J, Qureischi M, Beilhack A, Vaeth M, Kummerow C, Backes C, Schoppmeyer R, Hahn U, Hoth M, Bopp T, Berberich-Siebelt F, Patra A, Avots A, Müller N, Schulze A, Serfling E.

Nat Commun. 2017 Sep 11;8(1):511. doi: 10.1038/s41467-017-00612-6.


Corrigendum: NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.

Alrefai H, Muhammad K, Rudolf R, Pham DAT, Klein-Hessling S, Patra AK, Avots A, Bukur V, Sahin U, Tenzer S, Goebeler M, Kerstan A, Serfling E.

Nat Commun. 2016 Aug 2;7:12421. doi: 10.1038/ncomms12421. No abstract available.


A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development.

Klein-Hessling S, Rudolf R, Muhammad K, Knobeloch KP, Maqbool MA, Cauchy P, Andrau JC, Avots A, Talora C, Ellenrieder V, Screpanti I, Serfling E, Patra AK.

Nat Commun. 2016 Jun 17;7:11841. doi: 10.1038/ncomms11841.


NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.

Alrefai H, Muhammad K, Rudolf R, Pham DA, Klein-Hessling S, Patra AK, Avots A, Bukur V, Sahin U, Tenzer S, Goebeler M, Kerstan A, Serfling E.

Nat Commun. 2016 May 25;7:11724. doi: 10.1038/ncomms11724. Erratum in: Nat Commun. 2016 Aug 02;7:12421.


NFATc1 releases BCL6-dependent repression of CCR2 agonist expression in peritoneal macrophages from Saccharomyces cerevisiae infected mice.

Busch R, Murti K, Liu J, Patra AK, Muhammad K, Knobeloch KP, Lichtinger M, Bonifer C, Wörtge S, Waisman A, Reifenberg K, Ellenrieder V, Serfling E, Avots A.

Eur J Immunol. 2016 Mar;46(3):634-46. doi: 10.1002/eji.201545925. Epub 2016 Jan 8.


NF-κB factors control the induction of NFATc1 in B lymphocytes.

Muhammad K, Alrefai H, Marienfeld R, Pham DA, Murti K, Patra AK, Avots A, Bukur V, Sahin U, Kondo E, Klein-Hessling S, Serfling E.

Eur J Immunol. 2014 Nov;44(11):3392-402. doi: 10.1002/eji.201444756. Epub 2014 Sep 26.


Architecture and expression of the nfatc1 gene in lymphocytes.

Rudolf R, Busch R, Patra AK, Muhammad K, Avots A, Andrau JC, Klein-Hessling S, Serfling E.

Front Immunol. 2014 Feb 3;5:21. doi: 10.3389/fimmu.2014.00021. eCollection 2014. Review.


NFATc1 induction in peripheral T and B lymphocytes.

Hock M, Vaeth M, Rudolf R, Patra AK, Pham DA, Muhammad K, Pusch T, Bopp T, Schmitt E, Rost R, Berberich-Siebelt F, Tyrsin D, Chuvpilo S, Avots A, Serfling E, Klein-Hessling S.

J Immunol. 2013 Mar 1;190(5):2345-53. doi: 10.4049/jimmunol.1201591. Epub 2013 Jan 30.


An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development.

Patra AK, Avots A, Zahedi RP, Schüler T, Sickmann A, Bommhardt U, Serfling E.

Nat Immunol. 2013 Feb;14(2):127-35. doi: 10.1038/ni.2507. Epub 2012 Dec 23.


NFATc1/αA: The other Face of NFAT Factors in Lymphocytes.

Serfling E, Avots A, Klein-Hessling S, Rudolf R, Vaeth M, Berberich-Siebelt F.

Cell Commun Signal. 2012 Jul 5;10(1):16. doi: 10.1186/1478-811X-10-16.


NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network.

Bhattacharyya S, Deb J, Patra AK, Thuy Pham DA, Chen W, Vaeth M, Berberich-Siebelt F, Klein-Hessling S, Lamperti ED, Reifenberg K, Jellusova J, Schweizer A, Nitschke L, Leich E, Rosenwald A, Brunner C, Engelmann S, Bommhardt U, Avots A, Müller MR, Kondo E, Serfling E.

J Exp Med. 2011 Apr 11;208(4):823-39. doi: 10.1084/jem.20100945. Epub 2011 Apr 4.


Transcriptional programming in the immune system: report on the International Workshop of the Transregio TR52, November 17-20, 2010 in Würzburg, Germany.

Berberich-Siebelt F, Avots A, Serfling E.

Eur J Immunol. 2011 Apr;41(4):885-8. doi: 10.1002/eji.201190016. No abstract available.


Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1).

Vaeth M, Gogishvili T, Bopp T, Klein M, Berberich-Siebelt F, Gattenloehner S, Avots A, Sparwasser T, Grebe N, Schmitt E, Hünig T, Serfling E, Bodor J.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2480-5. doi: 10.1073/pnas.1009463108. Epub 2011 Jan 24.


Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling.

Akimzhanov A, Krenacs L, Schlegel T, Klein-Hessling S, Bagdi E, Stelkovics E, Kondo E, Chuvpilo S, Wilke P, Avots A, Gattenlöhner S, Müller-Hermelink HK, Palmetshofer A, Serfling E.

Am J Pathol. 2008 Jan;172(1):215-24. Epub 2007 Dec 21.


NFAT in lymphocytes: a factor for all events?

Serfling E, Berberich-Siebelt F, Avots A.

Sci STKE. 2007 Aug 7;2007(398):pe42. Review.


IL-2 induction by simian immunodeficiency virus involves MAP kinase signaling but is independent of calcineurin/NF-AT activity.

Muckenfuss H, Hamdorf M, Avots A, Sanzenbacher R, Tschulena U, Cichutek K, Flory E.

Mol Immunol. 2006 Mar;43(8):1172-82. Epub 2005 Aug 24.


HOXB4 confers a constant rate of in vitro proliferation to transduced bone marrow cells.

Schmittwolf C, Porsch M, Greiner A, Avots A, Müller AM.

Oncogene. 2005 Jan 20;24(4):561-72.


NFAT and NF-kappaB factors-the distant relatives.

Serfling E, Berberich-Siebelt F, Avots A, Chuvpilo S, Klein-Hessling S, Jha MK, Kondo E, Pagel P, Schulze-Luehrmann J, Palmetshofer A.

Int J Biochem Cell Biol. 2004 Jul;36(7):1166-70. Review.


Bruton's tyrosine kinase is activated upon CD40 stimulation in human B lymphocytes.

Brunner C, Avots A, Kreth HW, Serfling E, Schuster V.

Immunobiology. 2002 Oct;206(4):432-40.


The CD23b promoter is a target for NF-AT transcription factors in B-CLL cells.

Kneitz C, Goller M, Tony H, Simon A, Stibbe C, König T, Serfling E, Avots A.

Biochim Biophys Acta. 2002 Oct 9;1588(1):41-7.


Plasticity of hematopoietic stem cells and cellular memory.

Avots A, Harder F, Schmittwolf C, Petrovic S, Müller AM.

Immunol Rev. 2002 Sep;187:9-21. Review.


Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes.

Schulze-Luehrmann J, Santner-Nanan B, Jha MK, Schimpl A, Avots A, Serfling E.

Blood. 2002 Aug 1;100(3):954-60.


Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis.

Chuvpilo S, Jankevics E, Tyrsin D, Akimzhanov A, Moroz D, Jha MK, Schulze-Luehrmann J, Santner-Nanan B, Feoktistova E, König T, Avots A, Schmitt E, Berberich-Siebelt F, Schimpl A, Serfling E.

Immunity. 2002 Jun;16(6):881-95.


Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.

Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S.

Nat Med. 2001 Jun;7(6):725-31.


The role of NF-AT transcription factors in T cell activation and differentiation.

Serfling E, Berberich-Siebelt F, Chuvpilo S, Jankevics E, Klein-Hessling S, Twardzik T, Avots A.

Biochim Biophys Acta. 2000 Oct 20;1498(1):1-18. Review.


CD4-mediated signals induce T cell dysfunction in vivo.

Chirmule N, Avots A, LakshmiTamma SM, Pahwa S, Serfling E.

J Immunol. 1999 Jul 15;163(2):644-9.


CBP/p300 integrates Raf/Rac-signaling pathways in the transcriptional induction of NF-ATc during T cell activation.

Avots A, Buttmann M, Chuvpilo S, Escher C, Smola U, Bannister AJ, Rapp UR, Kouzarides T, Serfling E.

Immunity. 1999 May;10(5):515-24.


Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes.

Chuvpilo S, Avots A, Berberich-Siebelt F, Glöckner J, Fischer C, Kerstan A, Escher C, Inashkina I, Hlubek F, Jankevics E, Brabletz T, Serfling E.

J Immunol. 1999 Jun 15;162(12):7294-301.


Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells.

Chuvpilo S, Zimmer M, Kerstan A, Glöckner J, Avots A, Escher C, Fischer C, Inashkina I, Jankevics E, Berberich-Siebelt F, Schmitt E, Serfling E.

Immunity. 1999 Feb;10(2):261-9.


The GABP-responsive element of the interleukin-2 enhancer is regulated by JNK/SAPK-activating pathways in T lymphocytes.

Hoffmeyer A, Avots A, Flory E, Weber CK, Serfling E, Rapp UR.

J Biol Chem. 1998 Apr 24;273(17):10112-9.


GABP factors bind to a distal interleukin 2 (IL-2) enhancer and contribute to c-Raf-mediated increase in IL-2 induction.

Avots A, Hoffmeyer A, Flory E, Cimanis A, Rapp UR, Serfling E.

Mol Cell Biol. 1997 Aug;17(8):4381-9.


Cyclosporin A interferes with the inducible degradation of NF-kappa B inhibitors, but not with the processing of p105/NF-kappa B1 in T cells.

Marienfeld R, Neumann M, Chuvpilo S, Escher C, Kneitz B, Avots A, Schimpl A, Serfling E.

Eur J Immunol. 1997 Jul;27(7):1601-9.


Nuclear NF-ATp is a hallmark of unstimulated B cells from B-CLL patients.

Schuh K, Avots A, Tony HP, Serfling E, Kneitz C.

Leuk Lymphoma. 1996 Nov;23(5-6):583-92.


The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation.

Serfling E, Avots A, Neumann M.

Biochim Biophys Acta. 1995 Sep 19;1263(3):181-200. Review. No abstract available.


The interplay between lymphoid-specific and ubiquitous transcription factors controls the expression of interleukin 2 gene in T lymphocytes.

Avots A, Escher C, Müller-Deubert S, Neumann M, Serfling E.

Immunobiology. 1995 Jul;193(2-4):254-8. Review. No abstract available.


Combined laparoscopic and endoscopic management of cholelithiasis and choledocholithiasis.

Frazee RC, Roberts J, Symmonds R, Hendricks JC, Snyder S, Smith R, Custer MD, Stoltenberg P, Avots A.

Am J Surg. 1993 Dec;166(6):702-5; discussion 705-6.


Complete nucleotide sequence of the group I RNA bacteriophage fr.

Adhin MR, Avots A, Berzin V, Overbeek GP, van Duin J.

Biochim Biophys Acta. 1990 Aug 27;1050(1-3):104-9.


Sequence of the genes coding for the A-protein and coat protein of bacteriophage fr.

Berzin V, Avots A, Jansone I, Gintnere L, Tsimanis A.

Nucleic Acids Res. 1987 Aug 25;15(16):6741. No abstract available.


[Primary structure of a fragment of cDNA from phage fr].

Berzin' VM, Avots AIa, Iansone IV, Tsimanis AIu.

Bioorg Khim. 1986 Jan;12(1):149-52. Russian.


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